2025
Efficacy of anal botulinum toxin injection in children with functional constipation
Patel D, Saikumar P, Jayaraman M, Desai C, Rosen J, Rodriguez L. Efficacy of anal botulinum toxin injection in children with functional constipation. Journal Of Pediatric Gastroenterology And Nutrition 2025, 80: 956-962. PMID: 40123476, DOI: 10.1002/jpn3.70040.Peer-Reviewed Original ResearchConceptsResponse to therapyBotulinum toxin injectionFunctional constipationMedical therapyBotulinum toxinGroup 2Group 1No factorsGroup 3Side effectsRefractory to medical therapyResults of anorectal manometryDevelopmental delayDevelopment of side effectsPediatric age groupFrequency of BMPresence of developmental delayDose of botulinum toxinMedian doseMedian followAnorectal manometryMedian ageMulticenter studyBM frequencyLaxative regimens
2024
SAT-283 Tumor-Induced Osteomalacia Disease Monitoring Program: A Longitudinal Cohort Study on An Ultra-Rare Disease
De Beur S, Dahir K, Imel E, Zanchetta M, Li J, Hetzer J, Ciğeroğlu O, Carpenter T. SAT-283 Tumor-Induced Osteomalacia Disease Monitoring Program: A Longitudinal Cohort Study on An Ultra-Rare Disease. Journal Of The Endocrine Society 2024, 8: bvae163.2316. PMCID: PMC12047137, DOI: 10.1210/jendso/bvae163.2316.Peer-Reviewed Original ResearchTumor-induced osteomalaciaGroup 1Group 2Group 3Burosumab treatmentTreatment of tumor-induced osteomalaciaData cutoff dateDiagnosis to enrollmentSafety of burosumabComplete surgical removalRenal phosphate wastingHuman monoclonal antibodyEfficacy of burosumabLong-term safetyAge of subjectsTime of enrollmentBone painMean doseLongitudinal cohort studyMesenchymal tumorsSurgical removalMusculoskeletal painClinical manifestationsConventional therapyPhosphate wastingDiuretic dosing and outcomes with torsemide and furosemide following hospitalization for heart failure: The TRANSFORM‐HF trial
Nouhravesh N, Greene S, Clare R, Wojdyla D, Anstrom K, Velazquez E, Pitt B, Mentz R, Psotka M. Diuretic dosing and outcomes with torsemide and furosemide following hospitalization for heart failure: The TRANSFORM‐HF trial. European Journal Of Heart Failure 2024, 27: 317-324. PMID: 39363809, PMCID: PMC11859763, DOI: 10.1002/ejhf.3458.Peer-Reviewed Original ResearchLoop diuretic doseDiuretic doseHeart failureDiuretic typeKCCQ-CSSClinical outcomesKansas City Cardiomyopathy Questionnaire clinical summary scoreGroup 2High dosesHigher loop diuretic dosesGroup 3High doses of furosemideDose group 2Associated with increased riskDose of furosemideClinical summary scoreSecondary clinical outcomesPatient-reported outcomesPost Hoc AnalysisFurosemide equivalentsDose groupDischarge doseTRANSFORM-HFClinical eventsGroup 1Efficacy and Safety of Aficamten in Patients with Obstructive Hypertrophic Cardiomyopathy and Very High Left Ventricular Outflow Tract Gradients
Veselka J, Abraham T, Barriales-Villa R, Claggett B, Coats C, Hegde S, Januzzi J, Maron M, Masri A, Miao Z, Nassif M, Olivotto I, Jacoby D, Heitner S, Kupfer S, Malik F, Meng L, Wohltman A, Gimeno J. Efficacy and Safety of Aficamten in Patients with Obstructive Hypertrophic Cardiomyopathy and Very High Left Ventricular Outflow Tract Gradients. Journal Of Cardiac Failure 2024, 30: s9. DOI: 10.1016/j.cardfail.2024.08.014.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathyOutflow tract gradientSecondary endpointsHypertrophic cardiomyopathyCardiac biomarkersPhase 3 placebo-controlled trialsLeft ventricular outflow tract gradientGroup 2Group 1Symptomatic obstructive hypertrophic cardiomyopathyTreatment-emergent adverse eventsExercise capacityEmergent adverse eventsBaseline to weekEffective treatment optionInhibitor therapyNT-proBNPPrimary endpointEchocardiographic dataBetween-group differencesBaseline characteristicsAficamtenAdverse eventsTreatment optionsSymptom reliefThe Italian experience on liver transplantation for unresectable peri-hilar cholangiocarcinoma: a national survey and future perspectives
Gringeri E, Furlanetto A, Billato I, Cescon M, De Carlis L, Mazzaferro V, Romagnoli R, De Simone P, Vivarelli M, Di Benedetto F, Ravaioli M, Lauterio A, Sposito C, Patrono D, Ghinolfi D, Moccheggiani F, Di Sandro S, D’Amico F, Lanari J, Gambato M, Trapani S, Bergamo F, Cardillo M, Burra P, Cillo U. The Italian experience on liver transplantation for unresectable peri-hilar cholangiocarcinoma: a national survey and future perspectives. Updates In Surgery 2024, 76: 2505-2513. PMID: 39210194, DOI: 10.1007/s13304-024-01889-1.Peer-Reviewed Original ResearchNeoadjuvant radio-chemotherapyPerihilar cholangiocarcinomaLiver transplantationGroup 1Radio-chemotherapyGroup 2Standard of care chemotherapyRisk of cancer-related deathInclusion criteriaPeri-hilar cholangiocarcinomaRecurrence-free survivalResults of LTRisk regression analysisCancer-related deathsLiver transplant centersMayo protocolNeoadjuvant regimenNeoadjuvant treatmentCare chemotherapyOverall survivalProspective studyMayo ClinicHazard ratioTransplant centersIneffective treatmentWhat is the optimal number of embryos to transfer for POSEIDON group 1 and group 2? A retrospective study
Liu R, Zhang Q, Geng L, He H, Xu C, Feng J, Song M, Cao Y, Wang T, Xia X. What is the optimal number of embryos to transfer for POSEIDON group 1 and group 2? A retrospective study. Journal Of Ovarian Research 2024, 17: 117. PMID: 38822354, PMCID: PMC11140960, DOI: 10.1186/s13048-024-01443-y.Peer-Reviewed Original ResearchConceptsPatient-Oriented Strategies Encompassing IndividualizeD Oocyte NumberElective single embryo transferFrozen-thawed embryo transferDouble embryo transferLive birth rateElective single embryo transfer groupDouble embryo transfer groupEmbryo transfer strategyLow prognosis patientsMultiple birth rateEmbryo transferGroup 2Group 1Blastocyst transferFrozen cyclesFrozen-thawed embryo transfer cyclesBirth rateMethodsA retrospective cohort studyIndividualizeD Oocyte NumberPOSEIDON groups 1Single embryo transferRetrospective cohort studyPrognosis patientsPoor respondersTransferred embryosImmune checkpoint inhibitors in high‐grade upper tract urothelial carcinoma: Paradigm shift emphasizing organ preservation
Khalil M, Fishman A, Komorowski A, Franco I, Grasso M. Immune checkpoint inhibitors in high‐grade upper tract urothelial carcinoma: Paradigm shift emphasizing organ preservation. BJUI Compass 2024, 5: 604-610. PMID: 38751949, PMCID: PMC11090768, DOI: 10.1002/bco2.335.Peer-Reviewed Original ResearchImmune check point inhibitorsHigh-grade upper tract urothelial carcinomaUpper tract urothelial carcinomaMetastasis-free survival ratesGroup 2Group 1Survival rateUrothelial carcinomaSurvival outcomesMedian follow-up periodImpact of clinical characteristicsCheck-point inhibitorsImmune checkpoint inhibitorsEndoscopically treated patientsInitial tumor sizeImprove survival outcomesOverall survival rateKaplan-Meier analysisFollow-up periodImproved survival ratesCheckpoint inhibitorsPoint inhibitorsExtirpative surgeryTumor sizeClinical characteristics
2023
P1: Dosing and treatment outcomes of rTMS for treatment-resistant depressed older adults in a naturalistic outpatient clinic population.
Tan A, Patricia A, Hershenberg R, Chatham A, Giampetruzzi E, Tsygankova V, Job G, Crowell A, Posse P, McDonald W, Kitay B. P1: Dosing and treatment outcomes of rTMS for treatment-resistant depressed older adults in a naturalistic outpatient clinic population. International Psychogeriatrics 2023, 35: 191-192. DOI: 10.1017/s1041610223003368.Peer-Reviewed Original ResearchRepetitive transcranial magnetic stimulationTreatment-resistant depressionWithin-group reductionsAnxiety scoresAnxiety symptom severityGroup 2Repetitive transcranial magnetic stimulation studiesGroup 1Depressed older adultsCognitive side effectsSelf-reported depressionEffects of repetitive transcranial magnetic stimulationReduction of depressionOlder adultsReduction of anxietyInternational meta-analysesAdult patientsRetrospective chart review of patientsChart review of patientsOutpatient sampleAnxiety symptomsResponse rateTranscranial magnetic stimulationDepressive symptomsNon-older patientsHER2 amplification in cases with low HER2 expression by immunohistochemistry (IHC): A Single Institutional Experience
Podany P, Golastani R, Zhan H, Liang Y, Harigopal M, Krishnamurti U. HER2 amplification in cases with low HER2 expression by immunohistochemistry (IHC): A Single Institutional Experience. American Journal Of Clinical Pathology 2023, 160: s9-s10. DOI: 10.1093/ajcp/aqad150.021.Peer-Reviewed Original ResearchLow HER2 expressionInvasive breast carcinomaIHC scoreHER2 expressionGroup 1Group 3HER2 immunohistochemistryHER2 testingGroup 2HER2 FISHGroup 4ASCO/CAP guidelinesGroup 5Single institutional experienceRecent clinical trialsStandard of careASCO/CAP 2018 guidelinesHER2/CEP17 ratioEquivocal HER2HER2 positivityTrastuzumab deruxtecanMore patientsCAP guidelinesPatient eligibilityCase reportTreatment Patterns and Outcomes of Patients with Acute Myeloid Leukemia (AML) from 2013 to 2022: A Connect ® Myeloid Registry Study
Grinblatt D, Roboz G, Pollyea D, Sekeres M, Scott B, Seiter K, Zeidan A, Patel J, Garcia-Manero G, Komrokji R, Savona M, Degutis I, Kiselev P, Yu E, Heydendael W, Qiu Y, Vergara S, McBride A, Erba H. Treatment Patterns and Outcomes of Patients with Acute Myeloid Leukemia (AML) from 2013 to 2022: A Connect ® Myeloid Registry Study. Blood 2023, 142: 593. DOI: 10.1182/blood-2023-189963.Peer-Reviewed Original ResearchAcute myeloid leukemiaYears of ageMedian overall survivalProportion of patientsOverall survivalRate of transplantGroup 2Group 1Molecular testingTreatment patternsAML cohortMedian (95% CI) OSMyeloid diseasesReal-world clinical practiceWorld Health Organization criteriaIntensive chemotherapy regimensLow-intensity chemotherapyObservational cohort studyOutcomes of patientsFirst-line treatmentKaplan-Meier methodProspective observational studyYear of diagnosisDate of diagnosisTreatment of patients0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial
Sun H, Zinchuk A, Locascio J, Kushida C, Thomas R, Westover M. 0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial. Sleep 2023, 46: a230-a231. DOI: 10.1093/sleep/zsad077.0522.Peer-Reviewed Original ResearchObstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudyPrimary analysisIndividual treatment effectsIntroduction Obstructive sleep apneaSecondary analysisLong-term Efficacy StudyBaseline cognitive scoresBrain age indexBaseline AHIBaseline polysomnogramMulticenter trialRandomized trialsSleep apneaAdherence ratesOSA treatmentTwo-armGroup 2Group 1Efficacy studiesCognitive impairmentCPAPBaseline cognitionMore depressionCognitive scores
2022
OR13-2 Characterizing the Impact of Burosumab on Bone Health in Children with X-Linked Hypophosphatemia: Results from Year 1 of the Disease Monitoring Program
Carpenter T, Cassinelli H, Glorieux F, Hetzer J, Merritt J, Moreira C, Portale A, Ward L, Woo C, Imel E. OR13-2 Characterizing the Impact of Burosumab on Bone Health in Children with X-Linked Hypophosphatemia: Results from Year 1 of the Disease Monitoring Program. Journal Of The Endocrine Society 2022, 6: a191-a192. PMCID: PMC9624613, DOI: 10.1210/jendso/bvac150.395.Peer-Reviewed Original ResearchSerum alkaline phosphatase levelsNew safety concernsAlkaline phosphatase levelsLower limb deformitiesGroup 1Serum phosphorusGroup 2Group 3Burosumab therapyBone healthPhosphatase levelsHeight z-score changeLimb deformitiesHuman IgG1 monoclonal antibodyYear 1 visitRecombinant human IgG1 monoclonal antibodySerum phosphorus levelsZ-score changeYears of treatmentRadiographic Global ImpressionYear 1Safety concernsIgG1 monoclonal antibodyBone painDMP enrolmentPrediction of Adverse Pathology at Radical Prostatectomy in Grade Group 2 and 3 Prostate Biopsies Using Machine Learning.
Paulson N, Zeevi T, Papademetris M, Leapman MS, Onofrey JA, Sprenkle PC, Humphrey PA, Staib LH, Levi AW. Prediction of Adverse Pathology at Radical Prostatectomy in Grade Group 2 and 3 Prostate Biopsies Using Machine Learning. JCO Clinical Cancer Informatics 2022, 6: e2200016. PMID: 36179281, DOI: 10.1200/cci.22.00016.Peer-Reviewed Original ResearchConceptsGrade group 2Prostate biopsyRadical prostatectomyAdverse outcomesGroup 2GG-2Core prostate biopsyProstate cancer outcomesPatient's clinical riskClinical risk assessmentCore needle biopsyOngoing clinical needAdverse outcome predictionRetrospective reviewAdverse pathologyCAPRA scoreEntire cohortCancer outcomesPathologic diagnosisNeedle biopsyClinical riskDisease outcomeProstate cancerBiopsyDisease oneLeft Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial.
O'Neill WW, Wang DD, Polak S, Moses JW, Josephy N, Koenig G, Kim RJ, Lansky A, Bellumkonda L, Douglas PS, Kapur NK. Left Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial. Journal Of Invasive Cardiology 2022, 34: e611-e619. PMID: 35830361, DOI: 10.25270/jic/21.00401.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceLV ejection fractionInfarct sizeLeft ventricularLV unloadingEjection fractionPilot trialGroup 2Group 1ST-segment elevation myocardial infarction (STEMI) patientsImproved LV ejection fractionElevation myocardial infarction patientsLV end-diastolic volumeMajor cardiovascular outcomesPercutaneous coronary interventionMyocardial infarction patientsEnd-diastolic volumeEnd-systolic volumeAnterior STEMIEchocardiographic LVEFCardiogenic shockCardiovascular outcomesEchocardiographic parametersImmediate reperfusionCoronary interventionUtility of Perioperative Measurement of Cell-Free DNA and Circulating Tumor DNA in Informing the Prognosis of GI Cancers: A Systematic Review
Hsu P, Singh K, Dhiman A, Witmer H, He C, Eng O, Catenacci D, Posner M, Turaga K. Utility of Perioperative Measurement of Cell-Free DNA and Circulating Tumor DNA in Informing the Prognosis of GI Cancers: A Systematic Review. JCO Precision Oncology 2022, 6: e2100337. PMID: 35188804, PMCID: PMC8984241, DOI: 10.1200/po.21.00337.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalGI cancersGroup 2Tumor DNACurative-intent surgical resectionDecreased RFSGroup 1Median recurrence-free survivalMeasurement of circulating tumor DNAEarly detection of recurrenceGroup 3Measurement of cell-free DNAPrognosis of GI cancersDetection of recurrenceCirculating tumor DNARisk of recurrenceCell-free DNARisk stratification toolCox hazard ratiosAbsence of ctDNACurative resectionCurative surgerySurgical resectionDetectable ctDNATumor markersDoes underlying infertility in natural conception modify the epigenetic control of imprinted genes and transposable elements in newborns?
Barberet J, Binquet C, Guilleman M, Romain G, Bruno C, Martinaud A, Ginod P, Cavalieri M, Amblot C, Choux C, Fauque P. Does underlying infertility in natural conception modify the epigenetic control of imprinted genes and transposable elements in newborns? Reproductive BioMedicine Online 2022, 44: 706-715. PMID: 35219588, DOI: 10.1016/j.rbmo.2022.01.004.Peer-Reviewed Original Research
2021
Longitudinal imaging history in early identification of intimate partner violence
Park H, Gujrathi R, Gosangi B, Thomas R, Cai T, Chen I, Bay C, Hassan N, Boland G, Kohane I, Seltzer S, Rexrode K, Khurana B. Longitudinal imaging history in early identification of intimate partner violence. European Radiology 2021, 32: 2824-2836. PMID: 34797386, DOI: 10.1007/s00330-021-08362-2.Peer-Reviewed Original ResearchConceptsSelf-reported dateIPV-related injuriesGroup 1Neurological injuryMusculoskeletal injuriesGroup 2Early identificationGroup 2 patientsIntimate partner violencePhysical abuseTypes of abuseNeurologic injuryHigh suspicionCommon injuriesResultsA totalImaging reviewPartner violenceInjuryStudy datesLikelihood of IPVCommon typeRadiologistsPatientsSuspicionIPVB-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population
Klimczak AM, Herlihy NS, Scott CS, Hanson BM, Kim JG, Titus S, Seli E, Scott RT. B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population. Fertility And Sterility 2021, 117: 351-358. PMID: 34809978, DOI: 10.1016/j.fertnstert.2021.09.036.Peer-Reviewed Original ResearchConceptsB-cell lymphoma 6 (Bcl6) expressionLive birth groupLive birthsFertilization populationNormal respondersBirth groupProportion of patientsLive birth ratePopulation of patientsEuploid embryo transferCase-control studyEndometrial tissue samplesPreimplantation genetic testingGroup of womenIVF stimulationMean HSCOREIVF outcomesInfertility centerIVF successMAIN OUTCOMEGroup 2Group 1Embryo transferPatientsClinical decisionEquality in Hip Arthroscopy Outcomes Can Be Achieved Regardless of Patient Socioeconomic Status
Saks BR, Ouyang VW, Domb ES, Jimenez AE, Maldonado DR, Lall AC, Domb BG. Equality in Hip Arthroscopy Outcomes Can Be Achieved Regardless of Patient Socioeconomic Status. The American Journal Of Sports Medicine 2021, 49: 3915-3924. PMID: 34739305, DOI: 10.1177/03635465211046932.Peer-Reviewed Original ResearchConceptsPatient-reported outcome measuresPatient acceptable symptom stateNonarthritic Hip ScoreFemoroacetabular impingement syndromeSocial deprivation indexPatients' socioeconomic statusVisual analog scaleGroup 1Group 4Socioeconomic statusHip scoreSecondary surgeryHip arthroscopyLabral tearsGroup 2Postoperative patient-reported outcome measuresInternational Hip Outcome Tool-12Mean body mass indexVAS pain scoresAcceptable symptom stateHarris hip scoreBody mass indexArthroscopic hip surgeryHip arthroscopy outcomesPreoperative radiographic measurementsEffect of Eight Weeks Aerobic Exercise and Vitamin-D Supplementation on Osteocalcin and Alkaline Phosphatase Gene Expression in Male Rats Poisoned with Hydrogen Peroxide
Eimari Eskandari R, Homaee H, Moradi L. Effect of Eight Weeks Aerobic Exercise and Vitamin-D Supplementation on Osteocalcin and Alkaline Phosphatase Gene Expression in Male Rats Poisoned with Hydrogen Peroxide. Journal Of Shahid Sadoughi University Of Medical Sciences 2021 DOI: 10.18502/ssu.v29i7.7267.Peer-Reviewed Original ResearchEffects of exerciseVitamin DEight-week aerobic exerciseAlkaline phosphatase gene expressionInteraction effect of exerciseWeeks aerobic exerciseAlkaline phosphataseAdult male Wistar ratsVitamin D supplementationIndependent t-testBone tissue of ratsMale Wistar ratsAerobic exercisePost hoc testTissues of ratsExpression of alkaline phosphataseGene expressionDaily doseExerciseMale ratsWistar ratsIncreased alkaline phosphataseGroup 2Sham groupBone tissue
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