2025
A Digital Depression Treatment Program for Adults Treated in Primary Care
Dahne J, Wahlquist A, Carpenter M, Graboyes E, Lejuez C, Kustanowitz J, Natale N, Levins O, Player M, Diaz V. A Digital Depression Treatment Program for Adults Treated in Primary Care. JAMA Internal Medicine 2025, 185: 692-701. PMID: 40227715, PMCID: PMC11997856, DOI: 10.1001/jamainternmed.2025.0494.Peer-Reviewed Original ResearchElectronic health recordsBeck Depression Inventory-IIPrimary care settingBehavioral activation interventionDepressive symptomsClinically significant improvementUsual careActivity interventionsCare settingsElectronic health record featuresElectronic health record integrationPatient Health Questionnaire-9Depression remissionModerate symptoms of depressionPrimary care providersPrimary care clinicsDepression treatment programTreating depressive symptomsSymptoms of depressionPrimary careSignificant improvementCare clinicsIntervention engagementCare providersScalable interventionsDepressive Personality Vulnerability and Adaptation to Breast Cancer: A Matter of Self‐Criticism?
Shahar G, Aslan C, Rüdiger Z, Elmar B, Globus O, Beutel M. Depressive Personality Vulnerability and Adaptation to Breast Cancer: A Matter of Self‐Criticism? Stress And Health 2025, 41: e70054. PMID: 40448936, DOI: 10.1002/smi.70054.Peer-Reviewed Original ResearchConceptsSelf-CriticismPersonal vulnerabilitySupportive-expressive psychodynamic psychotherapyDepressive personality vulnerabilitySymptoms of depressionPsychodynamic psychotherapyPersonality dimensionsComorbid depressionAdaptive outcomesRandomized clinical trialsDepressionRank-orderConfounding roleGeneralized linear modelSymptomatic loadPersonal resilienceBreast cancerIllness managementDiagnosis of breast cancerSymptomsBreast symptomsPsychotherapyAnxietyNO effectVulnerabilityMental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study
Johnson A, Chimoyi L, Shenoi S, Brault M, Forastiere L, Charalambous S, Chihota V, Davis J. Mental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study. Open Forum Infectious Diseases 2025, 12: ofaf303. PMID: 40567997, PMCID: PMC12188208, DOI: 10.1093/ofid/ofaf303.Peer-Reviewed Original ResearchTuberculosis preventive therapyUnhealthy alcohol useMental healthDepressive symptomsAlcohol useTobacco useAssociation of mental healthInfluence of mental healthCohort studyMeasure symptoms of anxietyNegatively associated with adherenceDeductive content analysisMixed methods studySubstance useLongitudinal cohort studyPsychological support servicesSymptoms of anxietySymptoms of depressionPreventive therapyProspective cohort studyAntiretroviral therapyHIV mortalityMultivariate regression modelSubstance use disordersMethods studyAfrican Youth in Mind – Protocol of a Pilot feasibility trial of a brief psychological Intervention for older adolescents with depression delivered through senior high schools in Navrongo, Ghana
Jopling R, Attah D, Abas M, Adde K, Goldsmith K, Bere T, Nyamayaro P, Aborigo R, Barrett B, Owusu L, Glozah F, Akanlu A, Bawa S, Achana F, Danese A, Smith P, Seward N, Kumwenda M, Chibanda D, Weobong B. African Youth in Mind – Protocol of a Pilot feasibility trial of a brief psychological Intervention for older adolescents with depression delivered through senior high schools in Navrongo, Ghana. PLOS ONE 2025, 20: e0319462. PMID: 40168302, PMCID: PMC11960926, DOI: 10.1371/journal.pone.0319462.Peer-Reviewed Original ResearchConceptsPatient Health Questionnaire-9Enhanced usual careIntegration of mental health servicesPsychological interventionsRandomised controlled pilot trialMonths post baseline assessmentPilot trialPrimary healthcare systemMental health componentMental health servicesEvidence-based interventionsControlled Pilot TrialProblem-Solving TherapySymptoms of depressionAdolescent health policyPilot feasibility trialUsual careHealth servicesSchool-going youthFormative researchCost-effectiveness evaluationFeasibility trialHealth policyPost-baseline assessmentHealth componentAssessing Tobacco Harm Perceptions Among Transgender and Nonbinary Adults: Results From a Community Informed State-Wide Survey
DeAtley T, Baker A, Denlinger-Apte R, Ogunbajo A, Martinez U, Ceballos R, Wetter D, Operario D, Kershaw T, Gamarel K, Restar A. Assessing Tobacco Harm Perceptions Among Transgender and Nonbinary Adults: Results From a Community Informed State-Wide Survey. Nicotine & Tobacco Research 2025, ntaf050. PMID: 40059718, DOI: 10.1093/ntr/ntaf050.Peer-Reviewed Original ResearchTobacco harm perceptionsHarm perceptionsHarms of tobacco useE-cigarettesElevated symptoms of depressionTobacco-related harmGender-diverse identitiesLevels of smokingSymptoms of depressionE-cigarette useMultinomial regression modelsE-cigarette usersState-wide surveyTobacco useNonbinary adultsTrans womenTransgender adultsSexual identityTransgender individualsGender identityLow-incomeNonbinary individualsStudy participantsPersonal healthDocumented elevated levelsCross-cultural adaptation of mental health screening instruments for Samoan adolescents
Mew E, Lowe S, Galea’i A, Iopu F, Anderson J, Naseri J, Hunt L, Mulitalo-Cheung T, Fauolo-Manila O, Soliai-Lemusu S, Hawley N, McCutchan-Tofaeono J. Cross-cultural adaptation of mental health screening instruments for Samoan adolescents. PLOS Mental Health 2025, 2: e0000106. DOI: 10.1371/journal.pmen.0000106.Peer-Reviewed Original ResearchMental health screening instrumentCPSS-5Screening instrumentPTSD Symptom Scale-Self-ReportDeliberate Self-Harm QuestionnaireGeneralized Anxiety Disorder 7Measure symptoms of depressionSelf-injurious thoughtsSymptoms of depressionSamoan adolescentsPost-traumatic stressSelf-Harm QuestionnaireAvon Longitudinal Study of ParentsCross-cultural validityLongitudinal Study of ParentsMental health problemsAvon Longitudinal StudyStudy of parentsGAD-7English language wordsAdolescent focus groupsMeasure symptomsMeasurement equivalenceSelf-ReportFocus groupsA Retrospective Analysis of the Impact of Electroconvulsive Therapy on Anxiety Symptoms in Patients With Treatment-Resistant Depression.
Laszcz J, Wang C, Riva-Posse P, Kim J, Tsygankova V, Mandell A, Rice H, Hermida A, Kitay B, Crowell A, McDonald W, Hershenberg R. A Retrospective Analysis of the Impact of Electroconvulsive Therapy on Anxiety Symptoms in Patients With Treatment-Resistant Depression. Journal Of Ect 2025 PMID: 39853314, DOI: 10.1097/yct.0000000000001113.Peer-Reviewed Original ResearchTreatment-resistant depressionTreatment-resistant depressed patientsElectroconvulsive therapySymptoms of depressionSymptoms of anxietyAnxiety symptomsDepressive symptomsAcute course of ECTGeneralized Anxiety Disorder 7 scalePredictors of antidepressant responseImprovement of anxiety symptomsImpact of electroconvulsive therapyCourse of ECTImprove symptoms of anxietyHigher symptoms of anxietyBeck Depression Inventory IIAnxiety symptom severityNaturalistic outpatient settingAcute ECT courseHigher levels of anxietyElectroconvulsive therapy treatmentsLevels of anxietyTrajectory of improvementAntidepressant responseAnxious symptomsBridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia
Guo H, Xiao Y, Dong S, Yang J, Zhao P, Zhao T, Cai A, Tang L, Liu J, Wang H, Hua R, Liu R, Wei Y, Sun D, Liu Z, Xia M, He Y, Wu Y, Si T, Womer F, Xu F, Tang Y, Wang J, Zhang W, Zhang X, Wang F. Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia. BMC Medicine 2025, 23: 38. PMID: 39849528, PMCID: PMC11755933, DOI: 10.1186/s12916-025-03850-4.Peer-Reviewed Original ResearchConceptsIntermediate phenotypesCore symptoms of depressionAmplitude of low-frequency fluctuationNeuroimaging patternsSubtypes of depressionCore depressive symptomsExpression of risk genesDiverse clinical populationsSymptoms of depressionRodent modelsAssociated with depressionLow-frequency fluctuationsStress-related changesDepression subtypesCore symptomsCross-species validationPsychiatric disordersNeuropsychiatric disordersDepressive symptomsBehavioral manifestationsStress modelDepression cohortClinical populationsSensorimotor regionsAnhedonia
2024
Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic
Back A, Freeman-Young T, Morgan L, Sethi T, Baker K, Myers S, McGregor B, Harvey K, Tai M, Kollefrath A, Thomas B, Sorta D, Kaelen M, Kelmendi B, Gooley T. Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2449026. PMID: 39636638, PMCID: PMC11621983, DOI: 10.1001/jamanetworkopen.2024.49026.Peer-Reviewed Original ResearchConceptsAdvanced practice practitionersSymptoms of depressionMontgomery-Asberg Depression Rating ScalePosttraumatic stress disorderSymptoms of burnoutMontgomery-Asberg Depression Rating Scale scoreSymptoms of posttraumatic stress disorderFrontline carePsilocybin therapyRandomized clinical trialsSevere symptoms of depressionMental health diagnosesScore changesImprove symptoms of depressionCOVID-19 pandemicPCL-5Intention-to-treat principleMedication sessionsDepression Rating ScalePCL-5 scoresPsychological morbidityHealth diagnosisMain OutcomesPractice practitionersUS cliniciansImpact of pandemic-related worries on mental health in India from 2020 to 2022
Yang Y, Sun A, Zimmermann L, Mukherjee B. Impact of pandemic-related worries on mental health in India from 2020 to 2022. Npj Mental Health Research 2024, 3: 57. PMID: 39582077, PMCID: PMC11586416, DOI: 10.1038/s44184-024-00101-x.Peer-Reviewed Original ResearchMental healthCalendar timeSelf-reported symptoms of depressionMental health outcomesPandemic-related worriesSymptoms of depressionMental health trendsSelf-reported symptomsHealth outcomesPublic health crisisHealth trendsEffect modifiersImpact SurveyResidential statusSocial media platformsFinancial stressHealth crisisWorryHealthInteraction termsMedia platformsAnxietyDepressionSurvey dataCalendarMaternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression.
Lindley Baron-Cohen K, Fearon P, Meins E, Feldman R, Hardiman P, Rosan C, Fonagy P. Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression. Development And Psychopathology 2024, 1-12. PMID: 39363731, DOI: 10.1017/s0954579424001585.Peer-Reviewed Original ResearchMaternal mind-mindednessMind-mindednessMind-related commentsStudy 1Study 2Mothers' appropriate mind-related commentsLevels of mind-mindednessMothers' caregiving representationsPostnatal depressionSymptoms of depressionParent-child interactionsChildren's social developmentEffects of OTParent-child relationshipMaternal depression scoresChildren's early developmentSample of mothersCaregiving representationsChild OT levelsSalivary OTDepression scoresOT levelsMaternal-infant attachmentPlacebo-ControlledDepressionCharacterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter
Malamud J, Guloksuz S, van Winkel R, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Rutten B, Huys Q. Characterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter. PLOS Computational Biology 2024, 20: e1012457. PMID: 39312537, PMCID: PMC11449358, DOI: 10.1371/journal.pcbi.1012457.Peer-Reviewed Original ResearchConceptsEcological momentary assessmentEcological momentary assessment dataMood statesMood disordersDepressive stateMood dynamicsFeatures of mood disordersCombination of ecological momentary assessmentsControl of moodSymptoms of depressionInternal emotional statesAlterations to interactionsPsychopathological featuresMomentary assessmentMoodEmotional statesDepressionEnvironmental stimuliOral Contraceptives and the Risk of Psychiatric Side Effects: A Review
Ciarcia J, Huckins L. Oral Contraceptives and the Risk of Psychiatric Side Effects: A Review. Complex Psychiatry 2024, 10: 36-44. PMID: 39148498, PMCID: PMC11324216, DOI: 10.1159/000539515.Peer-Reviewed Original ResearchMood-related side effectsPsychiatric side effectsPsychiatric riskOral contraceptivesSide effectsSymptoms of depressionPrescription psychotropic medicationsOC usersMood side effectsSide effects of oral contraceptivesEffects of oral contraceptivesMood symptomsRisks of oral contraceptivesOC treatmentPsychotropic medicationsMood improvementPsychiatric disordersEating DisordersProgestin-only pillsSubgroups of usersPlacebo usersRandomized Controlled TrialsCombination pillMoodClinical significanceIdentifying Depression Through Machine Learning Analysis of Omics Data: Scoping Review
Taylor B, Hobensack M, de Rivera S, Zhao Y, Creber R, Cato K. Identifying Depression Through Machine Learning Analysis of Omics Data: Scoping Review. JMIR Nursing 2024, 7: e54810. PMID: 39028994, PMCID: PMC11297379, DOI: 10.2196/54810.Peer-Reviewed Original ResearchConceptsProvision of mental health careCritical Appraisal Checklist for Analytical Cross-Sectional StudiesJoanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional StudiesIncreased risk of depressionShortage of providersMental health careRisk of depressionAnalytical cross-sectional studyDiagnosis of depressionCross-sectional studySymptoms of depressionSelf-reported symptomsNursing workforceIdentifying DepressionPRISMA-ScRScoping ReviewHealth careCritical appraisalMental disordersIncreased riskNursesAssess individualsClinical InterviewDepressionScreening processSelf-stigma mediates the relationships between childhood maltreatment and symptom levels of PTSD, depression, and anxiety
Haim-Nachum S, Lazarov A, Zabag R, Martin A, Bergman M, Neria Y, Amsalem D. Self-stigma mediates the relationships between childhood maltreatment and symptom levels of PTSD, depression, and anxiety. European Journal Of Psychotraumatology 2024, 15: 2370174. PMID: 38985020, PMCID: PMC11238652, DOI: 10.1080/20008066.2024.2370174.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderChildhood maltreatmentSelf-StigmaChildhood abuseSymptom severity of depressionSymptom typeSubtypes of childhood maltreatmentSurvivors of childhood abuseChildhood trauma survivorsSeverity of depressionChildhood maltreatment experiencesSymptoms of depressionEffects of self-stigmaInternalization of negative stereotypesIncreased self-stigmaMental health problemsSignificant mediation effectAnxiety symptomsStress disorderChildhood neglectSymptom levelsMaltreatment experiencesTrauma survivorsSymptom severityPhysical neglectComparing in Person to Telehealth Delivery of a Family Violence Intervention
Stover C, Holland M, Martin E, Modanesi E, Fish M, Beebe R. Comparing in Person to Telehealth Delivery of a Family Violence Intervention. Clinical Psychology & Psychotherapy 2024, 31: e3034. PMID: 39089327, DOI: 10.1002/cpp.3034.Peer-Reviewed Original ResearchConceptsIntimate partner violenceTelehealth deliveryIn-personFamily violence interventionTested in-personSymptoms of depressionChild protective servicesMental health symptomsTelehealth-delivered interventionIn-person deliveryIPV interventionsPartner violenceTreatment engagementViolence interventionsHealth symptomsProtective servicesIntervention servicesTelehealthCompletion ratesFathersInterventionClinical outcome dataCompleted treatmentOutcome dataF4CClinical effectiveness and cost-effectiveness of a brief accessible cognitive behavioural therapy programme for stress in school-aged adolescents (BESST): a cluster randomised controlled trial in the UK
Brown J, James K, Lisk S, Shearer J, Byford S, Stallard P, Deighton J, Saunders D, Yarrum J, Fonagy P, Weaver T, Sclare I, Day C, Evans C, Carter B. Clinical effectiveness and cost-effectiveness of a brief accessible cognitive behavioural therapy programme for stress in school-aged adolescents (BESST): a cluster randomised controlled trial in the UK. The Lancet Psychiatry 2024, 11: 504-515. PMID: 38759665, DOI: 10.1016/s2215-0366(24)00101-9.Peer-Reviewed Original ResearchTreatment-as-usualCognitive behavioral therapyTreatment-as-usual groupCluster randomised controlled trialCognitive behavioral therapy workshopRandomised controlled trialsCognitive behavioural therapy programmeSymptoms of depressionBehavioural therapy programmePrimary intention-to-treat analysisSchools TrialIndex of Multiple DeprivationBehavioral therapyDepressive symptomsHealth Technology Assessment programmeSchool-aged adolescentsControlled TrialsSelf-referral systemIntention-to-treat populationDiscover interventionsFull school yearMental healthDepressionTherapy programmeIntention-to-treat analysisBrief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16–18-year-olds: recruitment and baseline characteristics
James K, Lisk S, Payne-Cook C, Farishta Z, Farrelly M, Sheikh A, Slusarczyk M, Byford S, Day C, Deighton J, Evans C, Fonagy P, Saunders D, Sclare I, Shearer J, Stallard P, Weaver T, Yarrum J, Carter B, Brown J. Brief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16–18-year-olds: recruitment and baseline characteristics. Trials 2024, 25: 302. PMID: 38702825, PMCID: PMC11069277, DOI: 10.1186/s13063-024-08116-7.Peer-Reviewed Original ResearchConceptsSchool-based cluster randomised controlled trialWarwick-Edinburgh Mental Wellbeing ScaleCluster randomised controlled trialRandomised controlled trialsSchools TrialEducational workshopsMental Wellbeing ScaleControlled TrialsOutcome data collectionSymptoms of depressionEthnic minority groupsSecondary schoolsReduce stigmaBaseline characteristicsPost-randomisationWellbeing ScaleSelf-referralSelf-referredLower wellbeingStudentsDistressed studentsEthnically diverse sampleSchoolWorkshop programmeGeneral wellbeingYouth adversity and trajectories of depression/anxiety symptoms in adolescence in the context of intersectionality in the United Kingdom.
Havers L, Shuai R, Fonagy P, Fazel M, Morgan C, Fancourt D, McCrone P, Smuk M, Bhui K, Shakoor S, Hosang G. Youth adversity and trajectories of depression/anxiety symptoms in adolescence in the context of intersectionality in the United Kingdom. Psychological Medicine 2024, 54: 2677-2687. PMID: 38623689, DOI: 10.1017/s0033291724000795.Peer-Reviewed Original ResearchDepression/anxiety symptomsAnxiety symptomsDevelopment of depressionPersistence of depressionSymptoms of depressionModerating effectContext of intersectionalityIndividual characteristicsLatent trajectoriesAdvantaged groupsSocietal groupsAnxietyDepressionMagnitude of effectAdversityAssociated with persistenceSymptomsModeratelyAdolescentsUnited KingdomIntersecting profilesYouthSESPersistent symptomsIntersectionVariation in symptoms of common mental disorders in the general population during the COVID-19 pandemic: longitudinal cohort study
Saunders R, Buckman J, Suh J, Fonagy P, Pilling S, Bu F, Fancourt D. Variation in symptoms of common mental disorders in the general population during the COVID-19 pandemic: longitudinal cohort study. BJPsych Open 2024, 10: e45. PMID: 38344903, PMCID: PMC10897705, DOI: 10.1192/bjo.2024.2.Peer-Reviewed Original ResearchClinically significant symptomsSymptoms of depressionMental health servicesMental disordersTrajectory classesClinically significant symptoms of depressionSignificant symptoms of depressionClinically significant symptom levelsSignificant symptomsHigher neuroticism scoresPersonality-related characteristicsGrowth mixture modelingMental health disordersMental health diagnosesNeuroticism scoresSymptom levelsGeneral populationClinical rangeExperience depressionAnxietyHealth disordersCOVID-19 Social StudyDepressionHealth diagnosisHealth services
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