2025
Comparison of two electroacupuncture regimens on symptoms and brain structures in breast cancer survivors: A randomized, controlled trial.
Chan A, Drayson O, Ng D, Heshmatipour M, Trudeau J, Lavasani S, Parajuli R, Lee S, Xie L, Acharya M, Limoli C, Malik S. Comparison of two electroacupuncture regimens on symptoms and brain structures in breast cancer survivors: A randomized, controlled trial. Journal Of Clinical Oncology 2025, 43: 12119-12119. DOI: 10.1200/jco.2025.43.16_suppl.12119.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsNeuropsychiatric symptomsPerceived cognitive functionEffect sizeNon-Hispanic whitesSelf-reported cognitive impairmentMedium to large effect sizesNEA groupPatient-reported outcomesQuality of lifeSham acupointsCognitive domains of attentionPsychological distressTreatment effect sizeLinear mixed modelsAcupointsEmotional functioningAdverse eventsDomains of attentionPilot trialControlled TrialsCognitive impairmentMultiple testingSurvivorsThe story of pain in people with dementia: a rationale for digital measures
Patrascu M, Berge L, Vahia I, Marty B, Achterberg W, Allore H, Fletcher R, Husebo B. The story of pain in people with dementia: a rationale for digital measures. BMC Medicine 2025, 23: 227. PMID: 40247335, PMCID: PMC12004839, DOI: 10.1186/s12916-025-04057-3.Peer-Reviewed Original ResearchConceptsPain treatmentPain assessmentEffects of pain treatmentMonitor health behaviorsAging-related challengesLevel of painUser involvementAssessment of painDementia careHealth behaviorsCare dependencyOlder adultsPain intensityImproved pain reliefDementiaReduced qualityNeuropsychiatric symptomsPain reliefPainAround-the-clockCareDigital phenotypingTransdisciplinary collaborationPatterns of sleepPain behavior
2024
EMOTION REGULATION IN PEOPLE LIVING WITH DEMENTIA AND THEIR SPOUSES: THE ROLE OF NEUROPSYCHIATRIC SYMPTOMS
Lou Y, Monin J, Vu T, Piechota A. EMOTION REGULATION IN PEOPLE LIVING WITH DEMENTIA AND THEIR SPOUSES: THE ROLE OF NEUROPSYCHIATRIC SYMPTOMS. Innovation In Aging 2024, 8: 830-830. PMCID: PMC11691875, DOI: 10.1093/geroni/igae098.2690.Peer-Reviewed Original ResearchPwD neuropsychiatric symptomsCare partnersEmotion regulation difficultiesEmotion regulationNeuropsychiatric symptomsEarly stages of dementiaStages of dementiaSelf-reports of emotion regulationMultivariate linear regression modelEmotion regulation capabilitiesEmotion regulation strategiesNeuropsychiatric subsyndromesHealth factorsDomains of difficultyLinear regression modelsPWDSelf-ReportRegulation difficultiesInterpersonal effectsEmotional behaviorEmotional awarenessRegulation strategiesControl impulsesDyad membersRegression modelsNeuropsychiatric symptoms in cognitive decline and Alzheimer’s disease: biomarker discovery using plasma proteomics
Rabl M, Clark C, Dayon L, Popp J, Weiner M, Aisen P, Jack C, Jagust W, Landau S, Rivera-Mindt M, Okonkwo O, Shaw L, Lee E, Toga A, Beckett L, Harvey D, Green R, Saykin A, Nho K, Perrin R, Tosun D, Sachdev P, Drake E, Montine T, Conti C, Nosheny R, Sacrey D, Fockler J, Miller M, Kwang W, Jin C, Diaz A, Ashford M, Flenniken D, Kormos A, Rafii M, Raman R, Jimenez G, Donohue M, Salazar J, Fidell A, Boatwright V, Robison J, Zimmerman C, Cabrera Y, Walter S, Clanton T, Shaffer E, Webb C, Hergesheimer L, Smith S, Ogwang S, Mahboubi P, Pizzola J, Jenkins C, Beckett L, Harvey D, Donohue M, Saito N, Diaz A, Hussen K, Amaza H, Thao M, Parkins S, Ayo O, Glittenberg M, Hoang I, Germano K, Strong J, Weisensel T, Magana F, Thomas L, Guzman V, Ajayi A, Benedetto J, Talavera S, Felmlee J, Fox N, Thompson P, DeCarli C, Forghanian-Arani A, Borowski B, Reyes C, Hedberg C, Ward C, Schwarz C, Reyes D, Gunter J, Moore-Weiss J, Kantarci K, Matoush L, Senjem M, Vemuri P, Reid R, Malone I, Thomopoulos S, Nir T, Jahanshad N, Knaack A, Fletcher E, Harvey D, Tosun-Turgut D, Chen S, Choe M, Crawford K, Yushkevich P, Das S, Koepp R, Rabinovici G, Villemagne V, LoPresti B, Morris J, Franklin E, Bernhardt H, Cairns N, Taylor-Reinwald L, Lee E, Lee V, Korecka M, Brylska M, Wan Y, Trojanowki J, Crawford K, Neu S, Foroud T, Jo T, Risacher S, Craft H, Apostolova L, Nudelman K, Faber K, Potter Z, Lacy K, Kaddurah-Daouk R, Shen L, Karlawish J, Erickson C, Grill J, Largent E, Harkins K, Thal L, Kachaturian Z, Frank R, Snyder P, Buckholtz N, Hsiao J, Ryan L, Molchan S, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Ryan L, Silverberg N, Silbert L, Kaye J, White S, Pierce A, Thomas A, Clay T, Schwartz D, Devereux G, Taylor J, Ryan J, Nguyen M, DeCapo M, Shang Y, Schneider L, Munoz C, Ferman D, Conant C, Martin K, Oleary K, Pawluczyk S, Trejo E, Dagerman K, Teodoro L, Becerra M, Fairooz M, Garrison S, Boudreau J, Avila Y, Brewer J, Jacobson A, Gama A, Kim C, Little E, Frascino J, Ferng N, Trujillo S, Heidebrink J, Koeppe R, MacDonald S, Malyarenko D, Ziolkowski J, O'Connor J, Robert N, Lowe S, Rogers V, Hackenmiller B, Boeve B, Albers C, Kreuger C, Jones D, Knopman D, Botha H, Magnuson J, Graff-Radford J, Crawley K, Schumacher M, McKinzie S, Smith S, Helland T, Lowe V, Ramanan V, Pavlik V, Faircloth J, Bishop J, Nath J, Chaudhary M, Kataki M, Yu M, Pacini N, Barker R, Brooks R, Aggarwal R, Honig L, Stern Y, Mintz A, Cordona J, Hernandez M, Long J, Arnold A, Groves A, Middleton A, Vogler B, McCurry C, Mayo C, Raji C, Amtashar F, Klemp H, Elmore H, Ruszkiewicz J, Kusuran J, Stewart J, Horenkamp J, Greeson J, Wever K, Vo K, Larkin K, Rao L, Schoolcraft L, Gallagher L, Paczynski M, McMillan M, Holt M, Gagliano N, Henson R, LaBarge R, Swarm R, Munie S, Cepeda S, Winterton S, Hegedus S, Wilson T, Harte T, Bonacorsi Z, Geldmacher D, Watkins A, Barger B, Smelser B, Bates C, Stover C, McKinley E, Ikner G, Hendrix H, Cooper H, Mahaffey J, Robbins L, Ashley L, Natelson-Love M, Carter, Solomon V, Grossman H, Groome A, Ardolino A, Kaplan A, Sheppard F, Burgos-Rivera G, Garcia-Camilo G, Lim J, Neugroschl J, Jackson K, Evans K, Soleimani L, Sano M, Ghesani N, Binder S, Apuango X, Sood A, Troutman A, Blanchard K, Richards A, Nelson G, Hendrickson K, Yurko E, Plenge J, Rufo V, Shah R, Duara R, Lynch B, Chirinos C, Dittrich C, Campbell D, Mejia D, Perez G, Colvee H, Gonzalez J, Gondrez J, Knaack J, Acevedo M, Cereijo M, Greig-Cust M, Villar M, Wishnia M, Detling S, Barker W, Albert M, Moghekar A, Rodzon B, Demsky C, Pontone G, Pekar J, Farrington L, Pomper M, Johnson N, Alo T, Sadowski M, Ulysse A, Masurkar A, Marti B, Mossa D, Geesey E, Petrocca E, Schulze E, Wong J, Boonsiri J, Kenowsky S, Martinez T, Briglall V, Doraiswamy P, Nwosu A, Adhikari A, Hellegers C, Petrella J, James O, Wong T, Hawk T, Vaishnavi S, McCoubrey H, Nasrallah I, Rovere R, Maneval J, Robinson E, Rivera F, Uffelman J, Combs M, O'Donnell P, Manning S, King R, Nieto A, Glueck A, Mandal A, Swain A, Gamble B, Meacham B, Forenback D, Ross D, Cheatham E, Hartman E, Cornell G, Harp J, Ashe L, Goins L, Watts L, Yazell M, Mandal P, Buckler R, Vincent S, Rudd T, Lopez O, Malia A, Chiado C, Zik C, Ruszkiewicz J, Savage K, Fenice L, Oakley M, Tacey P, Berman S, Bowser S, Hegedus S, Saganis X, Porsteinsson A, Mathewson A, Widman A, Holvey B, Clark E, Morales E, Young I, Ruszkiewicz J, Hopkins K, Martin K, Kowalski N, Hunt R, Calzavara R, Kurvach R, D'Ambrosio S, Thai G, Vides B, Lieb B, McAdams-Ortiz C, Toso C, Mares I, Moorlach K, Liu L, Corona M, Nguyen M, Tallakson M, McDonnell M, Rangel M, Basheer N, Place P, Romero R, Tam S, Nguyen T, Thomas A, Frolov A, Khera A, Browning A, Kelley B, Dawson C, Mathews D, Most E, Phillips E, Nguyen L, Nunez M, Miller M, Jones M, Martinez N, Logan R, McColl R, Pham S, Fox T, Moore T, Levey A, Brown A, Kippels A, Ellison A, Lyons C, Hales C, Parry C, Williams C, McCorkle E, Harris G, Rose H, Jooma I, Al-Amin J, Lah J, Webster J, Swiniarski J, Chapman L, Donnelly L, Mariotti L, Locke M, Vaughn P, Penn R, Carpentier S, Yeboah S, Basadre S, Malakauskas S, Lyron S, Villinger T, Burney T, Burns J, Abusalim A, Dahlgren A, Montero A, Arthur A, Dooly H, Kreszyn K, Berner K, Gillen L, Scanlan M, Madison M, Mathis N, Switzer P, Townley R, Fikru S, Sullivan S, Wright E, Beigi M, Daley A, Ko A, Luong B, Nyborg G, Morales J, Durbin K, Garcia L, Parand L, Macias L, Monserratt L, Farchi M, Wu P, Hernandez R, Rodriguez T, Graff-Radford N, Marolt A, Thomas A, Aloszka D, Moncayo E, Westerhold E, Day G, Chrestensen K, Imhansiemhonehi M, McKinzie S, Stephens S, Grant S, Brosch J, Perkins A, Saunders A, Kovac D, Polson H, Mwaura I, Mejia K, Britt K, King K, Nichols K, Lawrence K, Rankin L, Farlow M, Wiesenauer P, Bryant R, Herring S, Lynch S, Wilson S, Day T, Korst W, Dyck C, Mecca A, Miller A, Brennan A, Khan A, Ruan A, Gunnoud C, Mendonca C, Raynes-Goldfinger D, Salardini E, Hidalgo E, Cooper E, Singh E, Murphy E, May J, Stanhope J, Lam J, Waszak J, Nelsen K, Sacaza K, Hasbani M, Donahue M, Chen M, Barcelos N, Eigenberger P, Bonomi R, O'Dell R, Jefferson S, Khasnavis S, Smilowitz S, DeStefano S, Good S, Camarro T, Clayton V, Cavrel Y, Lu Y, Chertkow H, Bergman H, Hosein C, Black S, Kapadia A, Bhan A, Lam B, Scott C, Gabriel G, Bray J, Zotovic L, Gutierrez M, Masellis M, Farshadi M, Gui M, Mitchell M, Taylor R, Endre R, Taghi-Zada Z, Hsiung R, English C, Kim E, Yau E, Tong H, Barlow L, Jennings L, Assaly M, Nunes P, Marian T, Kertesz A, Rogers J, Trost D, Wint D, Bernick C, Munic D, Grant I, Korkoyah A, Raja A, Lapins A, Ryan C, Pejic J, Basham K, Lukose L, Haddad L, Quinlan L, Houghtaling N, Sadowsky C, Martinez W, Villena T, Reynolds B, Forero A, Ward C, Brennan E, Figueroa E, Esposito G, Mallory J, Johnson K, Turner K, Seidenberg K, McCann K, Bassett M, Chadwick M, Turner R, Bean R, Sharma S, Marshall G, Haviari A, Pietras A, Wallace B, Munro C, Rivera-Delpin G, Hustead H, Levesque I, Ramirez J, Nolan K, Glennon K, Palou M, Erkkinen M, DaSilva N, Friedman P, Silver R, Salazar R, Polleys R, McGinnis S, Gale S, Hall T, Luu T, Chao S, Lin E, Coleman J, Epperson K, Vasanawala M, Atri A, Rangel A, Evans B, Monarrez C, Cline C, Liebsack C, Bandy D, Goldfarb D, Intorcia D, Olgin J, Clark K, King K, York K, Reade M, Callan M, Glass M, Johnson M, Gutierrez M, Goddard M, Trncic N, Choudhury P, Reyes P, Lowery S, Hall S, Olgin S, Santiago S, Alosco M, Ton A, Jimenez A, Ellison A, Tran A, Anderson B, Carter D, Veronelli D, Lenio S, Steinberg E, Mez J, Weller J, Johns J, Harkins J, Hoti I, Mwicigi J, Schultz O, Lauture M, Denis R, Killiany R, Singh S, Lenio S, Qiu W, Devis Y, Obisesan T, Stone A, Ordor D, Udodong I, Okonkwo I, Khan J, Turner J, Hughes K, Kadiri O, Duffy C, Moss A, Stapleton K, Toth M, Sanders M, Ayres M, Hamski M, Fatica P, Ogrocki P, Ash S, Pot S, Chen D, Soto A, Tanase C, Bissig D, Vanya H, Russell H, Patel H, Zhang H, Wallace K, Ayers K, Gallegos M, Forloines M, Sinn M, Kahulugan Q, Isip R, Calderon S, Hamm T, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Perrin A, Tariot P, Fleisher A, Reeder S, Capote H, Emborsky A, Mattle A, Ajtai B, Wagner B, Myers B, Slazyk D, Fragale D, Fransen E, Macnamara H, Falletta J, Hirtreiter J, Mechtler L, King M, Asbach M, Rainka M, Zawislak R, Wisniewski S, O'Malley S, Jimenez-Knight T, Peehler T, Aladeen T, Bates V, Wenner V, Elmalik W, Scharre D, Ramamurthy A, Bouchachi S, Kataki M, Tarawneh R, Kelley B, Celmins D, Leader A, Figueroa C, Bauerle H, Patterson K, Reposa M, Presto S, Ahmed T, Stewart W, Pearlson G, Blank K, Anderson K, Santulli R, Schwartz E, Williamson J, Jessup A, Williams A, Duncan C, O'Connell A, Gagnon K, Zamora E, Bateman J, Crawford F, Thompson D, Walker E, Rowell J, White M, Ledford P, Bohlman S, Henkle S, Bottoms J, Moretz L, Hoover B, Shannon M, Rogers S, Baker W, Harrison W, Wu C, DeMarco A, Stipanovich A, Arcuri D, Clark J, Davis J, Doyon K, Amoyaw M, Acosta M, Bailey R, Warren S, Fogerty T, Sanborn V, Riddle M, Salloway S, Malloy P, Correia S, Windon C, Blackburn M, Rosen H, Miller B, Smith A, Mba I, Echevarria J, Janavs J, Roglaski E, Yong M, Devine R, Okhravi H, Rivera E, Kalowsky T, Smith C, Rosario C, Masdeu J, Le R, Gurung M, Sabbagh M, Garcia A, Slaughter M, Elayan N, Acothley S, Pomara N, Hernando R, Pomara V, Reichert C, Brawman-Mintzer O, Acree A, Williams A, Long C, Long R, Newhouse P, Hill S, Boegel A, Seshadri S, Saklad A, Jones F, Hu W, Sotelo V, Rojas Y, Mintzer J, Longmire C, Spicer K. Neuropsychiatric symptoms in cognitive decline and Alzheimer’s disease: biomarker discovery using plasma proteomics. Journal Of Neurology Neurosurgery & Psychiatry 2024, 96: 370-382. PMID: 39288961, PMCID: PMC12015082, DOI: 10.1136/jnnp-2024-333819.Peer-Reviewed Original ResearchConceptsAssociated with neuropsychiatric symptomsNeuropsychiatric symptomsReceiver operating characteristic analysisPlasma proteinsClinical disease progressionComplement factor HSerum glutamic oxaloacetic transaminaseClinical evolutionCognitive declineCognitive impairmentAlzheimer's Disease Neuroimaging Initiative cohortDisease progressionLuminex xMAPProtein panelAlzheimer's diseaseAssociated with cognitive declineFactor HMild AD dementiaMild cognitive impairmentGlutamic oxaloacetic transaminasePlasma proteomeLogistic regressionCharacteristic analysisTime pointsBiomarker discoveryMedial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer’s Disease
Li J, Tun S, Ficek-Tani B, Xu W, Wang S, Horien C, Toyonaga T, Nuli S, Zeiss C, Powers A, Zhao Y, Mormino E, Fredericks C. Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer’s Disease. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 1301-1311. PMID: 39059466, PMCID: PMC11625605, DOI: 10.1016/j.bpsc.2024.07.012.Peer-Reviewed Original ResearchAssociated with mood symptomsMood symptomsAmyloid-positive individualsMedial amygdalaSeed-based functional connectivity analysisAssociated with anxiety symptomsSelf-reported mood symptomsPost hoc correlation analysisAlzheimer's diseaseFunctional connectivity analysisPreclinical Alzheimer's diseaseTau bindingOrbitofrontal cortexTau depositionAmygdalar connectivityEmotional processingAnxiety symptomsRetrosplenial cortexBetween-group differencesAmygdalaFunctional connectivityLateral amygdalaConnectivity analysisDepression scoresNeuropsychiatric symptomsEmotion regulation in people living with dementia and their spouses: the role of neuropsychiatric symptoms
Lou Y, Vu T, Piechota A, Monin J. Emotion regulation in people living with dementia and their spouses: the role of neuropsychiatric symptoms. Aging & Mental Health 2024, 28: 1733-1740. PMID: 38940472, PMCID: PMC11560677, DOI: 10.1080/13607863.2024.2367038.Peer-Reviewed Original ResearchPwD neuropsychiatric symptomsCare partnersNeuropsychiatric symptomsSeverity of neuropsychiatric symptomsEarly stages of dementiaEmotion regulationSelf-reported difficultyStages of dementiaMultivariate linear regression modelProxy-reportSevere neuropsychiatric symptomsNeuropsychiatric subsyndromesHealth factorsSelf-reports of emotion regulationLinear regression modelsPWDSelf-ReportEmotion regulation capabilitiesEmotion regulation strategiesGoal-directed behaviorDementiaRegression modelsDomains of difficultyInterpersonal effectsEmotional awarenessVitamin B12 Supplementation in Psychiatric Practice
Kennedy K, Alexander J, Garakani A, Gross L, Mintz D, Parikh T, Pine J, Sumner C, Baron D. Vitamin B12 Supplementation in Psychiatric Practice. Current Psychiatry Reports 2024, 26: 265-272. PMID: 38696105, DOI: 10.1007/s11920-024-01505-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPsychiatric disordersB12 deficiencyB12 supplementationPsychiatric symptomsB12 levelsPharmacological treatment of psychiatric disordersTreatment of psychiatric disordersRisk factorsAssociated with neuropsychiatric symptomsSevere psychiatric presentationsManifestations of B12 deficiencyMild depressive symptomsVitamin B12 supplementationDepressive symptomsPsychiatric practicePsychiatric presentationsMedical workupNeuropsychiatric symptomsSymptoms of B12 deficiencyAugmentation strategiesPrevent depressionPharmacological treatmentCardinal symptomsDisordersSymptoms
2023
Neuropsychiatric symptoms are Predictors of Disturbed Sleep in Mexican American Caregivers
Cantu P, Milani S, Mroz E, Pan Y, Miner B, Sheehan C, Jody S. Neuropsychiatric symptoms are Predictors of Disturbed Sleep in Mexican American Caregivers. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.078489.Peer-Reviewed Original ResearchDisturbed sleepBehavioral symptomsDepressive symptomsNPI symptomsNeuropsychiatric symptomsMean ageCare recipientsSleep disturbancesMexican American caregiversMexican AmericansMultivariable logistic regressionHigh-risk groupNursing home useCare recipients' neuropsychiatric symptomsAmerican caregiversOlder Mexican AmericansMore depressive symptomsNeuropsychiatric InventoryAdvanced dementiaEpidemiologic studiesHigher oddsLower oddsRespite careSleep healthCognitive impairmentDEMENTIA STAGING, NEUROPSYCHIATRIC SYMPTOMS, AND DIVORCE OR SEPARATION IN LATE LIFE: A CASE CONTROL STUDY
Monin J, McAvay G, Zang E, Vander Wyck B, Carrión C, Allore H. DEMENTIA STAGING, NEUROPSYCHIATRIC SYMPTOMS, AND DIVORCE OR SEPARATION IN LATE LIFE: A CASE CONTROL STUDY. Innovation In Aging 2023, 7: 94-95. PMCID: PMC10735856, DOI: 10.1093/geroni/igad104.0307.Peer-Reviewed Original ResearchAlzheimer's Disease Research CenterCase-control studyNational Alzheimer's Coordinating CenterDisease Research CenterNPI symptomsDivorce/separationCoordinating CenterAgitation/aggressionDepression/dysphoriaAdjusted odds ratioDementia stagingConditional logistic regressionStages of dementiaCase/control statusInitial visitNeuropsychiatric symptomsOdds ratioNPI scoresMarried casesStandardized clinical informationClinical informationGreater oddsBehavioral symptomsControl studyControl statusNeuropsychiatric symptoms of post-COVID-19 condition in Mexican healthcare personnel.
Ruiz-Ramos D, Alonso-García C, Salazar-Rifka R, Martínez-Magaña J, Nolasco-Rosales G, Villar-Soto M. Neuropsychiatric symptoms of post-COVID-19 condition in Mexican healthcare personnel. Horizonte Sanitario 2023, 23: 11-19. DOI: 10.19136/hs.a23n1.5657.Peer-Reviewed Original ResearchHamilton Rating ScaleInflammatory markersHealthcare personnelHealthcare workersHealth personnelCOVID-19Rating ScaleBlood venous samplesFrequent acute symptomsBlood inflammatory markersCOVID-19 diseasePost COVID-19 conditionCommon comorbiditiesAcute symptomsNeuropsychiatric symptomsMean ageDepression ratingsVenous samplesMental disordersDepressionDisorders persistSymptomsAnxietyMarkersPresent studyP104: Heterogeneity of Response to methylphenidate in apathetic patients in the ADMET 2 Trial
Lanctôt K, Rivet L, Tumati S, Perin J, Vieira D, Rosenberg P, Herrmann N, Lerner A, Padala P, Brawman-Mintzer O, van Dyck C, Porsteinsson A, Craft S, Levey A, Mintzer J. P104: Heterogeneity of Response to methylphenidate in apathetic patients in the ADMET 2 Trial. International Psychogeriatrics 2023, 35: 125-126. DOI: 10.1017/s1041610223002557.Peer-Reviewed Original ResearchPotential predictors of treatment outcomePredictors of treatment outcomeResponse to methylphenidateClinically significant apathyAlzheimer's Disease Cooperative Study ActivitiesMedium effect sizeMonths of methylphenidateAlzheimer's diseaseNPI-aMethylphenidate treatmentSignificant apathyApathetic patientsBaseline anxietyAD participantsMethylphenidatePotential predictorsActivities of Daily Living ScaleCompared to placeboNeuropsychiatric symptomsIndex scoreDaily Living ScaleAlzheimer's Disease Cooperative Study Activities of Daily Living ScaleApathyEffect sizeLiving ScaleDepressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke
Sperber P, Gebert P, Broersen L, Kufner A, Huo S, Piper S, Teegen B, Heuschmann P, Prüss H, Endres M, Liman T, Siegerink B. Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke. Brain Behavior & Immunity - Health 2023, 34: 100705. PMID: 38033615, PMCID: PMC10684375, DOI: 10.1016/j.bbih.2023.100705.Peer-Reviewed Original ResearchNMDAR1-ABDepressive symptomsHigh titersIschemic strokeProspective cohortEpidemiological Studies Depression ScaleSevere neuropsychiatric symptomsSevere depressive symptomsAutoimmune encephalitisSeronegative patientsAntibody seropositivityIncident strokeSeropositive patientsNeuropsychiatric symptomsSymptoms yearsPatientsLow titersSymptomsTitersCell-based assaysSeropositivityCohortStrokeCESEncephalitisSelf-Reported Neuropsychiatric Post–COVID-19 Condition and CSF Markers of Neuroinflammation
Farhadian S, Reisert H, McAlpine L, Chiarella J, Kosana P, Yoon J, Spudich S. Self-Reported Neuropsychiatric Post–COVID-19 Condition and CSF Markers of Neuroinflammation. JAMA Network Open 2023, 6: e2342741. PMID: 37948085, PMCID: PMC10638645, DOI: 10.1001/jamanetworkopen.2023.42741.Peer-Reviewed Original ResearchEffects of methylphenidate on neuropsychiatric symptoms in Alzheimer's disease: Evidence from the ADMET 2 study
Clark E, Perin J, Herrmann N, Brawman‐Mintzer O, Lanctôt K, Lerner A, Mintzer J, Padala P, Rosenberg P, Sami S, Shade D, van Dyck C, Porsteinsson A, Group F. Effects of methylphenidate on neuropsychiatric symptoms in Alzheimer's disease: Evidence from the ADMET 2 study. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2023, 9: e12403. PMID: 37538343, PMCID: PMC10394740, DOI: 10.1002/trc2.12403.Peer-Reviewed Original ResearchNeuropsychiatric symptomsEffects of methylphenidateAlzheimer's diseaseSecondary analysisNeuropsychiatric Inventory scoresElation/euphoriaSymptoms of apathyIndividual neuropsychiatric symptomsPresentation of symptomsImpact of methylphenidateIndividual domain scoresAppetite/Catecholaminergic dysfunctionMonth 6Neuropsychiatric InventoryCaregiver scoresNPI domainsNew symptomsTreatment periodDomain scoresMeaningful improvementsMethylphenidateSymptomsPlaceboDiseaseElectroacupuncture for the management of symptom clusters in cancer patients and survivors (EAST)
Xie L, Ng D, Heshmatipour M, Acharya M, Coluzzi P, Guerrero N, Lee S, Malik S, Parajuli R, Stark C, Tain R, Zabokrtsky K, Torno L, Chan A. Electroacupuncture for the management of symptom clusters in cancer patients and survivors (EAST). BMC Complementary Medicine And Therapies 2023, 23: 92. PMID: 36973688, PMCID: PMC10041509, DOI: 10.1186/s12906-023-03926-9.Peer-Reviewed Original ResearchConceptsChildren's Hospital of Orange CountySymptom clustersManagement of symptom clustersAssessor-blinded clinical trialCancer symptom clustersIntegrative medicine modalitiesCancer patientsNeuropsychiatric symptom clustersMonths prior to enrollmentFollow-up appointmentsAcupuncture pointsVerum EABackgroundNeuropsychiatric symptomsEfficacy of EASham EAMedicine modalitiesElectroacupunctureControl armCognitive AssessmentDays prior to enrollmentRecruited patientsAcupunctureNeuropsychiatric symptomsAcupointsCognitive impairmentCost Consequence Analysis of ADMET 2
Mah E, Lanctôt K, Chen Q, Shade D, Scherer R, Vieira D, Coulibaly H, Rosenberg P, Lerner A, Padala P, Brawman-Mintzer O, van Dyck C, Porsteinsson A, Mintzer J, Herrmann N. Cost Consequence Analysis of ADMET 2. American Journal Of Geriatric Psychiatry 2023, 31: s101. DOI: 10.1016/j.jagp.2022.12.147.Peer-Reviewed Original ResearchCost-consequence analysisHealth utilityPlacebo groupMethylphenidate treatmentEuroQol-five dimensions-five levelsAlzheimer's diseaseHealth statesCommon neuropsychiatric symptomsHealth utility scoresQuality of lifeBinary logistic regressionApathy treatmentBaseline demographicsDifferent time pointsPreference-based measuresMethylphenidate groupNeuropsychiatric symptomsClinical trialsEQ-5DSignificant apathyPatientsUtility scoresBetter health stateLogistic regressionMethylphenidateUtility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure
Straus L, An X, Ji Y, McLean S, Neylan T, Cakmak A, Richards A, Clifford G, Liu M, Zeng D, House S, Beaudoin F, Stevens J, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Seamon M, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Harte S, Elliott J, Kessler R, Ressler K, Koenen K. Utility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure. JAMA Psychiatry 2023, 80: 220-229. PMID: 36630119, PMCID: PMC9857758, DOI: 10.1001/jamapsychiatry.2022.4533.Peer-Reviewed Original ResearchConceptsTraumatic stress exposureAdverse posttraumatic neuropsychiatric sequelaeEmergency departmentStress exposureNeuropsychiatric sequelaeGreater pain severityPain severityDerivation cohortNeuropsychiatric symptomsMean ageStudy criteriaSerial assessmentSleep disruptionMAIN OUTCOMEHigh incidenceUseful biomarkerBaseline assessmentPainSymptom severityDiverse cohortInformed consentPatientsSymptom domainsSleepDisadvantaged populationsDifferences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder
He L, Yang B, Ma Y, Wen L, Liu F, Zhang X, Liu T. Differences in clinical features and gut microbiota between individuals with methamphetamine casual use and methamphetamine use disorder. Frontiers In Cellular And Infection Microbiology 2023, 13: 1103919. PMID: 36909722, PMCID: PMC9996337, DOI: 10.3389/fcimb.2023.1103919.Peer-Reviewed Original ResearchConceptsMA use disorderClinical featuresGut microbiotaWithdrawal symptomsMA usersEnterotype 2Use disordersGM diversityBody mass indexMethamphetamine use disorderSemi-Structured AssessmentMass indexNeuropsychiatric symptomsHigh incidenceDiagnostic criteriaDifferential microbesDistinct enterotypesDrug dependenceGM differencesSymptomsClinical traitsPerformed network analysisStrong cravingsFecal samplesFurther studiesPrimary hypothyroidism presenting as neuropsychiatric symptoms and pituitary enlargement in a young woman: illustrative case
Haider S, Templeton K, Omay S, Inzucchi S. Primary hypothyroidism presenting as neuropsychiatric symptoms and pituitary enlargement in a young woman: illustrative case. Journal Of Neurosurgery Case Lessons 2023, 5: case22496. PMID: 36794728, PMCID: PMC10550602, DOI: 10.3171/case22496.Peer-Reviewed Original ResearchPituitary enlargementPrimary hypothyroidismPituitary hyperplasiaElevated thyroid-stimulating hormoneSevere primary hypothyroidismThyroid-stimulating hormoneComputed tomography scanMagnetic resonance imagingLevothyroxine replacementHormone replacementNeuropsychiatric symptomsRare presentationSellar massSurgical interventionTomography scanCommon causePituitary adenomasPhysiological causesResonance imagingPsychiatry departmentYoung womenHypothyroidismHyperplasiaSymptomsEnlargementHistone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease
Rodriguez G, Fisher D, McClarty B, Montalvo-Ortiz J, Cui Q, Chan C, Dong H. Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease. Frontiers In Psychiatry 2023, 13: 1020831. PMID: 36684015, PMCID: PMC9852991, DOI: 10.3389/fpsyt.2022.1020831.Peer-Reviewed Original ResearchMotor side effectsSevere neuropsychiatric symptomsAged miceSide effectsHDAC inhibitorsNeuropsychiatric symptomsDementia patientsHistone deacetylase inhibitor valproic acidAtypical antipsychotic risperidoneTypical antipsychotic haloperidolAntipsychotic drug targetsGreater side effectsInhibitor valproic acidHistone deacetylase inhibitorsAge-related sensitivityEpigenetic alterationsAtypical antipsychoticsD2R expressionAntipsychotic haloperidolLabel useAntipsychotic risperidoneAntipsychotic drugsMouse modelValproic acidClinical practice
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