2025
Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers
Wang J, Huang Q, Chen X, You Z, He K, Mao X, Huang Y, Franzmeier N, Schöll M, Guo T, Zhao J, Guan Y, Ni R, Li B, Xie F. Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers. Alzheimer's & Dementia 2025, 21: e70333. PMID: 40432308, PMCID: PMC12117192, DOI: 10.1002/alz.70333.Peer-Reviewed Original ResearchConceptsAssociated with longitudinal cognitive declineLongitudinal cognitive declineSynaptic lossCognitive declineSynapse lossPositron emission tomographyTau depositionTau positron emission tomographyTau burdenHealthy controlsAlzheimer's diseaseSynaptic densityMedial temporal lobePlasma glial fibrillary acidic proteinIncreased tau burdenPhosphorylated tau181Longitudinal changesCognitively impaired individualsAcidic proteinTau pathologyTemporal lobeAmyloid positron emission tomographyGlial fibrillary acidic proteinPlasma phosphorylated tau181CI groupNeurophysiological Progression in Alzheimer's Disease: Insights From Dynamic Causal Modelling of Longitudinal Magnetoencephalography
Jafarian A, Assem M, Kocagoncu E, Lanskey J, Fye H, Williams R, Quinn A, Pitt J, Raymont V, Lowe S, Singh K, Woolrich M, Nobre A, Henson R, Friston K, Rowe J. Neurophysiological Progression in Alzheimer's Disease: Insights From Dynamic Causal Modelling of Longitudinal Magnetoencephalography. Human Brain Mapping 2025, 46: e70234. PMID: 40396657, PMCID: PMC12093352, DOI: 10.1002/hbm.70234.Peer-Reviewed Original ResearchConceptsDynamic causal modelingAssociated with neurophysiological changesCognitive declineMedial prefrontal cortexAlzheimer's diseaseCausal modelEffects of Alzheimer's diseaseHuman neuroimaging dataExperimental medicine studiesRegion-SpecificLongitudinal changesApplication of dynamic causal modelingResting-state magnetoencephalographyMild cognitive impairmentPrefrontal cortexAmyloid-positive mild cognitive impairmentMode networkNMDA neurotransmissionTwenty-nine peopleNMDA type glutamate receptorsNeuroimaging dataCortical regionsEffective connectivityNeuropsychiatric diseasesNeuronal vulnerability
2024
Multimodal predictive modeling: Scalable imaging informed approaches to predict future brain health
Ajith M, Spence J, Chapman S, Calhoun V. Multimodal predictive modeling: Scalable imaging informed approaches to predict future brain health. Journal Of Neuroscience Methods 2024, 414: 110322. PMID: 39608579, PMCID: PMC11687617, DOI: 10.1016/j.jneumeth.2024.110322.Peer-Reviewed Original ResearchStatic functional network connectivityHealth constructsNeuroimaging dataBrain healthResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingSupport vector regressionFunctional network connectivityRandom forestCognitive performanceAssessment-onlyRs-fMRINeural patternsBehavioral outcomesBehavioral dataDiverse data sourcesNeural connectionsPsychological stateTraining stageMagnetic resonance imagingLongitudinal changesNetwork connectivityBrainPerformance evaluationVector regressionLongitudinal change and association between four types of social support and mental health among low-income U.S. veterans
Tsai J, Lai H, Maroufy V. Longitudinal change and association between four types of social support and mental health among low-income U.S. veterans. International Journal Of Social Psychiatry 2024, 71: 612-616. PMID: 39540431, DOI: 10.1177/00207640241299321.Peer-Reviewed Original ResearchSocial supportU.S. veteransMental healthLevels of perceived social supportLow socioeconomic statusMental health issuesPerceived Social SupportSocial support changesNationally Representative SampleLogistic mixed modelsSociodemographic characteristicsSocioeconomic statusHealth issuesRepresentative sampleVeteransPerceived levelSupport changeLongitudinal changesHealthMixed modelsSupportAssociationDepressionStatusNationalPlasma Proteomic Biomarkers in Alzheimer’s Disease and Cardiovascular Disease: A Longitudinal Study
Theeke L, Liu Y, Wang S, Luo X, Navia R, Xiao D, Xu C, Wang K, Initiative T. Plasma Proteomic Biomarkers in Alzheimer’s Disease and Cardiovascular Disease: A Longitudinal Study. International Journal Of Molecular Sciences 2024, 25: 10751. PMID: 39409080, PMCID: PMC11477191, DOI: 10.3390/ijms251910751.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentLinear mixed modelsAlzheimer's diseaseCardiovascular diseaseAlzheimer's Disease Neuroimaging InitiativeLongitudinal changesAssociated with longitudinal changesAssociation of ADAssociated with ADMultivariate linear mixed modelOlder adultsCardiovascular healthPlasma proteomic biomarkersRisk factorsCognitive declineCognitive impairmentLongitudinal studyProteomic biomarkersTamm-Horsfall proteinMixed modelsClinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights
Honhar P, Sadabad F, Tinaz S, Gallezot J, Dias M, Naganawa M, Yang Y, Henry S, Hillmer A, Gao H, Najafzadeh S, Comley R, Nabulsi N, Huang Y, Finnema S, Carson R, Matuskey D. Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights. Brain Communications 2024, 6: fcae345. PMID: 39429243, PMCID: PMC11487911, DOI: 10.1093/braincomms/fcae345.Peer-Reviewed Original ResearchDAT availabilityMotor severitySubstantia nigraDopamine transporter availabilityClinical trials of Parkinson's diseaseParkinson's diseaseLongitudinal studyTracking longitudinal changesClinical correlatesVentral striatumTransporter availabilityNigrostriatal regionParkinson's disease patientsPutamenMotor severity scoresAssociated with increasesSubstantiaDATLongitudinal changesTremor scoreNegative associationNigraSubstantia nigra of Parkinson's disease patientsTremor severityPET biomarkersRecommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose
Nagel C, Bishop N, Botoseneanu A, Allore H, Newsom J, Dorr D, Quiñones A. Recommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose. The Journals Of Gerontology Series A 2024, 79: glae122. PMID: 38742711, PMCID: PMC11163923, DOI: 10.1093/gerona/glae122.Peer-Reviewed Original ResearchConceptsStudy of multimorbidityHealth-related quality of lifeMeasures of multimorbidityEffect of multimorbidityPerson-centered outcomesHealth-related outcomesHealth-related qualityLongitudinal studyQuality of lifeHealth-related dataMultimorbidity researchHealth domainsMultimorbidityLate-lifePeriod of changeAging populationOperationalizing changeLongitudinal analysisLongitudinal changesMore advanced stagesQuantitative studyOutcomesResearch objectHealthPractical issuesRemodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery.
Ramachandra A, Jiang B, Jennings I, Manning E, Humphrey J. Remodeling of Murine Branch Pulmonary Arteries Under Chronic Hypoxia and Short-Term Normoxic Recovery. Journal Of Biomechanical Engineering 2024, 146 PMID: 38421341, DOI: 10.1115/1.4064967.Peer-Reviewed Original ResearchWeeks of hypoxiaBranch pulmonary arteriesWeeks of normoxic recoveryPulmonary arteryEndothelial cell responsesSmooth muscleChronic hypoxiaNormoxic recoveryPulmonary arterial remodelingCell responsesProximal pulmonary arteriesLongitudinal changesHypoxia-induced changesC57BL/6J micePulmonary pathologyThin collagen fibersArterial remodelingBiaxial mechanicsCircumferential stressEnergy storageNormal valuesHypoxiaWeeksVascular adaptationFraction of cytoplasmA Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age
Saha R, Saha D, Rahaman A, Fu Z, Liu J, Calhoun V. A Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age. Brain Connectivity 2024, 14: 130-140. PMID: 38308475, PMCID: PMC10954605, DOI: 10.1089/brain.2023.0040.Peer-Reviewed Original ResearchFunctional network connectivityFunctional connectivityPsychiatric problemsFunctional network connectivity matricesNetwork connectivityMultivariate patternsWhole-brain functional networksIntrinsic functional connectivityPattern of functional changesBrain functional connectivityIntrinsic functional relationshipLongitudinal changesAdolescent brainAge-related changesBrain networksStudy developmental changesScanning sessionBrain functionAssociated with longitudinal changesCognitive scoresDevelopmental changesBrain developmentFunctional changesCognitionLongitudinal change patterns
2023
Multimodal Fusion of Functional and Structural Data to Recognize Longitudinal Change Patterns in the Adolescent Brain
Saha R, Saha D, Fu Z, Silva R, Calhoun V. Multimodal Fusion of Functional and Structural Data to Recognize Longitudinal Change Patterns in the Adolescent Brain. 2023, 00: 1-5. DOI: 10.1109/bhi58575.2023.10313489.Peer-Reviewed Original ResearchFunctional network connectivityAdolescent brainPotential gender-related differencesBilateral sensorimotor cortexStructural magnetic resonance imagingMagnetic resonance imagingBrain functional connectivityGender-related differencesSensorimotor cortexLongitudinal change patternsGrey matter dataResonance imagingJoint independent component analysisLongitudinal changesFunctional connectivityBrain developmentBrain functionEntire brainBrain connectivityBrain connectionsBrain analysisBrainSensorimotor domainModalitiesSMRI dataNeural Changes in Children With Residual Speech Sound Disorder After Ultrasound Biofeedback Speech Therapy.
Spencer C, Vannest J, Preston J, Maas E, Sizemore E, McAllister T, Whalen D, Maloney T, Boyce S. Neural Changes in Children With Residual Speech Sound Disorder After Ultrasound Biofeedback Speech Therapy. Journal Of Speech Language And Hearing Research 2023, 66: 3223-3241. PMID: 37524116, PMCID: PMC10558148, DOI: 10.1044/2023_jslhr-22-00430.Peer-Reviewed Original ResearchConceptsResidual speech sound disorderFunctional magnetic resonance imagingSpeech sound disordersUltrasound visual feedbackSpeech therapy programSound disordersTD groupSpeech productionFunctional connectivityLeft visual association cortexFunctional magnetic resonance imaging experimentSeed-to-voxel approachRegion-of-interest approachSpeech therapySyllable repetition taskVisual association cortexTherapy programLongitudinal changesPatterns of activitySpeech motorWord probesNeural differencesLeft insulaNeural changesConnectivity differencesFunctional and Structural Longitudinal Change Patterns in Adolescent Brain
Saha R, Saha D, Fu Z, Silva R, Calhoun V. Functional and Structural Longitudinal Change Patterns in Adolescent Brain. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2023, 00: 1-4. PMID: 38082649, DOI: 10.1109/embc40787.2023.10340079.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingStructural magnetic resonance imagingFunctional network connectivityWhole-brainGray matterBrain functional magnetic resonance imagingMagnetic resonance imagingAdolescent brainFunctional connectivityResonance imagingMultivariate patternsLongitudinal change patternsUnivariate changesAdolescentsLongitudinal changesBrainIncreasing ageFunctional changesComplementary techniquesNetwork connectivityInterplay between uncertainty intolerance, emotion regulation, cognitive flexibility, and psychopathology during the COVID-19 pandemic: a multi-wave study
Godara M, Everaert J, Sanchez-Lopez A, Joormann J, De Raedt R. Interplay between uncertainty intolerance, emotion regulation, cognitive flexibility, and psychopathology during the COVID-19 pandemic: a multi-wave study. Scientific Reports 2023, 13: 9854. PMID: 37330557, PMCID: PMC10276821, DOI: 10.1038/s41598-023-36211-3.Peer-Reviewed Original ResearchConceptsIntolerance of uncertaintyEmotion regulation difficultiesCognitive controlMulti-wave studyRegulation difficultiesCognitive flexibilityEmotion regulationMental healthMaladaptive emotion regulationProtective factorsUncertainty intoleranceIndividual differencesMediation analysisMental health burdenCOVID-19 pandemicStress resilienceRisk factorsPsychopathologySignificant mental health burdenOnline assessmentLongitudinal changesNegative effectsDifficultiesHealth burdenAnxietyLongitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer’s disease
Chen C, McCullough A, Gordon B, Joseph-Mathurin N, Flores S, McKay N, Hobbs D, Hornbeck R, Fagan A, Cruchaga C, Goate A, Perrin R, Wang G, Li Y, Shi X, Xiong C, Pontecorvo M, Klein G, Su Y, Klunk W, Jack C, Koeppe R, Snider B, Berman S, Roberson E, Brosch J, Surti G, Jiménez-Velázquez I, Galasko D, Honig L, Brooks W, Clarnette R, Wallon D, Dubois B, Pariente J, Pasquier F, Sanchez-Valle R, Shcherbinin S, Higgins I, Tunali I, Masters C, van Dyck C, Masellis M, Hsiung R, Gauthier S, Salloway S, Clifford D, Mills S, Supnet-Bell C, McDade E, Bateman R, Benzinger T. Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer’s disease. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2669-2682. PMID: 37017737, PMCID: PMC10330155, DOI: 10.1007/s00259-023-06209-0.Peer-Reviewed Original ResearchConceptsStandardized uptake value ratioPhase 2/3 clinical trialsPositron emission tomographyAnti-Aβ monoclonal antibodyClinical trialsPlacebo armDrug effectsLongitudinal changesMonoclonal antibodiesGlobal cortical standardized uptake value ratioHead comparisonCortical standardized uptake value ratioRegional standardized uptake value ratiosAβ positron emission tomographyAmyloid-β positron emission tomographyAlzheimer's disease clinical trialsPET imagingUptake value ratioAβ PET imagingSimulated clinical trialTwo-sample t-testDrug armPittsburgh CompoundPET scansWelch two sample t-testDialectical Behavior Therapy for Justice-Involved Veterans: Changes in Treatment Targets in a Small, Pre-Post Design Clinical Trial
Edwards E, Epshteyn G, Snyder S, Gorman D, Coolidge B, Marcano E, Tsai J, Goodman M. Dialectical Behavior Therapy for Justice-Involved Veterans: Changes in Treatment Targets in a Small, Pre-Post Design Clinical Trial. Psychological Services 2023, 20: 98-107. PMID: 37053393, PMCID: PMC10570393, DOI: 10.1037/ser0000766.Peer-Reviewed Original ResearchConceptsDialectical behavior therapyJustice-involved veteransBehavioral therapySubstance usePre- to posttreatmentCase management needsTreatment targetIntegrative psychotherapyTherapeutic changePsychological distressCriminogenic riskMental healthVeteransLongitudinal changesPre-postQuality of lifeParticipantsPotential utilityPsychotherapyCase management interventionManagement interventionsInterventionDistressPosttreatmentSubstances
2022
New Therapeutics in Alzheimer’s Disease Longitudinal Cohort study (NTAD): study protocol
Lanskey J, Kocagoncu E, Quinn A, Cheng Y, Karadag M, Pitt J, Lowe S, Perkinton M, Raymont V, Singh K, Woolrich M, Nobre A, Henson R, Rowe J. New Therapeutics in Alzheimer’s Disease Longitudinal Cohort study (NTAD): study protocol. BMJ Open 2022, 12: e055135. PMID: 36521898, PMCID: PMC9756184, DOI: 10.1136/bmjopen-2021-055135.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentEarly-stage Alzheimer's diseaseCognitive impairmentPeer-reviewed scientific journalsLongitudinal cohort studyResearch Ethics CommitteeAlzheimer's diseaseAmyloid-positive mild cognitive impairmentAlzheimer's disease studyConference presentationsCohort studyMeasures of diseaseCognitive AssessmentDisease StudyStudy protocolPrimary analysisEthics CommitteeLongitudinal changesParticipantsCognitive changesWebsite publicationClinical trial durationNew therapeuticsEast of England-Cambridge Central Research Ethics CommitteeProgression of Alzheimer's diseaseKinetic evaluation and assessment of longitudinal changes in reference region and extracerebral [18F]MK-6240 PET uptake
Fu J, Lois C, Sanchez J, Becker J, Rubinstein Z, Thibault E, Salvatore A, Sari H, Farrell M, Guehl N, Normandin M, Fakhri G, Johnson K, Price J. Kinetic evaluation and assessment of longitudinal changes in reference region and extracerebral [18F]MK-6240 PET uptake. Cerebrovascular And Brain Metabolism Reviews 2022, 43: 581-594. PMID: 36420769, PMCID: PMC10063833, DOI: 10.1177/0271678x221142139.Peer-Reviewed Original ResearchConceptsPartial volume correctionLongitudinal changesReference regionStandardized uptake valueFollow-up scansExtracerebral signalsAssessment of longitudinal changesCross-sectional effect sizesUptake valuePET uptakeDistribution volumeRegional uptakeArterial samplesExtracerebral contaminationOne-yearCognitively-normalEffect sizePonsGroup differentiationVolume correctionSubject levelSubjectsLongitudinal clinical and biomarker characteristics of non-manifesting LRRK2 G2019S carriers in the PPMI cohort
Siderowf A, Seibyl J, Coffey C, Tosun-Turgut D, Shaw L, Trojanowski J, Singleton A, Kieburtz K, Toga A, Mollenhauer B, Galasko D, Poewe W, Foroud T, Poston K, Bressman S, Reimer A, Arnedo V, Clark A, Frasier M, Kopil C, Chowdhury S, Casaceli C, Dorsey R, Wilson R, Mahes S, Seibyl J, Salerno C, Ahrens M, Brumm M, Cho H, Fedler J, LaFontant D, Kurth R, Crawford K, Casalin P, Malferrari G, Weisz M, Orr-Urtreger A, Trojanowski J, Shaw L, Montine T, Baglieri C, Christini A, Russell D, Dahodwala N, Giladi N, Factor S, Hogarth P, Standaert D, Hauser R, Jankovic J, Saint-Hilaire M, Richard I, Shprecher D, Fernandez H, Brockmann K, Rosenthal L, Barone P, Espayc A, Rowe D, Marder K, Santiago A, Bressman S, Hu S, Isaacson S, Corvol J, Martinez J, Tolosa E, Tai Y, Politis M, Smejdir D, Rees L, Williams K, Kausar F, Williams K, Richardson W, Willeke D, Peacock S, Sommerfeld B, Freed A, Wakeman K, Blair C, Guthrie S, Harrell L, Hunter C, Thomas C, James R, Zimmerman G, Brown V, Mule J, Hilt E, Ribb K, Ainscough S, Wethington M, Ranola M, Santana H, Moreno J, Raymond D, Speketer K, Carvajal L, Carvalo S, Croitoru I, Garrido A, Payne L, Viswanth V, Severt L, Facheris M, Soares H, Mintun M, Cedarbaum J, Taylor P, Biglan K, Vandenbroucke E, Sheikh Z, Bingol B, Fischer T, Sardi P, Forrat R, Reith A, Egebjerg J, Hillert G, Saba B, Min C, Umek R, Mather J, De Santi S, Post A, Boess F, Taylor K, Grachev I, Avbersek A, Muglia P, Merchant K, Tauscher J. Longitudinal clinical and biomarker characteristics of non-manifesting LRRK2 G2019S carriers in the PPMI cohort. Npj Parkinson's Disease 2022, 8: 140. PMID: 36273008, PMCID: PMC9588016, DOI: 10.1038/s41531-022-00404-w.Peer-Reviewed Original ResearchNon-manifesting carriersParkinson's Progression Markers InitiativeHealthy controlsDAT deficitProgression Markers InitiativeLongitudinal changesBiofluid biomarkersCerebrospinal fluid AbetaNon-motor scalesDopamine transporter imagingPrevention clinical trialsNeurofilament light chainLRRK2 G2019S carriersClinical featuresClinical outcomesPhospho-tauTransporter imagingPPMI cohortTotal tauDAT bindingMean ageSerum biomarkersClinical trialsClinical measuresComprehensive motorLongitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy
Schurgers G, Walter S, Pishva E, Guloksuz S, Peerbooms O, Incio L, Arts B, Kenis G, Rutten B. Longitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy. European Neuropsychopharmacology 2022, 63: 60-70. PMID: 36067540, DOI: 10.1016/j.euroneuro.2022.07.183.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF/TrkBExpression of BDNFSerum BDNF protein levelsBDNF protein levelsElectroconvulsive therapyDepression scoresMRNA expressionPeripheral bloodTreatment-resistant depressed patientsProtein levelsMechanism of actionAntidepressant effectsNeurotrophic factorDepressed patientsLongitudinal alterationsSevere depressionBlood correlatesEffective treatmentLongitudinal changesTrkBStudy periodNR3C1PatientsTherapyUnderstanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records
Polimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, PMCID: PMC10986859, DOI: 10.1038/s41380-022-01735-z.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePosttraumatic stress disorderElectronic health recordsMillion Veteran ProgramArtery diseaseTotal scoreCAD diagnosisPlatelet amyloid precursor proteinHealth recordsPosttraumatic stress severityAmyloid precursor proteinEarly CAD diagnosisUK BiobankBidirectional relationshipTwo-sample Mendelian randomization (MR) analysisMendelian randomization analysisCAD riskHigh morbidityPTSD symptom severityCARDIoGRAMplusC4D consortiumPleiotropic mechanismsSymptom severityLongitudinal changesDiscordant effectsStress disorder
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