2025
Neuroprotective Strategies in Coronary Artery Disease Interventions
Fatima M, Bazarbaev A, Rana A, Khurshid R, Effiom V, Bajwa N, Nasir A, Candelario K, Tabraiz S, Colon S, Lee C, Dankwa S, Hameed I. Neuroprotective Strategies in Coronary Artery Disease Interventions. Journal Of Cardiovascular Development And Disease 2025, 12: 143. PMID: 40278202, PMCID: PMC12027976, DOI: 10.3390/jcdd12040143.Peer-Reviewed Original ResearchCoronary Artery Bypass GraftingDeep hypothermic circulatory arrestNeurological complicationsNerve injuryNeuroprotective strategiesOff-pump coronary artery bypass graftingHybrid revascularizationHypothermic circulatory arrestCranial nerve injuryNMDA receptor antagonistHigh-risk patientsEndoscopic coronary artery bypassCoronary artery bypassPeripheral nerve injuryArtery Bypass GraftingCerebral perfusion monitoringBloodless surgical fieldCoronary artery interventionRisk of strokeEmbolic protection devicesAntiplatelet administrationAortic manipulationReceptor antagonistCirculatory arrestTherapeutic hypothermia
2024
Fever and Therapeutic Hypothermia
Subramaniam T, Parasram M, Barnes E, Picard J, Sheth K. Fever and Therapeutic Hypothermia. 2024, 301-313. DOI: 10.1007/978-3-031-62220-5_19.Peer-Reviewed Original ResearchTargeted temperature managementTherapeutic hypothermiaInduction of hypothermiaPost-cardiac arrestNeurological diseasesCritical care settingManagement of feverNeurocritical care unitNeurologically injured patientsCare settingsSide effectsCare unitInjured brainFeverTemperature managementTherapeutic purposesPatientsHypothermia
2023
Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach
Valerio E, Stocchero M, Pirillo P, D’Errico I, Bonadies L, Galderisi A, Giordano G, Baraldi E. Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach. EBioMedicine 2023, 92: 104636. PMID: 37257315, PMCID: PMC10244906, DOI: 10.1016/j.ebiom.2023.104636.Peer-Reviewed Original ResearchConceptsAsphyctic infantsHypoxic-ischemic encephalopathyHealthy newbornsPerinatal asphyxiaMetabolic effectsSingle-center longitudinal studyDays of lifeTherapeutic hypothermiaUrinary metabolomePathobiological mechanismsSteroid levelsInfantsHypothermiaSteroidogenesis pathwayUntargeted metabolomics approachNewbornsSteroid contentTranslational researchLongitudinal studyPotential roleAsphyxiaEncephalopathyMetabolomics approachPathway analysisUntargeted metabolomics
2022
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study
Galderisi A, Tordin M, Suppiej A, Cainelli E, Baraldi E, Trevisanuto D. Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European Journal Of Pediatrics 2022, 182: 837-844. PMID: 36484862, PMCID: PMC9899169, DOI: 10.1007/s00431-022-04694-3.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyTherapeutic hypothermiaNeurodevelopmental outcomesLactate ratioDay 1Severe hypoxic-ischemic encephalopathyNew risk markerSevere hypoNeonatal hypoglycemiaMetabolic outcomesRisk markersObservational studyMetabolic variablesDay 2InfantsLactate concentrationEncephalopathyLactate kineticsNeurodevelopmentMetabolic fuelsNeonatesStrongest predictorHypothermiaOutcomesGlucose
2020
DTI parameters in neonates with hypoxic-ischemic encephalopathy after total body hypothermia
Longo D, Bottino F, Lucignani G, Scarciolla L, Pasquini L, Espagnet M, Polito C, Figà-Talamanca L, Calbi G, Savarese I, Giliberti P, Napolitano A. DTI parameters in neonates with hypoxic-ischemic encephalopathy after total body hypothermia. The Journal Of Maternal-Fetal & Neonatal Medicine 2020, 35: 4035-4042. PMID: 33203279, DOI: 10.1080/14767058.2020.1846180.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyApparent diffusion coefficientDiffusion tensor imaging parametersDiffusion tensor imagingCorticospinal tractInferior longitudinal fasciculusBasal gangliaDecrease of ADCModerate hypoxic-ischemic encephalopathyOptic tractNewborn hypoxic-ischemic encephalopathyAxial diffusivityLong-term outcomesNormalization of valuesTotal body coolingHIE newbornsCooled newbornsHealthy newbornsRadial diffusivityTherapeutic hypothermiaFollow-upHigher axial diffusivityHealthy controlsNewbornsDTI parameters
2019
Dynamic Thermal Mapping of Localized Therapeutic Hypothermia in the Brain
Walsh J, Huang Y, Simmons JW, Goodrich JA, McHugh B, Rothman DL, Elefteriades JA, Hyder F, Coman D. Dynamic Thermal Mapping of Localized Therapeutic Hypothermia in the Brain. Journal Of Neurotrauma 2019, 37: 55-65. PMID: 31311414, PMCID: PMC6922066, DOI: 10.1089/neu.2019.6485.Peer-Reviewed Original ResearchTargeted temperature management for cardiac arrest
Mody P, Kulkarni N, Khera R, Link MS. Targeted temperature management for cardiac arrest. Progress In Cardiovascular Diseases 2019, 62: 272-278. PMID: 31078561, DOI: 10.1016/j.pcad.2019.05.007.Peer-Reviewed Original ResearchConceptsHospital sudden cardiac arrestSudden cardiac arrestTemperature managementCardiac arrestSurvivors of SCAInitial shockable rhythmTargeted temperature managementInitial clinical trialsNon-shockable rhythmCore body temperatureTherapeutic hypothermiaDuration of coolingNeurological functionShockable rhythmPatient populationClinical trialsCurrent guidelinesNeurological damageCurrent evidenceSevere hypoxiaSurvivorsBody temperatureReview articleArrestSignificant improvement
2018
Somatosensory Neurons Enter a State of Altered Excitability during Hibernation
Hoffstaetter LJ, Mastrotto M, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO. Somatosensory Neurons Enter a State of Altered Excitability during Hibernation. Current Biology 2018, 28: 2998-3004.e3. PMID: 30174191, PMCID: PMC6173314, DOI: 10.1016/j.cub.2018.07.020.Peer-Reviewed Original ResearchConceptsSomatosensory neuronsAction potentialsPeripheral somatosensory neuronsVoltage-gated sodium channelsTherapeutic hypothermiaAltered excitabilityFunctional deficitsCase of neuronsSensory functionFiring patternsNeuronsCold exposureInput resistanceSodium channelsRapid restorationBody temperatureHypometabolismHypothermiaDevelopment of strategiesSensory informationProlonged periodAdaptive responseArousalCNSExcitability
2017
Prognostic Value of the Neurological Examination in Cardiac Arrest Patients After Therapeutic Hypothermia
Matthews EA, Magid-Bernstein J, Sobczak E, Velazquez A, Falo CM, Park S, Claassen J, Agarwal S. Prognostic Value of the Neurological Examination in Cardiac Arrest Patients After Therapeutic Hypothermia. The Neurohospitalist 2017, 8: 66-73. PMID: 29623156, PMCID: PMC5882011, DOI: 10.1177/1941874417733217.Peer-Reviewed Original ResearchPositive predictive valuePupillary light responseTherapeutic hypothermiaNeurological examinationCorneal reflexPredictive valueDay 3Poor outcomePrognostic valueDay 5Cerebral Performance Category scoreUniversity intensive care unitTime pointsCardiac arrest patientsCardiac arrest survivorsIntensive care unitLife-sustaining therapyNegative predictive valueLeast day 5False positive rateHospital dischargeArrest patientsArrest survivorsCare unitIdeal timing
2016
A major miss in prognostication after cardiac arrest: Burst suppression and brain healing
Becker D, Schiff N, Becker L, Holmes M, Fins J, Horowitz J, Devinsky O. A major miss in prognostication after cardiac arrest: Burst suppression and brain healing. Epilepsy & Behavior Reports 2016, 7: 1-5. PMID: 28053858, PMCID: PMC5198796, DOI: 10.1016/j.ebcr.2016.09.004.Peer-Reviewed Original ResearchCardiac arrestBurst suppressionTherapeutic hypothermiaLoss of brainstem reflexesMechanisms of therapeutic hypothermiaOut-of-hospital cardiac arrestAbsent motor responseStatus epilepticusBrainstem reflexesNeuronal cell deathFunctional capacityStandard criteriaCell deathArrestNegative endpointsHypothermiaMotor responseEnd-of-life decisionsBrain healingEnd-of-lifeEpilepticusSuppressionEndpointEffect of stimulus type and temperature on EEG reactivity in cardiac arrest
Fantaneanu T, Tolchin B, Alvarez V, Friolet R, Avery K, Scirica B, O’Brien M, Henderson G, Lee J. Effect of stimulus type and temperature on EEG reactivity in cardiac arrest. Clinical Neurophysiology 2016, 127: 3412-3417. PMID: 27693940, DOI: 10.1016/j.clinph.2016.09.002.Peer-Reviewed Original ResearchConceptsCardiac arrest patientsNipple pressureTherapeutic hypothermiaArrest patientsDifferent stimulus modalitiesTesting modalitiesModerate agreement ratesReliable outcome predictorsAgreement rateStimulus modalityInterrater agreementCardiac arrestOutcome predictorsEEG reactivityPressure reactivityReactive backgroundBetter outcomesHypothermiaPatientsOutcome determinationNormothermiaModalitiesBackground reactivityStimulus typePrior studies
2015
Systemic Administration of the TRPV3 Ion Channel Agonist Carvacrol Induces Hypothermia in Conscious Rodents
Feketa V, Marrelli S. Systemic Administration of the TRPV3 Ion Channel Agonist Carvacrol Induces Hypothermia in Conscious Rodents. PLOS ONE 2015, 10: e0141994. PMID: 26528923, PMCID: PMC4631363, DOI: 10.1371/journal.pone.0141994.Peer-Reviewed Original ResearchConceptsHypothermic effectConscious patientsNovel pharmacological methodHigh intravenous dosesInduction of hypothermiaTherapeutic hypothermiaBlood pressureIntravenous dosesSuboptimal effectivenessConscious rodentsPromising new strategySystemic administrationIntravenous administrationCold-seeking behaviorPharmacological methodsSubstantial toxicityHypothermia inductionSafe dosesHypothermiaChannel activationPatientsCore temperatureMiceAdministrationDosesTherapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis
Karvellas CJ, Stravitz R, Battenhouse H, Lee WM, Schilsky ML, Group F. Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis. Liver Transplantation 2015, 21: 4-12. PMID: 25308108, PMCID: PMC4939841, DOI: 10.1002/lt.24021.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAnalgesics, Non-NarcoticBrain EdemaChemical and Drug Induced Liver InjuryChi-Square DistributionFemaleHumansHypothermia, InducedLiver Failure, AcuteLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioRegistriesRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute liver failureNon-APAP patientsALF patientsTherapeutic hypothermiaAPAP patientsLiver failureUS Acute Liver Failure Study GroupAcute Liver Failure Study GroupImpact of THMulticenter retrospective cohort analysisTransplant-free survival rateEnd-stage liver diseaseAPAP-ALF patientsRetrospective cohort studyRetrospective cohort analysisAcetaminophen patientsSpontaneous survivalCerebral edemaCohort studyProspective trialHepatic encephalopathyLiver diseaseTracheal infectionGrade IIIWorse outcomes
2013
Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition
Feketa V, Balasubramanian A, Flores C, Player M, Marrelli S. Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. AJP Regulatory Integrative And Comparative Physiology 2013, 305: r1040-r1050. PMID: 24005250, PMCID: PMC3840321, DOI: 10.1152/ajpregu.00296.2013.Peer-Reviewed Original ResearchConceptsTachycardic responsesTRPV1 activationMuscle activityCore temperatureTRPM8 inhibitionConscious stroke patientsRole of TRPM8TRPM8 KO miceTreatment of strokeElectromyographic muscle activityInduction of hypothermiaCold-induced shiveringTherapeutic hypothermiaStroke patientsConscious miceTRPV1 agonistsKO miceAbdominal cavityTachycardiaBack musclesEffective hypothermiaMild decreaseProfound dropShiveringHypothermiaAssessment and management of cerebral edema and intracranial hypertension in acute liver failure
Mohsenin V. Assessment and management of cerebral edema and intracranial hypertension in acute liver failure. Journal Of Critical Care 2013, 28: 783-791. PMID: 23683564, DOI: 10.1016/j.jcrc.2013.04.002.Peer-Reviewed Original ResearchConceptsAcute liver failureLiver failureIntracranial pressureMultiorgan failureCerebral edemaIntracranial hypertensionLiver injuryBrain edemaIngestion of acetaminophenJugular venous oximetryLife-threatening complicationsBrain stem herniationIntracranial pressure monitoringLiver transplantationNeurologic deficitsRare complicationTherapeutic hypothermiaOsmotic therapyVenous oximetryTranscranial DopplerClinical symptomsPrimary insultGrade IIIHypertonic salinePropofol sedationAttenuation of cold‐induced shivering and tachycardia with modulators of thermosensitive TRPV1 and TRPM8 channels
Feketa V, Marrelli S. Attenuation of cold‐induced shivering and tachycardia with modulators of thermosensitive TRPV1 and TRPM8 channels. The FASEB Journal 2013, 27: 1201.27-1201.27. DOI: 10.1096/fasebj.27.1_supplement.1201.27.Peer-Reviewed Original ResearchCold-induced shiveringTRPV1 activationAfferent neural pathwaysCold-sensitive neuronsTRPM8 inhibitionCore temperatureTachycardic responsesTherapeutic hypothermiaAfferent pathwaysTRPM8 antagonistsCapsaicin receptorTRPM8 ion channelHeart rateMouse modelPharmacological modulationTachycardiaSkin warmingNeural pathwaysCombined treatmentShiveringTRPV1TRPM8 channelsIon channelsInhibitionComplete inhibition
2011
Neurologic Prognosis in Cardiac Arrest Patients Treated With Therapeutic Hypothermia
Blondin NA, Greer DM. Neurologic Prognosis in Cardiac Arrest Patients Treated With Therapeutic Hypothermia. The Neurologist 2011, 17: 241-248. PMID: 21881465, DOI: 10.1097/nrl.0b013e318224ee0e.Peer-Reviewed Original ResearchConceptsTherapeutic hypothermiaCardiac arrestNeurologic prognosisNeurologic outcomeGood neurologic outcomeCardiac arrest patientsNeurology practice parameterNeuromuscular blocking agentsCerebrospinal fluid biomarkersEligible patientsNeurologic prognosticationNeurophysiologic testingArrest patientsNeurophysiologic findingsPoor prognosisClinical examinationFluid biomarkersPharmacologic effectsBlocking agentPhysiologic effectsPractice parametersClinical examBetter outcomesPatientsPrognosis
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