2024
Heart lung axis in acute pulmonary embolism: Role of CT in risk stratification
Friedman R, Haramati L, Christian T, Sokol S, Alis J. Heart lung axis in acute pulmonary embolism: Role of CT in risk stratification. Clinical Imaging 2024, 116: 110311. PMID: 39413674, DOI: 10.1016/j.clinimag.2024.110311.Peer-Reviewed Original ResearchPathophysiology of pulmonary embolismRisk stratificationPulmonary embolismComputed tomographyRight ventricular (RV) dysfunctionRisk stratification of acute PEIndicator of RV dysfunctionRV/LV diameter ratioAcute pulmonary embolismLeft atrial volumeReview current guidelinesCause of mortalityRV dysfunctionAcute PEAtrial volumeCT findingsClot burdenCardiopulmonary reserveCurrent guidelinesLung axisClot locationPatient managementPatient populationRadiologist's reportPredictive value
2023
“Cancer’s a demon”: a qualitative study of fear and multilevel factors contributing to cancer treatment delays
Frosch Z, Jacobs L, O’Brien C, Brecher A, McKeown C, Lynch S, Geynisman D, Hall M, Edelman M, Bleicher R, Fang C. “Cancer’s a demon”: a qualitative study of fear and multilevel factors contributing to cancer treatment delays. Supportive Care In Cancer 2023, 32: 13. PMID: 38060063, DOI: 10.1007/s00520-023-08200-9.Peer-Reviewed Original ResearchPsychological distressPsychological sourcesPsychological factorsPsychological onesPsychological barriersQualitative studyTeam membersTreatment delayDistressCancer treatment delayHalf of patientsResultsTwenty-two patientsStart of therapyFearCommon solid tumorsCancer therapyCare team membersAnticipatory guidanceBeliefsMultilevel factorsPatients' beliefsMultiple aspectsCancer careCurrent guidelinesCare team1538. Is there value in performing yearly screening for latent tuberculosis infection by interferon-gamma release assay among patients living with HIV in non-endemic settings?
Palacios C, Achhra A, Barakat L, Virata M, Hao R, Baxter J, Malinis M. 1538. Is there value in performing yearly screening for latent tuberculosis infection by interferon-gamma release assay among patients living with HIV in non-endemic settings? Open Forum Infectious Diseases 2023, 10: ofad500.1373. PMCID: PMC10678242, DOI: 10.1093/ofid/ofad500.1373.Peer-Reviewed Original ResearchInterferon-gamma release assaysLatent tuberculosis infectionNew latent tuberculosis infectionsTuberculin skin testingNon-endemic settingRisk factorsCD4 countTuberculosis infectionCurrent guidelinesGroup APositive interferon-gamma release assaysHigher HIV viral loadUrban academic medical centerChest imaging resultsLow CD4 countTB exposure riskTB risk factorsCells/mm3HIV viral loadRetrospective chart reviewFeatures of patientsRisk of reactivationInterferon-gamma releaseCommon risk factorsAcademic medical centerImpact of same-admission percutaneous coronary intervention on periprocedural outcomes of transcatheter aortic valve implantation
Park D, An S, Arif A, Saini A, Golzar Y. Impact of same-admission percutaneous coronary intervention on periprocedural outcomes of transcatheter aortic valve implantation. Baylor University Medical Center Proceedings 2023, 37: 7-13. PMID: 38174009, PMCID: PMC10761096, DOI: 10.1080/08998280.2023.2273742.Peer-Reviewed Original ResearchAssociated with higher oddsHigher oddsPercutaneous coronary interventionCompare in-hospital outcomesAssociated with longer lengthNational Inpatient SamplePropensity score matchingCoronary artery diseaseIn-Hospital MortalityIn-Hospital OutcomesAcute myocardial infarctionArtery diseaseInpatient SampleScore matchingCoronary interventionHospital costsCardiac arrestTranscatheter aortic valve implantationCurrent guidelinesOddsMyocardial infarctionInterventionLonger lengthControl groupHospitalDevelopment of an innovative curriculum for paediatricians on peanut allergy prevention: How do we address current guidelines?
Leeds S, Slade M, Hafler J, Samady W, Jiang J, Bilaver L, Gupta R. Development of an innovative curriculum for paediatricians on peanut allergy prevention: How do we address current guidelines? The Clinical Teacher 2023, 21: e13689. PMID: 37935587, PMCID: PMC12199709, DOI: 10.1111/tct.13689.Peer-Reviewed Original ResearchPeanut allergy preventionAllergy preventionNeeds assessmentBroad clinical practiceSpecialty-specific guidelinesBaseline knowledge scoresPrimary preventionProspective studyPeanut allergyClinical guidelinesRisk infantsCurrent guidelinesClinical practiceKnowledge scoreClinical casesPediatriciansMajority of respondentsPreventionVariable evidenceEarly introductionKnowledge surveyAllergyKnowledge questionsInteractive curriculumGuidelinesTemperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions
Beekman R, Khosla A, Buckley R, Honiden S, Gilmore E. Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions. Journal Of Intensive Care Medicine 2023, 39: 611-622. PMID: 37787185, DOI: 10.1177/08850666231203596.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryCardiac arrestPopulation-based thresholdsDuration of therapyCardiac arrest survivorsCause of deathRobust preclinical evidencePatient-centered careCritical future stepNeurologic outcomeNeuroprotective therapiesPreclinical evidenceArrest survivorsClinical equipoiseBrain injuryCurrent guidelinesFever preventionIndividualized targetOnly interventionTherapeutic windowInsufficient evidenceResearch prioritiesPersonalized approachMetabolic demandsCore temperatureCancer Screening for Transgender Individuals Guidelines, Best Practices, and a Proposed Care Model
Sterling J, Carbonella J, Jones T, Hanchuk S, Kelly P, Garcia M. Cancer Screening for Transgender Individuals Guidelines, Best Practices, and a Proposed Care Model. Urologic Clinics Of North America 2023, 50: 563-576. PMID: 37775215, DOI: 10.1016/j.ucl.2023.06.014.Peer-Reviewed Original ResearchConceptsTransgender patientsGender-affirming hormone therapyCancer screening recommendationsEvidence-based dataHigh-risk behaviorsHormone therapyScreening recommendationsCancer screeningCurrent guidelinesPractice patternsCare modelLong-term effectsCancer riskIndividual guidelinesPatientsSufficient evidenceCancerGuidelinesTherapyPreventionRepresentativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines
Castro-Dominguez Y, Mena-Hurtado C, Algara M, Obas V, Ahmed Z, Romain G, Solaru K, Smolderen K. Representativeness of Peripheral Artery Disease Randomized Clinical Trials Supporting Current Guidelines. The American Journal Of Cardiology 2023, 201: 166-169. PMID: 37385170, DOI: 10.1016/j.amjcard.2023.05.053.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAD guidelinesArtery diseaseRecent American Heart Association/American CollegeAmerican Heart Association/American CollegeLower extremity peripheral artery diseaseOlder adult patientsRace/ethnicity distributionAdult patientsPooled proportionMean ageClinical trialsCurrent guidelinesEpidemiologic studiesAmerican CollegeTrial participantsRCTsEthnicity distributionOlder adultsTrialsWomenPatientsDiseaseGuidelinesEthnic groupsImpact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Akintoye E, Saijo Y, Braghieri L, Badwan O, Patel H, Dabbagh M, El Dahdah J, Jellis C, Desai M, Rodriguez L, Grimm R, Griffin B, Popović Z. Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. Journal Of The American College Of Cardiology 2023, 81: 1474-1487. PMID: 37045517, DOI: 10.1016/j.jacc.2023.02.037.Peer-Reviewed Original ResearchConceptsSmaller LV volumesAdverse eventsAortic regurgitationBody surface areaOlder patientsYounger patientsLV volumesImpact of ageLV remodelingSerial evaluationLV end-systolic volumeLV end-diastolic volumeSevere aortic regurgitationChronic aortic regurgitationLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volumeLower LV volumesAdult patientsConsecutive patientsMain endpointVentricular dimensionsVentricular remodelingCurrent guidelinesPatientsAntihypertensives in Pregnancy
Denoble A, Goldstein S, Pettker C. Antihypertensives in Pregnancy. Obstetrics And Gynecology Clinics Of North America 2023, 50: 39-78. PMID: 36822710, DOI: 10.1016/j.ogc.2022.10.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSignificant maternal morbidityTreatment of hypertensionAmniotic fluid volumeHypertensive disordersMaternal morbidityPregnant patientsFetal growthCurrent guidelinesEfficacy dataAvailable safetyPregnancyAntihypertensivesFluid volumeClose supervisionHypertensionMorbidityPatientsPostpartumMortalityAvailable dataDiagnosisClinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial
Nanna M, Yow E, Vemulapalli S, Mark D, Kelsey M, Patel M, Al-Khalidi H, Rogers C, Udelson J, Douglas P. Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial. American Heart Journal 2023, 261: 124-126. PMID: 36828202, PMCID: PMC10903188, DOI: 10.1016/j.ahj.2023.02.010.Peer-Reviewed Original Research
2022
Time in therapeutic range for targeted temperature management and outcomes following out-of-hospital cardiac arrest
Wheelock K, Chan P, Chen L, de Lemos J, Miller P, Nallamothu B, Girotra S, Khera R. Time in therapeutic range for targeted temperature management and outcomes following out-of-hospital cardiac arrest. Resuscitation 2022, 182: 109650. PMID: 36442596, PMCID: PMC9885789, DOI: 10.1016/j.resuscitation.2022.11.016.Peer-Reviewed Original ResearchConceptsFavorable neurologic outcomeHospital cardiac arrestTherapeutic rangeNeurologic outcomeOverall survivalTemperature managementCardiac arrestFavorable neurologic survivalFavorable neurological outcomeRetrospective cohort studyTargeted temperature managementHigh therapeutic rangeRisk-adjusted analysisComatose survivorsNeurologic survivalNeurological outcomeCohort studyHospital dischargeMedian durationMedian timeCurrent guidelinesCompression trialTreatment targetsSignificant associationGoal temperatureThe World Federation of Societies of Biological Psychiatry guidelines on the assessment and pharmacological treatment of compulsive sexual behaviour disorder
Turner D, Briken P, Grubbs J, Malandain L, Mestre-Bach G, Potenza M, Thibaut F. The World Federation of Societies of Biological Psychiatry guidelines on the assessment and pharmacological treatment of compulsive sexual behaviour disorder. Dialogues In Clinical Neuroscience 2022, 24: 10-69. PMID: 37522807, PMCID: PMC10408697, DOI: 10.1080/19585969.2022.2134739.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPharmacological treatmentCompulsive sexual behavior disorderBehavior disorderBiological Psychiatry (WFSBP) GuidelinesRelevant pharmacological treatmentFirst-choice treatmentTreatment of adultsType of medicationTreatment of patientsSexual behavior disorderParaphilic disordersStrength of evidenceChemsex behavioursHormonal agentsTreatment recommendationsCurrent guidelinesPsychiatric disordersPharmacological agentsClinical practiceExtensive literature searchLiterature searchPatientsGoogle ScholarDisordersWorld FederationDirect relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis
Yousef S, Amabile A, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Krane M, Geirsson A, Vallabhajosyula P. Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis. Journal Of Cardiac Surgery 2022, 37: 5052-5062. PMID: 36378856, DOI: 10.1111/jocs.17199.Peer-Reviewed Original ResearchConceptsDegree of ASCardiac structural changesAortic stenosisSevere symptomatic aortic stenosisEnd-organ morbiditiesStructural cardiac changesSymptomatic aortic stenosisEnd-organ diseaseKaplan-Meier curvesRisk of mortalityTransvalvular flow velocityCochran-Armitage testCause mortalityPatient characteristicsCardiac changesCardiac dysfunctionPatient morbidityTransvalvular velocityCurrent guidelinesGroup BGroup ACaucasian raceHigh riskCox modelEarly interventionGuidelines on Germline Testing for Urologic Tumor Syndromes
Gomella P, Mark J, Giri V, Kelly W, Gomella L. Guidelines on Germline Testing for Urologic Tumor Syndromes. European Urology Focus 2022, 8: 670-673. PMID: 35803854, DOI: 10.1016/j.euf.2022.06.010.Peer-Reviewed Original ResearchConceptsGermline testingCurrent guidelinesTumor syndromeTreatment of patientsScreening of patientsAvailability of testingDifferent organ systemsGenitourinary cancersGenitourinary tractUrologic cancersTreatment decisionsPatientsOrgan systemsGene mutationsCancerGenetic mutationsSyndromeFamily membersTreatmentGuidelinesMutationsTestingUse of geneticsTractCost‐effectiveness of second‐line therapies in adults with chronic immune thrombocytopenia
Goshua G, Sinha P, Kunst N, Pischel L, Lee AI, Cuker A. Cost‐effectiveness of second‐line therapies in adults with chronic immune thrombocytopenia. American Journal Of Hematology 2022, 98: 122-130. PMID: 35147241, PMCID: PMC9365880, DOI: 10.1002/ajh.26497.Peer-Reviewed Original ResearchConceptsThrombopoietin receptor agonistsChronic immune thrombocytopeniaSecond-line therapyImmune thrombocytopeniaEarly useCurrent practice trendsProbabilistic sensitivity analysesCost-effective treatmentFirst cost-effectiveness analysisCost-effectiveness analysisU.S. health systemLack of evidenceEarly splenectomyHematology (ASH) guidelinesReceptor agonistCurrent guidelinesSplenectomyClinical practicePractice trendsTherapyHealth systemCost-effective strategyRituximabThrombocytopeniaAmerican SocietyPrevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis
Nugent JT, Young C, Funaro MC, Jiang K, Saran I, Ghazi L, Wilson FP, Greenberg JH. Prevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis. The Journal Of Pediatrics 2022, 244: 30-37.e10. PMID: 35120981, PMCID: PMC9086113, DOI: 10.1016/j.jpeds.2022.01.047.Peer-Reviewed Original ResearchConceptsSecondary hypertensionPrimary careLow prevalenceNew diagnosisTime of diagnosisClinical practice guidelinesCochrane Library databasesBlood pressure deviceSignificant subgroup differencesParticipants' age rangeWeb of ScienceHypertension definitionReferral clinicProspective studyRetrospective studyOutpatient settingHealthy childrenSecondary causesCurrent guidelinesDiagnostic evaluationHypertensionObservational studyPractice guidelinesLibrary databasesPrevalence estimatesShort‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis
McGill MR, James LP, McCullough SS, Moran JH, Mathews SE, Peterson EC, Fleming DP, Tripod ME, Vazquez JH, Kennon‐McGill S, Spencer HJ, Dranoff JA. Short‐Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis. Hepatology Communications 2022, 6: 361-373. PMID: 34558847, PMCID: PMC8793989, DOI: 10.1002/hep4.1810.Peer-Reviewed Original ResearchConceptsAPAP-protein adductsAcetaminophen useCirrhosis groupClinical outcomesDay 5Sensitive biomarkerAdverse clinical outcomesShort-term administrationCompensated cirrhosisLiver injuryAPAP administrationLiver damagePK analysisCurrent guidelinesStudy initiationCirrhosisTerm safetyDay 1Day 3APAP metabolitesHigh dosesPatientsPilot studyAPAPLonger treatment
2021
Bridging Antiplatelet Therapy After Percutaneous Coronary Intervention JACC Review Topic of the Week
Sullivan AE, Nanna MG, Wang TY, Bhatt DL, Angiolillo DJ, Mehran R, Banerjee S, Cantrell S, Jones WS, Rymer JA, Washam JB, Rao SV, Ohman EM. Bridging Antiplatelet Therapy After Percutaneous Coronary Intervention JACC Review Topic of the Week. Journal Of The American College Of Cardiology 2021, 78: 1550-1563. PMID: 34620413, DOI: 10.1016/j.jacc.2021.08.013.Peer-Reviewed Original ResearchConceptsDual antiplatelet therapyAntiplatelet therapyBridging therapySmall-molecule glycoprotein IIb/IIIa inhibitorsGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsIntravenous antiplatelet agentsOptimal antiplatelet strategyPerioperative risk factorsCoronary stent implantationMultidisciplinary risk assessmentIntravenous P2YEarly surgeryHemorrhagic complicationsAntiplatelet strategiesClinical characteristicsAntiplatelet agentsPerioperative careRisk stratificationComplex patientsStent implantationRisk factorsCurrent guidelinesOptimal managementTherapyLI-RADS treatment response lexicon: review, refresh and resolve with emerging data
Ram R, Kampalath R, Shenoy-Bhangle AS, Arora S, Kielar AZ, Mendiratta-Lala M. LI-RADS treatment response lexicon: review, refresh and resolve with emerging data. Abdominal Radiology 2021, 46: 3549-3557. PMID: 34106301, DOI: 10.1007/s00261-021-03149-x.Peer-Reviewed Original ResearchConceptsTreatment response algorithmHepatocellular carcinomaRegional treatmentData System treatment response algorithmLI-RADS treatment response algorithmLoco-regional therapyLoco-regional treatmentLiver Imaging ReportingTreatment response assessmentCross-sectional modalitiesType of treatmentRegional therapyCurrent guidelinesTreatment responseResponse assessmentImaging ReportingCarcinomaTreatment
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