2023
Excluding Digenic Inheritance of PGAP2 and PGAP3 Variants in Mabry Syndrome (OMIM 239300) Patient: Phenotypic Spectrum Associated with PGAP2 Gene Variants in Hyperphosphatasia with Mental Retardation Syndrome-3 (HPMRS3)
Thompson M, Li X, Spencer-Manzon M, Andrade D, Murakami Y, Kinoshita T, Carpenter T. Excluding Digenic Inheritance of PGAP2 and PGAP3 Variants in Mabry Syndrome (OMIM 239300) Patient: Phenotypic Spectrum Associated with PGAP2 Gene Variants in Hyperphosphatasia with Mental Retardation Syndrome-3 (HPMRS3). Genes 2023, 14: 359. PMID: 36833286, PMCID: PMC9957281, DOI: 10.3390/genes14020359.Peer-Reviewed Original ResearchConceptsDigenic inheritanceDeficient CHO cell lineCell linesGPI deficiency disordersDeficient cell linesCHO cell linesBiosynthesis genesGPI attachmentMabry syndromeProtein geneStrong promoterCHO cellsUnknown significanceGenesInheritanceGene variantsAutosomal recessive inheritanceHomozygous variantNeurologic deficitsVariantsCase reportRecessive inheritanceSyndrome patientsCD55 expressionPGAP2
2022
Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort
Luo J, Ramlau-Hansen CH, Kesmodel US, Xiao J, Vasiliou V, Deziel NC, Zhang Y, Olsen J, Liew Z. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. Environmental Health Perspectives 2022, 130: 017006. PMID: 35080464, PMCID: PMC8791068, DOI: 10.1289/ehp9478.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortMaternal alcohol intakePrenatal PFAS exposurePalpebral fissure lengthShorter palpebral fissure lengthNational Birth CohortYears of agePFAS exposureSecond tertileAlcohol intakePrenatal exposureOdds ratioBirth cohortSpecific neurologic deficitsConfidence intervalsFetal brain developmentSex-specific associationsNeurologic deficitsFirst trimesterPotential confoundersNeurodevelopmental effectsAlcohol exposureStratified analysisNormal groupMultinomial logistic regression
2021
Endovascular and thrombolytic treatment eligibility in childhood arterial ischemic stroke
Hutchinson M, Beslow L, Shih E, Licht D, Kimmel A, Granath C, Ichord R. Endovascular and thrombolytic treatment eligibility in childhood arterial ischemic stroke. European Journal Of Paediatric Neurology 2021, 34: 99-104. PMID: 34454335, DOI: 10.1016/j.ejpn.2021.08.004.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeLarge vessel occlusionEndovascular therapyHyperacute therapyIV-tPAVessel occlusionIschemic strokeMedical contraindicationsScore 6Childhood arterial ischemic strokeIntravenous tissue plasminogen activatorNIH Stroke Scale scoreArterial ischemic strokeStroke Scale scoreSingle-center cohortMild neurologic deficitsTime of presentationComplete vessel occlusionTissue plasminogen activatorChildren ages 2Hyperacute treatmentClinical characteristicsNeurologic deficitsStroke pathwayTreatment eligibilityReducing the Cognitive Footprint of Brain Tumor Surgery
Dadario NB, Brahimaj B, Yeung J, Sughrue ME. Reducing the Cognitive Footprint of Brain Tumor Surgery. Frontiers In Neurology 2021, 12: 711646. PMID: 34484105, PMCID: PMC8415405, DOI: 10.3389/fneur.2021.711646.Peer-Reviewed Original ResearchOnco-functional balanceCognitive morbidityCortical regionsNew neurologic deficitsRate of resectionExtent of resectionBrain tumor surgeryHuman Connectome ProjectNeurologic deficitsSurgical managementPatient outcomesCortical mappingMotor functionTumor surgeryGlioma patientsStructural neuroanatomyInvasive techniquesBrain tumorsCerebral surgerySurgical armamentariumConnectomic dataEloquent tissueHigher-order cognitive functionsCognitive functionSurgeryUsing Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of Concept
Yeung JT, Taylor HM, Nicholas PJ, Young IM, Jiang I, Doyen S, Sughrue ME, Teo C. Using Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of Concept. World Neurosurgery 2021, 154: e734-e742. PMID: 34358688, DOI: 10.1016/j.wneu.2021.07.127.Peer-Reviewed Original ResearchConceptsIntracerebral surgeryNeurologic deficitsNew postoperative neurologic deficitsCases of leukoencephalopathyNew neurologic deficitsHigh-risk patientsPostoperative neurologic deficitsPostoperative neurologic outcomeIntra-axial tumorsFunctional localizationBrain networksEarlier retrospective studiesCritical brain networksDefault mode networkPostoperative strokeNeurologic outcomeMedian ageNeurological deficitsPreoperative findingsNew deficitsRetrospective studyPostsurgical outcomesIntracranial surgeryNeuronavigation platformStandard neuronavigationTeleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury.
Matiello M, Turner A, Estrada J, Whitney C, Kitch B, Lee P, Girkar U, Palacios R, Singla P, Schwamm L. Teleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury. Neurology 2021, 96: e1999-e2005. PMID: 33637632, DOI: 10.1212/wnl.0000000000011751.Peer-Reviewed Original ResearchConceptsIntensive care unitOrgan donorsNeurologic criteriaSevere neurologic damageSevere neurologic deficitsSevere neurologic injuryProportion of patientsDemographic informationPatient demographic informationPotential organ donorsDetermination of prognosisNumber of referralsProportion of donorsTeleneurology consultationsNeurologic deficitsNeurologic injuryMedian timeNeurologic damageCare unitComatose patientsCardiac arrestPatientsRetrospective dataConsultsOrgan donationValue of Emergent Neurovascular Imaging for “Seat Belt Injury”: A Multi-institutional Study
Sherbaf F, Chen B, Pomeranz T, Shahriari M, Adin M, Mirbagheri S, Beheshtian E, Jalilianhasanpour R, Pakpoor J, Lazor J, Kamali A, Yousem D. Value of Emergent Neurovascular Imaging for “Seat Belt Injury”: A Multi-institutional Study. American Journal Of Neuroradiology 2021, 42: 743-748. PMID: 33541893, PMCID: PMC8041015, DOI: 10.3174/ajnr.a6992.Peer-Reviewed Original ResearchConceptsBlunt cerebrovascular injurySeat belt signMotor vehicle collisionsCerebrovascular injurySeat belt injuryMulti-institutional studyBelt injuryVascular injuryNeurovascular imagingNew neurologic deficitsLarge-scale multi-institutional studyInternal carotid arteryLogistic regression analysisElectronic medical recordsCTA/MRANeurologic sequelaeMost patientsNeurologic deficitsAdult patientsPediatric patientsClinical findingsCTA findingsEmergency departmentAcute traumaRisk factors
2020
The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors
Faulkner H, Arnaout O, Hoshide R, Young IM, Yeung JT, Sughrue ME, Teo C. The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors. World Neurosurgery 2020, 146: e639-e650. PMID: 33152495, DOI: 10.1016/j.wneu.2020.10.147.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAstrocytomaAtaxiaBrain Stem NeoplasmsCerebrospinal Fluid LeakChildChild, PreschoolDiplopiaEpendymomaFemaleGlioblastomaGliomaHeadacheHumansHydrocephalusInfantInfant, NewbornKaplan-Meier EstimateKarnofsky Performance StatusMachine LearningMagnetic Resonance ImagingMaleMiddle AgedMultivariate AnalysisNauseaNeoplasm GradingNeoplasm, ResidualNeurosurgical ProceduresPostoperative ComplicationsPrognosisRetrospective StudiesSurvival RateTumor BurdenVomitingYoung AdultConceptsBrainstem gliomasSurgical resectionPrognostic factorsSurgical treatmentTransient neurologic deficitsRadical surgical resectionHigh-grade tumorsPostoperative radiographic evaluationMagnetic resonance imagingChart reviewNeurologic deficitsOverall survivalSurgical candidatesConfers survival advantageMedian ageSurgical indicationsPatient selectionSurvival outcomesRadiographic evaluationSelect subgroupRadiographic featuresPrimary treatmentPermanent deficitsSurvival advantageTreatment selection
2019
Intraoperative Use of O-arm in Pediatric Cervical Spine Surgery
Verhofste BP, Glotzbecker MP, Hresko MT, MacDougall RD, Birch CM, O’Neill N, Karlin LI, Emans JB, Proctor MR, Hedequist DJ. Intraoperative Use of O-arm in Pediatric Cervical Spine Surgery. Journal Of Pediatric Orthopaedics 2019, 40: e266-e271. PMID: 31192887, DOI: 10.1097/bpo.0000000000001416.Peer-Reviewed Original ResearchConceptsIntraoperative O-armCervical spine instrumentationO-armSpine instrumentationScrew positionPediatric cervical spine surgerySingle-center retrospective studyMean CT dose indexIntraoperative screw revisionsCervical spine surgeryVertebral artery injuryCervical spine fusionPostoperative CT scansDose-length productO-arm imagingCT dose indexFree-hand techniqueOptimal implant positionArtery injuryDural injuryNeurologic deficitsNeurovascular complicationsPediatric patientsPrimary outcomeFrequent indicationStereotactic Laser Ablation as Treatment of Brain Metastases Recurring after Stereotactic Radiosurgery: A Systematic Literature Review
Alattar AA, Bartek J, Chiang VL, Mohammadi AM, Barnett GH, Sloan A, Chen CC. Stereotactic Laser Ablation as Treatment of Brain Metastases Recurring after Stereotactic Radiosurgery: A Systematic Literature Review. World Neurosurgery 2019, 128: 134-142. PMID: 31051303, DOI: 10.1016/j.wneu.2019.04.200.Peer-Reviewed Original ResearchConceptsStereotactic laser ablationLocal controlContrast-enhancing volumeBrain metastasesFluid-attenuated inversion recovery volumeMalignant cerebral edemaPermanent neurologic injuryPreoperative lesion volumeMedian hospital stayDuration of therapyPotential treatment optionPercentage of tumorsHours of treatmentHospital stayNeurologic outcomePeriprocedural managementCerebral edemaCommon complicationMedian survivalNeurologic deficitsNeurologic injuryOverall survivalClinical courseTreatment optionsOptimal treatmentNeuroimaging of Pediatric Arteriopathies
Goyal P, Malhotra A, Almast J, Sapire J, Gupta S, Mangla M, Mangla R. Neuroimaging of Pediatric Arteriopathies. Journal Of Neuroimaging 2019, 29: 287-308. PMID: 30920080, DOI: 10.1111/jon.12614.Peer-Reviewed Original ResearchConceptsIschemic strokeMajor prognostic implicationsPediatric ischemic strokeSecondary stroke preventionAcute ischemic strokeFocal neurologic deficitsAdult stroke populationSmall vessel arteriopathyNoninflammatory etiologiesRecurrent strokeStroke preventionSystemic complicationsCerebral arteriopathyNeurologic deficitsStroke etiologyAcute managementPrompt diagnosisStroke populationNeuropsychiatric symptomsClinical manifestationsClinical symptomsPrognostic implicationsPredominant vesselRisk factorsSchool-aged childrenCerebral protection strategies in aortic arch surgery: A network meta-analysis
Hameed I, Rahouma M, Khan FM, Wingo M, Demetres M, Tam DY, Lau C, Iannacone EM, Di Franco A, Palaniappan A, Anderson H, Fremes SE, Girardi LN, Gaudino M. Cerebral protection strategies in aortic arch surgery: A network meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2019, 159: 18-31. PMID: 30902473, DOI: 10.1016/j.jtcvs.2019.02.045.Peer-Reviewed Original ResearchDeep hypothermic circulatory arrestAntegrade cerebral perfusionRetrograde cerebral perfusionHypothermic circulatory arrestAortic arch surgeryCerebral perfusionCirculatory arrestArch surgeryPostoperative strokeSecondary outcomesPrimary outcomeBilateral antegrade cerebral perfusionGeneric inverse variance methodCerebral protection strategiesCirculatory arrest durationTransient neurologic deficitsOperative mortality rateBetter postoperative outcomesInverse variance methodSystematic literature searchCerebral protectionOperative mortalityRespiratory complicationsNeurologic deficitsPostoperative outcomes
2018
Cost-effectiveness of Magnetic Resonance Imaging in Cervical Clearance of Obtunded Blunt Trauma After a Normal Computed Tomographic Finding
Wu X, Malhotra A, Geng B, Kalra VB, Abbed K, Forman HP, Sanelli P. Cost-effectiveness of Magnetic Resonance Imaging in Cervical Clearance of Obtunded Blunt Trauma After a Normal Computed Tomographic Finding. JAMA Surgery 2018, 153: 625-632. PMID: 29541757, PMCID: PMC5875318, DOI: 10.1001/jamasurg.2018.0099.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingBlunt traumaResonance imagingCervical clearanceNeurologic deficitsTomographic findingsHealth benefitsNational Spinal Cord Injury DatabaseSpinal Cord Injury DatabaseCost of MRISpecificity of MRIUse of MRIPermanent neurologic deficitsGroup of patientsComputed tomographic findingsNegative predictive valueProbabilistic sensitivity analysesCost-effectiveness analysisLower health benefitsCervical CTCT findingsInitial CTNormal CTCervical collarCervical spine
2017
Pneumocephalus and Sixth Nerve Palsy after Epidural Steroid Injection: Case Report and Review of the Literature
Li WF, Kovacs K, Fisayo AA. Pneumocephalus and Sixth Nerve Palsy after Epidural Steroid Injection: Case Report and Review of the Literature. Journal Of Emergency Medicine 2017, 53: e89-e92. PMID: 28987313, DOI: 10.1016/j.jemermed.2017.08.021.Peer-Reviewed Original ResearchCost-effectiveness of Magnetic Resonance Imaging in Cervical Spine Clearance of Neurologically Intact Patients With Blunt Trauma
Wu X, Malhotra A, Geng B, Liu R, Abbed K, Forman HP, Sanelli P. Cost-effectiveness of Magnetic Resonance Imaging in Cervical Spine Clearance of Neurologically Intact Patients With Blunt Trauma. Annals Of Emergency Medicine 2017, 71: 64-73. PMID: 28826754, DOI: 10.1016/j.annemergmed.2017.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAftercareCervical VertebraeCost-Benefit AnalysisDecision Support TechniquesHealth Care CostsHumansMagnetic Resonance ImagingMarkov ChainsModels, EconomicQuality-Adjusted Life YearsSensitivity and SpecificitySpinal InjuriesTomography, X-Ray ComputedUnited StatesWounds, NonpenetratingConceptsMagnetic resonance imagingCervical computed tomographyBlunt traumaIntact patientsUnstable injuriesCT resultsResonance imagingCost of MRICervical spine clearanceIncidence of patientsPermanent neurologic deficitsHealth benefitsNegative predictive valueProbabilistic sensitivity analysesInitial CT resultsCervical clearanceSpine clearanceNeurologic deficitsHard collarCord injuryPatient populationAlert patientsComputed tomographyPredictive valuePatientsDoes BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery?
Ma WG, Ziganshin BA, Guo CF, Zafar MA, Sieller RS, Tranquilli M, Elefteriades JA. Does BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery? Journal Of Thoracic Disease 2017, 9: 2491-2497. PMID: 28932555, PMCID: PMC5594166, DOI: 10.21037/jtd.2017.06.120.Peer-Reviewed Original ResearchAnastomotic pseudoaneurysm formationThoracic aortic diseaseThoracic aortic surgeryUse of BioGluePseudoaneurysm formationSurgical repairAortic diseaseAortic surgeryAnastomotic pseudoaneurysmFollow-up computed tomography scanEmergency/urgent surgeryAortic surgical proceduresThoracic aortic aneurysmComputed tomography scanArch replacementOperative survivorsAortic ulcerIntramural hematomaOperative mortalityUrgent surgeryNeurologic deficitsAortic dissectionSurgical indicationsHemostatic adjunctMean ageO-018 Flow diversion for the treatment of basilar apex aneurysms
Dmytriw, Adeeb N, Kumar A, Griessenauer C, Ogilvy C, Foreman P, Shallwani H, Limbucci N, Mangiafico S, Michelozzi C, Krings T, Pereira V, Matouk C, Zhang Y, Harrigan M, Phan K, Shakir H, Siqqiqui A, Levy E, Renieri L, Cognard C, Thomas A, Marotta T. O-018 Flow diversion for the treatment of basilar apex aneurysms. Journal Of NeuroInterventional Surgery 2017, 9: a11. DOI: 10.1136/neurintsurg-2017-snis.18.Peer-Reviewed Original ResearchBasilar apex aneurysmsPosterior circulation aneurysmsComplication rateFlow diversionCommon off-label useHigh complication rateAneurysmal subarachnoid hemorrhageOff-label useSignificant treatment challengePipeline Embolization DeviceRedirection Endoluminal DeviceSingle flow diverterPostprocedural settingSymptomatic thromboembolicHemorrhagic complicationsMinor complicationsNeurologic deficitsConsecutive patientsMajor complicationsAdditional patientsRetrospective reviewAdjunctive coilingSubarachnoid hemorrhagePED placementCerebellar strokeBrain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas
Jobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King‐Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia 2017, 58: 1005-1014. PMID: 28387951, DOI: 10.1111/epi.13739.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingCerebral CortexDeep Brain StimulationDrug Resistant EpilepsyElectric Stimulation TherapyElectrodes, ImplantedElectroencephalographyEpilepsies, PartialEpilepsy, Complex PartialEpilepsy, Partial, MotorEpilepsy, Tonic-ClonicFeasibility StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedNeocortexYoung AdultConceptsSeizure-free periodSeizure reductionNeocortical onsetSeizure onsetNeocortical originIntractable partial-onset seizuresMedian percent seizure reductionBrain-responsive neurostimulationChronic neurologic deficitsPercent seizure reductionPrior epilepsy surgeryPartial-onset seizuresPercent of patientsProspective clinical trialsNormal MRI findingsVagus nerve stimulationEffective treatment optionEloquent cortical areasRate of infectionMagnetic resonance imagingPreimplantation baselineMRI lesionsAdverse eventsNeurologic deficitsPerioperative hemorrhage
2016
Management of Complications of Acute Otomastoiditis in Solid Organ Transplant Patients.
Hildrew D, Adams A, Winters R, Aslam R. Management of Complications of Acute Otomastoiditis in Solid Organ Transplant Patients. Journal Of The Louisiana State Medical Society 2016, 168: 104-6. PMID: 27389380.Peer-Reviewed Original ResearchConceptsSolid organ transplantsAcute otomastoiditisSigmoid sinus thrombosisSinus thrombosisOrgan transplantsSolid organ transplant patientsCadaveric renal transplantsResidual neurologic deficitsAcute otitis mediaOrgan transplant patientsTympanostomy tube placementManagement of complicationsYear old manRenal transplantSystemic complicationsTransplant patientsAggressive treatmentNeurologic deficitsPrompt recognitionCortical mastoidectomyFatal sequelaeTube placementOtitis mediaCase reportEarly recognition
2015
Direct innominate artery cannulation: An alternate technique for antegrade cerebral perfusion during aortic hemiarch reconstruction
Jassar AS, Vallabhajosyula P, Bavaria JE, Gutsche J, Desai ND, Williams ML, Milewski RK, Hargrove WC, Szeto WY. Direct innominate artery cannulation: An alternate technique for antegrade cerebral perfusion during aortic hemiarch reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2015, 151: 1073-1078. PMID: 26725716, DOI: 10.1016/j.jtcvs.2015.11.027.Peer-Reviewed Original ResearchMeSH KeywordsAgedAorta, ThoracicAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationBrachiocephalic TrunkCatheterization, PeripheralCerebrovascular CirculationFemaleHeart Arrest, InducedHospital MortalityHumansHypothermia, InducedMaleMiddle AgedPerfusionPostoperative ComplicationsRegional Blood FlowReoperationTime FactorsTreatment OutcomeConceptsAntegrade cerebral perfusionModerate hypothermic circulatory arrestHypothermic circulatory arrestHemiarch reconstructionInnominate arteryCerebral perfusionCirculatory arrestReversible ischemic neurologic deficitExcellent cerebral protectionInnominate artery cannulationIschemic neurologic deficitAortic valve replacementRenal failure rateProximal aortic aneurysmIncidence of injuryACP timeAscending aorticCrossclamp timeArtery cannulationCerebral protectionCentral cannulationNeurologic deficitsPatient ageRoot replacementValve replacement
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply