2025
286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling
HE B, COPPS K, WHITE M, TAO R. 286-OR: Spatial Regulation of Glucose and Lipid Metabolism by Hepatic Insulin Signaling. Diabetes 2025, 74 DOI: 10.2337/db25-286-or.Peer-Reviewed Original ResearchInsulin signalingHepatic Insulin SignalingDisrupted insulin signalingRegulation of glucoseSpatial regulationLipid homeostasisMetabolic enzymesFunctional significanceGlycolytic metabolismSystemic glucoseLipid metabolismGlucose homeostasisHepatic insulin sensitivityExcessive lipogenesisLipogenesisHomeostasisElevated blood glucoseType 2 diabetesMetabolismMetabolic dysregulationGlucoseHepatosteatosisLiver-to-muscleInsulin resistanceLipid2070-LB: Modeling to Assess the Impact of Liquid, Stable Glucagon for Mini-dosing in Pediatrics—A Simulated Pharmacokinetic and Pharmacodynamic Study
FITCH R, MOULD D, SHERR J, LAFFEL L, NALLY L, FERGUSON N. 2070-LB: Modeling to Assess the Impact of Liquid, Stable Glucagon for Mini-dosing in Pediatrics—A Simulated Pharmacokinetic and Pharmacodynamic Study. Diabetes 2025, 74 DOI: 10.2337/db25-2070-lb.Peer-Reviewed Original ResearchMini-dose glucagonBaseline glucose levelsGlucagon doseGlucose levelsVisual predictive checkY/O groupMini-dosePediatric groupPediatric populationPharmacodynamic studiesClinical studiesPediatric studiesGlucose excursionsDose responseDoseAged 2Glucose responseAge-weight relationshipGlucagonImpending hypoglycemiaPredictive checksBaselineGlucoseMicro-dosingGroupSpatial regulation of glucose and lipid metabolism by hepatic insulin signaling
He B, Copps K, Stöhr O, Liu B, Hu S, Joshi S, Haigis M, White M, Zhu H, Tao R. Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling. Cell Metabolism 2025, 37: 1568-1583.e7. PMID: 40245868, DOI: 10.1016/j.cmet.2025.03.015.Peer-Reviewed Original ResearchInsulin signalingHepatic Insulin SignalingDisrupted insulin signalingRegulation of glucoseSpatial regulationLipid homeostasisElevated gluconeogenesisMetabolic enzymesFunctional significanceGlycolytic metabolismSystemic glucoseLipid metabolismGlucose homeostasisHepatic insulin sensitivityExcessive lipogenesisLipogenesisHomeostasisMetabolismMetabolic dysregulationHepatosteatosisHepatocytesGlucoseInsulin resistanceLipidType 2 diabetes
2024
Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care
Bonet J, Guiducci S, Res G, Brigadoi S, Sen S, Montaldo P, Priante E, Santoro N, Trevisanuto D, Baraldi E, Dalla Man C, Galderisi A. Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care. The Journal Of Pediatrics 2024, 278: 114416. PMID: 39579867, DOI: 10.1016/j.jpeds.2024.114416.Peer-Reviewed Original ResearchBlood glucoseContinuous glucose monitoringSensor glucoseNeonatal intensive care unitInfants born pretermWeeks of gestationNeonatal intensive careIntensive care unitVery pretermGlucose monitoringCare unitIntensive carePoint-of-care blood glucoseInfantsPretermNeonatesPaired measurementsCGM accuracyHoursBirthweightGestationGlucoseBirthWeeksSmall molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation
Mutlu B, Sharabi K, Sohn J, Yuan B, Latorre-Muro P, Qin X, Yook J, Lin H, Yu D, Camporez J, Kajimura S, Shulman G, Hui S, Kamenecka T, Griffin P, Puigserver P. Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation. Cell Chemical Biology 2024, 31: 1772-1786.e5. PMID: 39341205, PMCID: PMC11500315, DOI: 10.1016/j.chembiol.2024.09.001.Peer-Reviewed Original ResearchPhosphoenolpyruvate carboxykinase 1Lysine acetylationTricarboxylic acidAnti-diabetic effectsAnaplerotic reactionsGluconeogenic reactionsLiver-specific expressionGluconeogenic metabolitesLactate oxidationSmall moleculesAnti-diabetic actionSuppressed gluconeogenesisHepatic glucose productionPGC-1aAcetylationOxaloacetateGluconeogenesisObese miceGlucose productionIncreased glucoseGlucose oxidationSubstrate oxidationOxidationGlucoseMutantsA kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria
Faniyan T, Zhang X, Morgan D, Robles J, Bathina S, Brookes P, Rahmouni K, Perry R, Chhabra K. A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria. ELife 2024, 12 DOI: 10.7554/elife.91540.4.Peer-Reviewed Original ResearchGlucose productionEndogenous glucose productionReabsorption of nutrientsLoss of glucoseHypothalamic-pituitary-adrenal axisNormal energy supplyProteomic analysisCompensatory increaseAfferent renal nervesAfferent renal denervationPlasma proteomic analysisDefense mechanismsAcute phase proteinsRenal denervationKO miceSGLT2 inhibitorsKnockout miceRenal nervesAfferent nervesEfficiency of drugsBody's defense mechanismsGlycosuriaGlucosePhase proteinsTreat hyperglycemia326-OR: Activity Feature Attenuates Drop in Glucose for Individuals with Type 1 Diabetes Using Omnipod 5 Automated Insulin Delivery System
TURNER L, SHERR J, ZAHARIEVA D, BARAN J, BODE B, BROWN S, BZDICK S, MEI CHURCH M, HANSEN D, KINGMAN R, LAFFEL L, SHAH V, STONE S, VIENNEAU T, HUYETT L, DUMAIS B, LY T, RIDDELL M, 5 EXERCISE RESEARCH GROUP O. 326-OR: Activity Feature Attenuates Drop in Glucose for Individuals with Type 1 Diabetes Using Omnipod 5 Automated Insulin Delivery System. Diabetes 2024, 73 DOI: 10.2337/db24-326-or.Peer-Reviewed Original ResearchGeneralized Estimating EquationsInternational Society for Pediatric and Adolescent DiabetesActivity sessionsEstimating EquationsType 1 diabetesExerciseAdolescent DiabetesAF-30Glucose declineDeliveryInsulin deliveryInsuletSessionsDelivery systemInsulin delivery systemsDiabetesAutomated deliveryOmnipodRiskGlucoseT1DPeople
2023
Modeling the effect of non-exercise activity on peak post-prandial glucose in diabetes
Do E, Das A, Glanz N, Bevier W, Santiago R, Kerr D, Gutierrez-Osuna R, Mortazavi B. Modeling the effect of non-exercise activity on peak post-prandial glucose in diabetes. 2023, 00: 1-4. DOI: 10.1109/bsn58485.2023.10331072.Peer-Reviewed Original ResearchNon-exercise activity thermogenesisPost-prandial glucosePeak glucoseNon-exercise activityGlucose surgesPostprandial glucoseBlood glucoseGlucose excursionsPostprandial exerciseActivity thermogenesisClinical relevanceFree-living environmentGlucose reductionModerate intensityActivity intensityDiabetesEffects modelGlucoseExerciseGreater attenuationMinutesMealDurationImaging metabolism of deuterated glucose in patients with primary brain tumors
Corbin Z, Liu Y, Fulbright R, Thaw-Poon S, Baehring J, Blondin N, Kim P, Omuro A, Chiang V, Moliterno J, Omay S, Piepmeier J, Rothman D, de Graaf R, De Feyter H. Imaging metabolism of deuterated glucose in patients with primary brain tumors. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0142.Peer-Reviewed Original Research
2022
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study
Galderisi A, Tordin M, Suppiej A, Cainelli E, Baraldi E, Trevisanuto D. Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European Journal Of Pediatrics 2022, 182: 837-844. PMID: 36484862, PMCID: PMC9899169, DOI: 10.1007/s00431-022-04694-3.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyTherapeutic hypothermiaNeurodevelopmental outcomesLactate ratioDay 1Severe hypoxic-ischemic encephalopathyNew risk markerSevere hypoNeonatal hypoglycemiaMetabolic outcomesRisk markersObservational studyMetabolic variablesDay 2InfantsLactate concentrationEncephalopathyLactate kineticsNeurodevelopmentMetabolic fuelsNeonatesStrongest predictorHypothermiaOutcomesGlucoseGlucose variability increases during minimally invasive procedures in very preterm infants
Galderisi A, Res G, Guiducci S, Savio F, Brigadoi S, Forlani L, Mastrandrea B, Moschino L, Lolli E, Priante E, Trevisanuto D, Baraldi E. Glucose variability increases during minimally invasive procedures in very preterm infants. European Journal Of Pediatrics 2022, 182: 89-94. PMID: 36201017, PMCID: PMC9829573, DOI: 10.1007/s00431-022-04641-2.Peer-Reviewed Original ResearchConceptsVery preterm infantsContinuous glucose monitoringPreterm infantsGlucose variabilityNeonatal stressNappy changeInvasive proceduresMedian glucoseGlucose monitoringNon-invasive procedurePrimary outcomeAbsence of changesHeel prickMean glucoseNeonatal proceduresCare proceduresDay 2InfantsParental presenceGlucose variationCGM dataGlucoseSDNeonatesPrick342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth
GALDERISI A, LAT J, SAMUELS S, PIERPONT B, VAN NAME M, SANTORO N, CAPRIO S. 342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth. Diabetes 2022, 71 DOI: 10.2337/db22-342-or.Peer-Reviewed Original ResearchBeta-cell functionIncretin effectInsulin sensitivityInsulin secretionCell functionFirst-phase insulin secretionIsoglycemic intravenous glucose infusionLongitudinal declineReduced β-cell functionEarly insulin secretionLower insulin sensitivityIntravenous glucose infusionΒ-cell functionOral minimal modelIncretin groupsObese youthGlucose infusionRelative increaseNational InstituteTertileLongitudinal trajectoriesObesitySecretionGlucoseGroupDeuterium Metabolic Imaging of the Human Brain in vivo at 7T
Roig E, De Feyter H, Nixon T, Ruhm L, Avdievich N, Henning A, de Graaf R. Deuterium Metabolic Imaging of the Human Brain in vivo at 7T. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/0635.Peer-Reviewed Original ResearchCREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
Russell EM, Carlson JC, Krishnan M, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Viali S, Tuitele J, Major TJ, Miljkovic I, Merriman TR, Deka R, Weeks DE, McGarvey ST, Minster RL. CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand. BMJ Open Diabetes Research & Care 2022, 10: e002275. PMID: 35144939, PMCID: PMC8845200, DOI: 10.1136/bmjdrc-2021-002275.Peer-Reviewed Original ResearchConceptsBody mass indexType 2 diabetesAssociation of BMIHigher Body Mass IndexMinor alleleType 2 diabetes riskCross-sectional associationsPacific Island populationsRs373863828 genotypeMass indexDiabetes riskHigher oddsLower oddsDiabetesObesityEvidence of differencesMissense variantsRs373863828Regression analysisGlucoseAssociationOddsIndirect effectsPolynesian individuals
2021
The Optimal Cell Salvage Settings to Maximize Hematocrit and Minimize Potassium Using the Cobe BRAT2 Autologous Blood Recovery Unit
Smith N, Kim S, Simmons Q, Lin H, Romano D, Boydston E, DeMaria S, Zerillo J. The Optimal Cell Salvage Settings to Maximize Hematocrit and Minimize Potassium Using the Cobe BRAT2 Autologous Blood Recovery Unit. Journal Of Cardiothoracic And Vascular Anesthesia 2021, 36: 1893-1900. PMID: 34446326, DOI: 10.1053/j.jvca.2021.07.040.Peer-Reviewed Original ResearchConceptsRed blood cellsInfusion rateSingle-center studyRed cellsAssociated with decreased hematocritIndependent of infusion rateFaster infusion ratesHematocrit pre-Salvage settingPotassium changesBanked red blood cellsInfusionBlood cellsHigher hematocritHematocritML/minLow potassiumCellsLactateDevice settingsGlucoseGlucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH
Wang M, An Y, Gao L, Dong S, Zhou X, Feng Y, Wang P, Dimopoulos G, Tang H, Wang J. Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH. Cell Reports 2021, 35: 108992. PMID: 33882310, PMCID: PMC8116483, DOI: 10.1016/j.celrep.2021.108992.Peer-Reviewed Original ResearchConceptsPlasmodium infectionGlucose metabolismMalaria parasitesCommensal bacteriumMosquito midgutPlasmodium berghei infectionGut commensal bacteriumBerghei infectionMosquito-microbiota interactionsDietary glucoseInfectionMetabolome changesVector competencePlasmodium gametogenesisVector competencyGlucoseImportant determinantPlasmodiumProliferationMetabolismMosquitoesParasitesAsaia bogorensis
2020
Glycemic Variability and CNS Inflammation: Reviewing the Connection
Watt C, Sanchez-Rangel E, Hwang JJ. Glycemic Variability and CNS Inflammation: Reviewing the Connection. Nutrients 2020, 12: 3906. PMID: 33371247, PMCID: PMC7766608, DOI: 10.3390/nu12123906.Peer-Reviewed Original ResearchConceptsBlood-brain barrierGlycemic variabilityOxidative stressCentral nervous system outcomesImpact of hyperglycemiaType 2 diabetesCNS inflammationVascular complicationsVascular inflammationCognitive dysfunctionTherapeutic implicationsCognitive deficitsType 1Brain functionNeuroinflammationInflammationDysfunctionGlucoseLow levelsSystem outcomesHigh levelsComplicationsHyperglycemiaDiabetesLatest data
2019
Glycemic Index and Microstructure Evaluation of Four Cereal Grain Foods
RamyaBai M, Wedick N, Shanmugam S, Arumugam K, Nagarajan L, Vasudevan K, Gunasekaran G, Rajagopal G, Spiegelman D, Malik V, Anjana R, Hu F, Unnikrishnan R, Willett W, Malleshi N, Njelekela M, Gimbi D, Krishnaswamy K, Henry C, Mohan V, Sudha V. Glycemic Index and Microstructure Evaluation of Four Cereal Grain Foods. Journal Of Food Science 2019, 84: 3373-3382. PMID: 31762024, DOI: 10.1111/1750-3841.14945.Peer-Reviewed Original ResearchConceptsGlycemic indexMedium glycemic indexTest foodGrain foodsCapillary blood samplesHigh glycemic indexCereal grain foodsWhole grain foodsHigh GI foodsMean ageBlood glucoseBlood samplesGI valuesGI foodsHealthy participantsSeparate occasionsHealthy optionsRegular brown riceWhole grainsStandard protocolLoss of intactnessHealthy alternativeLoss of integrityAvailable carbohydrateGlucose
2018
Dietary sugar silences a colonization factor in a mammalian gut symbiont
Townsend GE, Han W, Schwalm ND, Raghavan V, Barry NA, Goodman AL, Groisman EA. Dietary sugar silences a colonization factor in a mammalian gut symbiont. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 116: 233-238. PMID: 30559205, PMCID: PMC6320540, DOI: 10.1073/pnas.1813780115.Peer-Reviewed Original Research
2017
Lung squamous cell carcinoma exhibits a targetable glucose dependency unique among non-small cell lung cancers
Goodwin J, Neugent ML, Kim JW. Lung squamous cell carcinoma exhibits a targetable glucose dependency unique among non-small cell lung cancers. Molecular & Cellular Oncology 2017, 4: e1364211. PMID: 29057314, PMCID: PMC5644473, DOI: 10.1080/23723556.2017.1364211.Peer-Reviewed Original ResearchNon-small cell lung cancerLung squamous cell carcinomaCell lung cancerSquamous cell carcinomaCell carcinomaLung cancerGlucose dependencySubtypes of NSCLCGlucose transporter Glut1 expressionLung cancer subtypesLung cancer therapyLung adenocarcinomaGlucose metabolismMajor subtypesCancer subtypesGLUT1 expressionCancer cellsSubtypesCancer therapyCarcinomaCancerMetabolic heterogeneityGlucoseAdenocarcinomaTherapy
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