2023
Challenges in determining death by neurologic criteria in extracorporeal membrane oxygenation – A single center experience
Zhao D, Caturegli G, Wilcox C, Stephens R, Kim B, Keller S, Geocadin R, Suarez J, Whitman G, Cho S. Challenges in determining death by neurologic criteria in extracorporeal membrane oxygenation – A single center experience. Perfusion 2023, 39: 1238-1246. PMID: 37387124, PMCID: PMC10756925, DOI: 10.1177/02676591231187548.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenation patientsExtracorporeal membrane oxygenationApnea testingWithdrawal of life-sustaining treatmentAncillary testsMembrane oxygenationSingle center experienceVV ECMO patientsTertiary care centerAbsent brainstem reflexesNeurological exam findingsLife-sustaining treatmentVV-ECMORetrospective reviewTertiary centerImaging findingsExam findingsBrainstem reflexesCenter's experienceNeurological examPatientsDiagnostic criteriaCare centerDetermination of DNCNeurologic criteria
2019
Teleneurology Consultations for Prognostication and Brain Death Diagnosis
Girkar U, Palacios R, Gupta A, Schwamm L, Singla P, May H, Estrada J, Whitney C, Matiello M. Teleneurology Consultations for Prognostication and Brain Death Diagnosis. Telemedicine Journal And E-Health 2019, 26: 482-486. PMID: 31503539, DOI: 10.1089/tmj.2019.0033.Peer-Reviewed Original ResearchConceptsBrain deathNeurology consultationIntensive care unitBrain death diagnosisPresence of apneaGood inter-rater reliabilityNeurologic prognosisTeleneurology consultationsApnea testingBrainstem reflexesCare unitNeurologic examinationBedside teamCardiac arrestBrain injuryComatose stateInter-rater reliabilityDeath diagnosisConsensus criteriaAmerican AcademyRemote neurologistDiagnosisDeathStandardized scalesConsultation
2018
Electro-clinical characteristics and prognostic significance of post anoxic myoclonus
Dhakar MB, Sivaraju A, Maciel CB, Youn TS, Gaspard N, Greer DM, Hirsch LJ, Gilmore EJ. Electro-clinical characteristics and prognostic significance of post anoxic myoclonus. Resuscitation 2018, 131: 114-120. PMID: 29964146, DOI: 10.1016/j.resuscitation.2018.06.030.Peer-Reviewed Original ResearchConceptsPost-anoxic myoclonusRecovery of consciousnessElectro-clinical characteristicsComatose cardiac arrest survivorsLow voltage backgroundRetrospective chart reviewCardiac arrest survivorsElectro-clinical correlationsTime of dischargeContinuous EEG monitoringRelevant clinical variablesChart reviewHospital dischargeSpontaneous circulationArrest survivorsBrainstem reflexesCA survivorsPrognostic implicationsPrognostic significanceClinical variablesEEG findingsMyoclonusEEG monitoringPatientsLack of recovery
2016
A major miss in prognostication after cardiac arrest: Burst suppression and brain healing
Becker D, Schiff N, Becker L, Holmes M, Fins J, Horowitz J, Devinsky O. A major miss in prognostication after cardiac arrest: Burst suppression and brain healing. Epilepsy & Behavior Reports 2016, 7: 1-5. PMID: 28053858, PMCID: PMC5198796, DOI: 10.1016/j.ebcr.2016.09.004.Peer-Reviewed Original ResearchCardiac arrestBurst suppressionTherapeutic hypothermiaLoss of brainstem reflexesMechanisms of therapeutic hypothermiaOut-of-hospital cardiac arrestAbsent motor responseStatus epilepticusBrainstem reflexesNeuronal cell deathFunctional capacityStandard criteriaCell deathArrestNegative endpointsHypothermiaMotor responseEnd-of-life decisionsBrain healingEnd-of-lifeEpilepticusSuppressionEndpoint
2015
Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome
Sivaraju A, Gilmore EJ, Wira CR, Stevens A, Rampal N, Moeller JJ, Greer DM, Hirsch LJ, Gaspard N. Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome. Intensive Care Medicine 2015, 41: 1264-1272. PMID: 25940963, DOI: 10.1007/s00134-015-3834-x.Peer-Reviewed Original ResearchConceptsBetter outcomesPoor outcomeEpileptiform dischargesPost-cardiac arrest comatose patientsCritical care EEG terminologyPost-cardiac arrest comaMethodsProspective cohort studyContinuous EEG monitoringLow-voltage EEGPositive predictive valueAbsence of reactivityEEG terminologyCohort studySpontaneous circulationBrainstem reflexesClinical outcomesComatose patientsFalse positive ratePoor prognosisPrognostic significanceSuppression burstsClinical variablesClinical correlatesElectroencephalographic patternsElectroencephalographic predictors
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