2018
Somatosensory Neurons Enter a State of Altered Excitability during Hibernation
Hoffstaetter LJ, Mastrotto M, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO. Somatosensory Neurons Enter a State of Altered Excitability during Hibernation. Current Biology 2018, 28: 2998-3004.e3. PMID: 30174191, PMCID: PMC6173314, DOI: 10.1016/j.cub.2018.07.020.Peer-Reviewed Original ResearchConceptsSomatosensory neuronsAction potentialsPeripheral somatosensory neuronsVoltage-gated sodium channelsTherapeutic hypothermiaAltered excitabilityFunctional deficitsCase of neuronsSensory functionFiring patternsNeuronsCold exposureInput resistanceSodium channelsRapid restorationBody temperatureHypometabolismHypothermiaDevelopment of strategiesSensory informationProlonged periodAdaptive responseArousalCNSExcitability
2005
Erythromelalgia: A hereditary pain syndrome enters the molecular era
Waxman SG, Dib‐Hajj S. Erythromelalgia: A hereditary pain syndrome enters the molecular era. Annals Of Neurology 2005, 57: 785-788. PMID: 15929046, DOI: 10.1002/ana.20511.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPain syndromeGanglion neuronsCentral nervous system neuronsDorsal root ganglion neuronsChronic neuropathic painSodium channelsSympathetic ganglion neuronsIon channel mutationsChannel functionSodium channel functionAutosomal dominant disorderNeuropathic painPain disordersChronic painAltered excitabilityModerate exerciseSystem neuronsPrimary erythermalgiaRational therapyErythromelalgiaPainFirst human disorderModel diseaseWarm stimuliSyndrome
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