2025
Pridopidine in early-stage manifest Huntington’s disease: a phase 3 trial
Reilmann R, Feigin A, Rosser A, Kostyk S, Saft C, Cohen Y, Schuring H, Hand R, Tan A, Chen K, Feng W, Navon-Perry L, Cruz-Herranz A, Syltevik C, Boot D, Squitieri F, Kayson E, Mehra M, Goldberg Y, Geva M, Hayden M. Pridopidine in early-stage manifest Huntington’s disease: a phase 3 trial. Nature Medicine 2025, 1-10. PMID: 40913168, DOI: 10.1038/s41591-025-03920-3.Peer-Reviewed Original ResearchLeast-squares mean differenceTotal functional capacityComposite Unified Huntington’s Disease Rating Scale,Phase 3 trialHuntington's diseasePlacebo-controlled phase 3 trialSigma-1 receptor agonistUnified Huntington's Disease Rating ScaleHuntington's Disease Rating ScaleTolerability profileDouble-blindManifest Huntington's diseaseReceptor agonistsSecondary endpointsSubgroup of participantsAntidopaminergic medicationsPridopidineSymptomatic treatmentSigma-1Rating ScaleDisease Rating ScaleOverall populationUnmet needsFunctional capacityNeurodegenerative disordersAccelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers
Abraham S, Parekh J, Lee S, Afrin H, Rozenblit M, Blenman K, Perry R, Ferrucci L, Liu J, Irwin M, Lustberg M. Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers. Cancer Medicine 2025, 14: e70929. PMID: 40322791, PMCID: PMC12051034, DOI: 10.1002/cam4.70929.Peer-Reviewed Original ResearchConceptsBiological age of patientsLeukocyte telomere lengthInterleukin-6Treatment-related toxicityAge of patientsTherapy-induced toxicityExpression of p16INK4aPredictors of toxicityStatus of biomarkersMarkers of cellular senescenceRadiation therapyBiological ageCancer patientsCancer therapyFunctional reserveAging biomarkersPhysiological reserveCancer treatmentCancerConfirmatory studiesTherapyClinical practiceFunctional capacityPatientsFunctional statusImplementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study
Carr Z, Agarkov D, Li J, Charchaflieh J, Brenes-Bastos A, Freund J, Zafar J, Schonberger R, Heerdt P. Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study. JMIR Perioperative Medicine 2025, 8: e65805. PMID: 39773953, PMCID: PMC11888076, DOI: 10.2196/65805.Peer-Reviewed Original ResearchConceptsDuke Activity Status IndexPeak oxygen uptakePeak METsEvaluation clinicParticipant satisfactionOxygen uptakeSubmaximal cardiopulmonary exercise testingFunctional capacity assessmentLow functional capacityCardiopulmonary exercise testingPerceived ExertionMET assessmentStructured surveyCapacity SurveyMedian patient satisfactionProvider-drivenExercise testMean session timePearson correlation coefficientSurvey scoresCardiopulmonary testFunctional capacityPatient satisfactionCohort studyInclusion criteriaSex Differences in Response to a 12-Week Resistance Training Exercise Intervention After Cardiac Surgery: A Proof-of-Concept Intervention Trial
Safdar B, Jarman A, Madsen T, DeLamielleure L, Zhou B, Axtell R, Geirsson A, Mangi A. Sex Differences in Response to a 12-Week Resistance Training Exercise Intervention After Cardiac Surgery: A Proof-of-Concept Intervention Trial. Clinical Therapeutics 2025, 47: 299-306. PMID: 39904658, DOI: 10.1016/j.clinthera.2025.01.002.Peer-Reviewed Original ResearchConceptsResistance training programExercise interventionResistance training exercise interventionResistance-based exercise programsTraining programFunctional capacityMeasurement of hand grip strengthTraditional cardiac rehabilitationResistance-based exerciseHand grip strengthTrends of improvementAcute cardiac eventsExercise programCardiac rehabilitationAerobic exerciseCardiac surgeryIntervention armCardiopulmonary rehabilitationFeasibility trialGrip strengthExercise parametersIntervention trialsControl armSecondary outcomesMeasured pre-
2024
Functional Capacity, Functional Performance, and Symptoms in People With Heart Failure
Wang Z, Redeker N, Tocchi C, Kim K, Conley S, Chyun D. Functional Capacity, Functional Performance, and Symptoms in People With Heart Failure. The Journal Of Cardiovascular Nursing 2024, 40: 413-430. PMID: 39454078, DOI: 10.1097/jcn.0000000000001152.Peer-Reviewed Original ResearchFunctional capacityFunctional statusDepressive symptomsFunctional performanceIntegrative reviewInsomnia symptomsMedical Outcomes Scale-Short Form 36Associated with decreased functional performanceJoanna Briggs Institute critical appraisal toolsMeasures of functional statusSix-minute walk testReview of observational studiesFunctional performance measuresCritical appraisal toolsAssociated with sleep difficultiesFunctional capacity measuresShort Form-36Quality of studiesSix-MinuteAppraisal toolWalk testPsychological symptomsAssess symptomsHeart failureAnxiety symptomsMyocardial Recovery in the Systemic Context: A Philosophic Shift for the Heart Failure Subspecialty to Optimize Patient Care
Kapoor A, Kayani J, Saad M, Lala A. Myocardial Recovery in the Systemic Context: A Philosophic Shift for the Heart Failure Subspecialty to Optimize Patient Care. Methodist DeBakey Cardiovascular Journal 2024, 20: 98-108. PMID: 39184157, PMCID: PMC11342849, DOI: 10.14797/mdcvj.1416.Peer-Reviewed Original ResearchConceptsDelivery of careImprove functional capacityPatient careHealthcare systemFunctional capacityHeart failure managementCareHeart failureAging populationFrequent hospitalizationsMedical optimizationIncreased prevalenceModern patientsHolistic definitionMortality rateAmbulatory heart failureSpectrum of diseasesPhilosophical shiftFailure managementClinical outcomesMyocardial recoverySystem contextHealthcareSubspecialtyPatientsEAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults
Keller D, Curtis N, Burt H, Ammirati C, Collings A, Polk H, Carrano F, Antoniou S, Hanna N, Piotet L, Hill S, Cuijpers A, Tejedor P, Milone M, Andriopoulou E, Kontovounisios C, Leeds I, Awad Z, Barber M, Al-Mansour M, Nassif G, West M, Pryor A, Carli F, Demartines N, Bouvy N, Passera R, Arezzo A, Francis N. EAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults. Surgical Endoscopy 2024, 38: 4104-4126. PMID: 38942944, PMCID: PMC11289045, DOI: 10.1007/s00464-024-10977-7.Peer-Reviewed Original ResearchEvidence-based recommendationsMinimally invasive surgeryOlder adultsOlder adult patientsAbdominal surgeryColorectal surgeryPerioperative carePerioperative care of older adultsAdult patientsCare of older adultsCorrection of anemiaOptimization of perioperative careInfluence surgical outcomesCertainty of evidenceCessation of smokingEvidence synthesisExpert opinionEvidence gapsSurgical outcomesPoor outcomeFunctional capacityERAS programOlder patientsPrehabilitationMeta-analysesFunctional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions
Mahgoub R, Bayram A, Spencer D, Alkawadri R. Functional parcellation of the cingulate gyrus by electrical cortical stimulation: a synthetic literature review and future directions. Journal Of Neurology Neurosurgery & Psychiatry 2024, 95: 704-721. PMID: 38242679, DOI: 10.1136/jnnp-2023-332246.Peer-Reviewed Original ResearchPosterior cingulate cortexCingulate gyrusElectrical cortical stimulationCingulate cortexFunctional capacitySystematic reviewInclusion criteriaAnterior cingulate cortexCortical stimulationCingulate functionComplex motor behaviorsCingulate subregionsComplex motorLimbic systemBrain structuresCingulateSpeech responsesSimple motorLiterature reviewMotor behaviorSurgical planningFunctional parcellationAutonomic responsesCorpus callosumImaging modalities
2023
Exercise Capacity in Patients With Obstructive Hypertrophic Cardiomyopathy SEQUOIA-HCM Baseline Characteristics and Study Design
Coats C, Maron M, Abraham T, Olivotto I, Lee M, Arad M, Cardim N, Ma C, Choudhury L, Düngen H, Garcia-Pavia P, Hagège A, Lewis G, Michels M, Oreziak A, Owens A, Tfelt-Hansen J, Veselka J, Watkins H, Heitner S, Jacoby D, Kupfer S, Malik F, Meng L, Wohltman A, Masri A, Investigators S. Exercise Capacity in Patients With Obstructive Hypertrophic Cardiomyopathy SEQUOIA-HCM Baseline Characteristics and Study Design. JACC Heart Failure 2023, 12: 199-215. PMID: 38032573, DOI: 10.1016/j.jchf.2023.10.004.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathyHealth-related qualityBaseline characteristicsClinical trialsExercise capacityPhase 3 trialRisk of arrhythmiaDesign of clinical trialsContemporary managementImpaired exercise capacityStandard-of-care medicationsHealth-related quality of lifeEffects of potential therapiesHypertrophic cardiomyopathyPersistent residual symptomsHeart failureEthnically diverse populationsResidual symptomsQuality of lifePotential therapiesSudden deathPatientsMortality rateSymptom burdenFunctional capacityFunctional Disability in US Military Veterans: The Importance of Integrated Whole Health Initiatives.
Meisler A, Gianoli M, Na P, Pietrzak R. Functional Disability in US Military Veterans: The Importance of Integrated Whole Health Initiatives. The Primary Care Companion For CNS Disorders 2023, 25 PMID: 37419488, DOI: 10.4088/pcc.22m03461.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderIADL disabilityFunctional disabilityInstrumental ADLUS veteransCognitive disordersOlder ageDeployment-related injuryUS veteran populationUS military veteransLow incomeADL disabilityChronic painMale sexBlack raceClinical managementRisk factorsNational HealthSleep disordersDaily livingPsychiatric correlatesFunctional capacityVeteran populationDisability riskHealth initiativesThe Association Between Body Mass Index And Functional Status In Minority Patients With Heart Failure With Preserved Ejection Fraction: The SCAN-MP Study
Driggin E, Rosenblum H, Teruya S, Rodriguez C, Kurian D, Raiszadeh F, Fine D, Sabogal N, Edmiston J, Massillon D, Winburn M, Miller E, Ruberg F, Maurer M. The Association Between Body Mass Index And Functional Status In Minority Patients With Heart Failure With Preserved Ejection Fraction: The SCAN-MP Study. Journal Of Cardiac Failure 2023, 29: 668-669. DOI: 10.1016/j.cardfail.2022.10.299.Peer-Reviewed Original ResearchBody mass indexKCCQ overall summary scoreExcess fat massFunctional statusOverall summary scoreObesity statusQuality of lifeMinority patientsFunctional capacityObese patientsEjection fractionHeart failureIndependent predictorsMass indexSPPB scoreFat massCardiac amyloidosisSummary scoresMuscle massShort Physical Performance Battery scoreFirst heart failure hospitalizationMedian body mass indexPhysical Performance Battery scoreHigher Body Mass IndexWorse SPPB scoreEffects of physical rehabilitation interventions in COVID-19 patients following discharge from hospital: A systematic review
Rahmati M, Molanouri Shamsi M, Woo W, Koyanagi A, Won Lee S, Keon Yon D, Shin J, Smith L. Effects of physical rehabilitation interventions in COVID-19 patients following discharge from hospital: A systematic review. Journal Of Integrative Medicine 2023, 21: 149-158. PMID: 36717302, PMCID: PMC9851951, DOI: 10.1016/j.joim.2023.01.003.Peer-Reviewed Original ResearchConceptsPhysical rehabilitation interventionsRehabilitation interventionsMental health statusQuality of lifeSystematic reviewFunctional capacityHealth statusOutpatient rehabilitation programMethodological quality assessmentRandomized Controlled TrialsPhysical activityRehabilitation programRestore functional capacityPhysical rehabilitationPulmonary functionMental healthClinically relevant outcomesBreathing trainingCohort studyData extractionCOVID-19Systematic searchControlled TrialsReview authorsCOVID-19 patients
2022
Heterogeneity of response to methylphenidate in apathetic patients in the ADMET 2 Trial
Lanctôt K, Perin J, Vieira D, Rosenberg P, Herrmann N, Shade D, Lerner A, Padala P, Brawman‐Mintzer O, van Dyck C, Porsteinsson A, Craft S, Levey A, Mintzer J. Heterogeneity of response to methylphenidate in apathetic patients in the ADMET 2 Trial. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.066932.Peer-Reviewed Original ResearchHeterogeneity of responseAlzheimer's diseaseAD patientsBaseline anxietyPlacebo-controlled clinical trialApathetic AD patientsDaily Living ScaleCommon neuropsychiatric symptomsLow functional capacityLower functional capabilityNPI apathy scoreLower baseline anxietyAD medicationsDifference of changesNeuropsychiatric InventoryNeuropsychiatric symptomsApathetic patientsClinical trialsMonth visitTreatment outcomesEffect differencesSignificant apathyLiving ScaleApathy scoresFunctional capacityTechnology and Mental Health: State of the Art for Assessment and Treatment
Harvey PD, Depp CA, Rizzo AA, Strauss GP, Spelber D, Carpenter LL, Kalin NH, Krystal JH, McDonald WM, Nemeroff CB, Rodriguez CI, Widge AS, Torous J. Technology and Mental Health: State of the Art for Assessment and Treatment. American Journal Of Psychiatry 2022, 179: 897-914. PMID: 36200275, DOI: 10.1176/appi.ajp.21121254.Peer-Reviewed Original ResearchConceptsHigh-quality evidenceEcological momentary assessmentTechnology-based interventionsMental health applicationsClinical trialsTreatment strategiesCognitive trainingFunctional capacityDrug AdministrationSystematic reviewVirtual reality approachMomentary assessmentU.S. FoodMental healthFunctional skillsTechnology-based assessmentInterventionTechnology-based approachesTreatmentAssessmentHealth applicationsPhysiological parametersReality approachReviewEmotionsSarcomere protein modulation: The new frontier in cardiovascular medicine and beyond
Morelli C, Ingrasciotta G, Jacoby D, Masri A, Olivotto I. Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond. European Journal Of Internal Medicine 2022, 102: 1-7. PMID: 35534374, DOI: 10.1016/j.ejim.2022.04.020.Peer-Reviewed Original ResearchConceptsHeart failureCardiovascular medicineVentricular outflow obstructionHeart muscle diseaseDegenerative neuromuscular diseaseSpecific disease mechanismsCardiovascular deathOutflow obstructionSystolic functionRandomized trialsUnderlying pathophysiologyCardiac patientsOmecamtiv mecarbilHypertrophic cardiomyopathyFunctional capacityNeuromuscular diseaseMuscle diseaseAvailable evidenceContractile proteinsSkeletal muscleTranslational researchPromising targetDiseaseDisease mechanismsFailureMultimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes
Selloni A, Bhatia G, Ranganathan M, De Aquino JP. Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes. Journal Of Dual Diagnosis 2022, 18: 81-91. PMID: 35430960, PMCID: PMC9794455, DOI: 10.1080/15504263.2022.2053264.Peer-Reviewed Original ResearchConceptsBD type IPost-traumatic stress disorderBipolar disorderDrug useU.S. veteransLifetime suicidal ideationHigher functional capacityType IPoor outcomeFunctional outcomeNationwide studyFunctional capacityAnalysis of covarianceSuicidal ideationBivariate analysisCannabis useFunctional measuresStress disorderCannabis increasesDisordersVeteransDorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data
Odonkor CA, AlFarra T, Adekoya P, Orhurhu V, Rodríguez T, Sottosanti E, Kaye AD. Dorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data. Current Pain And Headache Reports 2022, 26: 103-118. PMID: 35119602, DOI: 10.1007/s11916-022-01008-y.Peer-Reviewed Original ResearchConceptsSpinal cord stimulationNociceptive painLong-term healthcare costsPain treatment modalitiesDorsal column stimulationPre-clinical dataHigh safety profileCannabinoid-based medicationsPain-signaling pathwaysQuality of lifeMinimal side effectsOpioid consumptionNeuropathic painPain reliefAdjunctive therapySecondary outcomesPain managementCannabinoid therapyClinical efficacyCord stimulationSafety profileCombination therapyFunctional statusTreatment modalitiesFunctional capacity
2021
Spatial Characteristics of Colonic Mucosa-Associated Gut Microbiota in Humans
Jiao L, Kourkoumpetis T, Hutchinson D, Ajami N, Hoffman K, White D, Graham D, Hair C, Shah R, Kanwal F, Jarbrink-Sehgal M, Husain N, Hernaez R, Hou J, Cole R, Velez M, Ketwaroo G, Kramer J, El-Serag H, Petrosino J. Spatial Characteristics of Colonic Mucosa-Associated Gut Microbiota in Humans. Microbial Ecology 2021, 83: 811-821. PMID: 34223947, DOI: 10.1007/s00248-021-01789-6.Peer-Reviewed Original ResearchConceptsAmplicon sequence variantsBacterial community compositionCommunity compositionMucosa-associated gut microbiotaTaxonomic structureSignificant differencesRelative abundanceColonic biopsiesEscherichia/ShigellaInter-individual variabilityColonic segmentsColon segmentsFunctional capacityGut microbiotaLarge intestineFree adultsColonic bacteriaRRNA geneCompositional dissimilarityMajor phylaFecal bacteriaSequencing dataLimited dataCreation of an Evidence-Based Physical Therapy Program for Adults with XLH: Translational Application of an Interprofessional Clinical Study
Kanamalla K, Fuchs R, Herzog C, Steigbigel K, Macica C. Creation of an Evidence-Based Physical Therapy Program for Adults with XLH: Translational Application of an Interprofessional Clinical Study. Journal Of The Endocrine Society 2021, 5: a260-a260. PMCID: PMC8089516, DOI: 10.1210/jendso/bvab048.528.Peer-Reviewed Original ResearchLower Extremity Functional ScaleBerg Balance ScaleBalance ScaleActivities-specific Balance Confidence ScaleLifelong metabolic diseasePT programBalance Confidence ScaleIntestinal phosphate absorptionPhysical therapy programMusculoskeletal comorbiditiesStandard therapyClinical pictureBalance exercisesDegenerative arthritisActive ROMLower extremitiesClinical studiesFunctional scalesDaily livingFunctional capacityFunctional abilityFunctional comorbiditiesTrunk swayAdult disordersMetabolic diseases
2020
Diastolic stress test echocardiography in patients with hypertrophy cardiomyopathy: association with exercise capacity
Fava A, Mathias I, Alashi A, Saijo Y, Popovic Z, Thamilarasan M, Lever H, Desai M. Diastolic stress test echocardiography in patients with hypertrophy cardiomyopathy: association with exercise capacity. European Heart Journal 2020, 41: ehaa946.2087. DOI: 10.1093/ehjci/ehaa946.2087.Peer-Reviewed Original ResearchDiastolic dysfunctionExercise capacityLVOT gradientMaximal exerciseHCM patientsLate mitral inflow velocityLateral mitral annular velocityMitral E/eAbnormal diastolic responseSymptomatic HCM patientsAtrial volume indexReduced exercise capacityVentricular filling pressureMitral annular velocityMitral inflow velocityHypertrophic cardiomyopathy patientsLogistic regression analysisHypertrophy cardiomyopathyDiastolic responseMetabolic equivalentsCardiomyopathy patientsAnnular velocityFilling pressureFunctional capacityPatients
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