2023
Clinical Validation of Artificial Intelligence-Augmented Pathology Diagnosis Demonstrates Significant Gains in Diagnostic Accuracy in Prostate Cancer Detection.
Raciti P, Sue J, Retamero J, Ceballos R, Godrich R, Kunz J, Casson A, Thiagarajan D, Ebrahimzadeh Z, Viret J, Lee D, Schüffler P, DeMuth G, Gulturk E, Kanan C, Rothrock B, Reis-Filho J, Klimstra D, Reuter V, Fuchs T. Clinical Validation of Artificial Intelligence-Augmented Pathology Diagnosis Demonstrates Significant Gains in Diagnostic Accuracy in Prostate Cancer Detection. Archives Of Pathology & Laboratory Medicine 2023, 147: 1178-1185. PMID: 36538386, DOI: 10.5858/arpa.2022-0066-oa.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceBiopsy, NeedleHumansImage Interpretation, Computer-AssistedMaleProstateProstatic NeoplasmsConceptsDiagnostic accuracyProstate biopsy specimensProstate cancer detectionProstate cancer diagnosisCancer diagnosisUS Food and Drug Administration authorityWhole slide imagesGenitourinary subspecialistsTumor sizeHistological gradeApplication of artificial intelligenceBiopsy specimensProstateSimulated clinical settingClinical validationAssessment of tissueClinical settingClinical applicationCancerCancer detectionDiagnosisPathologistsDeep learning-based systemDigital whole slide imagesLearning-based system
2020
T-cell and NK-cell lymphomas in the lung
Pan Z, Xu ML. T-cell and NK-cell lymphomas in the lung. Seminars In Diagnostic Pathology 2020, 37: 273-282. PMID: 32448591, DOI: 10.1053/j.semdp.2020.04.003.Peer-Reviewed Original ResearchConceptsT-cell lymphomaWorld Health Organization classificationNK-cell lymphomasAdequate antibiotic therapyTypical radiologic featuresPrinciples of treatmentDifferent histologic typesPrecise pathologic diagnosisHilar adenopathyEmpirical antibioticsSystemic lymphomaWedge biopsyAntibiotic therapyLymphomas accountRadiologic featuresRadiologic findingsBronchoscopic examinationHistologic typePleural effusionClinical symptomsRecurrent infectionsCystic changesOrganization classificationPathologic diagnosisPulmonary opacities
2019
Income disparities in needle biopsy patients prior to breast cancer surgery across physician peer groups
Killelea BK, Herrin J, Soulos PR, Pollack CE, Forman HP, Yu J, Xu X, Tannenbaum S, Wang SY, Gross CP. Income disparities in needle biopsy patients prior to breast cancer surgery across physician peer groups. Breast Cancer 2019, 27: 381-388. PMID: 31792804, PMCID: PMC7512133, DOI: 10.1007/s12282-019-01028-4.Peer-Reviewed Original ResearchConceptsPhysician peer groupsLow-income patientsNeedle biopsyOdds ratioHigh-income patientsBreast cancer surgeryMethodsThe SurveillanceCancer surgeryIncome patientsMedicare databaseBiopsy patientsMedicare beneficiariesPatientsBiopsyLow incomeGroupDisparitiesReceiptEnd resultHigher incomeSurgeryPeer groupEpidemiologyFurther workGroup-level effectsPhotodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness
Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2019, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAminolevulinic AcidAnalysis of VarianceBiopsy, NeedleCarcinoma in SituCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleHumansImmunohistochemistryLogistic ModelsMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingPhotochemotherapyPrognosisRetrospective StudiesSkin NeoplasmsSurvival AnalysisTreatment OutcomeTumor BurdenConceptsCutaneous squamous cell carcinomaALA incubation timeSquamous cell carcinomaTumor diameterALA-PDTSubsequent recurrenceCell carcinomaAnatomic locationInitial complete response ratePhotodynamic therapyCases of SCCISMultivariate analysis factorsComplete response rateMedical record reviewEffectiveness of PDTPatient demographicsClinical responseMedian timeRetrospective reviewRecord reviewRetrospective studyTreatment detailsSingle institutionEffective treatmentResponse rateGastrointestinal Adverse Events Observed After Chimeric Antigen Receptor T-Cell Therapy
Abu-Sbeih H, Tang T, Ali F, Luo W, Neelapu S, Westin J, Okhuysen P, Foo W, Curry J, Richards D, Ge P, Wang Y. Gastrointestinal Adverse Events Observed After Chimeric Antigen Receptor T-Cell Therapy. American Journal Of Clinical Oncology 2019, 42: 789-796. PMID: 31478934, DOI: 10.1097/coc.0000000000000596.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAntineoplastic Combined Chemotherapy ProtocolsAsparaginaseBiopsy, NeedleCohort StudiesCytarabineDaunorubicinFemaleGastric MucosaGastritisGastrointestinal DiseasesHematologic NeoplasmsHumansImmunohistochemistryImmunotherapy, AdoptiveIncidenceMaleMiddle AgedPrognosisReceptors, Chimeric AntigenRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionThioguanineConceptsChimeric antigen receptor T-cell therapyCytokine release syndromeGastrointestinal adverse eventsGI AEsT-cell therapyRefractory colitisEncephalopathy syndromeRelease syndromeAdverse eventsHematologic malignanciesDiffuse large B-cell lymphomaLarge B-cell lymphomaGastrointestinal tract inflammationGrade 1 diarrheaOnly symptomatic treatmentStandard of careCertain hematologic malignanciesB-cell lymphomaCART infusionAbdominal distensionAbdominal painBloody stoolGastrointestinal symptomsMedian durationExperienced diarrheaUltrasound-Guided Transthoracic Fine-Needle Aspiration: A Reliable Tool in Diagnosis and Molecular Profiling of Lung Masses
Rodriguez EF, Pastorello R, Osmani L, Hopkins M, Kryatova M, Kawamoto S, Maleki Z. Ultrasound-Guided Transthoracic Fine-Needle Aspiration: A Reliable Tool in Diagnosis and Molecular Profiling of Lung Masses. Acta Cytologica 2019, 64: 208-215. PMID: 31362293, DOI: 10.1159/000501421.Peer-Reviewed Original ResearchConceptsLung massPulmonary adenocarcinomaMedical recordsTransthoracic fine needle aspirationConcurrent core biopsyAdvanced stage diseaseInstitutional review board approvalMajority of patientsTransthoracic needle aspirationCarcinoma/adenocarcinomaPatients' medical recordsFine-needle aspirationReview board approvalStage diseaseCommon diagnosisMean agePulmonary lesionsCore biopsyMalignant diagnosisNeedle aspirationPrior historyCytologic diagnosisInvasive proceduresBoard approvalCytology specimensAdult xanthogranulomatous disease of the orbit: case report of spontaneous regression and review of treatment modalities
Maeng M, Godfrey K, Jalaj S, Kazim M. Adult xanthogranulomatous disease of the orbit: case report of spontaneous regression and review of treatment modalities. Orbit 2019, 39: 31-37. PMID: 31021176, DOI: 10.1080/01676830.2019.1590421.Peer-Reviewed Original ResearchConceptsAdult xanthogranulomatous diseaseXanthogranulomatous diseaseOrbital xanthogranulomaCase report of spontaneous regressionSystemic diseaseReports of spontaneous regressionAssociated with systemic diseasesOrbital xanthogranulomatous diseaseAdult orbital xanthogranulomaStandard of careRadiographic regressionSurgical resectionImmunomodulatory medicationsOcular functionOrbital involvementSpontaneous regressionCase reportTreatment strategiesSystem surveillanceDiseaseXanthogranulomaLesionsObservation of lesionsYears of observationRadiotherapyVisual perception, cognition, and error in dermatologic diagnosis: Key cognitive principles
Ko CJ, Braverman I, Sidlow R, Lowenstein EJ. Visual perception, cognition, and error in dermatologic diagnosis: Key cognitive principles. Journal Of The American Academy Of Dermatology 2019, 81: 1227-1234. PMID: 30797839, DOI: 10.1016/j.jaad.2018.10.082.Peer-Reviewed Original Research
2018
Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort
Tricò D, Caprio S, Umano G, Pierpont B, Nouws J, Galderisi A, Kim G, Mata MM, Santoro N. Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort. Hepatology 2018, 68: 1376-1390. PMID: 29665034, PMCID: PMC6173637, DOI: 10.1002/hep.30035.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentBiopsy, NeedleBody Mass IndexCross-Sectional StudiesFemaleGene Expression RegulationGlucose Tolerance TestHumansImmunohistochemistryInsulin ResistanceMagnetic Resonance ImagingMaleMembrane ProteinsNon-alcoholic Fatty Liver DiseasePediatric ObesityPolymerase Chain ReactionPolymorphism, Single NucleotidePrognosisProspective StudiesROC CurveConceptsNonalcoholic fatty liverNonalcoholic fatty liver diseaseOral glucose tolerance testHepatic fat fractionObese adolescentsFatty liverMagnetic resonance imagingLiver diseaseMultiethnic cohortAbdominal magnetic resonance imagingC-peptide levelsChronic liver diseaseFatty liver diseaseGlucose tolerance testSingle nucleotide polymorphismsAltered glucose homeostasisGlucose toleranceLiver steatosisProspective studyInsulin resistanceTolerance testInsulin sensitivityRisk factorsCommon causeHigh prevalenceGenomic Heterogeneity and the Small Renal Mass
Ueno D, Xie Z, Boeke M, Syed J, Nguyen KA, McGillivray P, Adeniran A, Humphrey P, Dancik GM, Kluger Y, Liu Z, Kluger H, Shuch B. Genomic Heterogeneity and the Small Renal Mass. Clinical Cancer Research 2018, 24: 4137-4144. PMID: 29760223, PMCID: PMC6125159, DOI: 10.1158/1078-0432.ccr-18-0214.Peer-Reviewed Original ResearchDeterioration of Regional Lung Strain and Inflammation during Early Lung Injury
Motta-Ribeiro G, Hashimoto S, Winkler T, Baron R, Grogg K, Paula L, Santos A, Zeng C, Hibbert K, Harris R, Bajwa E, Vidal Melo M. Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2018, 198: 891-902. PMID: 29787304, PMCID: PMC6173064, DOI: 10.1164/rccm.201710-2038oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAnalysis of VarianceAnimalsBiopsy, NeedleBlood Gas AnalysisDisease Models, AnimalEndotoxemiaEndotoxinsFemaleFluorodeoxyglucose F18HumansImmunohistochemistryInfusions, IntravenousLinear ModelsMultivariate AnalysisPositron-Emission TomographyPulmonary AtelectasisRandom AllocationRespiration, ArtificialRespiratory Distress SyndromeRespiratory Function TestsRisk FactorsSheepTidal VolumeTime FactorsTomography, X-Ray ComputedConceptsLung injurySupine lungConsistent with clinical practiceBlood volumeF-FDG phosphorylation rateLocal neutrophilic inflammationAssociated with increased inflammationF-FDG uptakeEarly mechanical ventilationClinical practiceEarly lung injuryPositive end-expiratory pressureLung strainEnd-expiratory pressurePositron emission tomographyF-FDGUninjured lungsImaging findingsRegional inflammationNeutrophilic inflammationSystemic endotoxemiaProne positionComputed tomographyVentilated patientsIntravenous endotoxinPediatric Salivary Cancer: Epidemiology, Treatment Trends, and Association of Treatment Modality with Survival
Morse E, Fujiwara RJT, Husain Z, Judson B, Mehra S. Pediatric Salivary Cancer: Epidemiology, Treatment Trends, and Association of Treatment Modality with Survival. Otolaryngology 2018, 159: 553-563. PMID: 29688836, DOI: 10.1177/0194599818771926.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBiopsy, NeedleCarcinoma, MucoepidermoidChemotherapy, AdjuvantChildChild, PreschoolCombined Modality TherapyCross-Sectional StudiesDatabases, FactualFemaleHumansImmunohistochemistryLogistic ModelsMaleMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingPrognosisProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesSalivary Gland NeoplasmsSurvival AnalysisTreatment OutcomeConceptsImproved overall survivalOverall survivalHigh tumor gradeTreatment modalitiesTumor gradeSalivary cancerAdjuvant radiationMultivariable Cox proportional hazards regressionNational Cancer Database 2004Cox proportional hazards regressionTreatment factorsPatients 19 yearsHigh-risk patientsSubset of patientsMultivariable logistic regressionProportional hazards regressionUS national databaseHigh-grade tumorsSalivary gland cancerAcinar cell carcinomaPediatric patientsTumor characteristicsHazards regressionCell carcinomaGland cancer
2017
Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma.
Berry JL, Xu L, Murphree AL, Krishnan S, Stachelek K, Zolfaghari E, McGovern K, Lee TC, Carlsson A, Kuhn P, Kim JW, Cobrinik D, Hicks J. Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma. JAMA Ophthalmology 2017, 135: 1221-1230. PMID: 29049475, PMCID: PMC5710399, DOI: 10.1001/jamaophthalmol.2017.4097.Peer-Reviewed Original ResearchConceptsTumor-derived DNACell-free DNARB eyesIntravitreous injectionAqueous humorAH samplesCopy number variationsSalvage therapyRB1 mutationsTumor biopsiesNumber variationsTertiary care hospitalCase series studyDNA copy number variationsDNA copy number alterationsCopy number variation profilesHigh-sensitivity kitChromosomal copy number variationsTumor DNA fractionPolymerase chain reaction primersWhole-genome sequencingPrimary enucleationCare hospitalDisease courseNumber variation profilesLimitations of poor bone marrow aspirations (for an accurate diagnosis) despite the multimodal analytical era: A longitudinal retrospective study
Astle JM, Xu ML, Friedman T, Brown E. Limitations of poor bone marrow aspirations (for an accurate diagnosis) despite the multimodal analytical era: A longitudinal retrospective study. American Journal Of Hematology 2017, 92: e600-e602. PMID: 28670759, DOI: 10.1002/ajh.24839.Peer-Reviewed Original ResearchTranstubular excisional biopsy as a rescue for a non-diagnostic stereotactic needle biopsy—case report and literature review
Chen YN, Omay SB, Shetty SR, Liang B, Almeida JP, Ruiz-Treviño AS, Lavi E, Schwartz TH. Transtubular excisional biopsy as a rescue for a non-diagnostic stereotactic needle biopsy—case report and literature review. Acta Neurochirurgica 2017, 159: 1589-1595. PMID: 28688051, DOI: 10.1007/s00701-017-3260-7.Peer-Reviewed Original ResearchEstablishing and Validating an Ichthyosis Severity Index
Marukian NV, Deng Y, Gan G, Ren I, Thermidor W, Craiglow BG, Milstone LM, Choate KA. Establishing and Validating an Ichthyosis Severity Index. Journal Of Investigative Dermatology 2017, 137: 1834-1841. PMID: 28596001, DOI: 10.1016/j.jid.2017.04.037.Peer-Reviewed Original ResearchConceptsIchthyosis severityDisorders of keratinizationIntrarater intraclass correlation coefficientsIntraclass correlation coefficientTherapeutic responseClinical trialsClinical phenotypingLevels of severityBody sitesErythemaSeverity IndexSeverityInterrater reliabilityPerson evaluationDermatologistsVisual indexSubjectsIndexVisual standardsSettingKeratinizationTrialsDifferent settingsExtracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood
Eguchi A, Lazaro R, Wang J, Kim J, Povero D, Willliams B, Ho S, Stärkel P, Schnabl B, Ohno‐Machado L, Tsukamoto H, Feldstein A. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology 2017, 65: 475-490. PMID: 27639178, PMCID: PMC5407075, DOI: 10.1002/hep.28838.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceAnimalsBiopsy, NeedleCells, CulturedDisease Models, AnimalExtracellular VesiclesFatty Liver, AlcoholicHepatocytesHumansImmunoblottingImmunohistochemistryMiceMicroRNAsMiddle AgedRandom AllocationReal-Time Polymerase Chain ReactionSampling StudiesSeverity of Illness IndexStatistics, NonparametricYoung AdultConceptsBlood extracellular vesiclesLiver injuryExtracellular vesiclesNuclear factor kappa BAlcoholic liver diseaseChronic liver injuryWeeks of infusionBile duct ligationB-cell lymphoma 2Levels of EVsFactor kappa BSteatohepatitis developmentNonalcoholic steatohepatitisLiver diseaseObese miceHepatic macrophagesDuct ligationKappa BMiR-340Cell originLymphoma 2Intragastric infusionMiceMiRNA signatureTime pointsCytology assessment can predict survival for patients with metastatic pancreatic neuroendocrine neoplasms
Sigel C, Guo H, Sigel K, Zhang M, Rekhtman N, Lin O, Klimstra D, Jungbluth A, Tang L. Cytology assessment can predict survival for patients with metastatic pancreatic neuroendocrine neoplasms. Cancer Cytopathology 2017, 125: 188-196. PMID: 28094897, PMCID: PMC5352475, DOI: 10.1002/cncy.21817.Peer-Reviewed Original ResearchConceptsConcurrent core needle biopsyMetastatic pancreatic neuroendocrine neoplasmsCore needle biopsyPancreatic neuroendocrine neoplasmsKi-67 indexNeedle biopsyNeuroendocrine neoplasmsKi-67Cell blocksCytological differentiationFine-needle aspirationKi-67 assessmentPredictive of survivalPredictors of outcomeStage-adjusted analysisGrading of pancreatic neuroendocrine neoplasmsMedian survivalCytological gradeNeuroendocrine tumorsCytology specimensCytologic smearsPredicting PrognosisCytological assessmentGrade 3Well-differentiated
2016
Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants
Fischer S, Diehm Y, Henzler T, Berger M, Kolbenschlag J, Latz A, Bueno E, Hirche C, Kneser U, Pomahac B. Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants. Aesthetic Plastic Surgery 2016, 41: 211-220. PMID: 28008464, DOI: 10.1007/s00266-016-0724-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsy, NeedleBreast ImplantationBreast ImplantsClostridium histolyticumDisease Models, AnimalFemaleFibrosisHumansImmunohistochemistryImplant Capsular ContractureInjections, IntralesionalMagnetic Resonance ImagingMicrobial CollagenasePregnancyRandom AllocationRatsRats, Inbred LewReal-Time Polymerase Chain ReactionReference ValuesSilicone GelsTreatment OutcomeUltrasonography, DopplerConceptsMagnetic resonance imagingBacterium Clostridium histolyticumSilicone implantsCapsular fibrosisCollagenase injectionTreatment groupsSkin perforationFrequent long-term complicationMethodsForty-eight ratsMiniature silicone implantsLong-term complicationsClostridium histolyticumViable treatment optionLevel of evidenceHigh-resolution ultrasoundCapsule thicknessInjection of collagenaseExpression levelsDays post injectionLevel AssignedThis journalLong-term effectivenessBackgroundCapsular contractureAnti-fibrotic genesTreatment optionsImplant pocketUpgrading and upstaging at radical prostatectomy in the post–prostate-specific antigen screening era: an effect of delayed diagnosis or a shift in patient selection?
Edmund L, Rotker KL, Lakis NS, Brito JM, Lepe M, Lombardo KA, Renzulli JF, Matoso A. Upgrading and upstaging at radical prostatectomy in the post–prostate-specific antigen screening era: an effect of delayed diagnosis or a shift in patient selection? Human Pathology 2016, 59: 87-93. PMID: 27720731, DOI: 10.1016/j.humpath.2016.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsy, NeedleCytoreduction Surgical ProceduresDelayed DiagnosisEarly Detection of CancerHumansKallikreinsMaleMiddle AgedNeoplasm GradingNeoplasm StagingPatient SelectionPredictive Value of TestsProstate-Specific AntigenProstatectomyProstatic NeoplasmsTime FactorsWatchful WaitingConceptsGroup 2Group 1Group 3Needle biopsyActive surveillanceProstate-specific antigen (PSA) screeningPathologic stage pT3Radical prostatectomy findingsLow-risk diseaseGleason score 4High-risk diseaseGleason score 8Prostate needle biopsyProstate cancer managementProstatectomy findingsCytoreductive surgeryStage pT3Screening eraMore patientsPatient selectionAntigen screeningScore 8Radical prostatectomyGleason 6Cancer management
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