2025
Correlates of Loneliness in Parkinson Disease During the COVID-19 Pandemic: A Longitudinal Study
de Figueiredo J, Kohn R, Patel A, Parsons E, Louis E, Koo B. Correlates of Loneliness in Parkinson Disease During the COVID-19 Pandemic: A Longitudinal Study. Behavioral Sciences 2025, 15: 1233. PMID: 41009263, PMCID: PMC12466522, DOI: 10.3390/bs15091233.Peer-Reviewed Original ResearchCorrelates of lonelinessEmotional supportHealth-related quality of lifeCOVID-19 pandemicLongitudinal studyAssociated with lonelinessParkinson's diseaseQuality of lifeEffects of lonelinessConsecutive PD outpatientsPublic health emergencyLinear regression analysisPD outpatientsPsychological variablesSocial isolationCOVID-19LonelinessHealth emergencyPD patientsRegression analysisTreatment planningDemoralizationMicrostructural patterns in substantia nigra subregions are associated with depression and olfactory impairments in Parkinson’s disease
Mozafar M, Manshadi Z, Molaei Z, Babaei H, Mansouri M, Shahbazi S, Shakeri S, Mirhosseini H, Gulisashvili D, Mayeli M, Initiative P. Microstructural patterns in substantia nigra subregions are associated with depression and olfactory impairments in Parkinson’s disease. Clinical Neurology And Neurosurgery 2025, 251: 108817. PMID: 40080943, DOI: 10.1016/j.clineuro.2025.108817.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingNon-motor symptomsDopaminergic deficitOlfactory dysfunctionHealthy controlsSubstantia nigraPD patientsParkinson's diseaseDiffusion tensor imaging findingsAssociated with depressionRates of depressionHigher rates of depressionNon-motor testsEvidence of dopaminergic deficitNon-depressed onesOlfactory impairmentAnxiety scoresPrevalence of olfactory dysfunctionDepressionSWEDD groupTensor imagingPPMI databaseDeficitsFA valuesSWEDD
2024
Pancreaticoduodenectomy in trauma patients with grade IV–V duodenal or pancreatic injuries: a post hoc analysis of an EAST multicenter trial
Choron R, Piplani C, Kuzinar J, Teichman A, Bargoud C, Sciarretta J, Smith R, Hanos D, Afif I, Beard J, Dhillon N, Zhang A, Ghneim M, Devasahayam R, Gunter O, Smith A, Sun B, Cao C, Reynolds J, Hilt L, Holena D, Chang G, Jonikas M, Echeverria-Rosario K, Fung N, Anderson A, Fitzgerald C, Dumas R, Levin J, Trankiem C, Yoon J, Blank J, Hazelton J, McLaughlin C, Al-Aref R, Kirsch J, Howard D, Scantling D, Dellonte K, Vella M, Hopkins B, Shell C, Udekwu P, Wong E, Joseph B, Lieberman H, Ramsey W, Stewart C, Alvarez C, Berne J, Nahmias J, Puente I, Patton J, Rakitin I, Perea L, Pulido O, Ahmed H, Keating J, Kodadek L, Wade J, Henry R, Schreiber M, Benjamin A, Khan A, Mann L, Mentzer C, Mousafeiris V, Mulita F, Reid-Gruner S, Sais E, Foote C, Palacio C, Argandykov D, Kaafarani H, Manderski M, Moko L, Narayan M, Seamon M. Pancreaticoduodenectomy in trauma patients with grade IV–V duodenal or pancreatic injuries: a post hoc analysis of an EAST multicenter trial. Trauma Surgery & Acute Care Open 2024, 9: e001438. PMID: 39717488, PMCID: PMC11664373, DOI: 10.1136/tsaco-2024-001438.Peer-Reviewed Original ResearchLonger intensive care unit length of stayGrade IV-VBlood product requirementsNon-PD patientsGI complicationsPancreatic injuryPD patientsMulticenter retrospective comparative studyLonger intensive care unit lengthAmerican Association for the SurgeryNon-PDIntensive care unit length of stayGrade VUnit length of stayMultivariate logistic regression analysisIV-VPancreatic ductal injuryProcedure-related morbiditySubanalysis of patientsRetrospective comparative studyLevel 1 trauma centerNon-PD groupLogistic regression analysisYears of agePost Hoc AnalysisPresynaptic terminal integrity is associated with glucose metabolism in Parkinson’s disease
Wang W, Wang Y, Xu L, Liu X, Hu Y, Li J, Huang Q, Ren S, Huang Y, Guan Y, Li Y, Hua F, Ye Q, Xie F. Presynaptic terminal integrity is associated with glucose metabolism in Parkinson’s disease. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 1510-1519. PMID: 39572432, DOI: 10.1007/s00259-024-06993-3.Peer-Reviewed Original ResearchPositron emission tomographyDopamine transporterSynaptic densityGlucose metabolismDopamine transporter availabilityPD patientsPost-commissural caudateParkinson's diseaseReduced synaptic densityAssociated with glucose metabolismDopaminergic transporterMethodsA totalHealthy controlsSynaptic vesicle protein 2PatientsEmission tomographyCaudatePD groupMetabolic patternsTerminal integrityProtein 2DiseaseNC groupCaudate regionsMetabolismDirect and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder
Liu S, Wan X, Zhao M, Wang J, Wu W, You L, Yuan Y, Xu Q, Gao R. Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder. Science China Chemistry 2024, 68: 377-384. DOI: 10.1007/s11426-024-2150-5.Peer-Reviewed Original ResearchPanic disorderDART-MSMonoamine neurotransmittersClinical diagnosis of PDAnalysis of mass spectrometryMagnetic solid phase extraction methodSerum amino acidsSolid phase extraction methodDiagnosis of panic disorderSerum of PD patientsSolid phase extractionMetabolic abnormalitiesPhase extraction methodDiagnostic accuracyKyn pathwayDiagnosis of PDClinical diagnosisPD patientsPhase extractionNeurotransmitterMass spectrometryNeurotransmitter detectionMagnetic Fe3O4Measurement of amino acidsBiological samplesFallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies
Chen X, Chen Z, Du Y, Tian X, Fu R. Fallopian tube wrapping as a cause of catheter malfunction in peritoneal dialysis: a report of two cases and management strategies. AME Case Reports 2024, 0: 0-0. PMID: 39091550, PMCID: PMC11292095, DOI: 10.21037/acr-23-201.Peer-Reviewed Original ResearchCatheter malfunctionPeritoneal dialysisCatheter functionFemale PD patientsCatheter dysfunctionCatheter fixationUtilization of laparoscopyPD patientsAbdominal X-rayIntra-abdominal organsPD catheterFallopian tubePotential causesCatheter displacementCatheter obstructionCatheter migrationCatheter implantationLaparoscopic surgeryCatheter insertionFavorable outcomeLaparoscopic examinationOmental wrappingDays post-implantationCatheterCatheter kinkingDepression is associated with the nonmotor symptoms of Parkinson's disease: A comparative analysis
Mayeli M, Shafie M, Shiravi M, Parvar T, Mirsepassi Z, Rahiminejad F, Sattarpour R, Aghamollaii V. Depression is associated with the nonmotor symptoms of Parkinson's disease: A comparative analysis. Health Science Reports 2024, 7: e2106. PMID: 38803654, PMCID: PMC11128496, DOI: 10.1002/hsr2.2106.Peer-Reviewed Original ResearchBeck Depression InventoryBeck Depression Inventory scoresPD patientsNonmotor symptomsOrthostatic hypotensionSubgroup analysisEarly diagnosisParkinson's diseaseNonmotor symptoms of Parkinson's diseaseSevere depression groupManagement of PD patientsSymptoms of Parkinson's diseaseCourse of PDNonmotor symptoms of PDDepression severityMontreal Cognitive AssessmentDepression groupLogistic regression modelsDepression InventoryBinary logistic regression modelIntervention Longitudinal StudyPatientsSevere groupCognitive AssessmentSleep disordersSynaptic loss and its association with symptom severity in Parkinson’s disease
Holmes S, Honhar P, Tinaz S, Naganawa M, Hilmer A, Gallezot J, Dias M, Yang Y, Toyonaga T, Esterlis I, Mecca A, Van Dyck C, Henry S, Ropchan J, Nabulsi N, Louis E, Comley R, Finnema S, Carson R, Matuskey D. Synaptic loss and its association with symptom severity in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 42. PMID: 38402233, PMCID: PMC10894197, DOI: 10.1038/s41531-024-00655-9.Peer-Reviewed Original ResearchSynaptic density lossPositron emission tomographyBinds to synaptic vesicle glycoprotein 2AAssociated with symptom severityParkinson's diseaseHigh-resolution positron emission tomographySynaptic vesicle glycoprotein 2ADuration of illnessPositron emission tomography scanBrain perfusionIllness durationSymptom severitySeverity of symptomsHC groupSubstantia nigraSynaptic densityLiving brainPD individualsClinical insightsDensity lossPD patientsEmission tomographyBrainSynaptic lossSynapse loss
2023
Autophagy markers, cognitive deficits and depressive symptoms in Parkinson’s disease
Li Y, Yang H, Zhao P, Yang J, Yao C, Zhou C, Yang C, Sun X, Li S, Li J. Autophagy markers, cognitive deficits and depressive symptoms in Parkinson’s disease. Journal Of Neural Transmission 2023, 131: 73-81. PMID: 37801108, DOI: 10.1007/s00702-023-02702-w.Peer-Reviewed Original ResearchConceptsDepressed PD patientsDepressive symptomsNaming abilityPD patientsHamilton Depression Rating Scale-17Cognitive impairmentNon-depressed PD patientsLC3-II/LC3-IAssociated with delayed recallParkinson's diseaseAssociated with cognitive functionAssociated with MoCA scoresHAMD-17Cognitive deficitsMontreal Cognitive AssessmentDelayed RecallCognitive functionCognitive AssessmentGlycolipid parametersAutophagy markersMoCA scoresSymptomsMotor functionImpairmentRecallSerum BDNF levels and state anxiety are associated with somatic symptoms in patients with panic disorder
Li J, Li R, Li D, Zhang J, Luo X, Zhang Y. Serum BDNF levels and state anxiety are associated with somatic symptoms in patients with panic disorder. Frontiers In Psychiatry 2023, 14: 1168771. PMID: 37533888, PMCID: PMC10393281, DOI: 10.3389/fpsyt.2023.1168771.Peer-Reviewed Original ResearchPanic Disorder Severity Scale-Chinese VersionSerum BDNF levelsState-Trait Anxiety InventoryBDNF levelsSomatic symptomsPanic disorderPHQ-15State anxietyPD patientsSerum BDNFBaseline serum BDNF levelsHealthy controlsAssociated with somatic symptomsAnxiety-related symptomsAnxiety-related variablesMeasure somatic symptomsPHQ-15 scoresEscitalopram treatmentPanic severityAssess panicNinety PD patientsState-TraitAnxiety InventoryPanicPartial correlation analysisThe Influence of GBA and LRRK2 on Mood Disorders in Parkinson's Disease
DeBroff J, Omer N, Cohen B, Giladi N, Kestenbaum M, Shirvan J, Cedarbaum J, Gana‐Weisz M, Goldstein O, Orr‐Urtreger A, Mirelman A, Thaler A. The Influence of GBA and LRRK2 on Mood Disorders in Parkinson's Disease. Movement Disorders Clinical Practice 2023, 10: 606-616. PMID: 37070047, PMCID: PMC10105114, DOI: 10.1002/mdc3.13722.Peer-Reviewed Original ResearchDiagnosis of PDParkinson's diseaseMood-related disordersTime of assessmentMood disordersIdiopathic PDNon-motor comorbiditiesNon-motor featuresIdiopathic Parkinson's diseaseNon-motor phenotypeFrequency of depressionMood related disordersState of depressionPD patientsSuch medicationsWorse motorGenetic statusMedicationsProdromal stageRelated disordersGBA genePD diagnosisDiseaseDiagnosisDisordersSerum BDNF levels are involved in the diagnosis and treatment response in patients with PD
Li R, Li J, Liu Y, Li D, Chu L, Zhang J, Luo X, Zhang Y. Serum BDNF levels are involved in the diagnosis and treatment response in patients with PD. Journal Of Affective Disorders 2023, 327: 31-37. PMID: 36739005, DOI: 10.1016/j.jad.2023.01.107.Peer-Reviewed Original ResearchConceptsBaseline serum BDNF levelsSerum BDNF levelsBrain-derived neurotrophic factorState-Trait Anxiety InventoryBDNF levelsPanic disorderTrait anxietyHAMA-14PD patientsHealthy controlsBrain-derived neurotrophic factor serum levelsDiagnosis of panic disorderTreatment response to escitalopramHamilton Anxiety Rating ScaleResponse to escitalopramAnxiety Rating ScaleTreatment responseEscitalopram treatmentAnxiety symptomsNeuropsychological testsNinety PD patientsState-TraitAnxiety InventoryRating ScaleWeeks of treatmentStroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanisms
Elfil M, Bayoumi A, Sayed A, Aladawi M, Aboutaleb P, Grieb L, Tolba H, Tinaz S. Stroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanisms. Acta Neurologica Belgica 2023, 123: 773-783. PMID: 36710306, DOI: 10.1007/s13760-023-02202-4.Peer-Reviewed Original ResearchConceptsParkinson's diseaseEpidemiological studiesNeurological disordersRate of PDCumulative cardiovascular riskRisk of strokePost-stroke complicationsPotential pathophysiological mechanismsRecent epidemiological studiesQuality of lifeCardiovascular riskIschemic insultPathophysiological mechanismsPD patientsNeurological causesEtiological factorsSleep disordersMotor impairmentStrokeDiseasePathological processesDisordersRiskReviewMorbidityAn Update on Nondopaminergic Treatments for Motor and Non-motor Symptoms of Parkinson’s Disease
Jing XZ, Yuan XZ, Luo X, Zhang SY, Wang XP. An Update on Nondopaminergic Treatments for Motor and Non-motor Symptoms of Parkinson’s Disease. Current Neuropharmacology 2023, 21: 1806-1826. PMID: 35193486, PMCID: PMC10514518, DOI: 10.2174/1570159x20666220222150811.Peer-Reviewed Original ResearchConceptsNon-motor symptomsDopamine replacement therapyPD patientsMotor fluctuationsParkinson's diseaseNondopaminergic treatmentsReplacement therapyCertain non-motor symptomsTraditional dopamine replacement therapyLower urinary tract symptomsUrinary tract symptomsOngoing clinical trialsPotential adverse eventsManagement of motorPositive clinical implicationsManagement of hallucinationsDopaminergic strategiesMotor complicationsNondopaminergic drugsPD psychosisOrthostatic hypotensionTract symptomsAdverse eventsClinical benefitClinical efficacy
2022
Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson’s Disease following Dopaminergic Treatment
Stylianou O, Kaposzta Z, Czoch A, Stefanovski L, Yabluchanskiy A, Racz F, Ritter P, Eke A, Mukli P. Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson’s Disease following Dopaminergic Treatment. Fractal And Fractional 2022, 6: 737. PMID: 38106971, PMCID: PMC10723163, DOI: 10.3390/fractalfract6120737.Peer-Reviewed Original ResearchHealthy control individualsMini-Mental State ExaminationDopaminergic treatmentParkinson's diseaseFunctional connectivityMental State ExaminationStandard therapyPD patientsPD populationHC groupState ExaminationFunctional brain networksControl individualsPharmacological studiesSignificant positive correlationDiseaseBrain networksPatientsCognitive performanceAdult Reading TestPositive correlationTreatmentLong-term memoryTherapyThe immunology of Parkinson’s disease
Zhu B, Yin D, Zhao H, Zhang L. The immunology of Parkinson’s disease. Seminars In Immunopathology 2022, 44: 659-672. PMID: 35674826, PMCID: PMC9519672, DOI: 10.1007/s00281-022-00947-3.Peer-Reviewed Original ResearchConceptsAdaptive immune responsesImmune responseParkinson's diseaseT cellsGut-brain axis hypothesisOnset of PDΑ-synucleinGastro-intestinal symptomsCommon neurodegenerative disorderInnate immune responseΑ-synuclein aggregationPD patientsDopaminergic neuronsLewy bodiesSubstantia nigraNeuronal deathDisease progressionNeuropathological hallmarksProdromal phaseCurrent treatmentNeurodegenerative disordersDiseaseBrainMicrogliaPatientsAberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers
Droby A, Artzi M, Lerman H, Hutchison R, Bashat D, Omer N, Gurevich T, Orr-Urtreger A, Cohen B, Cedarbaum J, Sapir E, Giladi N, Mirelman A, Thaler A. Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers. Npj Parkinson's Disease 2022, 8: 20. PMID: 35241697, PMCID: PMC8894349, DOI: 10.1038/s41531-022-00285-z.Peer-Reviewed Original ResearchStriatal binding ratiosGBA-NMCFunctional connectivity patternsDopamine transporterHealthy first-degree relativesNigrostriatal dopaminergic activityGBA mutation carriersStriatal dopamine uptakeRs-fMRI scansFirst-degree relativesPre-clinical stageResting-state fMRIClinical assessment batteryConnectivity patternsPD patientsDopaminergic deficiencyDopaminergic activityRight putamenMutation carriersStudy groupClinical measuresStriatal regionsParkinson's diseaseDopamine uptakeFunctional alterationsThe steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting
Floris G, Scheggi S, Pes R, Bortolato M. The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting. Brain Research Bulletin 2022, 181: 157-166. PMID: 35122898, PMCID: PMC9012661, DOI: 10.1016/j.brainresbull.2022.01.020.Peer-Reviewed Original ResearchConceptsProbability discountingNucleus accumbensMonoamine-depleting agent reserpinePathological gambling severityImpulse-control disordersEffects of reserpineHighest dose of finasterideRisk of pathological gamblingParkinson's diseaseLever pressPathological gamblingDopamine receptorsGambling severityDoses of finasteridePramipexole treatmentRat's propensityAccumbensPramipexoleRestless legs syndromeImpact of finasterideReceptor upregulationNormalizing effectPD patientsReserpineReceptor expressionDeciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease
Gonzalez-Escamilla G, Koirala N, Bange M, Glaser M, Pintea B, Dresel C, Deuschl G, Muthuraman M, Groppa S. Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease. Neurology And Therapy 2022, 11: 265-282. PMID: 35000133, PMCID: PMC8857357, DOI: 10.1007/s40120-021-00318-4.Peer-Reviewed Original ResearchSupplementary motor areaClinical outcomesParkinson's diseaseDBS locationPostoperative MRIBrain stimulationIntroductionDeep brain stimulationMotor symptom improvementPostoperative clinical outcomesIdiopathic PD patientsPrimary motor cortexOptimal clinical outcomesDeep brain stimulationSTN-DBS outcomesSuperior frontal cortexDBS electrode positionUse of MRIUse of DBSSubcortical volumetryDBS outcomesPD patientsSubcortical targetsSymptom improvementDBS surgeryMotor cortex
2021
Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease
Taximaimaiti R, Luo X, Wang XP. Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease. Current Neuropharmacology 2021, 19: 2233-2249. PMID: 33998990, PMCID: PMC9185775, DOI: 10.2174/1570159x19666210517115706.Peer-Reviewed Original ResearchConceptsNon-pharmacological treatmentExcessive daytime sleepinessRestless legs syndromeRapid eye movementSleep disordersParkinson's diseaseSide effectsCommon non-motor symptomSleep behavior disorderNon-motor symptomsCommon sleep disorderDeep brain stimulationSleep hygiene educationRelative side effectsQuality of lifeCognitive behavior therapyLegs syndromePD patientsPharmacological treatmentComplementary therapiesDaytime sleepinessSleep qualityBrain stimulationBehavior disorderDisease
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