Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms
Sadot E, Basturk O, Klimstra D, Gönen M, Lokshin A, Gian R, D’Angelica M, DeMatteo R, Kingham T, Jarnagin W, Allen P. Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms. Annals Of Surgery 2015, 262: 1102-1107. PMID: 25563865, PMCID: PMC4643387, DOI: 10.1097/sla.0000000000001044.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmTumor-associated neutrophilsGrade of dysplasiaPapillary mucinous neoplasmSurrogate markerMalignant progressionMucinous neoplasmsIdentification of high-risk diseaseResected intraductal papillary mucinous neoplasmsHigher grades of dysplasiaIPMN progressionLow/intermediate-grade dysplasiaAssociated with malignant progressionAssociated with high gradeHigh-risk diseaseHigh-grade dysplasiaHigh gradeInvasive carcinomaLow/intermediate-gradeParenchymal inflammationInflammatory markersInflammatory mediatorsDysplasiaSignificant positive correlationLow risk
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