2025
Oxytocin in the Amygdala Sustains Prosocial Behavior via State-Dependent Amygdala–Prefrontal Modulation
Meisner O, Dal Monte O, Fagan N, Nandy A, Chang S. Oxytocin in the Amygdala Sustains Prosocial Behavior via State-Dependent Amygdala–Prefrontal Modulation. Journal Of Neuroscience 2025, 45: e2416242025. PMID: 40789657, PMCID: PMC12410040, DOI: 10.1523/jneurosci.2416-24.2025.Peer-Reviewed Original ResearchConceptsBasolateral amygdalaProsocial behaviorNeural activityProsocial choicesBehavioral effectsProsocial decisionsModulation of social behaviorMinimal behavioral effectsAnterior cingulate cortexSocial decision-makingControl conditionMale rhesus macaquesCingulate cortexNeural levelOxytocin's abilityOxytocin effectsMotivational stateTask engagementSustaining prosocial behaviorNeural responsesSocial salienceSocial behaviorSocial informationACCGAmygdalaElectroencephalographic Functional Connectivity Patterns in Children With Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder
Morand-Beaulieu S, Zhong J, Ibrahim K, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Electroencephalographic Functional Connectivity Patterns in Children With Tourette Syndrome and Attention-Deficit/Hyperactivity Disorder. Pediatric Neurology 2025, 172: 53-62. PMID: 40884873, DOI: 10.1016/j.pediatrneurol.2025.08.001.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderTourette syndromeFunctional connectivityAttention-deficit/hyperactivityBehavioral difficultiesAssociated with externalizing problemsPatterns of functional connectivityChild Behavior ChecklistFunctional connectivity patternsNeural levelNeural underpinningsBehavior ChecklistControl subjectsExternalizing problemsBrain regionsBehavior problemsBehavioral functionsResting-state electroencephalographyEmotional problemsConnectivity patternsConnectivity disruptions
2022
Mechanisms of Action in Exposure Therapy
Knowles K, Tolin D. Mechanisms of Action in Exposure Therapy. Current Psychiatry Reports 2022, 24: 861-869. PMID: 36399234, DOI: 10.1007/s11920-022-01391-8.Peer-Reviewed Original ResearchConceptsExposure-based interventionsExposure therapyReturn of fearAnxiety-related disordersExtinction learningFear extinctionNeural levelPrefrontal regionsNeurobiological mechanismsSafety behaviorSuch translational researchTherapy workPromising future directionsBehavioral mechanismsPharmacological augmentationMixed resultsBehavioral changesIncreased activationFull symptom reliefMultiple levelsFuture directionsRecent FindingsRecent studiesSymptom improvementMechanism of actionSymptom reliefTop-down sensory prediction in the infant brain at 6 months is correlated with language development at 12 and 18 months
Wang S, Zhang X, Hong T, Tzeng OJL, Aslin R. Top-down sensory prediction in the infant brain at 6 months is correlated with language development at 12 and 18 months. Brain And Language 2022, 230: 105129. PMID: 35576737, PMCID: PMC11956832, DOI: 10.1016/j.bandl.2022.105129.Peer-Reviewed Original ResearchConceptsMacArthur-Bates Communicative Development InventoriesLanguage developmentSensory predictionsVocabulary scoresVocabulary developmentVisual stimuliOccipital cortex activationCommunicative Development InventoryInfant language developmentExpressive vocabulary scoresInfants' vocabulary developmentNeural levelUnexpected omissionAuditory stimuliDevelopment InventoryNeural responsesCortex activationInfant brainNeural signalsPrevious researchStimuliSignificant positive correlationRobust supportMonthsScores
2018
The Comorbidity Between Internet Gaming Disorder and Depression: Interrelationship and Neural Mechanisms
Liu L, Yao YW, Li CR, Zhang JT, Xia CC, Lan J, Ma SS, Zhou N, Fang XY. The Comorbidity Between Internet Gaming Disorder and Depression: Interrelationship and Neural Mechanisms. Frontiers In Psychiatry 2018, 9: 154. PMID: 29740358, PMCID: PMC5924965, DOI: 10.3389/fpsyt.2018.00154.Peer-Reviewed Original ResearchInternet gaming disorderDorsolateral prefrontal cortexNeural mechanismsLeft amygdalaGaming disorderRight dorsolateral prefrontal cortexDepression symptomsPrecentral gyrusAutoregressive cross-lagged modelingBrain imaging researchExecutive control networkResting-state functional connectivity studyCross-lagged modelingFunctional connectivity studiesLongitudinal survey studyNeural levelBrain mechanismsEmotional deficitsPrefrontal cortexCognitive deficitsPsychotherapy interventionsControl participantsIGD severityCollege studentsConnectivity studies
2017
Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation
Hoffmann F, Puetz V, Viding E, Sethi A, Palmer A, McCrory E. Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation. Social Cognitive And Affective Neuroscience 2017, 13: nsx124-. PMID: 29069467, PMCID: PMC5793726, DOI: 10.1093/scan/nsx124.Peer-Reviewed Original ResearchConceptsRight anterior insulaMT groupBalloon Analogue Risk TaskMore anxiety symptomsPsychiatric disordersAnterior insulaFuture psychopathologyAnxiety symptomsChildrenDifferential effectsNeural correlatesNeurocognitive investigationsRisk-taking behaviorPeer influenceChild maltreatmentRiskGroupNeural levelMaltreatmentRisk TaskSymptomsInsula
2014
Perceiving the passage of time: neural possibilities
Muller T, Nobre A. Perceiving the passage of time: neural possibilities. Annals Of The New York Academy Of Sciences 2014, 1326: 60-71. PMID: 25257798, PMCID: PMC4336553, DOI: 10.1111/nyas.12545.Peer-Reviewed Original ResearchNeural bases of Theory of Mind in children with autism spectrum disorders and children with conduct problems and callous‐unemotional traits
O'Nions E, Sebastian C, McCrory E, Chantiluke K, Happé F, Viding E. Neural bases of Theory of Mind in children with autism spectrum disorders and children with conduct problems and callous‐unemotional traits. Developmental Science 2014, 17: 786-796. PMID: 24636205, PMCID: PMC4316185, DOI: 10.1111/desc.12167.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAutism Diagnostic Observation ScheduleCP/HCUASD groupTemporoparietal junctionConduct problemsSpectrum disorderMedial prefrontal cortex responsesAtypical neural processingRight temporoparietal junctionPrefrontal cortex responsesCallous-unemotional traitsMedial prefrontal cortexAtypical processingToM processingVignette taskNeural levelNeural underpinningsNeural basisTD controlsNeural processingSocial difficultiesNeural responsesObservation ScheduleFMRI responses
2013
Neural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits
Sebastian C, McCrory E, Dadds M, Cecil C, Lockwood P, Hyde Z, De Brito S, Viding E. Neural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits. Psychological Medicine 2013, 44: 99-109. PMID: 23510564, DOI: 10.1017/s0033291713000482.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSubgenual anterior cingulate cortexImportant translational implicationsNeural responsesAnterior cingulate cortexAmygdala responseMagnetic resonance imagingFearful eyesConduct problemsTrial participantsEye conditionsCingulate cortexCortex responsesResonance imagingEvidence baseAmygdala reactivityTranslational implicationsHeterogeneous groupTD controlsEyesChildrenFear recognition deficitsNeural levelParticipantsLow levels
2012
Linking Microcircuit Dysfunction to Cognitive Impairment: Effects of Disinhibition Associated with Schizophrenia in a Cortical Working Memory Model
Murray JD, Anticevic A, Gancsos M, Ichinose M, Corlett PR, Krystal JH, Wang XJ. Linking Microcircuit Dysfunction to Cognitive Impairment: Effects of Disinhibition Associated with Schizophrenia in a Cortical Working Memory Model. Cerebral Cortex 2012, 24: 859-872. PMID: 23203979, PMCID: PMC3948492, DOI: 10.1093/cercor/bhs370.Peer-Reviewed Original ResearchConceptsWorking memoryNeural levelSpatial WM taskWorking Memory ModelSpatial working memoryPersistent activity patternsWM representationsWM taskWM maintenanceBrain mechanismsWM deficitsMicrocircuit dysfunctionPrefrontal cortexCognitive deficitsBehavioral dataMemory modelBehavioral variabilityWM deteriorationCognitive impairmentCortical disinhibitionExcitation-inhibition balanceMain model predictionsDisinhibitionBehavioral deficitsDeficits
2008
Poor response inhibition: At the nexus between substance abuse and attention deficit/hyperactivity disorder
Groman SM, James AS, Jentsch JD. Poor response inhibition: At the nexus between substance abuse and attention deficit/hyperactivity disorder. Neuroscience & Biobehavioral Reviews 2008, 33: 690-698. PMID: 18789354, PMCID: PMC2728075, DOI: 10.1016/j.neubiorev.2008.08.008.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderSubstance abuseSubstance abuse/dependenceHyperactivity disorderAnimal model studiesAbuse/dependenceAttention-deficit/hyperactivity disorderDeficit/hyperactivity disorderResponse inhibition functionDeficit hyperactivity disorderUltimate progressionDependence disordersUnderlying biological mechanismsAnimal modelsBehavioral impairmentsCingulate cortexDisordersMultiple causesExhibit deficitsADHD-like traitsDrug takingResponse inhibitionBiological mechanismsImpairmentNeural level
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