2021
Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice
Sadleir K, Popovoic J, Zhu W, Reidel C, Do H, Silverman R, Vassar R. Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice. Current Alzheimer Research 2021, 18: 283-297. PMID: 34259145, PMCID: PMC9527523, DOI: 10.2174/1567205018666210713125333.Peer-Reviewed Original ResearchConceptsVoltagegated calcium channelsPlacebo-treated miceNeuropathic painPregabalin treatmentStatistically significant positive correlationCalcium channelsCalcium influxAb levelsDecreased markersPregabalinSignificant positive correlationCerebral concentrationsEffective treatmentAmyloid depositsCausative roleDystrophyCalcium dysregulationMiceNeuritic dystrophyProgression of amyloid pathologyPathologyImmunofluorescence imagingNeuronal processesPlaqueTreatment
1995
In Vivo Measurement of Phenylalanine in Human Brain by Proton Nuclear Magnetic Resonance Spectroscopy
Novotny E, Avison M, Herschkowitz N, Petroff O, Prichard J, Seashore M, Rothman D. In Vivo Measurement of Phenylalanine in Human Brain by Proton Nuclear Magnetic Resonance Spectroscopy. Pediatric Research 1995, 37: 244-249. PMID: 7731764, DOI: 10.1203/00006450-199502000-00020.Peer-Reviewed Original ResearchConceptsPhe concentrationsPlasma Phe concentrationsEfficacy of therapyCerebral concentrationsUntreated subjectsCerebral metabolitesNeurometabolic disorderControl studyPKU patientsPlasma PheMagnetic resonance spectroscopyMajor causePhenylketonuriaClinical magnetic resonance imaging systemNuclear magnetic resonance spectroscopyMagnetic resonance imaging systemHuman brainResonance imaging systemDisordersSubjectsImaging systemProton nuclear magnetic resonance spectroscopic studiesMagnetic resonance spectroscopic studiesResonance spectroscopyPHE signal
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