2025
Modulation of dopaminergic transmission and brain activity by frontotemporal tDCS: A multimodal PET-MR imaging study
Fonteneau C, Merida I, Redoute J, Haesebaert F, Lancelot S, Costes N, Mondino M, Brunelin J. Modulation of dopaminergic transmission and brain activity by frontotemporal tDCS: A multimodal PET-MR imaging study. Brain Stimulation 2025, 18: 1065-1073. PMID: 40340023, DOI: 10.1016/j.brs.2025.05.006.Peer-Reviewed Original ResearchTranscranial direct current stimulationPositron emission tomographyArterial spin labelingMagnetic resonance imagingWhite matter microstructural integrityModulation of dopaminergic transmissionParallel-group studyNo significant effects of tDCSOptimization of therapeutic strategiesNon-displaceable binding potentialEffects of transcranial direct current stimulationCerebral blood flowNeurophysiological mechanismsDiffusion weighted imagingMicrostructural integrityPET-MR imagingActive transcranial direct current stimulationDopaminergic transmissionDouble-blindSimultaneous positron emission tomographyDopamine releaseDopamine transmissionClinical benefitDirect current stimulationDopamine system20. Imaging Sex Differences in Amphetamine-Induced Dopamine Release in the Prefrontal Cortex in Individuals With Alcohol Use Disorder
Zakiniaeiz Y, Riordan W, Gallezot J, Nabulsi N, Huang Y, Bonomi R, Matuskey D, Cosgrove K. 20. Imaging Sex Differences in Amphetamine-Induced Dopamine Release in the Prefrontal Cortex in Individuals With Alcohol Use Disorder. Biological Psychiatry 2025, 97: s82-s83. DOI: 10.1016/j.biopsych.2025.02.210.Peer-Reviewed Original ResearchPreclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review
Barrios N, Riordan W, Garcia-Rivas V, Peltier M, Roberts W, Verplaetse T, Kohler R, Zhou H, Banini B, McKee S, Cosgrove K, Zakiniaeiz Y. Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review. Biology Of Sex Differences 2025, 16: 24. PMID: 40200334, DOI: 10.1186/s13293-025-00706-7.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol-induced dopamine releaseEffects of alcoholSex differencesAlcohol exposureDopamine measurementsMu-opioid receptorsDopamine releaseEffects of sexProgression of alcohol use disorderDopamine D1 receptor availabilityAlcohol use disorder developmentEffects of prenatal alcohol exposureD1 receptor availabilityStriatal dopamine concentrationsAir-exposed controlsAlcohol-exposed animalsMu-opioid receptor activationPrenatal alcohol exposureDuration of alcohol exposureVentral striatumBrain dopamineReward processingNeurobiological mechanismsReceptor availabilityContextual cues facilitate dynamic value encoding in the mesolimbic dopamine system
Fraser K, Collins V, Wolff A, Ottenheimer D, Bornhoft K, Pat F, Chen B, Janak P, Saunders B. Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system. Current Biology 2025, 35: 746-760.e5. PMID: 39855205, PMCID: PMC11859769, DOI: 10.1016/j.cub.2024.12.031.Peer-Reviewed Original ResearchConceptsMesolimbic dopamine systemConditioned stimulusDopamine systemNucleus accumbensDopamine functionDopamine releaseOccasion setterDopamine neuronsActivity of ventral tegmental area dopamine neuronsVentral tegmental area dopamine neuronsTheory of dopamine functionNon-overlapping presentationSucrose deliverySucrose rewardContextual cuesBehavioral outputAdaptive behaviorDynamic environmental contextBehavioral responsesFemale ratsAccumbensStimuliSeeking behaviorDopamineMotor control
2024
Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study
Worhunsky P, Mignosa M, Gallezot J, Pittman B, Nabulsi N, Stryjewski A, Jalilian-Khave L, Trinko R, DiLeone R, Carson R, Malison R, Potenza M, Angarita G. Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study. Biological Psychiatry 2024, 97: 651-658. PMID: 39395473, PMCID: PMC11839384, DOI: 10.1016/j.biopsych.2024.09.028.Peer-Reviewed Original ResearchVentral striatumEffects of medicationDorsal caudateDopamine releaseDorsal putamenDopaminergic tonePlacebo-controlled within-subject studyIncreased amphetamine-induced dopamine releaseAmphetamine-induced dopamine releaseAmphetamine-stimulated dopamine releaseSubstantia nigraDysregulated dopamine functionPositron emission tomography studiesTreatment of ADHDEmission tomography studiesWithin-subject studyPost-amphetamineD2/3 receptorsDopamine functionTransdiagnostic relevanceVitamin DPhasic releaseGlobus pallidusStriatumTyrosine hydroxylaseβ1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexStress-induced cognitive dysfunctionTreat stress-related disordersPrimate dorsolateral prefrontal cortexImpaired working memoryWorking Memory DeficitsWorking Memory TaskCalcium-binding proteins calbindinStress-related disordersClasses of inhibitory neuronsLevels of norepinephrineFast-spikingMemory taskDopamine releaseWorking memoryMemory deficitsInhibitory neuronsCognitive dysfunctionPV interneuronsGABAergic interneuronsDLPFCBehavior analysisCortexPyramidal cellsLower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls
Cheung F, Calakos K, Gueorguieva R, Hillmer A, Cosgrove K, Zakiniaeiz Y. Lower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls. Nicotine & Tobacco Research 2024, 26: 1038-1044. PMID: 38367211, PMCID: PMC11260895, DOI: 10.1093/ntr/ntae031.Peer-Reviewed Original ResearchAmphetamine-induced dopamine releaseBrain-behavior relationshipsAbstinent peopleDorsal striatumCognitive functionDopamine releasePoorer cognitive functionD2/3R availabilityDelayed RecallHealthy controlsTests of verbal learningDysregulated dopamine signalingD2/3 receptor availabilityDrug-seeking behaviorDorsolateral prefrontal cortexCogState computerized batteryPositron emission tomography scanAmphetamine administrationMesocortical pathwayMesolimbic pathwayDopamine systemPrefrontal cortexVerbal learningBaseline BPNDDopamine signalingGenes and Genetic Testing in Addiction Medicine
Blum K, Madigan M, Fuehrlein B, Thanos P, Lewandrowski K, Sharafshah A, Elman I, Baron D, Bowirrat A, Pinhasov A, Braverman E, Zeine F, Jafari N, Gold M. Genes and Genetic Testing in Addiction Medicine. 2024, 303-318. DOI: 10.1016/b978-0-323-95702-1.00227-x.Peer-Reviewed Original ResearchReward Deficiency SyndromeDopamine releaseDopamine D2 receptor geneBrain reward mechanismsBrain reward circuitryD2 receptor geneBrain Reward CascadeEffects of naloxoneOpioid receptor antagonistReward circuitryMesolimbic systemImpulsive behaviorAlcohol dependenceNeurotransmitter systemsDopaminergic dysfunctionNeurotransmitter interactionsSevere alcoholismDeficiency syndromeReward mechanismsNon-drugGenetic testingChronic deficitsAddiction medicineRewardBlum's group
2023
Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study
van Galen K, Schrantee A, ter Horst K, la Fleur S, Booij J, Constable R, Schwartz G, DiLeone R, Serlie M. Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study. Nature Metabolism 2023, 5: 1059-1072. PMID: 37308722, DOI: 10.1038/s42255-023-00816-9.Peer-Reviewed Original ResearchConceptsDiet-induced weight lossCerebral neuronal activityStriatal dopamine releaseWeight lossCrossover studyDopamine releaseNeuronal activityIntragastric glucoseNeuronal responsesSuccessful weight lossHealthy body weightSignificant weight lossBrain responsesPathological feeding behaviorsWeight regainHunger scoresLipid infusionLean participantsCaloric intakePlasma hormonesObesityBody weightInfusionNutrient signalsHigh rateVentral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner
Nunes E, Kebede N, Haight J, Foster D, Lindsley C, Conn P, Addy N. Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner . Journal Of Pharmacology And Experimental Therapeutics 2023, 385: 146-156. PMID: 36828630, PMCID: PMC10108441, DOI: 10.1124/jpet.122.001438.Peer-Reviewed Original ResearchConceptsNucleus accumbens coreVentral tegmental areaM5 receptorsDA releaseMale ratsVTA infusionsDepressive disorderNucleus accumbensMuscarinic M5 receptorsSelective negative allosteric modulatorM5 muscarinic receptorsNegative allosteric modulatorsEffort-related choicePhasic DA releasePotential sex differencesSex-specific mannerACh toneVTA administrationCholinergic effectsMuscarinic receptorsFemale ratsTegmental areaPreclinical modelsDopamine releaseTherapeutic target
2022
Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Roberts W, Verplaetse T, Burke C, Morris E, McKee S, Cosgrove K. Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes. Nicotine & Tobacco Research 2022, 25: 1047-1051. PMID: 36107715, PMCID: PMC10077933, DOI: 10.1093/ntr/ntac215.Peer-Reviewed Original ResearchConceptsCognitive functionVerbal learningPrefrontal cortexCognitive deficitsWorse verbal learningBrain-behavior relationshipsD2R availabilityDorsolateral prefrontal cortexCognitive performanceComputerized testsTask performanceCogState batteryInhibitory controlNeurocognitive testsReceptor availabilityMesocortical dopaminePositron emission tomographyDopamine D2/3 receptor availabilityMemoryCognitionD2/3 receptor availabilityDopamine releaseSmoking variablesSubject samplesDeficitsNicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response
Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response. Nicotine & Tobacco Research 2022, 24: 1597-1606. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyDopamine releasePlacebo patchDorsal striatumTobacco smokingReplacement therapyFirst-line pharmacological treatmentVentral striatumMajor public health burdenPositron emission tomography scanEmission tomography scanPublic health burdenNicotine dependence levelNicotine metabolism rateNicotinic acetylcholine receptorsCounter-balanced orderTobacco smokersCigarette smokingSmoking cessationDopamine terminalsPharmacological treatmentDependent smokersFast metabolizersSlow metabolizersNicotine acts
2021
Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine
Shokri‐Kojori E, Naganawa M, Ramchandani VA, Wong DF, Wang G, Volkow ND. Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine. Human Brain Mapping 2021, 43: 1419-1430. PMID: 34873784, PMCID: PMC8837588, DOI: 10.1002/hbm.25733.Peer-Reviewed Original ResearchConceptsOpioid receptor availabilityStriatal DA releaseDA releaseOpioid receptorsReceptor availabilityDopamine releaseStriatal dopamine releaseOpioid use disorderBrain-wide distributionInverse associationHealthy controlsStriatal distributionClinical studiesStriatal patternUse disordersSubcortical regionsVentral striatumGray matter segmentsReceptorsNaloxoneMorphineStriatumDA targetsRelease patternReleaseRecently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study
Calakos KC, Hillmer AT, Angarita GA, Baldassarri SR, Najafzadeh S, Emery PR, Matuskey D, Huang Y, Cosgrove KP. Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study. Nicotine & Tobacco Research 2021, 24: 745-752. PMID: 34628508, PMCID: PMC8962719, DOI: 10.1093/ntr/ntab208.Peer-Reviewed Original ResearchConceptsSmoking cessationAbstinent smokersDopamine releaseVentral striatumPercent changeTobacco smokersDopamine dysfunctionDopamine functionPHNO scansPositron emission tomography brainHigher CES-D scoresAbstinent tobacco smokersEarly quit attemptsHuman tobacco smokersPHNO PET StudyStriatal dopamine dysfunctionEpidemiologic Studies Depression ScaleStriatal dopamine releaseChronic nicotine exposureCES-D scoresSmoking cessation attemptNegative mood symptomsReceptor agonist radioligandStriatal dopamine functionLong-term abstinence
2020
Granulocyte-Colony Stimulating Factor Reduces Cocaine-Seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex
Hofford RS, Euston TJ, Wilson RS, Meckel KR, Peck EG, Godino A, Landry JA, Calipari ES, Lam TT, Kiraly DD. Granulocyte-Colony Stimulating Factor Reduces Cocaine-Seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex. Journal Of Neuroscience 2020, 41: 1553-1565. PMID: 33361463, PMCID: PMC7896012, DOI: 10.1523/jneurosci.1452-20.2020.Peer-Reviewed Original ResearchConceptsGranulocyte-colony stimulating factorMedial prefrontal cortexPsychostimulant use disordersPrefrontal cortexNucleus accumbensUse disordersDrug AdministrationMale Sprague-Dawley ratsMajor public health issueG-CSF treatmentSprague-Dawley ratsSynaptic dopamine releasePublic health issueTranslational research strategiesG-CSF effectsCue-induced drugDrug seeking behaviorRapid clinical translationAlters behavioral responsesRecombinant G-CSFReinstatement of cocaineGlutamatergic mechanismsPharmacological treatmentDawley ratsDopamine releaseDopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans
Lissemore J, Nagano-Saito A, Smart K, Gravel P, Leyton M, Benkelfat C. Dopaminergic Plasticity in the Bilateral Hippocampus Following Threat Reversal in Humans. Scientific Reports 2020, 10: 7627. PMID: 32376865, PMCID: PMC7203150, DOI: 10.1038/s41598-020-63977-7.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBilateral anterior hippocampusThreat reversalDopamine D2/3 receptor availabilityGreater dopamine releaseD2/3 receptor availabilityStress-related disordersClear clinical relevanceDopaminergic plasticityDopaminergic neurotransmissionHigh-resolution positron emission tomographyBilateral hippocampusDopamine releaseHealthy volunteersNeurochemical mechanismsHealthy humansPET scansClinical relevanceReceptor availabilityModerate evidenceAnterior hippocampusEmission tomographyFirst preliminary evidenceHippocampusDiminished ability
2019
Binge alcohol use is not associated with alterations in striatal dopamine receptor binding or dopamine release
Wai JM, Grassetti A, Slifstein M, Matuskey D, Nabulsi N, Ropchan J, Labaree D, Huang Y, Martinez D. Binge alcohol use is not associated with alterations in striatal dopamine receptor binding or dopamine release. Drug And Alcohol Dependence 2019, 205: 107627. PMID: 31669800, PMCID: PMC6893096, DOI: 10.1016/j.drugalcdep.2019.107627.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPositron emission tomographyDopamine releaseBinge drinkersHealthy controlsBinge drinkingReceptor bindingUse disordersStriatal dopamine receptor bindingYoung adult binge drinkersAdult binge drinkersAlcohol Use Disorders Identification Test (AUDIT) scoresDopamine receptor bindingFuture alcohol use disordersSubstance use disordersSignificant differencesPrevious imaging studiesOral methylphenidateRisk factorsDopamine transmissionHC subjectsAlcoholism criteriaAlcohol abuseDrinking historySignificant associationCorticostriatal plasticity in the nucleus accumbens core
Bamford NS, Wang W. Corticostriatal plasticity in the nucleus accumbens core. Journal Of Neuroscience Research 2019, 97: 1559-1578. PMID: 31298422, PMCID: PMC6801067, DOI: 10.1002/jnr.24494.Peer-Reviewed Original ResearchConceptsPrefrontal cortical projectionsCortical projectionsNAc coreDrug reinstatementSaline-treated miceSpiny projection neuronsMotor learningNew therapeutic targetsNucleus accumbens coreUse of amphetaminesStriatal glutamateGlutamate releaseCortical stimulationPresynaptic depressionProjection neuronsStriatal circuitryD1 receptorsDrug challengeLocomotor sensitizationMale miceCorticostriatal plasticityGlutamatergic boutonsDopamine releaseNucleus accumbensParadoxical excitationSex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers
Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers. Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDA releasePositron emission tomographyD2R availabilityDorsolateral prefrontal cortexMale smokersFemale smokersTobacco smokingPrefrontal cortexAmphetamine-induced DA releaseAmphetamine-induced dopamine releaseCortical DA releaseMesocortical DA systemEffects of nicotineSmoking-related behaviorsMesolimbic dopamine systemLong-term abstinenceSex differencesGender-specific treatmentFemale nonsmokersTobacco smokersAmphetamine administrationDopamine releaseNeurochemical mechanismsNonsmokersSmokersThe Striatum’s Role in Executing Rational and Irrational Economic Behaviors
Bamford IJ, Bamford NS. The Striatum’s Role in Executing Rational and Irrational Economic Behaviors. The Neuroscientist 2019, 25: 475-490. PMID: 30678530, PMCID: PMC6656632, DOI: 10.1177/1073858418824256.Peer-Reviewed Original ResearchConceptsIrrational economic behaviorExecutive functionStriatum's roleMotor learningMotor movementsSensory stimulationExcitatory glutamatergic activityBehavioral economicsHabit formationNovel stimulationNeural pathwaysReflexive actionDecision makingReflexive movementsRational behaviorEconomic behaviorRational responseRewardDopamine releaseBehaviorStriatumGlutamatergic activityLearningCortexThalamus
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