2025
Phenotypic variation in neural sensory processing by deletion size, age, and sex in Phelan-McDermid syndrome
Smith M, Berry-Kravis E, Thaliath A, Isenstein E, Durkin A, Foss-Feig J, Siper P, Nelson C, Baczewski L, Levin A, Powell C, Pulver S, Mosconi M, Kolevzon A, Ethridge L. Phenotypic variation in neural sensory processing by deletion size, age, and sex in Phelan-McDermid syndrome. Journal Of Neurodevelopmental Disorders 2025, 17: 51. PMID: 40855273, PMCID: PMC12376477, DOI: 10.1186/s11689-025-09642-4.Peer-Reviewed Original ResearchConceptsInter-trial coherenceAuditory processing abnormalitiesEvent-related spectral perturbationReactivity to sensory stimuliDeletion sizeAuditory stimuliRepetitive auditory stimuliSensory processingGenetic conditionsEvent-related potentialsComparison of event-related potentialsPhelan-McDermid syndromeBackgroundPhelan-McDermid syndromeNeonatal hypotoniaElectroencephalography studyDysmorphic featuresInhibitory modulationNeurophysiological abnormalitiesMethodsA totalEarly recognitionSHANK3 geneClinical characterizationProcessing abnormalitiesDevelopmental delayImpaired processingGaze responses in children with cerebral palsy, cerebral visual impairment, and severe intellectual and developmental disabilities
Ferziger N, Feldman R, Zivotofsky A. Gaze responses in children with cerebral palsy, cerebral visual impairment, and severe intellectual and developmental disabilities. Developmental Medicine & Child Neurology 2025 PMID: 40685842, DOI: 10.1111/dmcn.16426.Peer-Reviewed Original ResearchCerebral palsyCerebral visual impairmentVisual impairmentGaze responsesDyskinetic CPDevelopmental disabilitiesSevere IDDGaze frequencyMicroanalysis of video recordingsCVI groupUnimodal auditory stimuliOverall gaze durationsPalsyGaze durationGaze latencyBimodal stimuliResponses of childrenDisabilityChildrenSensory enhancementVisual-auditory stimuliAuditory stimuliIDDSensory stimuliImpairment
2024
Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness
Sieu L, Singla S, Liu J, Zheng X, Sharafeldin A, Chandrasekaran G, Valcarce-Aspegren M, Niknahad A, Fu I, Doilicho N, Gummadavelli A, McCafferty C, Crouse R, Perrenoud Q, Picciotto M, Cardin J, Blumenfeld H. Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness. Cell Reports 2024, 43: 115012. PMID: 39643969, PMCID: PMC11817788, DOI: 10.1016/j.celrep.2024.115012.Peer-Reviewed Original ResearchCortical slow wavesFocal seizuresBehavioral responsesAuditory stimuliImpaired behavioral responsesFocal temporal lobe seizuresImpaired consciousnessMouse modelAwake mouse modelResponses to auditory stimuliBehavioral responses to auditory stimuliDecreased cortical arousalImpaired behaviorSlow wavesTemporal lobe seizuresCholinergic releaseModel of focal seizuresHigh-frequency activityCortical functionCortical arousalDepressed cortical functionSubcortical arousalArousalAcetylcholine releaseRat modelHow the cognitive load of simulated driving affects the brain dynamics underlying auditory attention
Banz B, Wu J, Camenga D, Mayes L, Crowley M, Vaca F. How the cognitive load of simulated driving affects the brain dynamics underlying auditory attention. Traffic Injury Prevention 2024, 25: s167-s174. PMID: 39485699, DOI: 10.1080/15389588.2024.2373950.Peer-Reviewed Original ResearchBrain responses to auditory stimuliResponses to auditory stimuliAuditory attentional processingCortical regionsTarget tonesNo-Load ConditionTemporal cortical regionsRight frontal cortical regionsTarget earFrontal cortical regionsMotor vehicle crashesAlpha responsesBrain levelsPosterior cortical regionsTheta oscillationsEvent-related brain responsesTheta powerBrain-based measuresAuditory stimuliAuditory attentionEarly time windowStudy designVehicle crashesCognitive loadWorking memoryFrontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty
Basu A, Yang J, Yu A, Glaeser-Khan S, Rondeau J, Feng J, Krystal J, Li Y, Kaye A. Frontal Norepinephrine Represents a Threat Prediction Error Under Uncertainty. Biological Psychiatry 2024, 96: 256-267. PMID: 38316333, PMCID: PMC11269024, DOI: 10.1016/j.biopsych.2024.01.025.Peer-Reviewed Original ResearchPrediction error signalsResponses to conditioned stimuliThreat prediction errorsReinforcement learning modelThreat learningAnticipation of dangerAversive learningMemory strengthConditioned stimulusNoradrenergic signalingDefensive behaviorError signalPrediction errorAuditory stimuliTask structureNorepinephrine releaseNorepinephrineLearning modelsPredictive signalsStimuliFootshockDopamineLearningRewardError
2023
Modulation of potassium conductances optimizes fidelity of auditory information
Kaczmarek L. Modulation of potassium conductances optimizes fidelity of auditory information. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2216440120. PMID: 36930599, PMCID: PMC10041146, DOI: 10.1073/pnas.2216440120.Peer-Reviewed Original ResearchConceptsPotassium currentAuditory brainstem neuronsAuditory stimuliHigh-frequency firingGroups of neuronsLow-frequency stimuliBrainstem neuronsHigh-frequency stimuliIntrinsic excitabilityEnsembles of neuronsPostsynaptic neuronsAuditory neuronsNeurotransmitter releaseModulatory mechanismsAuditory stimulationFiring ratePotassium conductanceNeuronsPotassium channelsSingle neuronsAmplitude of currentsLoud soundsEnvironmental sound levelsChannel activityPositive membrane potentials
2022
Cognitive-Motor Dissociation Following Pediatric Brain Injury
Kim N, O'Sullivan J, Olafson E, Caliendo E, Nowak S, Voss H, Lowder R, Watson W, Ivanidze J, Fins J, Schiff N, Hill N, Shah S. Cognitive-Motor Dissociation Following Pediatric Brain Injury. Neurology Clinical Practice 2022, 12: 248-257. PMID: 35733619, PMCID: PMC9208423, DOI: 10.1212/cpj.0000000000001169.Peer-Reviewed Original ResearchCognitive-motor dissociationCognitive functionParticipants' EEGSemantic processing of wordsCovert cognitionBrain injuryProcessing of wordsIntact semantic processingIdentifying such personsResponses to auditory stimuliDiverse batteryCognitive abilitiesMinimally conscious stateCognitive-motorCognitive capacityPediatric brain injuryCommunication attemptsAuditory stimuliAged 9CognitionNeuroimagingMotor outputConscious stateParticipantsBrainTop-down sensory prediction in the infant brain at 6 months is correlated with language development at 12 and 18 months
Wang S, Zhang X, Hong T, Tzeng OJL, Aslin R. Top-down sensory prediction in the infant brain at 6 months is correlated with language development at 12 and 18 months. Brain And Language 2022, 230: 105129. PMID: 35576737, PMCID: PMC11956832, DOI: 10.1016/j.bandl.2022.105129.Peer-Reviewed Original ResearchConceptsMacArthur-Bates Communicative Development InventoriesLanguage developmentSensory predictionsVocabulary scoresVocabulary developmentVisual stimuliOccipital cortex activationCommunicative Development InventoryInfant language developmentExpressive vocabulary scoresInfants' vocabulary developmentNeural levelUnexpected omissionAuditory stimuliDevelopment InventoryNeural responsesCortex activationInfant brainNeural signalsPrevious researchStimuliSignificant positive correlationRobust supportMonthsScores
2021
Audiovisual Speech Perception in Children with Autism Spectrum Disorders: Evidence from Visual Phonemic Restoration
Irwin J, Avery T, Kleinman D, Landi N. Audiovisual Speech Perception in Children with Autism Spectrum Disorders: Evidence from Visual Phonemic Restoration. Journal Of Autism And Developmental Disorders 2021, 52: 28-37. PMID: 33630253, DOI: 10.1007/s10803-021-04916-x.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderSpeech perceptionPhonemic restorationAudiovisual speech perceptionPhonemic restoration paradigmAudiovisual processingVisual speechNeural signaturesDiscrimination responsesAuditory cuesSpeaker's faceAuditory stimuliOnly childRestoration paradigmSyllablesReduced influenceChildrenPerceptionSpeakersDisordersFaceASDAuditoryConsonantsModulation of Neuronal Potassium Channels During Auditory Processing
Wu J, Kaczmarek LK. Modulation of Neuronal Potassium Channels During Auditory Processing. Frontiers In Neuroscience 2021, 15: 596478. PMID: 33613177, PMCID: PMC7887315, DOI: 10.3389/fnins.2021.596478.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPotassium channelsAuditory brainstem neuronsAuditory brainstem nucleiNeuronal potassium channelsAuditory informationBrainstem neuronsBrainstem nucleiCertain neuronsPotassium currentFiring patternsNeuronsGene mutationsAuditory processingAuditory stimuliHigh rateLong-term modulationComplex auditory informationIntrinsic electrical propertiesSuch modulationHuman gene mutationsIntensity of soundAuditory environmentModulation
2020
Spoken Word Recognition in the Visual World Paradigm Reflects the Structure of the Entire Lexicon
Magnuson J, Tanenhaus M, Aslin R, Dahan D. Spoken Word Recognition in the Visual World Paradigm Reflects the Structure of the Entire Lexicon. 2020, 331-336. DOI: 10.4324/9781410603494-63.Peer-Reviewed Original ResearchVisual world paradigmWord recognitionHigh-frequency itemsWorld paradigmEye tracking methodHigher frequency neighborsCrucial comparisonNames of objectsArtificial lexiconLexical activationLanguage comprehensionNovel namesSentence contextAuditory stimuliUnrelated itemsContinuous measureVisual displayLexical itemsNative speakersEntire lexiconEye movementsProcessing phenomenaSpeech signalLexiconAmbiguity resolutionBrain-based limitations in attention and secondary task engagement during high-fidelity driving simulation among young adults.
Banz BC, Wu J, Camenga DR, Mayes LC, Crowley MJ, Vaca FE. Brain-based limitations in attention and secondary task engagement during high-fidelity driving simulation among young adults. Neuroreport 2020, 31: 619-623. PMID: 32366810, DOI: 10.1097/wnr.0000000000001451.Peer-Reviewed Original ResearchConceptsAuditory attention taskP3 responseAttention taskNo-Load ConditionSelective auditory attention taskEvent-related potential componentHigh-fidelity driving simulationPosterior sitesSecondary task engagementPosterior midline sitesPosterior P2Auditory attentionAttention processingAuditory taskAttention conditionAttention capabilitiesCognitive loadTask engagementNeural processingFrontal sitesAuditory stimuliAuditory tonesP3 componentDistracted drivingP2 responsesS197. PAVLOVIAN CONDITIONED HALLUCINATIONS TASKS AND PSYCHOMETRIC THRESHOLDING IN ENRICHED ONLINE SAMPLE
Kafadar E, Lim C, Powers A. S197. PAVLOVIAN CONDITIONED HALLUCINATIONS TASKS AND PSYCHOMETRIC THRESHOLDING IN ENRICHED ONLINE SAMPLE. Schizophrenia Bulletin 2020, 46: s113-s114. PMCID: PMC7234405, DOI: 10.1093/schbul/sbaa031.263.Peer-Reviewed Original ResearchAuditory verbal hallucinationsEmergence of hallucinationsAuditory stimuliNeural signaturesVisual stimuliUnusual experiencesOnline sampleIncoming sensory evidencePavlovian conditioning taskPredictive coding frameworkSalient auditory stimuliPrior beliefsPerceptual inferenceSensory evidencePerceptual experienceConditioning taskBrain processesTask methodologyResponses of participantsSensory modalitiesVerbal hallucinationsPotential therapeutic targetTask consistHallucinatory experiencesDiagnosis of psychosis
2018
Expectation affects neural repetition suppression in infancy
Emberson LL, Boldin AM, Robertson CE, Cannon G, Aslin RN. Expectation affects neural repetition suppression in infancy. Developmental Cognitive Neuroscience 2018, 37: 100597. PMID: 30473471, PMCID: PMC6918478, DOI: 10.1016/j.dcn.2018.11.001.Peer-Reviewed Original ResearchConceptsInfants' neural responsesRepetition suppressionNeural responsesInfant brainNeural repetition suppressionAuditory repetition suppressionControl conditionSame stimulus resultsPredictive processingAuditory stimuliStimulus presentationNeural activationNeural phenomenaPredictive codingStimuli resultsStimuliRecent workFNIRSExpectationsContextBrainParadigmRepetitionProcessingInfancyClassifying the mental representation of word meaning in children with Multivariate Pattern Analysis of fNIRS
Gemignani J, Bayet L, Kabdebon C, Blankertz B, Pugh K, Aslin R. Classifying the mental representation of word meaning in children with Multivariate Pattern Analysis of fNIRS. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2018, 00: 295-298. PMID: 30440396, DOI: 10.1109/embc.2018.8512209.Peer-Reviewed Original ResearchElectrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?
Foss-Feig JH, Stavropoulos KKM, McPartland JC, Wallace MT, Stone WL, Key AP. Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder? Developmental Neuropsychology 2018, 43: 109-122. PMID: 29436853, PMCID: PMC5972824, DOI: 10.1080/87565641.2017.1365869.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAuditory gap detectionSpectrum disorderP2 event-related potential (ERP) componentsEvent-related potential componentGap detectionLanguage-related impairmentsAuditory processing deficitsElectrophysiological responsesProcessing deficitsAuditory stimuliNeural responsesAuditory inputASD biomarkersSilent gapsPotential componentsCommunication alterationsTemporal aspectsDeficitsAmplitude reductionDisordersStimuliSensory symptomsTreatment responseImpairment
2016
Using fNIRS to examine occipital and temporal responses to stimulus repetition in young infants: Evidence of selective frontal cortex involvement
Emberson LL, Cannon G, Palmeri H, Richards JE, Aslin RN. Using fNIRS to examine occipital and temporal responses to stimulus repetition in young infants: Evidence of selective frontal cortex involvement. Developmental Cognitive Neuroscience 2016, 23: 26-38. PMID: 28012401, PMCID: PMC5253300, DOI: 10.1016/j.dcn.2016.11.002.Peer-Reviewed Original ResearchConceptsRepetition suppressionPerceptual corticesAuditory repetition suppressionFrontal cortexAuditory stimuliStimulus repetitionExperiment 1Experiment 2Cortex involvementInfant brainTemporal cortexFrontal lobeAdult brainYoung infantsCortexRepetitionRecent experienceBrainFNIRSExperienceStimuliFirst evidenceSuggestive evidenceInfantsEvidencePresynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics
Raccuglia D, McCurdy LY, Demir M, Gorur-Shandilya S, Kunst M, Emonet T, Nitabach MN. Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics. ENeuro 2016, 3: eneuro.0080-16.2016. PMID: 27588305, PMCID: PMC4994068, DOI: 10.1523/eneuro.0080-16.2016.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsPeripheral responsesGABA receptorsSensory neuronsContrast enhancementOSN axon terminalsInhibitory GABA receptorsPresynaptic GABAAxon terminalsDrosophila olfactory sensory neuronsPresynaptic terminalsNervous systemAuditory stimuliTemporal edgeOlfactory systemTime courseNeuronsInnate behavioral responsesReceptorsOptical electrophysiologyTemporal contrast enhancementBehavioral responsesLateral inhibitionResponseGABA
2015
Top-down modulation in the infant brain: Learning-induced expectations rapidly affect the sensory cortex at 6 months
Emberson LL, Richards JE, Aslin RN. Top-down modulation in the infant brain: Learning-induced expectations rapidly affect the sensory cortex at 6 months. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 9585-9590. PMID: 26195772, PMCID: PMC4534272, DOI: 10.1073/pnas.1510343112.Peer-Reviewed Original ResearchConceptsInfant brainSensory cortexFuture sensory inputsRole of expectationsRepetition suppressionInfants' expectationsVisual eventsOmission paradigmNeural processingStimulus noveltyAuditory stimuliCortical hierarchyInfant cortexNeural organizationNonhuman animalsNeural maturationSensory inputOccipital cortexEmpirical supportCortexRudimentary formExpectationsAdult humansHemodynamic responseExtensive feedback
2014
The Goldilocks Effect in Infant Auditory Attention
Kidd C, Piantadosi ST, Aslin RN. The Goldilocks Effect in Infant Auditory Attention. Child Development 2014, 85: 1795-1804. PMID: 24990627, PMCID: PMC4807134, DOI: 10.1111/cdev.12263.Peer-Reviewed Original ResearchConceptsAuditory attentionAttentional selectionInfant attentionCognitive resourcesVisual attentionCognitive domainsStimulus complexityAuditory stimuliImplicit beliefsAcoustic inputBehavioral methodsTheorized mechanismsHuman infantsPrevious researchCapacity limitsTransitional statisticsGoldilocks effectAttentionStimuliInfantsBeliefsBroad principlesSoundPrevious studiesExpectations
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