2022
Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL
Feng Q, Zhou M, Li S, Morimoto L, Hansen H, Myint SS, Wang R, Metayer C, Kang A, Fear AL, Pappas D, Erlich H, Hollenbach JA, Mancuso N, Trachtenberg E, de Smith AJ, Ma X, Wiemels JL. Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL. Blood Advances 2022, 6: 3756-3766. PMID: 35500222, PMCID: PMC9631572, DOI: 10.1182/bloodadvances.2021006821.Peer-Reviewed Original ResearchConceptsKiller immunoglobulin-like receptorsMaternal killer immunoglobulin-like receptorsAcute lymphoblastic leukemiaChild-mother pairsImmunoglobulin-like receptorsArginase IIKIR interactionsLower riskNon-Latino white subjectsLower tumor necrosisCase-control studyEtiology of childhoodDevelopment of childhoodHLA-KIRNeonatal cytokinesCytokine levelsCytokine profileLymphoblastic leukemiaImmune factorsImmune phenotypeTumor necrosisHigh riskChildhood leukemiaCytokine controlSignificant association
2021
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
Askenase MH, Goods BA, Beatty HE, Steinschneider AF, Velazquez SE, Osherov A, Landreneau MJ, Carroll SL, Tran TB, Avram VS, Drake RS, Gatter GJ, Massey JA, Karuppagounder SS, Ratan RR, Matouk CC, Sheth KN, Ziai WC, Parry-Jones AR, Awad IA, Zuccarello M, Thompson RE, Dawson J, Hanley DF, Love JC, Shalek AK, Sansing LH, Barrer S, MacKenzie L, Jonczak K, Bussinger P, Nakaji P, Wright S, Honea N, Zomorodi A, James M, Yeh E, Galicich W, Bergman T, France K, Leiphart J, Ramesh S, Brennan T, Huang J, Ziai W, White M, Camarata P, Abraham M, Gorup J, Reimer R, Freeman W, Williams C, Edwards E, Pollack A, Terry J, Shoen A, Jahromi B, Maas M, Yip B, Amidei C, Muñoz L, Lopez G, Holtz R, Gupta G, Rybinnik I, Moccio M, Lovick D, Brion B, Titus K, Jallo J, Rincon F, Pigott K, Boyden L, Dougherty J, Harrigan M, Miller D, Nelson L, Thompson G, Rajajee V, Pandey A, Ball R, Carlson A, Tran H, Alchbli A, James R, Jerde A, Taussky P, Ansari S, Neate C, Martinez J, Letsinger J, Fagatele L, Eaquinto C, Matouk C, Sheth K, Sansing L, Ryall L, Kunze K, Mampre D, Jasak S, Abdul-Rahim A, Abou-Hamden A, Abraham M, Ahmed A, Alba C, Aldrich E, Ali H, Altschul D, Amin-Hanjani S, Anderson C, Anderson D, Ansari S, Antezana D, Ardelt A, Arikan F, Awad R, Baguena M, Baker A, Barrer S, Barzo P, Becker K, Bergman T, Betz J, Bistran-Hall A, Boström A, Braun J, Brindley P, Broaddus W, Brown R, Buki A, Bulters D, Camarata P, Cao B, Cao Y, Carhuapoma J, Carlson A, Caron J, Carrion-Penagos J, Chalela J, Chang T, Chicoine M, Chorro I, Chowdhry S, Cobb C, Corral L, Csiba L, Davies J, Dawson J, Díaz A, Derdeyn C, Diringer M, Dlugash R, Dodd R, Ecker R, Economas T, Enriquez P, Ezer E, Fan Y, Feng H, Franz D, Freeman W, Fusco M, Galicich W, Gandhi D, Gelea M, Goldstein J, Gonzalez A, Grabarits C, Greenberg S, Gregson B, Gress D, Gu E, Gupta G, Hall C, Hanley D, Hao Y, Harnof S, Harrigan M, Hernandez F, Hoesch R, Hoh B, Houser J, Hu R, Huang J, Huang Y, Hussain M, Insinga S, Jadhav A, Jaffe J, Jahromi B, Jallo J, James M, James R, Janis S, Jankowitz B, Jeon E, Jichici D, Jonczak K, Jonker B, Karlen N, Kase C, Keric N, Kerz T, Kitagawa R, Knopman J, Koenig C, Krishnamurthy S, Kumar A, Kureshi I, Laidlaw J, Lakhanpal A, Lane K, Latorre J, LeDoux D, Lees K, Leifer D, Leiphart J, Lenington S, Li Y, Lopez G, Lovick D, Lumenta C, Luo J, Maas M, MacDonald J, MacKenzie L, Madan V, Majkowski R, Major O, Malhorta R, Malkoff M, Mangat H, Maswadeh A, Matouk C, Mayo S, McArthur K, McBee N, McCaul S, Medow J, Mendelow A, Mezey G, Mighty J, Miller D, Mitchell P, Mohan K, Money P, Mould W, Muir K, Muñoz L, Nakaji P, Nee A, Nekoovaght-Tak S, Nyquist P, O’Kane R, Okasha M, O'Kelly C, Ostapkovich N, Pandey A, Parry-Jones A, Patel H, Perla K, Pollack A, Polster S, Pouratian N, Quinn T, Rajajee V, Reddy K, Rehman M, Reimer R, Rincon F, Rosenblum M, Rybinnik I, Sanchez B, Sansing L, Sarabia R, Schneck M, Schuerer L, Schul D, Schweitzer J, Seder D, Seyfried D, Sheth K, Spiotta A, Stadnik A, Stechison M, Sugar E, Szabo K, Tamayo G, Tanczos K, Taussky P, Teitelbaum J, Terry J, Testai F, Thomas K, Thompson C, Thompson G, Thompson R, Torner J, Tran H, Tucker K, Ullman N, Ungar L, Unterberg A, Varelas P, Vargas N, Vatter H, Venkatasubramanian C, Vermillion K, Vespa P, Vollmer D, Wang W, Wang Y, Wang Y, Wen J, Whitworth L, Willis B, Wilson A, Wolfe S, Wrencher M, Wright S, Xu Y, Yanase L, Yenokyan G, Yi X, Yu Z, Ziai W, Zomorodi A, Zuccarello M. Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage. Science Immunology 2021, 6 PMID: 33891558, PMCID: PMC8252865, DOI: 10.1126/sciimmunol.abd6279.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageHypoxia-inducible factorMyeloid activationBrain injuryImmune responseAnti-inflammatory circuitsSubtypes of strokeAnti-inflammatory factorsInflammatory gene expressionPositive patient outcomesMonocytes/macrophagesDynamics of inflammationAcute sterile injuryLongitudinal transcriptional profilingHuman brainNeurological recoveryMyeloid responseProinflammatory profileImmune resolutionPatient cohortImmune factorsClinical trialsPatient outcomesSterile injuryProstaglandin E
2020
The Role of Immune Factors in Shaping Fetal Neurodevelopment
Lu-Culligan A, Iwasaki A. The Role of Immune Factors in Shaping Fetal Neurodevelopment. Annual Review Of Cell And Developmental Biology 2020, 36: 1-28. PMID: 32722920, PMCID: PMC9034439, DOI: 10.1146/annurev-cellbio-021120-033518.Peer-Reviewed Original ResearchConceptsMaternal immune activationImmune factorsFetal neurodevelopmentMaternal immunityPoor neurological outcomeMaternal-fetal interfaceNeurological outcomeNormal pregnancyImmune activationImmune pathwaysPostnatal lifeNeurological disordersExperimental modelNeurodevelopmentNormal physiologyPregnancyVivo roleImmunityCritical participantsMaternal pathwayFactorsSequence of eventsPathogenesisUteroFetusesHuman Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua
Silasi M, You Y, Simpson S, Kaislasuo J, Pal L, Guller S, Peng G, Ramhorst R, Grasso E, Etemad S, Durosier S, Aldo P, Mor G. Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua. Scientific Reports 2020, 10: 5785. PMID: 32238853, PMCID: PMC7113245, DOI: 10.1038/s41598-020-62593-9.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinCXCL10 expressionChorionic gonadotropinPotent immune-modulatory effectsImmune system undergoesImmune modulatory effectsEndometrial stromal cellsImmune cell recruitmentMaternal-fetal interfaceImmune regulatory functionsProcess of implantationCD8 cellsCytokine profilePregnancy progressesFetal interfaceDecidual samplesImmune populationsImmune factorsHuman deciduaT cellsDecidual cellsCell recruitmentModulatory effectsEarly hormoneStromal cellsCutaneous Photoprotection: A Review of the Current Status and Evolving Strategies.
Suozzi K, Turban J, Girardi M. Cutaneous Photoprotection: A Review of the Current Status and Evolving Strategies. The Yale Journal Of Biology And Medicine 2020, 93: 55-67. PMID: 32226337, PMCID: PMC7087054.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaBasal cell carcinomaCell carcinomaRisk factorsMajor environmental risk factorSquamous cell carcinomaAdditional risk factorsEnvironmental risk factorsDevelopment of melanomaUltraviolet radiation exposureLifestyle modificationTopical therapyImmune statusCutaneous carcinogenesisImmune factorsCell malignant transformationDrug Administration regulationsInsufficient evidenceMultifactorial mechanismsSkin cancerMalignant transformationFavorable aestheticsTumor developmentClonal expansionRadiation exposure
2019
Transfusion-related red blood cell alloantibodies: induction and consequences
Tormey CA, Hendrickson JE. Transfusion-related red blood cell alloantibodies: induction and consequences. Blood 2019, 133: 1821-1830. PMID: 30808636, PMCID: PMC6484385, DOI: 10.1182/blood-2018-08-833962.Peer-Reviewed Original ResearchConceptsTransfusion recipientsBlood donorsPreventative strategiesBlood product exposureCompatible RBC unitsRBC alloantibody formationHemolytic transfusion reactionsDevelopment of alloantibodiesAdaptive immune factorsJudicious transfusionRBC alloimmunizationImmunomodulatory therapyAlloantibody formationBlood transfusionRBC alloantibodiesRecipient variablesFuture pregnanciesImmune factorsTransfusion reactionsBlood productsHemolytic diseaseFuture transfusionsHuman studiesTransfusionAlloantibodies
2018
Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion
Patel SR, Gibb DR, Girard-Pierce K, Zhou X, Rodrigues LC, Arthur CM, Bennett AL, Jajosky RP, Fuller M, Maier CL, Zerra PE, Chonat S, Smith NH, Tormey CA, Hendrickson JE, Stowell SR. Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion. Frontiers In Immunology 2018, 9: 2516. PMID: 30505302, PMCID: PMC6250814, DOI: 10.3389/fimmu.2018.02516.Peer-Reviewed Original ResearchConceptsMZ B cellsMarginal zone B cellsRBC transfusionB cellsKEL RBCsImmune factorsAntibody formationRBC antigensRed blood cell alloimmunizationKey immune factorsSpecific immune compartmentCD4 T cellsFollicular B cellsAlloantibody formationImmune compartmentAntibody responseT cellsTherapeutic modalitiesTransfusionImmunological challengeImmune pathwaysMarginal sinusSplenic compartmentsImmune constituentsAlloimmunization
2017
West Nile Virus Seroprevalence, Connecticut, USA, 2000–2014 - Volume 23, Number 4—April 2017 - Emerging Infectious Diseases journal - CDC
Cahill ME, Yao Y, Nock D, Armstrong PM, Andreadis TG, Diuk-Wasser MA, Montgomery RR. West Nile Virus Seroprevalence, Connecticut, USA, 2000–2014 - Volume 23, Number 4—April 2017 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2017, 23: 708-710. PMID: 28322715, PMCID: PMC5367428, DOI: 10.3201/eid2304.161669.Peer-Reviewed Original Research
2016
Lipids and bariatric procedures Part 2 of 2: scientific statement from the American Society for Metabolic and Bariatric Surgery (ASMBS), the National Lipid Association (NLA), and Obesity Medicine Association (OMA)1
Bays H, Kothari SN, Azagury DE, Morton JM, Nguyen NT, Jones PH, Jacobson TA, Cohen DE, Orringer C, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures Part 2 of 2: scientific statement from the American Society for Metabolic and Bariatric Surgery (ASMBS), the National Lipid Association (NLA), and Obesity Medicine Association (OMA)1. Surgery For Obesity And Related Diseases 2016, 12: 468-495. PMID: 27050404, DOI: 10.1016/j.soard.2016.01.007.Peer-Reviewed Original ResearchConceptsNational Lipid AssociationObesity Medicine AssociationBariatric proceduresLipid levelsBariatric surgeryLipid effectsRisk factorsCardiovascular disease risk factorsMajor cardiovascular risk factorsCardiovascular risk factorsDisease risk factorsTissue lipid metabolismScientific statementAmerican SocietyClinical lipidologyGut hormonesImmune factorsLipid associationIntestinal microbiotaBile acidsLipid metabolismTrace element deficienciesSurgeryAssociationMetabolic
2015
Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: EXECUTIVE SUMMARY
Bays HE, Jones PH, Jacobson TA, Cohen DE, Orringer CE, Kothari S, Azagury DE, Morton J, Nguyen NT, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: EXECUTIVE SUMMARY. Journal Of Clinical Lipidology 2015, 10: 15-32. PMID: 26892119, DOI: 10.1016/j.jacl.2015.12.003.Peer-Reviewed Original ResearchConceptsNational Lipid AssociationObesity Medicine AssociationBariatric proceduresLipid levelsBariatric surgeryScientific statementCholesterol metabolismCardiovascular disease risk factorsDisease risk factorsBile acid metabolismAmerican SocietyLipid benefitsGut hormonesImmune factorsRisk factorsCardiovascular diseaseLipid associationIntestinal microbiotaEndocrine factorsBile acidsExecutive summaryLipid effectsTrace element deficienciesAcid metabolismObesityLipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: FULL REPORT
Bays HE, Jones PH, Jacobson TA, Cohen DE, Orringer CE, Kothari S, Azagury DE, Morton J, Nguyen NT, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: FULL REPORT. Journal Of Clinical Lipidology 2015, 10: 33-57. PMID: 26892120, DOI: 10.1016/j.jacl.2015.12.002.Peer-Reviewed Original ResearchConceptsNational Lipid AssociationObesity Medicine AssociationBariatric proceduresLipid levelsBariatric surgeryScientific statementCholesterol metabolismCardiovascular disease risk factorsDisease risk factorsBile acid metabolismAmerican SocietyLipid benefitsGut hormonesImmune factorsRisk factorsLipid associationIntestinal microbiotaEndocrine factorsBile acidsLipid effectsTrace element deficienciesFull reportAcid metabolismObesitySurgery
2014
mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium
Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e2610-e2619. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsTNF-α expressionTIA-1 expressionEndometrial stromal cellsIL-6Pathogenesis of endometriosisMenstrual cycleTIA-1Endometrial tissueEctopic endometriumImmune factorsHistological scoresCultured human endometrial stromal cellsSteroid hormonesStromal cellsGrowth factorElevated IL-6Ectopic endometrial tissueNormal menstrual cycleEutopic endometrial tissuesGrowth factor expressionT-cell intracellular antigenEndometrial cytokinesEndometrial functionControl womenT-cell intracellular antigen (TIA-1) modulates the expression of immune factors in endometrial cells and may contribute to endometriosis
Duke C, Karalok H, Choe G, Flannery C, Kallen C, Seli E. T-cell intracellular antigen (TIA-1) modulates the expression of immune factors in endometrial cells and may contribute to endometriosis. Fertility And Sterility 2014, 102: e5. DOI: 10.1016/j.fertnstert.2014.07.024.Peer-Reviewed Original Research
2012
Serum levels of soluble CD25 as a marker for hepatocellular carcinoma
CABRERA R, FITIAN A, ARARAT M, XU Y, BRUSKO T, WASSERFALL C, ATKINSON M, LIU C, NELSON D. Serum levels of soluble CD25 as a marker for hepatocellular carcinoma. Oncology Letters 2012, 4: 840-846. PMID: 23205111, PMCID: PMC3506698, DOI: 10.3892/ol.2012.826.Peer-Reviewed Original ResearchSerum levelsEarly hepatocellular carcinomaHepatocellular carcinomaHCC presenceSoluble CD25Pg/Levels of sCD25Healthy control subjectsNovel predictive markerAdvanced cirrhosisPresent study studyAdvanced fibrosisTumor burdenTumor stageControl subjectsHCC patientsPredictive markerImmune factorsGlobal unmet needLarge cohortSCD25PatientsSmall seriesUnmet needSignificant positive correlation
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