2021
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi
Almeida GG, Costa PAC, da Silva Araujo M, Gomes GR, Carvalho AF, Figueiredo MM, Pereira DB, Tada MS, Medeiros JF, da Silva Soares I, Carvalho LH, Kano FS, de Castro M, Vinetz JM, Golenbock DT, do Valle Antonelli L, Gazzinelli RT. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLOS Neglected Tropical Diseases 2021, 15: e0009077. PMID: 34714821, PMCID: PMC8555776, DOI: 10.1371/journal.pntd.0009077.Peer-Reviewed Original ResearchConceptsAsymptomatic individualsP. vivaxP. vivax malaria patientsP. vivax infectionVivax malaria patientsPlasmodium vivax malariaLow endemicity areaMalaria patientsSymptomatic patientsAsymptomatic infectionVivax malariaVivax infectionInfectious reservoirLow parasitemiaUninfected controlsEndemic regionsMalaria transmissionInfectivity ratesMalaria parasitesBiochemical parametersParasitemiaBloodPotential rolePatientsInfectionEffective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection
Chiu JE, Renard I, Pal AC, Singh P, Vydyam P, Thekkiniath J, Kumar M, Gihaz S, Pou S, Winter RW, Dodean R, Frueh L, Nilsen AC, Riscoe MK, Doggett JS, Mamoun C. Effective Therapy Targeting Cytochrome bc1 Prevents Babesia Erythrocytic Development and Protects from Lethal Infection. Antimicrobial Agents And Chemotherapy 2021, 65: 10.1128/aac.00662-21. PMID: 34152821, PMCID: PMC8370247, DOI: 10.1128/aac.00662-21.Peer-Reviewed Original ResearchConceptsEndochin-like quinolonesLethal infectionBlood-borne diseasesBlood-borne pathogensEffective therapyRelated apicomplexan parasitesExperimental therapiesLow doseMouse modelInfectious agentsHuman infectionsInfectionClinical candidatesStrong efficacyB. microtiExcellent safetyMode of actionTherapyErythrocytic developmentAtovaquoneEfficacyApicomplexan parasitesSafetyStructure-activity relationshipsParasitemiaPersistent Submicroscopic Plasmodium falciparum Parasitemia 72 Hours after Treatment with Artemether-Lumefantrine Predicts 42-Day Treatment Failure in Mali and Burkina Faso
Beshir K, Diallo N, Somé F, Sombie S, Zongo I, Fofana B, Traore A, Dama S, Bamadio A, Traore O, Coulibaly S, Maurice O, Diarra A, Kaboré J, Kodio A, Togo A, Dara N, Coulibaly M, Dao F, Nikiema F, Compaore Y, Kabore N, Barry N, Soulama I, Sagara I, Sirima S, Ouédraogo J, Djimde A, Sutherland C. Persistent Submicroscopic Plasmodium falciparum Parasitemia 72 Hours after Treatment with Artemether-Lumefantrine Predicts 42-Day Treatment Failure in Mali and Burkina Faso. Antimicrobial Agents And Chemotherapy 2021, 65: 10.1128/aac.00873-21. PMID: 34060901, PMCID: PMC8284475, DOI: 10.1128/aac.00873-21.Peer-Reviewed Original ResearchConceptsArtemether-lumefantrineClinical episodesFirst treatment episodeComplete parasite clearanceDrug treatment groupPlasmodium falciparum parasitemiaQuantitative PCRMalaria transmission intensityEvaluable patientsParasitological efficacyParasite clearanceTreatment failureSubmicroscopic parasitemiaTreatment episodesTreatment outcomesTreatment groupsBetter efficacyDay 42Short intervalsH posttreatmentParasitemiaRegimensPatientsBurkina FasoTransmission intensity
2020
Clofazimine, a Promising Drug for the Treatment of Babesia microti Infection in Severely Immunocompromised Hosts
Tuvshintulga B, Vannier E, Tayebwa DS, Gantuya S, Sivakumar T, Guswanto A, Krause PJ, Yokoyama N, Igarashi I. Clofazimine, a Promising Drug for the Treatment of Babesia microti Infection in Severely Immunocompromised Hosts. The Journal Of Infectious Diseases 2020, 222: 1027-1036. PMID: 32310272, DOI: 10.1093/infdis/jiaa195.Peer-Reviewed Original ResearchConceptsB. microti parasitesMicroti infectionHigh-grade parasitemiaDrug-resistant tuberculosisB. microtiBabesia microti infectionAdditional preclinical studiesB. microti infectionImmunocompromised hostB. microti DNAPolymerase chain reactionPreclinical studiesIncidence of babesiosisPromising drugRadical cureMinimal doseClofazimineDay 10Blood smearsBabesia microtiNovel drugsParasitemiaChain reactionMicroscopic examinationAntimicrobial agents
2019
Repeat exchange transfusion for treatment of severe babesiosis
Radcliffe C, Krause PJ, Grant M. Repeat exchange transfusion for treatment of severe babesiosis. Transfusion And Apheresis Science 2019, 58: 638-640. PMID: 31526674, DOI: 10.1016/j.transci.2019.07.010.Peer-Reviewed Case Reports and Technical NotesConceptsRepeat exchange transfusionExchange transfusionSevere babesiosisHospital day 5Second exchange transfusionBabesia microti infectionHigh feverRheumatoid arthritisMicroti infectionTransfusionDay 5Literature searchDearth of informationParasitemiaInfectionBabesiosisEtanerceptArthritisFeverClindamycinHypoxiaCasesWeeksWomen
2018
A Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood
Glanternik JR, Baine IL, Rychalsky MR, Tormey CA, Shapiro ED, Baltimore RS. A Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood. The Pediatric Infectious Disease Journal 2018, 37: 269-271. PMID: 28945680, DOI: 10.1097/inf.0000000000001803.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitHigh-grade parasitemiaTransfusion-transmitted babesiosisIntensive care unitCluster of casesBlood transfusionPremature infantsCare unitExchange transfusionDonor bloodInfantsBabesia microtiTransfusionBabesiosisNeonatesParasitemiaAzithromycinCliniciansAtovaquoneSingle unitBlood
2016
Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria
Tchaparian E, Sambol NC, Arinaitwe E, McCormack SA, Bigira V, Wanzira H, Muhindo M, Creek DJ, Sukumar N, Blessborn D, Tappero JW, Kakuru A, Bergqvist Y, Aweeka FT, Parikh S. Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria. The Journal Of Infectious Diseases 2016, 214: 1243-1251. PMID: 27471317, PMCID: PMC5034953, DOI: 10.1093/infdis/jiw338.Peer-Reviewed Original ResearchConceptsArtemether-lumefantrineRecurrent parasitemiaLumefantrine exposurePopulation pharmacokineticsUgandan childrenYoung Ugandan childrenPlasmodium falciparum malariaDay 7 concentrationsAge 6 monthsFirst-order absorptionWhole blood concentrationsYoung childrenUncomplicated malariaFalciparum malariaBlood concentrationsTreatment outcomesLumefantrine concentrationsSignificant positive correlationParasitemiaOlder childrenPharmacokineticsLumefantrineMalariaExposure levelsOpen model
2015
The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity
Tubman VN, Mejia P, Shmukler BE, Bei AK, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT. The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity. Antimicrobial Agents And Chemotherapy 2015, 60: 613-616. PMID: 26459896, PMCID: PMC4704178, DOI: 10.1128/aac.01668-15.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAnimalsAntimalarialsBiological TransportErythrocytesHost-Parasite InteractionsHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsMacaca mulattaMiceMice, Inbred C57BLPlasmodium falciparumPlasmodium knowlesiPlasmodium yoeliiTriphenylmethyl CompoundsTrophozoitesWaterConceptsGardos channel inhibitorChannel inhibitorsSickle cell diseaseC57BL/6 miceClinical trialsCell diseaseAntimalarial developmentPlasmodium growthErythrocyte dehydrationGardos channelSenicapocBlood stagesBiochemical profileAntimalarial activityPrimate plasmodiaVitro growthInhibitorsPatientsParasitemiaBlockadeDiseaseMiceTrialsMeasuring Plasmodium falciparum Erythrocyte Invasion Phenotypes Using Flow Cytometry
Bei AK, Duraisingh MT. Measuring Plasmodium falciparum Erythrocyte Invasion Phenotypes Using Flow Cytometry. Methods In Molecular Biology 2015, 1325: 167-186. PMID: 26450388, DOI: 10.1007/978-1-4939-2815-6_14.Peer-Reviewed Original ResearchConceptsPlasmodium falciparum merozoite invasionParasite multiplication rateErythrocyte invasion phenotypesInvasion of erythrocytesFlow cytometry methodVaccine mechanismDisease severityInvasion inhibitionEx vivoFlow cytometryMerozoite invasionCytometry methodRing stageInvasion phenotypeInvasionResearch settingsVivoImportant determinantLow levelsAlternative pathwayParasitesParasitemia
2013
The effects of the acute phase response on biomarkers of iron status differ in the presence of malaria infection
Wessells R, Hess S, Ouedraogo Z, Rouamba N, Erhardt J, Ouedraogo J, Brown K. The effects of the acute phase response on biomarkers of iron status differ in the presence of malaria infection. The FASEB Journal 2013, 27: 107.7-107.7. DOI: 10.1096/fasebj.27.1_supplement.107.7.Peer-Reviewed Original ResearchC-reactive proteinAcute phase responseIron statusAsymptomatic childrenSubclinical inflammationPlasma ferritinMalaria infectionMalarial parasitemiaPhase responseHigh prevalenceHigher geometric meanMalariaPrevalenceAP proteinInflammationChildrenInfectionGrant funding sourcesDeficiencyAGPGeometric meanStatusAntigenemiaBurkina FasoParasitemia
2012
Cellular basis for clearance of the protozoan parasite Babesia microti in immunocompromised hosts (43.13)
Vannier E, Silver Z, Wilson C, Su J, Chiam J, Laurie S, Telford S, Gelfand J, Krause P, Wortis H. Cellular basis for clearance of the protozoan parasite Babesia microti in immunocompromised hosts (43.13). The Journal Of Immunology 2012, 188: 43.13-43.13. DOI: 10.4049/jimmunol.188.supp.43.13.Peer-Reviewed Original ResearchCD4-/- miceB cellsT cellsMild flu-like illnessBabesia microtiResolution of parasitemiaAbsence of CD4Flu-like illnessRag1-/- miceRole of complementB-cell lymphomaCourse of infectionPrimary etiologic agentMature B cellsCD4-CD8Specific IgGAnti-CD20Athymic miceCell lymphomaFc receptorsHealthy individualsCD4ParasitemiaEtiologic agentInfectious diseases
2010
A flow cytometry‐based assay for measuring invasion of red blood cells by Plasmodium falciparum
Bei AK, DeSimone TM, Badiane AS, Ahouidi AD, Dieye T, Ndiaye D, Sarr O, Ndir O, Mboup S, Duraisingh MT. A flow cytometry‐based assay for measuring invasion of red blood cells by Plasmodium falciparum. American Journal Of Hematology 2010, 85: 234-237. PMID: 20196166, PMCID: PMC3089760, DOI: 10.1002/ajh.21642.Peer-Reviewed Original ResearchConceptsParasite invasionMalaria parasite Plasmodium falciparumParasite Plasmodium falciparumPlasmodium falciparumFlow cytometry-based assayParasite multiplication rateFlow cytometry-based methodParasite developmentCytometry-based assayCytometry-based methodRed blood cellsDisease severityDye SYBR Green IRing stageVariable invasionMultiplication rateBlood cellsInvasionSYBR Green IHuman erythrocytesFalciparumGreen IImportant determinantErythrocytesParasitemia
2007
Sulfadoxine-pyrimethamine efficacy and selection of Plasmodium falciparum DHFR mutations in Burkina Faso before its introduction as intermittent preventive treatment for pregnant women.
Tinto H, Ouédraogo J, Zongo I, van Overmeir C, van Marck E, Guiguemdé T, D'Alessandro U. Sulfadoxine-pyrimethamine efficacy and selection of Plasmodium falciparum DHFR mutations in Burkina Faso before its introduction as intermittent preventive treatment for pregnant women. American Journal Of Tropical Medicine And Hygiene 2007, 76: 608-13. PMID: 17426157, DOI: 10.4269/ajtmh.2007.76.608.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnimalsAntimalarialsBurkina FasoChildChild, PreschoolChloroquineDrug Administration ScheduleDrug CombinationsDrug ResistanceFemaleGenotypeHumansInfantMalaria, FalciparumMaleMutationPlasmodium falciparumPregnancyPregnancy Complications, ParasiticPyrimethamineSelection, GeneticSulfadoxineTetrahydrofolate DehydrogenaseConceptsSulfadoxine-pyrimethamine efficacyTriple dhfr mutationDHFR mutationsRecurrent parasitemiaIntermittent preventive treatmentSulfadoxine-pyrimethamine resistanceYears of ageSuch high prevalenceDihydropteroate synthetase (Pfdhps) mutationsPCR-restriction fragment length polymorphismSulfadoxine-pyrimethamineTreatment failurePregnant womenPolymerase chain reactionPreventive treatmentHigh prevalenceNew infectionsChain reactionMutant parasitesPatientsParasitemiaTreatmentFragment length polymorphismPrevalenceEfficacy
2004
Molecular Evaluation of the Natural History of Asymptomatic Parasitemia in Ugandan Children
Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR, Rosenthal PJ, Dorsey G. Molecular Evaluation of the Natural History of Asymptomatic Parasitemia in Ugandan Children. The Journal Of Infectious Diseases 2004, 189: 2220-2226. PMID: 15181569, DOI: 10.1086/421281.Peer-Reviewed Original ResearchConceptsSymptomatic malariaPolymerase chain reactionAsymptomatic parasitemiaDetectable parasitemiaNatural historySubsequent clinical malariaClinical malariaAsymptomatic childrenSymptomatic episodesMalarial parasitemiaUgandan childrenPersistent infectionParasitemiaMalariaFirst monthChain reactionMolecular evaluationChildrenHigh ratePrevalenceSimilar ratesMonthsPersistent strainsEpisodesInfection
2001
Erythrocytapheresis for Plasmodium falciparum infection complicated by cerebral malaria and hyperparasitemia
Zhang Y, Telleria L, Vinetz J, Yawn D, Rossmann S, Indrikovs A. Erythrocytapheresis for Plasmodium falciparum infection complicated by cerebral malaria and hyperparasitemia. Journal Of Clinical Apheresis 2001, 16: 15-18. PMID: 11309825, DOI: 10.1002/jca.1002.Peer-Reviewed Original ResearchConceptsRed blood cell exchangeCell exchangeAnti-malarial chemotherapyWhole blood exchangeEnd-organ dysfunctionLife-threatening complicationsPlasmodium falciparum infectionRed cell exchangeCirculation of patientsDegree of parasitemiaComplicated malariaCerebral malariaRenal dysfunctionFalciparum infectionHigher parasite loadsBlood exchangePatientsP. falciparumFull recoveryPlasmodium falciparumMalariaParasite loadHyperparasitemiaChemotherapyParasitemia
1998
Persistent Parasitemia after Acute Babesiosis
Krause P, Spielman A, Telford S, Sikand V, McKay K, Christianson D, Pollack R, Brassard P, Magera J, Ryan R, Persing D. Persistent Parasitemia after Acute Babesiosis. New England Journal Of Medicine 1998, 339: 160-165. PMID: 9664092, DOI: 10.1056/nejm199807163390304.Peer-Reviewed Original ResearchConceptsDuration of parasitemiaSpecific therapySide effectsInfected peopleCommunity-based studyEpisodes of illnessProtozoan Babesia microtiBabesial DNASymptoms of babesiosisRecrudescent diseaseQuinine therapyThin blood smearsPersistent parasitemiaInfected subjectsSerologic testsIll subjectsSpecific symptomsAcute babesiosisMore monthsParasitemiaBlood smearsBabesial infectionTherapyBabesia microtiSymptoms
1981
Raccoon babesiosis in Connecticut, USA: Babesia lotori sp. n.
Anderson J, Magnarelli L, Sulzer A. Raccoon babesiosis in Connecticut, USA: Babesia lotori sp. n. Journal Of Parasitology 1981, 67: 417-25. PMID: 7021788, DOI: 10.2307/3280566.Peer-Reviewed Original ResearchConceptsYoung raccoonsInfected raccoonsIndirect fluorescent antibody testSpecies of BabesiaFluorescent antibody testAntibody titersIxodes texanusSeropositive raccoonsBabesiaLow infection rateProcyon lotorRaccoonsAntibody testInfected bloodInfection rateParasitemiaBabesiosisTicksIxodesTitersProcyonSpeciesSp.
1980
Canine babesiosis: indirect fluorescent antibody test for a North American isolate of Babesia gibsoni.
Anderson J, Magnarelli L, Sulzer A. Canine babesiosis: indirect fluorescent antibody test for a North American isolate of Babesia gibsoni. American Journal Of Veterinary Research 1980, 41: 2102-5. PMID: 7011131, DOI: 10.2460/ajvr.1980.41.12.2102.Peer-Reviewed Original ResearchConceptsIndirect fluorescent antibody testFluorescent antibody testNorth American isolatesB gibsoniAntibody testDiagnosis of dogsLow parasitemiaB bigeminaB equiNonsplenectomized dogsSplenectomized dogsTiter of 1:256Negative seraHomologous antigenDogsHeterologous speciesMaximum titerTitersDaysGibsoniSignificant titersParasitemiaWeeksDilutionBlind test
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