2025
Transgenic expression of endoplasmic reticulum proteins in C. elegans neurons is prone to causing ER stress
Park J, Yogev S. Transgenic expression of endoplasmic reticulum proteins in C. elegans neurons is prone to causing ER stress. MicroPublication Biology 2025, 2025: 10.17912/micropub.biology.001547. PMID: 40519643, PMCID: PMC12163624, DOI: 10.17912/micropub.biology.001547.Peer-Reviewed Original ResearchER-associated degradationER stressLevels of ER stressOrganelle-specific markersC. elegans neuronsEndoplasmic reticulum proteinEndomembrane systemOrganelle biologyOrganelle markersIndividual organellesFluorescent proteinTransgenic markersOrganellesProteinPhenotypeMarkersEndomembraneExpressionTransgene expressionLow levelsBiologyStress
2023
Understanding the Co-occurrence of Gambling Disorder and Problematic Pornography Use: Exploring Sociodemographic and Clinical Factors
Mestre-Bach G, Potenza M, Granero R, Uríszar J, Tarragón E, Chiclana Actis C, Testa G, Fernández-Aranda F, Jiménez-Murcia S. Understanding the Co-occurrence of Gambling Disorder and Problematic Pornography Use: Exploring Sociodemographic and Clinical Factors. Journal Of Gambling Studies 2023, 40: 1295-1314. PMID: 38151657, DOI: 10.1007/s10899-023-10274-3.Peer-Reviewed Original ResearchProblematic pornography useGambling disorderEmotion regulationGD severitySubstance useTreatment-seeking individualsPornography useHigh impulsivityPersonality featuresPersonality profilesImpulsivityGroup differencesMore difficultyPsychopathologySociodemographic measuresWorse psychopathologySociodemographic variablesIndividualsDisordersCooperativenessPersonalityPresent studyLow levelsVariablesDifficultiesThe Relationship of Self-identified Weight Status With Perceived Mental and Physical Health
Hamilton A, Smith S, Lydecker J. The Relationship of Self-identified Weight Status With Perceived Mental and Physical Health. Journal Of Psychiatric Practice 2023, 29: 430-438. PMID: 37948168, PMCID: PMC10653675, DOI: 10.1097/pra.0000000000000744.Peer-Reviewed Original ResearchConceptsOW/OBBinge-eating disorderDisorder psychopathologyPhysical healthMental healthStudy groupBulimia nervosaOW/OB groupBN groupOverweight/obesityFuture clinical researchOB groupWeight statusObesityClinical researchBED groupOverweightDepressionHealthPsychopathologyDisordersGroupOBLow levelsAnalysis of variancePsychologically aggressive parenting and later aggression: Salivary alpha-amylase reactivity and sex as moderators
Chong L, Senich K, Ahmad S, Olezeski C, Gordis E. Psychologically aggressive parenting and later aggression: Salivary alpha-amylase reactivity and sex as moderators. International Journal Of Psychophysiology 2023, 194: 112260. PMID: 37939902, DOI: 10.1016/j.ijpsycho.2023.112260.Peer-Reviewed Original ResearchConceptsSAA reactivityVerbal aggressionLater aggressionAggressive parentingSalivary alpha-amylaseSNS reactivitySalivary alpha-amylase reactivitySocial stress taskAlpha-amylase reactivityThree-way interactionMore angerCurrent aggressionPhysical aggressionEarly adversityChild developmentStress taskAngerAggressionHigh levelsAggressive behaviorTwo-way interactionParentingLow levelsNervous system activityModeratorLongitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer
Huang S, Zhan Y, Jeon S, Bruner D, Miller A, Felger J, Wommack E, Saba N, Higgins K, Irwin M, Gary R, Xiao C. Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer. Head & Neck 2023, 45: 1952-1966. PMID: 37288586, PMCID: PMC10330673, DOI: 10.1002/hed.27420.Peer-Reviewed Original ResearchConceptsPhysical activityInflammatory markersQuality of lifeLower inflammationNeck cancerTotal QOL scoreHigh physical activityObservational longitudinal studyInactive patientsQOL scoresActive patientsStrength exercisesPatientsInflammationLongitudinal associationsMixed effects modelsSTNFR2Longitudinal studyCancerMarkersAssociationMore researchSubject correlationLow levelsPostradiotherapyCovid-19 vaccine acceptance among individuals incarcerated in Connecticut state jails
Lind M, Kennedy B, Nieto M, Houde A, Sosensky P, Borg R, Cummings D, Ko A, Richeson R. Covid-19 vaccine acceptance among individuals incarcerated in Connecticut state jails. Health & Justice 2023, 11: 16. PMID: 36913159, PMCID: PMC10009345, DOI: 10.1186/s40352-023-00216-x.Peer-Reviewed Original ResearchCOVID-19 vaccine programVaccine acceptanceVaccination programCOVID-19 vaccine acceptanceAge-adjusted hazardRetrospective cohort analysisOutcome of vaccinationTime-varying exposureTime of incarcerationVaccination ratesVaccine programVaccine offerCohort analysisVaccinationSurvival analysisStudy periodIncarcerated populationsLow levelsIncarcerationResidentsJailPopulationIntake
2022
The role of attentional shifting in the relation between error monitoring and anxiety in youth
Ramos ML, Bechor M, Casas A, Pettit JW, Silverman WK, Reeb-Sutherland BC. The role of attentional shifting in the relation between error monitoring and anxiety in youth. Psychiatry Research Neuroimaging 2022, 324: 111507. PMID: 35675720, PMCID: PMC9730549, DOI: 10.1016/j.pscychresns.2022.111507.Peer-Reviewed Original ResearchConceptsError-related negativityAttentional controlERN amplitudeNeural responsesMaintenance of anxietyLarger neural responsesSelf-report measuresSmaller neural responseAttentional shiftingFlanker taskError monitoringThreat signalsAnxiety symptomsNeural markersAnxietyYouthSimultaneous EEGResponse magnitudeAttentionNegativityAbilityHigh abilityTaskLow levelsEEGThe mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project
Alicandro G, Bertuccio P, Collatuzzo G, Pelucchi C, Bonzi R, Liao LM, Rabkin CS, Sinha R, Negri E, Dalmartello M, Zaridze D, Maximovich D, Vioque J, Garcia de la Hera M, Tsugane S, Hidaka A, Hamada GS, López-Carrillo L, Hernández-Ramírez RU, Malekzadeh R, Pourfarzi F, Zhang ZF, Kurtz RC, Camargo MC, Curado MP, Lunet N, Boffetta P, La Vecchia C. The mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project. British Journal Of Cancer 2022, 127: 855-862. PMID: 35624300, PMCID: PMC9427973, DOI: 10.1038/s41416-022-01857-9.Peer-Reviewed Original ResearchConceptsLifestyle factorsGastric cancerOdds ratioStomach cancer Pooling (StoP) ProjectWarrants further investigationNatural direct effectNatural indirect effectReduced riskPooling ProjectReference categoryGC casesLower educationComplete dataCausal pathwaysCancerFurther investigationDirect effectMediation analysisLow levelsIndirect effectsPotential pathwaysMediation effectFactorsPathwayCharacteristics associated with common reasons to pursue genomic profiling among patients with metastatic genitourinary cancers.
Malhotra J, Philip E, Govindarajan A, Salgia S, Meza L, Zengin Z, Muddasani R, Chawla N, Castro D, Chehrazi-Raffle A, Dizman N, Bergerot P, Hsu J, Dorff T, Pal S, Bergerot C. Characteristics associated with common reasons to pursue genomic profiling among patients with metastatic genitourinary cancers. Journal Of Clinical Oncology 2022, 40: 327-327. DOI: 10.1200/jco.2022.40.6_suppl.327.Peer-Reviewed Original ResearchPhysician indicationGenitourinary cancersTreatment responseCommon reasonAdvanced genitourinary cancersMetastatic genitourinary cancerGenomic profiling testsCross-sectional studyEffective provider communicationChart reviewOlder patientsPatient characteristicsYounger patientsClinicopathologic characteristicsPatients' perceptionsProvider communicationPatient responsePatientsOlder ageGenomic profilingLow levelsCancerImportant associationProfiling testsGPsSociodemographic and clinical characteristics of youths and parents seeking psychological treatment for school attendance problems
Johnsen DB, Lomholt JJ, Heyne D, Jeppesen P, Jensen MB, Silverman WK, Thastum M. Sociodemographic and clinical characteristics of youths and parents seeking psychological treatment for school attendance problems. PLOS ONE 2022, 17: e0261449. PMID: 35081106, PMCID: PMC8791456, DOI: 10.1371/journal.pone.0261449.Peer-Reviewed Original ResearchConceptsMental health problemsSchool attendance problemsPsychological treatmentHelp-seeking youthHealth problemsAttendance problemsClinical characteristicsBehavioral difficultiesCross-sectional designNegative outcomesOlder youthYouthEarly interventionClinical levelParentsTreatment startBaseline assessmentSchool absenceSociodemographic characteristicsTreatmentAnxietyHigh levelsLow levelsDepressionAbsence
2021
Reach and Adoption of a Geriatric Emergency Department Accreditation Program in the United States
Kennedy M, Lesser A, Israni J, Liu SW, Santangelo I, Tidwell N, Southerland LT, Carpenter CR, Biese K, Ahmad S, Hwang U. Reach and Adoption of a Geriatric Emergency Department Accreditation Program in the United States. Annals Of Emergency Medicine 2021, 79: 367-373. PMID: 34389196, PMCID: PMC10015385, DOI: 10.1016/j.annemergmed.2021.06.013.Peer-Reviewed Original ResearchConceptsGeriatric Emergency DepartmentEmergency departmentCare processesUrinary catheter useUS emergency departmentsHealth care utilizationPatient-oriented outcomesAccreditation programCatheter useCare utilizationEmergency physiciansAmerican CollegeRural designationStudy periodInterquartile rangeSignificant heterogeneityPotential needContinuous dataLow levelsLevel 1Level 2CohortPhysiciansPreventionA Mini-Review of Relationships Between Cannabis Use and Neural Foundations of Reward Processing, Inhibitory Control and Working Memory
Morie KP, Potenza MN. A Mini-Review of Relationships Between Cannabis Use and Neural Foundations of Reward Processing, Inhibitory Control and Working Memory. Frontiers In Psychiatry 2021, 12: 657371. PMID: 33967859, PMCID: PMC8100188, DOI: 10.3389/fpsyt.2021.657371.Peer-Reviewed Original ResearchReward processingInhibitory controlAddictive behaviorsDual-process modelWorking memoryNeurocognitive processesNeural foundationsNeural underpinningsNeural correlatesCognitive functionCannabis useSocial acceptanceMemoryCannabisΔ9-tetrahydrocannabinolProcessingCannabis productsUnderpinningsAddictionLow levelsCorrelatesRelationshipBehaviorAttentionCannabidiol
2020
Glycemic Variability and CNS Inflammation: Reviewing the Connection
Watt C, Sanchez-Rangel E, Hwang JJ. Glycemic Variability and CNS Inflammation: Reviewing the Connection. Nutrients 2020, 12: 3906. PMID: 33371247, PMCID: PMC7766608, DOI: 10.3390/nu12123906.Peer-Reviewed Original ResearchConceptsBlood-brain barrierGlycemic variabilityOxidative stressCentral nervous system outcomesImpact of hyperglycemiaType 2 diabetesCNS inflammationVascular complicationsVascular inflammationCognitive dysfunctionTherapeutic implicationsCognitive deficitsType 1Brain functionNeuroinflammationInflammationDysfunctionGlucoseLow levelsSystem outcomesHigh levelsComplicationsHyperglycemiaDiabetesLatest dataReduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics
Steinman JB, Lum FM, Ho PP, Kaminski N, Steinman L. Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 24620-24626. PMID: 32883878, PMCID: PMC7547272, DOI: 10.1073/pnas.2012358117.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptorT helper 2 (Th2) immune responsesCross-reactive humoral immunityCOVID-19T cell immunityT helper 2SARS-CoV-2Cell immunityCommon coronavirusesHelper 2Humoral immunityInflammatory cytokinesRespiratory tractImmune responseCommon coldPandemic virusPotential therapeuticsChildrenPathogenesisImmunityReduced developmentMolecular checkpointsCoronavirusLow levelsEosinophiliaObjective Measurement of Carcinogens Among Dominican Republic Firefighters Using Silicone-Based Wristbands
Caban-Martinez A, Feliciano P, Baum J, Bakali U, Santiago K, Solle N, Rivera G, Ramirez C, Deo S, Miric M, Perez-Then E, Kobetz E, Daunert S. Objective Measurement of Carcinogens Among Dominican Republic Firefighters Using Silicone-Based Wristbands. JCO Global Oncology 2020, 6: 15-15. DOI: 10.1200/go.20.90000.Peer-Reviewed Original ResearchCancer riskTotal PAH exposureElevated cancer riskLow-resource settingsObjective measurementsOccupational epidemiologic studiesTypical work shiftExcess cancer riskLymphohematopoietic organsEpidemiologic studiesGeneral populationCarcinogenic exposuresPilot studyCarcinogenic compoundsPAH exposureWork shiftExposureDirect exposureRiskPhysical hazardsLow levelsFirefightersFirst respondersDominican RepublicChemical agentsOxygen nipple and nut (Christmas tree) adaptor contamination rates and decontamination with disinfecting wipes
Colandrea NA, Cleary ML, Peaper DR, Sullivan LK, Martinello RA, Murray TS. Oxygen nipple and nut (Christmas tree) adaptor contamination rates and decontamination with disinfecting wipes. Infection Control And Hospital Epidemiology 2020, 41: 396-399. PMID: 31983357, DOI: 10.1017/ice.2020.9.Peer-Reviewed Original Research
2019
Sexual orientation openness and depression symptoms: A population-based study
van der Star A, Pachankis J, Bränström R. Sexual orientation openness and depression symptoms: A population-based study. European Journal Of Public Health 2019, 29: ckz185.139. DOI: 10.1093/eurpub/ckz185.139.Peer-Reviewed Original ResearchPopulation-based studyEuropean Health Interview SurveySocial supportFollow-back studyHealth Interview SurveyPopulation-based sampleHigh riskLower riskDepression symptomsMental healthHigher depressionNegative mental healthInterview SurveyPotential mediatorsDepressionAssociationDirect associationSexual minoritiesRiskRepresentative surveyLow levelsHeterosexual individualsIndividualsNonheterosexual identityMinorityQuantitative assessment of PD-L1 as an analyte in immunohistochemistry diagnostic assays using a standardized cell line tissue microarray
Martinez-Morilla S, McGuire J, Gaule P, Moore L, Acs B, Cougot D, Gown AM, Yaziji H, Wang WL, Cartun RW, Hornick JL, Sholl LM, Qiu J, Mino-Kenudson M, Yi ES, Beasley MB, Merrick DT, Ambaye AB, Zhang ZJ, Walker J, Rimm DL. Quantitative assessment of PD-L1 as an analyte in immunohistochemistry diagnostic assays using a standardized cell line tissue microarray. Laboratory Investigation 2019, 100: 4-15. PMID: 31409885, PMCID: PMC6920558, DOI: 10.1038/s41374-019-0295-9.Peer-Reviewed Original ResearchConceptsTissue microarrayPD-L1Quantitative immunofluorescencePD-L1 expressionPD-L1 immunohistochemistryMulti-institutional settingRoutine clinical samplesCell linesPredictive markerClinical trialsTumor typesIHC assaysQuantitative digital image analysisImmunohistochemistryCut pointsClinical samplesAntibodiesFDAInter-assay comparisonsDiagnostic assaysIsogenic cell linesAssaysDigital image analysisSubjective assessmentLow levels
2018
Risk and protective factors associated with depressive symptoms in young adults with overweight and obesity
Kaufman CC, Thurston IB, Maclin-Akinyemi C, Hardin RN, Decker KM, Kamody RC. Risk and protective factors associated with depressive symptoms in young adults with overweight and obesity. Journal Of American College Health 2018, 68: 148-154. PMID: 30557089, DOI: 10.1080/07448481.2018.1536057.Peer-Reviewed Original ResearchConceptsOverweight/obesityDepressive symptomsElevated weightProtective factorsOverweight/obeseContribution of BMIHealth behaviorsExercise engagementSymptomsObesityYoung adultsMutable factorsHierarchical linear regressionOne-thirdBody image variablesPositivityPerson surveyRiskNovel avenuesLow levelsBody dissatisfactionLinear regressionObeseOverweightBMIOptimizing access to PrEP based on MSM preferences: results of a discrete choice experiment
Dubov A, Ogunbajo A, Altice FL, Fraenkel L. Optimizing access to PrEP based on MSM preferences: results of a discrete choice experiment. AIDS Care 2018, 31: 545-553. PMID: 30554519, PMCID: PMC6408226, DOI: 10.1080/09540121.2018.1557590.Peer-Reviewed Original ResearchConceptsYoung MSMInjectable PrEPPrEP uptakeUptake of PrEPPre-exposure prophylaxisHigh HIV burdenMSM of colorMSM preferencesPrEP administrationDaily PrEPPrEP initiationHIV burdenDemand PrEPConsultation visitMSMPrEP programPrEPLatent class analysisDelivery programsMenGroupClass analysisStructural barriersLow levelsUptake
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