2025
Functional Trajectories After COVID‐19 Hospitalization Among Older Adults
Ho J, McAvay G, Murphy T, Acampora D, Araujo K, Geda M, Gill T, Hajduk A, Cohen A, Ferrante L. Functional Trajectories After COVID‐19 Hospitalization Among Older Adults. Journal Of The American Geriatrics Society 2025, 73: 1733-1741. PMID: 40096163, PMCID: PMC12213203, DOI: 10.1111/jgs.19420.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumFunction trajectoriesFactors associated with trajectory membershipTrajectory membershipAssociation of potential risk factorsCommunity-dwelling adultsRisk factorsModifiable risk factorsMedical decision-makingOlder survivorsPotential risk factorsOlder adultsSeverity of illnessAssociated with membershipYears of ageCOVID-19 hospitalizationModerate trajectoryLatent class analysisMultinomial regressionSurvive hospitalizationCOVID-19DisabilitySeverity trajectoriesHospitalClass analysisPhoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018
Sanchez-Pinto L, Daniels L, Atreya M, Faustino E, Farris R, Geva A, Khemani R, Rogerson C, Shah S, Weiss S, Bennett T. Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018. Pediatric Critical Care Medicine 2025, 26: e155-e165. PMID: 39982153, PMCID: PMC11792981, DOI: 10.1097/pcc.0000000000003675.Peer-Reviewed Original ResearchConceptsInternational Pediatric Sepsis Consensus ConferenceInternational Pediatric Sepsis Consensus Conference criteriaPhoenix criteriaCritically Ill ChildrenSepsis criteriaPICU admissionCohort of critically ill childrenOrgan dysfunction scoreIll childrenMulticenter cohort studyHigher risk of mortalityMortality of patientsAge groupsIn-Hospital MortalityRisk of mortalitySeverity of illnessDiscrimination of mortalityBloodstream infectionsSuspected infectionMulticenter cohortSeptic shockSepsis scoreDysfunction scorePatient subgroupsRetrospective analysis
2024
Opportunities for Incorporation of Primary Palliative Care in Acute Care Surgery: A Narrative Review.
Lynn A, Miller S, Brackett A, Kodadek L. Opportunities for Incorporation of Primary Palliative Care in Acute Care Surgery: A Narrative Review. American Journal Of Hospice And Palliative Medicine® 2024, 10499091241309087. PMID: 39680802, DOI: 10.1177/10499091241309087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPrimary palliative careAcute care surgeryPalliative carePalliative care principlesPractice of acute care surgeryAcute care surgical patientsNarrative reviewPrimary surgical teamCaregiver supportSymptom managementCare principlesClinician perspectivesSeverity of illnessPalliative interventionsCareSignificant barriersPractice existPromote educationIdentification of patientsIncreased awarenessBenefit patientsSurgical traineesSurgical settingPatient populationCultural factorsSex, Acute Kidney Injury, and Age: A Prospective Cohort Study
Golestaneh L, Basalely A, Linkermann A, El-Achkar T, Kim R, Neugarten J. Sex, Acute Kidney Injury, and Age: A Prospective Cohort Study. American Journal Of Kidney Diseases 2024, 85: 329-338.e1. PMID: 39447957, DOI: 10.1053/j.ajkd.2024.10.003.Peer-Reviewed Original ResearchConceptsRisk of acute kidney injuryAcute kidney injuryFemale sex hormonesSex hormonesKidney injuryRelative risk of acute kidney injuryOdds of acute kidney injuryAnimal models of kidney diseaseRisk factorsAcute kidney injury incidenceHospital-acquired acute kidney injuryWomen of fertile ageModels of kidney diseaseAbstractText Label="PLAIN-LANGUAGE SUMMARYAge groupsEquation logistic regressionSeverity of illnessPostmenopausal womenKDIGO definitionAbstractText Label="RATIONALEObstetric diagnosisAge categoriesMale sexCounts of hospitalizationsMontefiore Health SystemBiomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock
Atreya M, Bennett T, Geva A, Faustino E, Rogerson C, Lutfi R, Cvijanovich N, Bigham M, Nowak J, Schwarz A, Baines T, Haileselassie B, Thomas N, Luo Y, Sanchez-Pinto L, Investigators F. Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock. Pediatric Critical Care Medicine 2024, 25: 512-517. PMID: 38465952, PMCID: PMC11153020, DOI: 10.1097/pcc.0000000000003499.Peer-Reviewed Original ResearchElectronic health recordsMultiple organ dysfunction syndromePediatric septic shock patientsSeptic shock patientsRisk strataElectronic health record dataSepsis phenotypesShock patientsPersistent multiple organ dysfunction syndromeAssociated with poor clinical outcomesDegree of systemic inflammationIncreased adjusted oddsHigh riskOrgan dysfunction syndromePoor clinical outcomesHealth recordsReceiver operating characteristic curveHigh-risk stratumArea under the receiver operating characteristic curveCritically ill patientsPredictive of deathSeverity of illnessAdjusted oddsIdentification of childrenOperating characteristics curve
2023
1108. Severity of Illness among Adults Hospitalized with Respiratory Syncytial Virus Compared with COVID-19 and Influenza — IVY Network, 25 Hospitals, 20 U.S. States, January 31, 2022 – April 11, 2023
Yuengling K, Surie D, DeCuir J, Zhu Y, Gaglani M, Ginde A, Gibbs K, Prekker M, Mohamed A, Johnson N, Peltan I, Bender W, Mallow C, Kwon J, Lauring A, Columbus C, Vaughn I, Safdar B, Chappell J, Baughman A, Swan S, Johnson C, McMorrow M, Self W, Martin E. 1108. Severity of Illness among Adults Hospitalized with Respiratory Syncytial Virus Compared with COVID-19 and Influenza — IVY Network, 25 Hospitals, 20 U.S. States, January 31, 2022 – April 11, 2023. Open Forum Infectious Diseases 2023, 10: ofad500.081. PMCID: PMC10678102, DOI: 10.1093/ofid/ofad500.081.Peer-Reviewed Original ResearchInvasive mechanical ventilationAcute respiratory illnessAdvanced respiratory supportSARS-CoV-2Respiratory supportRespiratory illnessCOVID-19Use of IMVHigh-flow nasal cannulaMultivariable logistic regression modelAsahi Kasei PharmaMedical condition categoriesSeverity of RSVFlow nasal cannulaInfluenza-associated hospitalizationsNon-invasive ventilationShortness of breathSeverity of illnessRespiratory syncytial virusSevere respiratory illnessGrant/research supportChi-square testLogistic regression modelsPrevalence of RSVMedian ageRacial and Ethnic Differences Among Adult Patients Hospitalized for Skin and Soft Tissue Infection: A Cross-Sectional Analysis of 2012-2017 New York State Data.
Sedghi T, Cohen J, Feng H. Racial and Ethnic Differences Among Adult Patients Hospitalized for Skin and Soft Tissue Infection: A Cross-Sectional Analysis of 2012-2017 New York State Data. The Journal Of Clinical And Aesthetic Dermatology 2023, 16: 19-21. PMID: 38076657, PMCID: PMC10703506.Peer-Reviewed Original ResearchSoft tissue infectionsEthnic differencesStructural vulnerabilityHealthcare accessTissue infectionsAdult patientsNew York StateEthnic disparitiesDisparitiesEthnic minority patientsCost of hospitalizationLength of staySeverity of illnessIncreased healthcare costsClinical outcomesCross-sectional analysisWhite patientsPatientsInvestigate such differencesNewDying in the Hospital: A Quality Improvement Project to Increase Inpatient Hospice Utilization (QI105)
Prestia B, Kozhevnikov D, Loho H. Dying in the Hospital: A Quality Improvement Project to Increase Inpatient Hospice Utilization (QI105). Journal Of Pain And Symptom Management 2023, 65: e623-e624. DOI: 10.1016/j.jpainsymman.2023.02.220.Peer-Reviewed Original ResearchCMO patientsHospice utilizationInsurance statusSurgery serviceEducation interventionClinician related factorsSeverity of illnessLength of stayQuality improvement projectStudy-Act cyclesAcademic medical centerIllness scoresInpatient hospiceUnivariate analysisMultivariate regression modelMedical CenterComfort measuresPatientsHospital unitsPlan-DoHospitalICUEducational interventionMedical servicesRelated factorsThe Effects of Expectation Setting and Bundle Consent on Acute Caregiver Stress in the PICU: A Randomized Controlled Trial
Goldstein G, Karam O, Miller Ferguson N. The Effects of Expectation Setting and Bundle Consent on Acute Caregiver Stress in the PICU: A Randomized Controlled Trial. Pediatric Critical Care Medicine 2023, 24: 692-700. PMID: 37125809, DOI: 10.1097/pcc.0000000000003265.Peer-Reviewed Original ResearchConceptsBundled consentSeverity of illnessParents' perceptionsParents/guardians of patientsParents' perceived severityNegative mental health consequencesMental health consequencesPercentage of parentsCaregiver stressPersonal vulnerabilityChild's illnessChild's admissionControl groupChild's conditionExperimental groupPatients admitted to PICUDemographic surveyHealth consequencesLife-threatening natureStress burdenExpectation settingDemographic variablesControl weekIllnessAdmitted to PICUOutcomes on an inpatient oncology service after the introduction of hospitalist comanagement
Morris J, Rothberg BE, Prsic E, Parker N, Weber U, Gombos E, Kottarathara M, Billingsley K, Adelson K. Outcomes on an inpatient oncology service after the introduction of hospitalist comanagement. Journal Of Hospital Medicine 2023, 18: 391-397. PMID: 36891947, DOI: 10.1002/jhm.13071.Peer-Reviewed Original ResearchConceptsLength of stayInpatient oncology serviceSmilow Cancer HospitalSeverity of illnessOncology servicesOncologists' experiencesReadmission ratesEarly dischargeHospitalist comanagementAverage LOSTime of dischargeMean discharge timeEarly discharge ratesImpact of hospitalistsRace/ethnicityDischarge dispositionMultiple admissionsCancer HospitalMAIN OUTCOMEStudy durationPatient volumeCancer typesStudy periodHospitalistsOutcomesDifferentiation of Spontaneous Bacterial Peritonitis from Secondary Peritonitis in Patients with Liver Cirrhosis: Retrospective Multicentre Study
Würstle S, Hapfelmeier A, Karapetyan S, Studen F, Isaakidou A, Schneider T, Schmid R, von Delius S, Gundling F, Burgkart R, Obermeier A, Mayr U, Ringelhan M, Rasch S, Lahmer T, Geisler F, Turner P, Chan B, Spinner C, Schneider J. Differentiation of Spontaneous Bacterial Peritonitis from Secondary Peritonitis in Patients with Liver Cirrhosis: Retrospective Multicentre Study. Diagnostics 2023, 13: 994. PMID: 36900138, PMCID: PMC10000989, DOI: 10.3390/diagnostics13050994.Peer-Reviewed Original ResearchSpontaneous bacterial peritonitisRetrospective multicentre studySecondary peritonitisLiver cirrhosisSBP episodesBacterial peritonitisMulticentre studySeverity of illnessHigh-risk groupAscitic fluid infectionSelection operator (LASSO) regression modelPeritonitis episodesLaboratory parametersFluid infectionSerious complicationsUnivariable analysisInfected ascitesClinicopathological parametersPeritonitisTreatment approachesCirrhosisAscitesPatientsGerman hospitalsPoint scoreDelirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications
Akgün K, Krishnan S, Tate J, Bryant K, Pisani M, Re V, Rentsch C, Crothers K, Gordon K, Justice A, team F. Delirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications. Journal Of The American Geriatrics Society 2023, 71: 1861-1872. PMID: 36786300, PMCID: PMC10258127, DOI: 10.1111/jgs.18265.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification Test-ConsumptionActive medicationAlcohol useOdds ratioRelative riskDose-response associationDate of admissionSeverity of illnessIndependent dose-response associationsRace/ethnicityInpatient deliriumIndex dateMedication exposureRole of alcoholHIV statusMultivariable analysisMedication countNeurocognitive dysfunctionUnderappreciated causeDeliriumHigh incidencePWHMedicationsPWOHLogistic regression
2022
Polypharmacy and medical intensive care unit (MICU) admission and 10-year all-cause mortality risk among hospitalized patients with and without HIV
Gordon KS, Crothers K, Butt AA, Edelman EJ, Gibert C, Pisani MM, Rodriguez-Barradas M, Wyatt C, Justice AC, Akgün KM. Polypharmacy and medical intensive care unit (MICU) admission and 10-year all-cause mortality risk among hospitalized patients with and without HIV. PLOS ONE 2022, 17: e0276769. PMID: 36302039, PMCID: PMC9612570, DOI: 10.1371/journal.pone.0276769.Peer-Reviewed Original ResearchConceptsMedical intensive care unit admissionIntensive care unit admissionCare unit admissionMICU admissionSeverity of illnessHazard ratioHIV statusUnit admissionCause mortalityHospitalized patientsElectronic health record cohortLevel of polypharmacyRetrospective cohort studyCause mortality riskCohort studyHIV infectionCox regressionPolypharmacyMortality riskFiscal year 2009AdmissionPatientsMortalitySubstance useStrong associationAssociations between hospitalist physician workload, length of stay, and return to the hospital
Djulbegovic M, Chen K, Cohen AB, Heacock D, Canavan M, Cushing W, Agarwal R, Simonov M, Chaudhry SI. Associations between hospitalist physician workload, length of stay, and return to the hospital. Journal Of Hospital Medicine 2022, 17: 445-455. PMID: 35662410, PMCID: PMC9248905, DOI: 10.1002/jhm.12847.Peer-Reviewed Original ResearchConceptsLength of stayEmergency departmentPhysician workloadYale-New Haven HospitalMedian patient ageSeverity of illnessElectronic health record dataNumber of patientsHealth record dataWeekend admissionHospital daysPatient ageClinical outcomesObservational studyHospitalist serviceMAIN OUTCOMEPatient complexityHospitalist workloadSociodemographic factorsPatient encountersPatientsLogistic regressionMultilevel PoissonRecord dataOutcomes0583 Tolerance and feasibility of daytime bright light in medical intensive care unit patients
Intihar T, Samojedny V, Korwin A, Knauert M. 0583 Tolerance and feasibility of daytime bright light in medical intensive care unit patients. Sleep 2022, 45: a256-a257. DOI: 10.1093/sleep/zsac079.580.Peer-Reviewed Original ResearchMICU patientsCritical illnessMedical ICUControl trialChronic Health Evaluation II scoreMedical intensive care unit patientsIntensive care unit patientsMean patient ageCare unit patientsSeverity of illnessBright light exposureRandomized control trialOngoing randomized control trialAcute PhysiologyII scoreUsual carePatient ageUnit patientsIll patientsBright-light interventionSixteen patientsPoor outcomeClinical investigationBright lightPatientsRelation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome
Biondi M, Jain S, Fuery M, Thomas A, Ali T, Alviar CL, Desai NR, Miller PE. Relation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome. The American Journal Of Cardiology 2022, 176: 24-29. PMID: 35606175, DOI: 10.1016/j.amjcard.2022.04.034.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseVentilator-free daysHeart diseaseHistory of IHDImpact of IHDAcute respiratory distress syndromePredictors of mortalityRespiratory distress syndromeSeverity of illnessMultivariable logistic regressionMultivariable adjustmentSecondary outcomesDistress syndromeOrgan failurePrimary outcomeClinical outcomesIll subgroupStudy criteriaTreatment paradigmClinical trialsARDS severityPatientsHigh mortalityEnd pointMortalityEarly Palliative Care Consultation Reduces Length Of Stay And Cost In Patients Hospitalized With Acute Decompensated Heart Failure
Esstman B, Cyr P, Wakefield D, Soucier R, Tabtabai S. Early Palliative Care Consultation Reduces Length Of Stay And Cost In Patients Hospitalized With Acute Decompensated Heart Failure. Journal Of Cardiac Failure 2022, 28: s39-s40. DOI: 10.1016/j.cardfail.2022.03.106.Peer-Reviewed Original ResearchPalliative care consultationLength of stayEarly palliative care involvementAssociated with increased health care costsNon-cancer diagnosesPalliative care involvementReduce length of staySt Francis HospitalAcute decompensated heart failureHealth care costsReduced quality of lifeQuality of lifePredictors of length of stayAssociated with reduced lengthCare consultationPalliative careHigher severity of illnessCare involvementProlonged length of stayMedian length of staySeverity of illnessCare costsIn-Hospital MortalityPractice advisoryAssociated with decreased LOSThe Effect of Primary Care Visits on Total Patient Care Cost: Evidence From the Veterans Health Administration
Gao J, Moran E, Grimm R, Toporek A, Ruser C. The Effect of Primary Care Visits on Total Patient Care Cost: Evidence From the Veterans Health Administration. Journal Of Primary Care & Community Health 2022, 13: 21501319221141792. PMID: 36564889, PMCID: PMC9793026, DOI: 10.1177/21501319221141792.Peer-Reviewed Original ResearchConceptsTotal patient care costsPatient care costsVeterans Health AdministrationPrimary care visitsPC visitsCare costsPrimary careCare visitsHealth AdministrationOverall health care costsHigh-risk patientsSeverity of illnessHealth care costsPatient care outcomesClinical outcomesPC providersRetrospective studyComplex patientsPerson visitsPreventive servicesPatient riskComprehensive careMAIN OUTCOMECare outcomesPatients
2021
The influence of comorbidities on achieving an N‐terminal pro‐b‐type natriuretic peptide target: a secondary analysis of the GUIDE‐IT trial
Ezekowitz JA, Alemayehu W, Rathwell S, Grant AD, Fiuzat M, Whellan DJ, Ahmad T, Adams K, Piña IL, Cooper LS, Januzzi JL, Leifer ES, Mark D, O'Connor CM, Felker GM. The influence of comorbidities on achieving an N‐terminal pro‐b‐type natriuretic peptide target: a secondary analysis of the GUIDE‐IT trial. ESC Heart Failure 2021, 9: 77-86. PMID: 34784657, PMCID: PMC8787989, DOI: 10.1002/ehf2.13692.Peer-Reviewed Original ResearchConceptsBody mass indexLower body mass indexNT-proBNPAtrial fibrillationN-terminal pro B-type natriuretic peptide valuesMedian body mass indexHigher Body Mass IndexGUIDE-IT trialNT-proBNP targetWorse renal functionNT-proBNP levelsReduced ejection fractionCent of patientsNatriuretic peptide valuesGlomerular filtration rateHeart failure therapyInfluence of comorbiditiesSeverity of illnessEvidence-based therapiesPg/mLCare armLower eGFRRenal dysfunctionUsual careRenal functionTransition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes
Miller PE, Chouairi F, Thomas A, Kunitomo Y, Aslam F, Canavan ME, Murphy C, Daggula K, Metkus T, Vallabhajosyula S, Carnicelli A, Katz JN, Desai NR, Ahmad T, Velazquez EJ, Brennan J. Transition From an Open to Closed Staffing Model in the Cardiac Intensive Care Unit Improves Clinical Outcomes. Journal Of The American Heart Association 2021, 10: e018182. PMID: 33412899, PMCID: PMC7955420, DOI: 10.1161/jaha.120.018182.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitIntensive care unitHospital mortalityCare unitCICU mortalityClinical outcomesModern cardiac intensive care unitSurgical intensive care unitTotal hospital chargesSeverity of illnessMultivariable logistic regressionCICU lengthMultivariable adjustmentRespiratory insufficiencyPrimary outcomeUnique admissionsHospital chargesCardiac arrestSubgroup analysisImproved outcomesMortalityLogistic regressionAdmissionClosed unitStaffing models
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