2025
ABO blood group and COVID-19 severity: Associations with endothelial and adipocyte activation in critically ill patients
Stukas S, Goshua G, Conway E, Lee A, Hoiland R, Sekhon M, Chen L. ABO blood group and COVID-19 severity: Associations with endothelial and adipocyte activation in critically ill patients. PLOS ONE 2025, 20: e0320251. PMID: 40173171, PMCID: PMC11964209, DOI: 10.1371/journal.pone.0320251.Peer-Reviewed Original ResearchConceptsABO blood groupCritically ill patientsIntensive care unitAB blood typeBlood groupEndothelial injuryInflammatory cytokinesLength of intensive care unitRetrospective single-center studyMarkers of endothelial activationIll patientsMarkers of endothelial injuryDays of ICU staySerum inflammatory markersSingle-center studySeverity of COVID-19 infectionSerum inflammatory cytokinesBlood typeVancouver General HospitalSevere COVID-19SARS-CoV-2 infectionSeverity of diseaseCOVID-19 severityAdipsin levelsEndothelial activationSleep and Circadian-Related Outcomes after Critical Illness
Pisani M. Sleep and Circadian-Related Outcomes after Critical Illness. Seminars In Respiratory And Critical Care Medicine 2025 PMID: 40164118, DOI: 10.1055/a-2531-1137.Peer-Reviewed Original ResearchPost-intensive care syndromeCircadian disruptionExamined symptomsConstellation of symptomsSleep complaintsInfluence long-term outcomesSurvivors of critical illnessIntensive care unitIntensive care unit environmentSleepCritical illnessQuality of lifeCritically ill patientsIll patientsIllnessPost-ICUSymptomsStudy of critically ill patientsAn approach to improving efficiency of actigraphy data in research: use of statistical software to facilitate batch import.
Ezeokeke O, Fine J, Martin J, Gupta P, Malhotra A, Knauert M, Feldman E, Kamdar B. An approach to improving efficiency of actigraphy data in research: use of statistical software to facilitate batch import. Journal Of Clinical Sleep Medicine 2025 PMID: 40110621, DOI: 10.5664/jcsm.11612.Peer-Reviewed Original ResearchThe effects of hypnosis and music intervention on comfort and anxiety during weaning from mechanical ventilation: A pilot study
Devroey M, Orbegozo Cortes D, Gaspard N, Foucart J, Preiser J, Taccone F. The effects of hypnosis and music intervention on comfort and anxiety during weaning from mechanical ventilation: A pilot study. Journal Of Critical Care 2025, 87: 155044. PMID: 40036993, DOI: 10.1016/j.jcrc.2025.155044.Peer-Reviewed Original ResearchConceptsMusic intervention groupMusic interventionMV weaningIntervention groupVisual analog scaleCalm musicMusicCritically ill patientsAnxiety levelsIll patientsPilot studyMechanical ventilationReduce anxietyCriticismCortisol blood levelsEfficacy of hypnosisDistressing symptomsEffects of hypnosisHypnosis groupInclusion criteriaPrimary outcomeEligible patientsInterventionSpontaneous breathing trialAnalog scale
2024
Acute Decompensated Valvular Disease in the Intensive Care Unit
Miller P, Senman B, Gage A, Carnicelli A, Jacobs M, Rali A, Senussi M, Bhatt A, Hollenberg S, Kini A, Menon V, Grubb K, Morrow D, Section A. Acute Decompensated Valvular Disease in the Intensive Care Unit. JACC Advances 2024, 3: 101402. PMID: 39735779, PMCID: PMC11681797, DOI: 10.1016/j.jacadv.2024.101402.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIntensive care unitCardiac intensive care unitValvular diseaseCritically ill patientsCare unitIll patientsPrimary cardiac disorderMultidisciplinary heart teamModern cardiac intensive care unitPercutaneous interventional therapyDefinitive treatmentSurgical riskClinical presentationSocietal guidelinesHeart teamValvular disordersTreatment optionsInterventional therapyCardiac disordersDiseasePatientsTreatmentDisordersSurgeryTherapyChallenges with Formulating Accurate Prognosis for Patients with Severe Acute Brain Injury
Carhuapoma L, Hwang D. Challenges with Formulating Accurate Prognosis for Patients with Severe Acute Brain Injury. Neurocritical Care 2024, 42: 772-779. PMID: 39627563, DOI: 10.1007/s12028-024-02170-4.Peer-Reviewed Original ResearchSevere acute brain injuryAcute brain injuryBrain injurySelf-Fulfilling ProphecyClinical grading scaleCritically ill patientsEarly withdrawalPrognostic outcomesGrading scaleIll patientsPatientsAccurate prognosisHigher mortalityPredicting OutcomeLack of complete dataWithdrawal of life-sustaining treatmentComplete dataOutcomesPrognosticationInjuryLife-sustaining treatmentProtective mechanical ventilation in critically ill patients after surgery
Zorrilla-Vaca A, Arevalo J, Grant M. Protective mechanical ventilation in critically ill patients after surgery. Current Opinion In Critical Care 2024, 30: 679-683. PMID: 39503212, DOI: 10.1097/mcc.0000000000001215.Peer-Reviewed Original ResearchIntensive care unitVentilator-induced lung injuryLung protective strategyCritically ill patientsMechanical ventilationCare unitLung injurySurgical patientsFast-track extubation protocolOpen-lung ventilation strategyIll patientsRisk of ventilator-induced lung injuryHigh-flow nasal cannulaHigh-risk surgical patientsOpen lung ventilationOperating roomNoninvasive ventilation supportProtective mechanical ventilationPositive-end expiratory pressureAcute lung injuryMechanically Ventilated PatientsStandard of careThoracic surgeryNasal cannulaRetrospective studyTalking About Suffering in the Intensive Care Unit
Kious B, Vick J, Ubel P, Sutton O, Blumenthal-Barby J, Cox C, Ashana D. Talking About Suffering in the Intensive Care Unit. AJOB Empirical Bioethics 2024, 16: 52-59. PMID: 39250770, PMCID: PMC11785475, DOI: 10.1080/23294515.2024.2399534.Peer-Reviewed Original ResearchSecondary qualitative content analysisIntensive care unitInductive approach to data analysisEnd of lifeSuffering of personsAdult intensive care unitQualitative content analysisCare unitFamily meetingsReviewed transcriptsEmotional distressPatient's familyCritically ill patientsApproach to data analysisLimited treatmentCoding guideStudy authorsResearch teamContent analysisMulticenter trialPoor prognosisCliniciansLow qualityIll patientsSufferingCyclic Alternating EEG Patterns: From Sleep to Encephalopathy
Misirocchi F, Mutti C, Hirsch L, Parrino L, Florindo I. Cyclic Alternating EEG Patterns: From Sleep to Encephalopathy. Journal Of Clinical Neurophysiology 2024, 41: 485-494. PMID: 39186585, DOI: 10.1097/wnp.0000000000001082.Peer-Reviewed Original ResearchConceptsCyclic alternating patternStandardized Critical Care EEG TerminologyCritical care EEG terminologyNon-rapid eye movement sleepAmerican Clinical Neurophysiology SocietyEye movement sleepCritically ill patientsEEG terminologyPrognostic significancePrognostic valueMovement sleepClinical significanceImpact of confounding factorsSleep instabilityCritical care settingIll patientsClinical importanceEEG activityEEG phenomenaSedative agentsElectrophysiological biomarkersAlternating patternEncephalopathySleepCare settingsCerebral Edema Monitoring and Management Strategies: Results from an International Practice Survey
Greige T, Tao B, Dangayach N, Gilmore E, O’Hana Nobleza C, Hinson H, Chou S, Jha R, Wahlster S, Gebrewold M, Lele A, Ong C. Cerebral Edema Monitoring and Management Strategies: Results from an International Practice Survey. Neurocritical Care 2024, 42: 207-221. PMID: 39085504, PMCID: PMC11782636, DOI: 10.1007/s12028-024-02077-0.Peer-Reviewed Original ResearchCerebral edemaPractice variationLife-threatening complicationsAttending physiciansFactors associated with practice variationFisher's exact testCritically ill patientsUniversity-affiliated centerAcute brain injuryMonitoring cerebral edemaOsmotic therapyExact testDecompressive hemicraniectomyBackgroundCerebral edemaRadiographic findingsTreatment strategiesIll patientsRadiographic indicatorsPractice patternsUniversity affiliationEdemaSociety web sitesLogistic regressionProvider preferencesPractice surveyUltrasonography for Procedural Guidance
Munoz-Acuna R, Leibowitz A, Bose S. Ultrasonography for Procedural Guidance. 2024, 493-507. DOI: 10.1007/978-3-031-45731-9_21.Peer-Reviewed Original ResearchIntensive care unitCare unitEvaluate cardiac functionCritically ill patientsStandard of careSonographic evaluationPelvic contentsCardiac functionExtracorporeal supportAbnormal anatomyVenous structuresLung parenchymaVascular accessIll patientsCritical care unitsClinical practiceUltrasound machineDiagnostic toolUltrasoundUltrasonographyProcedural guidanceSeizure Assessment and Forecasting With Efficient Rapid-EEG
Kalkach-Aparicio M, Fatima S, Selte A, Sheikh I, Cormier J, Gallagher K, Avagyan G, Cespedes J, Krishnamurthy P, Elazim A, Khan N, Hussein O, Maganti R, Larocque J, Holla S, Desai M, Westover B, Hirsch L, Struck A. Seizure Assessment and Forecasting With Efficient Rapid-EEG. Neurology 2024, 103: e209621. PMID: 38875512, DOI: 10.1212/wnl.0000000000209621.Peer-Reviewed Original ResearchConceptsMonitoring of at-risk patientsRecords of patientsTertiary care centerReceiver operating characteristic curveCritically ill patientsAt-risk patientsClass II evidenceDiagnostic accuracy studiesOperating characteristics curveMedian ageSecondary endpointsPrevent overtreatmentNo significant differenceEEG reviewRisk stratificationNoninferiority marginAntiseizure medicationsClinical correlatesPrimary outcomeII evidenceEEG technologistsSeizure assessmentIll patientsComparative effectiveness studiesLow riskUltrasound-guided Axillary Artery Catheter Placement and Associated Complications in Critically Ill Patients
Cardona S, Gross A, Yu A, Bassily-Marcus A, Oropello J, Manasia A. Ultrasound-guided Axillary Artery Catheter Placement and Associated Complications in Critically Ill Patients. Journal Of Intensive Care Medicine 2024, 39: 916-921. PMID: 38794858, DOI: 10.1177/08850666241257417.Peer-Reviewed Original ResearchConceptsArtery catheter placementCritically ill patientsCatheter placementBody mass indexCatheter malfunctionArtery catheterVascular complicationsIll patientsMedian body mass indexCenter of patientsCatheter related complicationsRate of complicationsTertiary care centerIntensive care unitFemoral artery accessMedian ageAssociated complicationsRelated complicationsRetrospective studySurgical interventionCompartment syndromeUnivariate analysisMultiple cathetersMass indexClinical variablesCirculating Glucagon-Like Peptide 1 Predicts Mortality in Critically Ill Patients With Acute Respiratory Failure
Hansell C, Kitsios G, Bain W, Zhao Y, Suber T, Evankovich J, Morris A, Ray P, Ray A, Prendergast N, Hensley M, Petro N, Patel J, Nouraie S, Dela Cruz C, Mcverry B, Zhang Y, Shah F. Circulating Glucagon-Like Peptide 1 Predicts Mortality in Critically Ill Patients With Acute Respiratory Failure. 2024, a1109-a1109. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a1109.Peer-Reviewed Original ResearchLong-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial
Mart M, Boehm L, Kiehl A, Gong M, Malhotra A, Owens R, Khan B, Pisani M, Schmidt G, Hite R, Exline M, Carson S, Hough C, Rock P, Douglas I, Feinstein D, Hyzy R, Schweickert W, Bowton D, Masica A, Orun O, Raman R, Pun B, Strength C, Rolfsen M, Pandharipande P, Brummel N, Hughes C, Patel M, Stollings J, Ely E, Jackson J, Girard T. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine 2024, 12: 599-607. PMID: 38701817, PMCID: PMC11296889, DOI: 10.1016/s2213-2600(24)00077-8.Peer-Reviewed Original ResearchEffects of antipsychotic treatmentCognitive impairmentAssociated with long-term cognitive impairmentTreat deliriumLong-term cognitive impairmentLong-term outcomesTreatment of deliriumCritically ill patientsAntipsychotic treatmentZiprasidone groupHaloperidol groupFollow-upQuality-of-life outcomesAssessed survivorsZiprasidoneHaloperidolAntipsychoticsCognitive outcomesTreatment group assignmentDepartment of Veterans AffairsQuality-of-lifeIll patientsPlacebo-ControlledCritical illnessLong-term follow-upEarly Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study
Kelly-Hedrick M, Liu S, Komisarow J, Hatfield J, Ohnuma T, Treggiari M, Colton K, Arulraja E, Vavilala M, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Krishnamoorthy V. Early Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study. Journal Of Intensive Care Medicine 2024, 39: 875-882. PMID: 38449336, DOI: 10.1177/08850666241236724.Peer-Reviewed Original ResearchAssociated with hospital mortalityRetrospective cohort studyLength of stayModerate-severe TBITraumatic brain injuryCohort studyIntensive care unitBeta-blocker classHospital mortalityUtilization patternsClaims-based datasetHospital length of stayIll patientsCritically ill patientsIntensive care unit length of stayBrain injuryBeta-blockersHealthcare databasesInclusion criteriaSecondary outcomesPremier Healthcare DatabasePrimary outcomeVasopressor utilizationIntensive care unit stayHospital
2023
WHS guidelines for the treatment of pressure ulcers—2023 update
Gould L, Alderden J, Aslam R, Barbul A, Bogie K, Masry M, Graves L, White‐Chu E, Ahmed A, Boanca K, Brash J, Brooks K, Cockron W, Kennerly S, Livingston A, Page J, Stephens C, West V, Yap T. WHS guidelines for the treatment of pressure ulcers—2023 update. Wound Repair And Regeneration 2023, 32: 6-33. PMID: 37970711, PMCID: PMC11403384, DOI: 10.1111/wrr.13130.Peer-Reviewed Original ResearchPressure ulcersSpinal cord injury/diseaseHospital-acquired pressure ulcersBurden of painAcute care facilitiesMultiple risk factorsImplementation of hospitalInjury/diseaseIll patientsGuideline updatePressure injuriesCostly conditionRisk factorsWound careNursing facilitiesCare facilitiesUlcersHealth systemAvailable evidenceOlder adultsGuidelines projectPreventive measuresStage 3CliniciansTreatmentResearch Priorities in Critical Care Cardiology JACC Expert Panel
Miller P, Huber K, Bohula E, Krychtiuk K, Pöss J, Roswell R, Tavazzi G, Solomon M, Kristensen S, Morrow D, Care A. Research Priorities in Critical Care Cardiology JACC Expert Panel. Journal Of The American College Of Cardiology 2023, 82: 2329-2337. PMID: 38057075, PMCID: PMC10752230, DOI: 10.1016/j.jacc.2023.09.828.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac intensive care unitCritical care cardiologyHigh-quality evidencePatient populationIntensive care unitCritical care researchCare unitIll patientsSociety guidelinesClinical trialsPractice patternsCare researchExpert panelDiagnosisResearch prioritiesComorbiditiesPatientsPopulationLimited guidanceCliniciansCardiologyTrialsCareRates, patterns, and predictors of specialty palliative care consultation among patients with acute-on-chronic liver failure
Patel A, Walling A, Kanwal F, Serper M, Hernaez R, Sundaram V, Kaplan D, Taddei T, Mahmud N. Rates, patterns, and predictors of specialty palliative care consultation among patients with acute-on-chronic liver failure. JHEP Reports 2023, 6: 100976. PMID: 38274489, PMCID: PMC10808910, DOI: 10.1016/j.jhepr.2023.100976.Peer-Reviewed Original ResearchSpecialty palliative care consultationPalliative care consultationChronic liver failureFacility-level variationCare consultationsLiver failurePalliative careTime of deathACLF-3Significant facility-level variationRetrospective cohort studyTiming of consultationFacility factorsMixed-effects regression analysisQuality improvement effortsACLF gradeACLF-1ACLF-2Acute hospitalizationCohort studyIll patientsACLFGrade 3Hepatocellular carcinomaSick patientsCommentary: Mania in Medically Ill Patients
Garakani A. Commentary: Mania in Medically Ill Patients. Journal Of Psychiatric Practice 2023, 29: 426-427. PMID: 37678372, DOI: 10.1097/pra.0000000000000731.Commentaries, Editorials and LettersConceptsBipolar disorderBehçet's diseasePatient's symptomsManic symptomsMedical settingsMedically Ill PatientsComprehensive medical evaluationPrimary bipolar disorderSecondary maniaIll patientsMedical illnessMedical floorPsychiatric providersCase reportThorough historyEmergency roomEmergency settingMedical evaluationPsychiatric consultationPsychiatric treatmentPatientsFrontal lobeSymptomsDiseaseDisorders
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply