2025
Functional Trajectories After COVID‐19 Hospitalization Among Older Adults
Ho J, McAvay G, Murphy T, Acampora D, Araujo K, Geda M, Gill T, Hajduk A, Cohen A, Ferrante L. Functional Trajectories After COVID‐19 Hospitalization Among Older Adults. Journal Of The American Geriatrics Society 2025, 73: 1733-1741. PMID: 40096163, PMCID: PMC12213203, DOI: 10.1111/jgs.19420.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumFunction trajectoriesFactors associated with trajectory membershipTrajectory membershipAssociation of potential risk factorsCommunity-dwelling adultsRisk factorsModifiable risk factorsMedical decision-makingOlder survivorsPotential risk factorsOlder adultsSeverity of illnessAssociated with membershipYears of ageCOVID-19 hospitalizationModerate trajectoryLatent class analysisMultinomial regressionSurvive hospitalizationCOVID-19DisabilitySeverity trajectoriesHospitalClass analysis
2024
Caribbean data-sharing initiatives: activities of the Eastern Caribbean Health Outcomes Research Network
Wang K, Britton M, Hambleton I, Howitt C, Jeyaseelan S, Fraser K, Martinez-Brockman J, Whiteman S, Rajeevan H, Nunez-Smith M. Caribbean data-sharing initiatives: activities of the Eastern Caribbean Health Outcomes Research Network. BULL PAN AM HEALTH ORGAN 2024, 48: 1. PMID: 39687248, PMCID: PMC11648151, DOI: 10.26633/rpsp.2024.121.Peer-Reviewed Original ResearchEastern Caribbean Health Outcomes Research NetworkLongitudinal data resourcesCommunity-engaged processCommunity-engaged approachCommunity-dwelling adultsGovernment focusPower dynamicsResearch NetworkData-sharing infrastructureGreater accessParticipating communitiesCare principlesNoncommunicable diseasesUnited StatesDemocratize data accessCohort studyImpact of researchProtective factorsData dashboardsSecondary useIdentifying opportunitiesDissemination of dataDissemination of informationDemocracyFunding agenciesImpact of sleep quality and physical activity on blood pressure variability
de Havenon A, Falcone G, Rivier C, Littig L, Petersen N, de Villele P, Prabhakaran S, Kimberly W, Mistry E, Sheth K. Impact of sleep quality and physical activity on blood pressure variability. PLOS ONE 2024, 19: e0301631. PMID: 38625967, PMCID: PMC11020843, DOI: 10.1371/journal.pone.0301631.Peer-Reviewed Original ResearchConceptsSleep qualityPhysical activityOdds ratioCohort of community-dwelling adultsCommunity-dwelling adultsExcess relative riskBlood pressure variabilityExamined sleep qualityPoor sleep qualitySystolic blood pressure standard deviationSleep interruptionBody mass indexPhysical inactivityPrimary study outcomeStep countsImpact of sleep qualityLowest tertileRelative riskHigh blood pressure variabilityHome measurement devicesActivity levelsExposure statusPoor sleepMass indexStudy outcomesApplication of the Sleep C.A.L.M. Tool for Assessing Nocturia in a Large Nationally Representative Cohort
Boroda J, De Leon B, Khosla L, Chobufo M, Rahman S, Lazar J, Weiss J, Monaghan T. Application of the Sleep C.A.L.M. Tool for Assessing Nocturia in a Large Nationally Representative Cohort. International Neurourology Journal 2024, 28: s55-61. PMID: 38461857, PMCID: PMC10932577, DOI: 10.5213/inj.2346258.129.Peer-Reviewed Original ResearchOdds of nocturiaNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveySex subgroupsCommunity-dwelling adultsNutrition Examination SurveyAssociated with greater oddsAssociation of nocturiaAssociated with increased oddsNationally Representative CohortDose-dependent fashionImpact patient qualityQuality of lifePhysical examination dataYears of ageAssess nocturiaNighttime voidsExamination SurveyNationally representative datasetNocturiaRepresentative cohortRetrospective analysisGreater oddsPertinent questionnairesPatients' quality
2023
ADAPTING A PHYSICAL ACTIVITY INTERVENTION FOR RURAL AREAS: PEOPLE WITH MCI AND CARE PARTNER DYADS
Hoffman R, Watanabe-Galloway S, Riffin C, Monin J. ADAPTING A PHYSICAL ACTIVITY INTERVENTION FOR RURAL AREAS: PEOPLE WITH MCI AND CARE PARTNER DYADS. Innovation In Aging 2023, 7: 398-398. PMCID: PMC10736847, DOI: 10.1093/geroni/igad104.1318.Peer-Reviewed Original ResearchCare partner dyadsPhysical activityMild cognitive impairmentCare partnersPartner dyadsIncreasing daily step countSelf-monitor physical activityOlder community-dwelling adultsPhysical activity interventionsImprove physical activityDaily step countRural older adultsModifiable risk factors of ADCommunity-dwelling adultsRural communitiesIncreased risk of Alzheimer's diseaseRisk of Alzheimer's diseaseOlder adult populationPerson-based approachModifiable risk factorsPhysical inactivityStep countsRural patientsActivity interventionsTelehealth technologyPragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale
Joseph J, Pajewski N, Dolor R, Sellers M, Perdue L, Peeples S, Henrie A, Woolard N, Jones W, Benziger C, Orkaby A, Mixon A, VanWormer J, Shapiro M, Kistler C, Polonsky T, Chatterjee R, Chamberlain A, Forman D, Knowlton K, Gill T, Newby L, Hammill B, Cicek M, Williams N, Decker J, Ou J, Rubinstein J, Choudhary G, Gazmuri R, Schmader K, Roumie C, Vaughan C, Effron M, Cooper‐DeHoff R, Supiano M, Shah R, Whittle J, Hernandez A, Ambrosius W, Williamson J, Alexander K, Group P. Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale. Journal Of The American Geriatrics Society 2023, 71: 1701-1713. PMID: 37082807, PMCID: PMC10258159, DOI: 10.1111/jgs.18312.Peer-Reviewed Original ResearchConceptsOlder adultsHigh-intensity statin therapyRandomized pragmatic clinical trialCognitive testingBenefits of lipidInitiation of statinsBenefits of statinsNational Death Index searchEffect of statinsPragmatic clinical trialsCommunity-dwelling adultsMild cognitive impairmentLow participant burdenBaseline cognitive testingElectronic health recordsCardiovascular deathCardiovascular eventsCoronary revascularizationLipid panelStatin therapyStatin useUnstable anginaHeart failurePrimary outcomeMyocardial infarctionPerceived stigma related to TB preventive therapy
Palacios C, Hough M, Shrestha R, Moll A, Kompala T, Andrews L, Shenoi S. Perceived stigma related to TB preventive therapy. The International Journal Of Tuberculosis And Lung Disease 2023, 27: 209-214. PMID: 36855038, DOI: 10.5588/ijtld.22.0570.Peer-Reviewed Original ResearchConceptsTB preventative therapyTB preventive therapyAnonymous cross-sectional surveyBurden of TBCommunity-dwelling adultsRural South African communityCross-sectional surveyPreventive therapyMean agePreventative therapyEndemic settingsPatient's familyKruskal-Wallis testStigma scoresRural South AfricaPoisson regressionNovel interventionsSouth African communityTherapyLess stigmaDescriptive statisticsFamily membersStigmaTBTwo-factor solution
2022
Serum bicarbonate levels and gait abnormalities in older adults: a cross-sectional study
Ho J, Verghese J, Abramowitz M. Serum bicarbonate levels and gait abnormalities in older adults: a cross-sectional study. Scientific Reports 2022, 12: 9171. PMID: 35654910, PMCID: PMC9163170, DOI: 10.1038/s41598-022-12907-w.Peer-Reviewed Original ResearchConceptsAssociated with worse performanceOlder adultsGait abnormalitiesGait variabilityAssociated with gait abnormalitiesAssociated with impaired physical functionQuantitative measures of gaitDouble support timeMeasures of gaitQuantitative gait analysisShorter stride lengthCommunity-dwelling adultsImpaired physical functionSevere gait abnormalitiesChronic kidney diseaseAssociation of serum bicarbonateCross-sectional studyGait analysisStride lengthPhysical functionSupport timeWorse performanceMiddle tertileMultivariable adjustmentGaitPerceived dementia risk and advance care planning among older adults
Lee YK, Fried TR, Costello DM, Hajduk AM, O'Leary JR, Cohen AB. Perceived dementia risk and advance care planning among older adults. Journal Of The American Geriatrics Society 2022, 70: 1481-1486. PMID: 35274737, PMCID: PMC9106856, DOI: 10.1111/jgs.17721.Peer-Reviewed Original ResearchConceptsAdvance care planningDementia riskOlder adultsTreatment preferencesCare planningForm of ACPMultivariable-adjusted logistic regressionDurable powerCross-sectional studyCommunity-dwelling adultsHealth behavior modelsMedical conditionsLower oddsACP activityCognitive impairmentLogistic regressionDementiaAdultsHealthcare decisionsSubstantial minorityLiving willsRiskRetirement StudyAppointmentsAssociation
2021
Association of neighbourhood-level poverty with outcomes and clinical care following atrial fibrillation diagnosis in a universal healthcare system
Akioyamen L, Abdel-Qadir H, Pang A, Ha A, Jackevicius C, Alter D, Bhatia R, Dhalla I, Krumholz H, Roifman I, Wijeysundera H, Atzema C, Ko D, Schull M, Lee D, Investigators T. Association of neighbourhood-level poverty with outcomes and clinical care following atrial fibrillation diagnosis in a universal healthcare system. European Heart Journal 2021, 42: ehab724.0447. DOI: 10.1093/eurheartj/ehab724.0447.Peer-Reviewed Original ResearchAF diagnosisAtrial fibrillation diagnosisUniversal healthcare systemCardiology visitsIschemic strokeDeprivation quintileMedication coverageVascular diseaseCause-specific hazard regression modelStroke/transient ischemic attackPopulation-based cohort studyNeighborhood-level povertyAnti-arrhythmic medicationsHighest deprivation quintileRhythm control interventionsWorse baseline healthHeart failure hospitalizationTransient ischemic attackUniversal healthcareHazards regression modelsHealthcare systemProcess of careCommunity-dwelling adultsEquitable health careLong-term careObesity Prevalence and Risks Among Chinese Adults: Findings From the China PEACE Million Persons Project, 2014–2018
Mu L, Liu J, Zhou G, Wu C, Chen B, Lu Y, Lu J, Yan X, Zhu Z, Nasir K, Spatz ES, Krumholz HM, Zheng X. Obesity Prevalence and Risks Among Chinese Adults: Findings From the China PEACE Million Persons Project, 2014–2018. Circulation Cardiovascular Quality And Outcomes 2021, 14: e007292-e007292. PMID: 34107739, PMCID: PMC8204767, DOI: 10.1161/circoutcomes.120.007292.Peer-Reviewed Original ResearchConceptsAbdominal obesitySocio-demographic subgroupsSocio-demographic associationsOverall obesityHigh riskMillion Persons ProjectEpidemic of obesityAge-standardized ratesCommunity-dwelling adultsAssociation of ageMultivariable mixed modelsObesity prevalenceOlder womenLower riskObesityOlder menChinese adultsPrevalenceWomenRiskMenPersons ProjectSubgroupsAssociationAdults
2020
Day-to-day Relationships between Physical Activity and Sleep Characteristics among People with Heart Failure and Insomnia
Ash G, Jeon S, Conley S, Knies AK, Yaggi HK, Jacoby D, Hollenbeak CS, Linsky S, O’Connell M, Redeker NS. Day-to-day Relationships between Physical Activity and Sleep Characteristics among People with Heart Failure and Insomnia. Behavioral Sleep Medicine 2020, 19: 602-614. PMID: 33048589, PMCID: PMC8496686, DOI: 10.1080/15402002.2020.1824918.Peer-Reviewed Original ResearchConceptsNext-day physical activityHeart failureTotal sleep timePhysical activityCounts/minuteSleep characteristicsSleep timeSleep variablesNYHA class IIAdvanced heart failureStable heart failureDaytime physical activityBody mass indexCommunity-dwelling adultsWrist actigraphy recordingsCognitive behavioral therapyNYHA classHF classMass indexSleep improvementActigraphy recordingsLong sleepBehavioral therapyClass IIInsomniaRisk Factors for Coronavirus Disease 2019 (COVID-19)–Associated Hospitalization: COVID-19–Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System
Ko JY, Danielson ML, Town M, Derado G, Greenlund KJ, Kirley PD, Alden NB, Yousey-Hindes K, Anderson EJ, Ryan PA, Kim S, Lynfield R, Torres SM, Barney GR, Bennett NM, Sutton M, Talbot HK, Hill M, Hall AJ, Fry AM, Garg S, Kim L, Whitaker M, O’Halloran A, Holstein R, Garvin W, Chai S, Kawasaki B, Meek J, Openo K, Monroe M, Henderson J, Como-Sabetti K, Davis S, Spina N, Felsen C, West N, Schaffner W, George A. Risk Factors for Coronavirus Disease 2019 (COVID-19)–Associated Hospitalization: COVID-19–Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System. Clinical Infectious Diseases 2020, 72: e695-e703. PMID: 32945846, PMCID: PMC7543371, DOI: 10.1093/cid/ciaa1419.Peer-Reviewed Original ResearchConceptsCOVID-19-Associated Hospitalization Surveillance NetworkCOVID-19-associated hospitalizationChronic kidney diseaseHospitalization ratesRace/ethnicitySevere obesityKidney diseaseRisk factorsMedical conditionsLaboratory-confirmed COVID-19Chronic obstructive pulmonary diseaseBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemHigher hospitalization riskRace/ethnicity strataHistory of strokeObstructive pulmonary diseaseUnderlying medical conditionsCoronary artery diseaseHigher hospitalization ratesCommunity-dwelling adultsCoronavirus disease 2019Surveillance networkPoisson regression modelsSurveillance systemA Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent rates
2019
Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies
Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guðnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. The Lancet Neurology 2019, 19: 61-70. PMID: 31706889, PMCID: PMC7391421, DOI: 10.1016/s1474-4422(19)30393-x.Peer-Reviewed Original ResearchConceptsBlood pressure strataAntihypertensive medicationsBlood pressureRisk of dementiaIndividual participant dataIncident dementiaAlzheimer's diseaseDementia eventsDrug classesAging Intramural Research ProgramHigh blood pressure strataProspective community-based studyStudy-specific effect estimatesParticipant dataSpecific antihypertensive medicationsAlzheimer's Drug Discovery FoundationNormal blood pressureProspective cohort studyEligible observational studiesHigh blood pressureClinical Alzheimer's diseaseBurden of diseaseCommunity-based studyFuture clinical guidelinesCommunity-dwelling adults
2017
Prevalence, awareness, treatment, and control of hypertension in China: data from 1·7 million adults in a population-based screening study (China PEACE Million Persons Project)
Lu J, Lu Y, Wang X, Li X, Linderman GC, Wu C, Cheng X, Mu L, Zhang H, Liu J, Su M, Zhao H, Spatz ES, Spertus JA, Masoudi FA, Krumholz HM, Jiang L. Prevalence, awareness, treatment, and control of hypertension in China: data from 1·7 million adults in a population-based screening study (China PEACE Million Persons Project). The Lancet 2017, 390: 2549-2558. PMID: 29102084, DOI: 10.1016/s0140-6736(17)32478-9.Peer-Reviewed Original ResearchConceptsControl of hypertensionBlood pressureAntihypertensive medicationsCardiac Events Million Persons ProjectSelf-reported antihypertensive medication usePopulation-based screening studyPopulation-based screening projectMillion Persons ProjectPrescribed antihypertensive medicationsPrevious cardiovascular eventsAntihypertensive medication useDiastolic blood pressureSystolic blood pressureManagement of hypertensionCalcium channel blockersProportion of participantsSelf-reported diagnosisCommunity-dwelling adultsSex-standardised ratesCardiovascular eventsHypertensive adultsMedication classesHypertension awarenessHypertension prevalenceClinical factorsGuideline‐Recommended Medications and Physical Function in Older Adults with Multiple Chronic Conditions
McAvay G, Allore HG, Cohen AB, Gnjidic D, Murphy TE, Tinetti ME. Guideline‐Recommended Medications and Physical Function in Older Adults with Multiple Chronic Conditions. Journal Of The American Geriatrics Society 2017, 65: 2619-2626. PMID: 28905359, PMCID: PMC5729049, DOI: 10.1111/jgs.15065.Peer-Reviewed Original ResearchConceptsGuideline-recommended medicationsMultiple chronic conditionsCoronary artery diseasePhysical functionChronic conditionsHeart failureAtrial fibrillationSelf-reported declineOlder adultsArtery diseaseDiabetes mellitusRenin-angiotensin system blockersAngiotensin system blockersProspective observational cohortCommunity-dwelling adultsHealth risk factorsOverall sampleLess polypharmacyPolypharmacy exposureSystem blockersObservational cohortSingle medicationRisk factorsMedicationsLower riskSerum Matrix Metalloproteinase-7, Respiratory Symptoms, and Mortality in Community-Dwelling Adults. MESA (Multi-Ethnic Study of Atherosclerosis)
Armstrong HF, Podolanczuk AJ, Barr RG, Oelsner EC, Kawut SM, Hoffman EA, Tracy R, Kaminski N, McClelland RL, Lederer DJ. Serum Matrix Metalloproteinase-7, Respiratory Symptoms, and Mortality in Community-Dwelling Adults. MESA (Multi-Ethnic Study of Atherosclerosis). American Journal Of Respiratory And Critical Care Medicine 2017, 196: 1311-1317. PMID: 28570100, PMCID: PMC5694831, DOI: 10.1164/rccm.201701-0254oc.Peer-Reviewed Original ResearchConceptsInterstitial lung abnormalitiesMatrix metalloproteinase-7Serum MMP-7Serum MMP-7 levelsMMP-7 levelsCommunity-dwelling adultsRespiratory symptomsOutcome dataOdds of ILAMetalloproteinase-7Serum matrix metalloproteinase-7Subclinical interstitial lung diseaseCause mortality ratesIdiopathic pulmonary fibrosisInterstitial lung diseaseLog unit incrementExertional dyspneaCause mortalityLung functionPulmonary fibrosisCox regressionLung diseasePotential confoundersPrognostic biomarkerLung abnormalitiesInfluenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza
Arriola C, Garg S, Anderson EJ, Ryan PA, George A, Zansky SM, Bennett N, Reingold A, Bargsten M, Miller L, Yousey-Hindes K, Tatham L, Bohm SR, Lynfield R, Thomas A, Lindegren ML, Schaffner W, Fry AM, Chaves SS. Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza. Clinical Infectious Diseases 2017, 65: 1289-1297. PMID: 28525597, PMCID: PMC5718038, DOI: 10.1093/cid/cix468.Peer-Reviewed Original ResearchConceptsLaboratory-confirmed influenzaInfluenza vaccinationDisease severityInfluenza seasonIntensive care unit admissionCare unit admissionMultivariable logistic regressionProbability of vaccinationCommunity-dwelling adultsHospital LOSICU LOSUnvaccinated patientsHospital deathICU admissionICU lengthUnit admissionAntiviral treatmentIllness onsetAdverse outcomesOutcome measuresVaccine virusAge strataVaccinationLogistic regressionPropensity score
2015
Impact of Prompt Influenza Antiviral Treatment on Extended Care Needs After Influenza Hospitalization Among Community-Dwelling Older Adults
Chaves S, Pérez A, Miller L, Bennett N, Bandyopadhyay A, Farley M, Fowler B, Hancock E, Kirley P, Lynfield R, Ryan P, Morin C, Schaffner W, Sharangpani R, Lindegren M, Tengelsen L, Thomas A, Hill M, Bradley K, Oni O, Meek J, Zansky S, Widdowson M, Finelli L. Impact of Prompt Influenza Antiviral Treatment on Extended Care Needs After Influenza Hospitalization Among Community-Dwelling Older Adults. Clinical Infectious Diseases 2015, 61: 1807-1814. PMID: 26334053, DOI: 10.1093/cid/civ733.Peer-Reviewed Original ResearchConceptsIllness onsetCommunity-dwelling adultsAntiviral treatmentExtended careCare needsEarly treatmentInfluenza hospitalizationsHospital dischargeIntensive care unit admissionLaboratory-confirmed influenza hospitalizationsOlder adultsCommunity-dwelling older adultsInfluenza antiviral treatmentPrompt antiviral treatmentCare unit admissionImpact of influenzaLength of stayRisk survival analysisUnit admissionHospital lengthInfluenza seasonShortens hospitalizationNeurologic disordersRehabilitation facilityAntiviral agents
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