2024
Dexmedetomidine for agitation in dementia: Current data and future direction
Murphy K, Golden J, Tampi R. Dexmedetomidine for agitation in dementia: Current data and future direction. Journal Of The American Geriatrics Society 2024, 73: 552-557. PMID: 39295447, DOI: 10.1111/jgs.19196.Peer-Reviewed Original ResearchConceptsPrevalence of dementiaDementia-relatedHospital deliriumPsychological symptomsDementiaCochrane DatabaseEnglish-language journalsBPSDStudy typeLanguage journalsDeliriumControlled studiesSample sizeBipolar disorderSymptomsRoute of administrationCochraneHospitalEfficacious optionPubMedEffective treatmentPrevalenceIntensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review
Wilcox M, Burry L, Englesakis M, Coman B, Daou M, van Haren F, Ely E, Bosma K, Knauert M. Intensive care unit interventions to promote sleep and circadian biology in reducing incident delirium: a scoping review. Thorax 2024, 79: 988-997. PMID: 38350730, DOI: 10.1136/thorax-2023-220036.Peer-Reviewed Original ResearchSeverity of deliriumIntensive care unitIncident deliriumCare bundleReducing incident deliriumSensitive search of electronic databasesSearch of electronic databasesEnglish-language studiesPromote sleepPromotion interventionsEvaluate interventionsIntensive care unit interventionsElectronic databasesNon-pharmacologicalInclusion criteriaIntervention strategiesDeliriumInterventionCare unitEye maskConference proceedingsVariable reportingSleepPharmacological interventionsAssociation
2023
Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU
Greenfield K, Karam O, O'Meara A. Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU. Journal Of Pediatric Intensive Care 2023 DOI: 10.1055/s-0043-1770081.Peer-Reviewed Original ResearchPediatric intensive care unitDevelopment of deliriumAssociated with deliriumCornell Assessment of Pediatric DeliriumPediatric DeliriumPediatric intensive care unit patientsIntensive care unitEtiology of deliriumModifiable risk factorsNo significant associationPresence of deliriumTreatment strategiesCare unitIndividual patientsRisk factorsCritical illnessStudy daysPatientsOpiate infusionsSignificant associationCornell AssessmentYounger ageDelirium prevalenceDeliriumNeurological diagnosisNeurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC
Locke S, O’Bryan J, Zubair A, Rethana M, Moffarah A, Krause P, Farhadian S. Neurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1127-1135. PMID: 37209667, PMCID: PMC10202888, DOI: 10.3201/eid2906.221890.Peer-Reviewed Original ResearchConceptsNeurologic complicationsNeurologic symptomsRisk factorsYale-New Haven HospitalInfectious Diseases journal - CDCHigh-grade parasitemiaNeurologic risk factorsRange of symptomsAdult patientsRenal failureDiabetes mellitusFrequent symptomsHospital admissionImpaired consciousnessMedical recordsEndemic areasParasitic infectionsPatientsSymptomsIntraerythrocytic protozoaComplicationsBabesiosisNew HavenDeliriumMellitusDelirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications
Akgün K, Krishnan S, Tate J, Bryant K, Pisani M, Re V, Rentsch C, Crothers K, Gordon K, Justice A, team F. Delirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications. Journal Of The American Geriatrics Society 2023, 71: 1861-1872. PMID: 36786300, PMCID: PMC10258127, DOI: 10.1111/jgs.18265.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification Test-ConsumptionActive medicationAlcohol useOdds ratioRelative riskDose-response associationDate of admissionSeverity of illnessIndependent dose-response associationsRace/ethnicityInpatient deliriumIndex dateMedication exposureRole of alcoholHIV statusMultivariable analysisMedication countNeurocognitive dysfunctionUnderappreciated causeDeliriumHigh incidencePWHMedicationsPWOHLogistic regressionRevisiting “Excited Delirium”: Does the Diagnosis Reflect and Promote Racial Bias?
Walsh B, Agboola I, Agboola I, Coupet E, Rozel J, Wong A. Revisiting “Excited Delirium”: Does the Diagnosis Reflect and Promote Racial Bias? Western Journal Of Emergency Medicine 2023, 24: 152-159. PMID: 36976592, PMCID: PMC10047747, DOI: 10.5811/westjem.2022.10.56478.Peer-Reviewed Original Research
2022
Postoperative delirium in older adults: a surgeon’s guide and clinical practice review
Miller S, Glerum K, Jones R, Yildiz F, Katlic M, Vrees M, Cioffi W, Besdine R, Cizginer S. Postoperative delirium in older adults: a surgeon’s guide and clinical practice review. Video-Assisted Thoracic Surgery 2022, 0: 0-0. DOI: 10.21037/vats-22-23.Peer-Reviewed Original ResearchDelirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study
Spiller TR, Tufan E, Petry H, Böttger S, Fuchs S, Duek O, Ben-Zion Z, Korem N, Harpaz-Rotem I, von Känel R, Ernst J. Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study. Journal Of Psychiatric Research 2022, 156: 194-199. PMID: 36252349, DOI: 10.1016/j.jpsychires.2022.10.018.Peer-Reviewed Original ResearchConceptsDelirium Observation ScaleAcute care settingNursing dataCare settingsSingle tertiary teaching hospitalPatients 18 yearsTertiary teaching hospitalDelirium prediction modelSuch screening programsDelirium screeningAcute careMean ageTeaching hospitalInclusion criteriaScreening programDeliriumPatientsClinical practiceTotal scoreDemographic characteristicsCharacteristic curveScreening procedureModel development studiesRiskAdditional measuresCatatonia After COVID-19
Nikayin S, Chaffkin J, Ostroff RB. Catatonia After COVID-19. Journal Of Ect 2022, 38: e43-e44. PMID: 35220361, PMCID: PMC9426344, DOI: 10.1097/yct.0000000000000838.Peer-Reviewed Original Research
2021
Delirium
Munoz-Acuna R, O'Gara B. Delirium. 2021, 205-210. DOI: 10.1201/9781003042136-35.Peer-Reviewed Original ResearchIntensive care unitNewer atypical antipsychotic agentsLong-term cognitive functionIncidence of deliriumMechanical ventilation timeNumerous pharmacological strategiesUnderlying medical disorderAtypical antipsychotic agentsDelirium preventionICU lengthCare unitMechanical ventilationVentilation timeClinical trialsPharmacological strategiesSimilar efficacyAntipsychotic agentsMedical disordersDeliriumBehavioral disturbancesSide effectsMental disordersCognitive functionStatistical ManualExcess costsNeurological Side Effects of Psychotropic Medications
Malik S, Sahl R, Elzamzamy K, Nakhla M, Azeem M. Neurological Side Effects of Psychotropic Medications. Psychiatric Annals 2021, 51: 402-409. DOI: 10.3928/00485713-20210802-01.Peer-Reviewed Original ResearchNeurological side effectsSide effectsPotential side effectsPotential neurological side effectsExtrapyramidal side effectsMechanism of actionAcute dystoniaPsychotropic medicationsPsychotropic agentsMotor ticsSignificant negative factorCliniciansAkathisiaTolerabilityDeliriumMedicationsMyoclonusDystoniaParkinsonismSeizuresDiagnosisAnalysis of risk factor for pediatric intensive care unit delirium in children: a case-control study.
Ge X, Wei W, Feng T, Xu L, Hu Y, Yuan C. Analysis of risk factor for pediatric intensive care unit delirium in children: a case-control study. American Journal Of Translational Research 2021, 13: 9143-9151. PMID: 34540029, PMCID: PMC8430069.Peer-Reviewed Original ResearchPediatric intensive care unitPediatric DeliriumMultivariate logistic regression analysisDuration of infectionLogistic regression analysisRisk factorsGeneral HospitalIV scorePrevalence of deliriumIntensive care unit deliriumMechanical ventilationCase-control studyRegression analysisICU retention timeLength of stayChinese versionAnalysis of risk factorsNon-delirium groupROC curve analysisIntensive care unitPrimary outcomeRisk factor analysisDelirium groupDeliriumUnivariate analysisEmergent and Non-Emergent Agitation in the Older Adult: Evaluation and Management
Subramanian S, Fahed M, Dix E, Wilkins K. Emergent and Non-Emergent Agitation in the Older Adult: Evaluation and Management. Current Geriatrics Reports 2021, 10: 73-81. DOI: 10.1007/s13670-021-00358-6.Peer-Reviewed Original ResearchCohen-Mansfield Agitation InventoryElectroconvulsive therapyOlder adultsPsychiatric disordersNon-pharmacological managementAlcohol withdrawalDistressing symptomsBenzodiazepine usePharmacological treatmentTreatment optionsExcited catatoniaHeterogenous presentationSuccessful treatmentSignificant disabilitySubstance intoxicationNeuropsychiatric conditionsMotor behaviorCognitive enhancersPolypharmacyAdultsDeliriumPatientsCatatoniaReviewThis paperTreatmentPredictors and Sequelae of Postoperative Delirium in a Geriatric Patient Population With Hip Fracture
Haynes MS, Alder KD, Toombs C, Amakiri IC, Rubin LE, Grauer JN. Predictors and Sequelae of Postoperative Delirium in a Geriatric Patient Population With Hip Fracture. JAAOS Global Research And Reviews 2021, 5: e20.00221. PMID: 33989253, PMCID: PMC8133215, DOI: 10.5435/jaaosglobal-d-20-00221.Peer-Reviewed Original ResearchConceptsHip fracture populationPostoperative deliriumPreoperative dementiaHip fractureGeriatric hip fracture populationDependent functional statusFracture populationAdverse postoperative outcomesHigher American SocietyIndependent risk factorPostoperative adverse outcomesGeriatric patient populationNongeneral anesthesiaPreoperative diabetesPostoperative outcomesIndependent predictorsMale sexAdverse outcomesPatient populationFunctional statusRevision surgeryRisk factorsDeliriumHigher oddsRisk subpopulationsED‐DEL: Development of a change package and toolkit for delirium in the emergency department
Kennedy M, Webb M, Gartaganis S, Hwang U, Biese K, Stuck A, Lesser A, Hshieh T, Inouye SK. ED‐DEL: Development of a change package and toolkit for delirium in the emergency department. Journal Of The American College Of Emergency Physicians Open 2021, 2: e12421. PMID: 33969341, PMCID: PMC8082702, DOI: 10.1002/emp2.12421.Peer-Reviewed Original ResearchEmergency departmentED settingGeriatric Emergency Department GuidelinesManagement of deliriumOlder adult patientsEmergency Department GuidelinesEmergency department environmentAvailable patient informationAdult patientsChange packageInpatient unitDelirium identificationPatient acuityDeliriumDelirium programOlder populationOlder adultsDepartment guidelinesPatient crowdingPatient informationDepartment environmentDeadly problemUnique needsDepartmentMultistep processIs there evidence for using anticonvulsants in the prevention and/or treatment of delirium among older adults?
Gupta A, Joshi P, Bhattacharya G, Lehman M, Funaro M, Tampi DJ, Tampi RR. Is there evidence for using anticonvulsants in the prevention and/or treatment of delirium among older adults? International Psychogeriatrics 2021, 34: 889-903. PMID: 33757611, DOI: 10.1017/s1041610221000235.Peer-Reviewed Educational MaterialsConceptsTreatment of deliriumTotal knee arthroplastyTotal hip arthroplastyPostoperative deliriumUse of anticonvulsantsPerioperative useSpinal surgeryOlder adultsElective total knee arthroplastyElective total hip arthroplastyUse of gabapentinCochrane Central RegisterAnalysis of RCTsPerioperative gabapentinCentral RegisterKnee arthroplastyHip arthroplastyDeliriumCurrent evidenceGabapentinRCTsAnticonvulsantsSystematic reviewArthroplastyComprehensive search
2020
The impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage.
Reznik ME, Moody S, Murray K, Costa S, Grory BM, Madsen TE, Mahta A, Wendell LC, Thompson BB, Rao SS, Stretz C, Sheth KN, Hwang DY, Zahuranec DB, Schrag M, Daiello LA, Asaad WF, Jones RN, Furie KL. The impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage. Neurology 2020, 95: e2727-e2735. PMID: 32913011, PMCID: PMC7734724, DOI: 10.1212/wnl.0000000000010738.Peer-Reviewed Original ResearchConceptsImpact of deliriumIntracerebral hemorrhageLife-sustaining treatmentScore-based modelSingle-center cohort studyCox regression modelCharacteristic curve analysisDSM-5 criteriaHospital daysCohort studyConsecutive patientsMedian timeDelirium groupPoor outcomeDeliriumWLSTPatientsLogistic regressionCurve analysisHemorrhage
2019
Strengths and Limitations of the Veterans Aging Cohort Study Index as a Measure of Physiologic Frailty
Justice A, Tate J. Strengths and Limitations of the Veterans Aging Cohort Study Index as a Measure of Physiologic Frailty. AIDS Research And Human Retroviruses 2019, 35: 1023-1033. PMID: 31565954, PMCID: PMC7133454, DOI: 10.1089/aid.2019.0136.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort Study (VACS) IndexPhysiologic frailtyStudy indicesRoutine clinical laboratory testsClinical laboratory testsVACS IndexCause mortalityFragility fracturesHIV infectionFunctional declineCognitive declineSerious fallsFrailtyRelated outcomesEarly indicatorMortalityLaboratory testsIndexDeliriumHospitalizationPneumoniaHIVInfectionCircadian Biology and Its Importance to Intensive Care Unit Care and Outcomes
Gao C, Knauert M. Circadian Biology and Its Importance to Intensive Care Unit Care and Outcomes. Seminars In Respiratory And Critical Care Medicine 2019, 40: 629-637. PMID: 31826263, DOI: 10.1055/s-0039-1698394.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIll patientsIntensive care unit careIntensive care unit practiceCircadian rhythmCurrent ICU practiceLow-risk interventionNumerous adverse outcomesUnit careCritical illnessImmune compromiseCardiovascular instabilityMetabolic derangementsAdverse outcomesICU practiceUnit practicesSleep disruptionCare improvementPatientsOutcomesSleepRhythmBright lightDaysCircadian biologyDeliriumFunctional Outcomes After Hip Fracture in Independent Community‐Dwelling Patients
Ouellet JA, Ouellet GM, Romegialli AM, Hirsch M, Berardi L, Ramsey CM, Cooney LM, Walke LM. Functional Outcomes After Hip Fracture in Independent Community‐Dwelling Patients. Journal Of The American Geriatrics Society 2019, 67: 1386-1392. PMID: 30964203, PMCID: PMC6941577, DOI: 10.1111/jgs.15870.Peer-Reviewed Original ResearchConceptsNumber of medicationsHospital deliriumCare hoursADL disabilityHip fractureCommunity-dwelling adults 65Community-dwelling patientsNew ADL disabilityHip fracture surgeryRetrospective cohort studyDaily living (ADL) disabilityHip fracture patientsProportion of patientsCharacteristics of hospitalizationsIndependent older adultsChart reviewCohort studyFracture patientsFracture surgeryPatient chartsPoor outcomeFunctional outcomeAcademic hospitalOpiate useDelirium
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