2024
Opioid prescribing trends and pain scores among adult patients with cancer in a large health system.
Baum L, Soulos P, KC M, Jeffery M, Ruddy K, Lerro C, Lee H, Graham D, Liberatore M, Rivera D, Leapman M, Jairam V, Dinan M, Gross C, Park H. Opioid prescribing trends and pain scores among adult patients with cancer in a large health system. Journal Of Clinical Oncology 2024, 42: 11059-11059. DOI: 10.1200/jco.2024.42.16_suppl.11059.Peer-Reviewed Original ResearchDocumented painHealth systemOpioid prescribingOpioid prescriptionsOpioid prescribing trendsYale New Haven Health SystemPrescribing trendsMetastatic cancerDocumented pain scoresUS health systemOpioid usePain scoresAdult patientsCalculated predicted probabilitiesFlowsheet dataRetrospective cohort studyRelated harmSolid tumor malignanciesCohort studyCancer painPrescribingContext of cancer treatmentStudy criteriaPainSurgery cohortPrehospital use of point-of-care tests by community health workers: a scoping review
Ebbs D, Taricia M, Funaro M, O’Daniel M, Cappello M. Prehospital use of point-of-care tests by community health workers: a scoping review. Frontiers In Public Health 2024, 12: 1360322. PMID: 38721545, PMCID: PMC11076783, DOI: 10.3389/fpubh.2024.1360322.Peer-Reviewed Original ResearchConceptsCommunity health workersHealth workersPoint-of-care testingPrehospital settingLocal community health workersFull-text reviewMedical Subject HeadingsPRISMA extensionPrehospital useImplementation strategiesResource settingsEarly risk stratificationMedical librariansStudy criteriaSubject headingsPoint-of-carePrehospitalRisk stratificationWorkersCommunitySetsReviewPRISMAHIVMalaria
2023
Race and Intention to Breastfeed are the Strongest Predictors of Exclusive Breastfeeding: a Retrospective Study
Sartor L, Pyram-Vincent C, Lin H, Ouyang Y, Wax D, Beilin Y. Race and Intention to Breastfeed are the Strongest Predictors of Exclusive Breastfeeding: a Retrospective Study. Journal Of Racial And Ethnic Health Disparities 2023, 11: 3704-3713. PMID: 37796430, DOI: 10.1007/s40615-023-01819-8.Peer-Reviewed Original ResearchConceptsBlack patientsInitiation of skin-to-skin contactPredictors of EBFFeeding practicesSkin-to-skin contactSkin-to-skinIn-hospital practiceFisher's exact statistical testsElectronic medical recordsRacial groupsConclusionsThe main findingFeeding planVaginal deliveryNeonatal careRetrospective studyRace/ethnic groupsStudy criteriaExclusive breastfeedingWhite patientsIntroductionRacial disparitiesStrongest predictorsPatientsMedical recordsResultsThe studyBreastfeedingImpact of COVID-19 on the gastrointestinal surgical oncology patient population
Bakkila B, Marks V, Kerekes D, Kunstman J, Salem R, Billingsley K, Ahuja N, Laurans M, Olino K, Khan S. Impact of COVID-19 on the gastrointestinal surgical oncology patient population. Heliyon 2023, 9: e18459. PMID: 37534012, PMCID: PMC10391949, DOI: 10.1016/j.heliyon.2023.e18459.Peer-Reviewed Original ResearchGI cancer surgeryPreoperative chemotherapyCancer surgerySurgical careCOVID-19 pandemicCOVID-19Tertiary referral centerOncology patient populationFirst COVID-19 waveGI cancer casesCOVID-19 burdenHigh COVID-19 burdenEmergency surgeryReferral centerCOVID-19 waveOncology visitsGastrointestinal cancerGI cancersPatient populationStudy criteriaCancer careTreatment characteristicsCancer casesCase volumePatientsPediatric renal malignancy diagnosis is associated with significant burden of care for families
Leraas H, Thompson S, Sandoe E, Robles J, Wagner L, Scales C, Gow K, Ehrlich P, Greenup R, Tracy E. Pediatric renal malignancy diagnosis is associated with significant burden of care for families. Pediatric Blood & Cancer 2023, 70: e30494. PMID: 37337248, DOI: 10.1002/pbc.30494.Peer-Reviewed Original ResearchHealthcare utilizationRenal malignancySolid tumor diagnosisNorth Carolina MedicaidComplex care coordinationBurden of careChildhood cancer diagnosisRenal tumor diagnosisTumor diagnosisSubsequent nephrectomyMedian ageStudy criteriaCare coordinationRenal tumorsCancer regimensPatient visitsDiseases codesMalignancy diagnosisInternational ClassificationSignificant burdenMedical careDiagnosisCancer diagnosisMonthsMedical facilitiesDisparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma
Chow R, Long J, Hassan S, Wheeler S, Spees L, Leapman M, Hurwitz M, McManus H, Gross C, Dinan M. Disparities in immune and targeted therapy utilization for older US patients with metastatic renal cell carcinoma. JNCI Cancer Spectrum 2023, 7: pkad036. PMID: 37202354, PMCID: PMC10276895, DOI: 10.1093/jncics/pkad036.Peer-Reviewed Original ResearchConceptsOral anticancer agentsTherapy utilizationMedicare beneficiariesNon-Hispanic white raceMetastatic renal cell carcinomaNon-Hispanic black raceOlder US patientsUS Medicare beneficiariesRenal cell carcinomaLogistic regression modelsTherapy receiptMultivariable adjustmentSystemic therapyMale sexUS patientsCell carcinomaStudy criteriaBlack raceFemale sexPatient raceWhite raceImmunotherapyOutcomes persistSexPatientsUtility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure
Straus L, An X, Ji Y, McLean S, Neylan T, Cakmak A, Richards A, Clifford G, Liu M, Zeng D, House S, Beaudoin F, Stevens J, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Seamon M, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Harte S, Elliott J, Kessler R, Ressler K, Koenen K. Utility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure. JAMA Psychiatry 2023, 80: 220-229. PMID: 36630119, PMCID: PMC9857758, DOI: 10.1001/jamapsychiatry.2022.4533.Peer-Reviewed Original ResearchConceptsTraumatic stress exposureAdverse posttraumatic neuropsychiatric sequelaeEmergency departmentStress exposureNeuropsychiatric sequelaeGreater pain severityPain severityDerivation cohortNeuropsychiatric symptomsMean ageStudy criteriaSerial assessmentSleep disruptionMAIN OUTCOMEHigh incidenceUseful biomarkerBaseline assessmentPainSymptom severityDiverse cohortInformed consentPatientsSymptom domainsSleepDisadvantaged populationsEvolution of systemic therapy from 2015 to 2019 for older patients in the United States with metastatic renal cell carcinoma.
Chow R, Long J, Hassan S, Wheeler S, Spees L, Leapman M, Hurwitz M, McManus H, Gross C, Dinan M. Evolution of systemic therapy from 2015 to 2019 for older patients in the United States with metastatic renal cell carcinoma. Journal Of Clinical Oncology 2023, 41: 610-610. DOI: 10.1200/jco.2023.41.6_suppl.610.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaImmune checkpoint inhibitorsOral anti-cancer agentsNon-Hispanic white patientsSystemic therapyRenal cell carcinomaNHW patientsWhite patientsCell carcinomaMedicare beneficiariesService Medicare Parts ARetrospective cohort studyOverall treatment rateMedicare Part AIO therapyMRCC therapyAnti-cancer agentsCheckpoint inhibitorsCohort studyOlder patientsRandomized trialsSurvival improvementFirst therapyStudy criteriaTreatment receipt
2022
Oral Anticancer Agent (OAA) Adherence and Survival in Elderly Patients With Metastatic Renal Cell Carcinoma (mRCC)
Dinan MA, Wilson LE, Greiner MA, Spees LP, Pritchard JE, Zhang T, Kaye D, George D, Scales CD, Baggett CD, Gross CP, Leapman MS, Wheeler SB. Oral Anticancer Agent (OAA) Adherence and Survival in Elderly Patients With Metastatic Renal Cell Carcinoma (mRCC). Urology 2022, 168: 129-136. PMID: 35878815, PMCID: PMC9588695, DOI: 10.1016/j.urology.2022.07.012.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaOral anticancer agentsRenal cell carcinomaCell carcinomaMedicare beneficiariesPocket costsOdds of adherenceRetrospective cohort studyDisease-specific survivalReal-world adherenceRCC-specific survivalProportion of daysNon-significant trendAdherent useOAA therapyCohort studyElderly patientsMultivariable analysisStudy criteriaUnivariate analysisOAA treatmentPatientsCarcinomaAdherenceSurvivalRelation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome
Biondi M, Jain S, Fuery M, Thomas A, Ali T, Alviar CL, Desai NR, Miller PE. Relation of Ischemic Heart Disease to Outcomes in Patients With Acute Respiratory Distress Syndrome. The American Journal Of Cardiology 2022, 176: 24-29. PMID: 35606175, DOI: 10.1016/j.amjcard.2022.04.034.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseVentilator-free daysHeart diseaseHistory of IHDImpact of IHDAcute respiratory distress syndromePredictors of mortalityRespiratory distress syndromeSeverity of illnessMultivariable logistic regressionMultivariable adjustmentSecondary outcomesDistress syndromeOrgan failurePrimary outcomeClinical outcomesIll subgroupStudy criteriaTreatment paradigmClinical trialsARDS severityPatientsHigh mortalityEnd pointMortalityFeasibility of establishing a multi-center research database using the electronic health record: The PURSUIT network
Vemulakonda VM, Janzen N, Hittelman AB, Deakyne Davies S, Sevick C, Richardson AC, Schissel J, Dash D, Hintz R, Grider R, Adams P, Buck M, King J, Ewing E, Beltran G, Corbett S, Chiang G. Feasibility of establishing a multi-center research database using the electronic health record: The PURSUIT network. Journal Of Pediatric Urology 2022, 18: 788.e1-788.e8. PMID: 35644792, DOI: 10.1016/j.jpurol.2022.05.004.Peer-Reviewed Original ResearchConceptsManual chart reviewChart reviewMulti-centre researchEligible patientsClinic visitsStructured data elementsRadiology resultsElectronic health record toolsInitial clinic visitPediatric urology practiceElectronic health recordsActive medicationClinic encountersRenal ultrasoundVesicoureteral refluxCongenital hydronephrosisStudy criteriaOperative notesUrology practicePrior historyEpic EHRPhysician documentationResearch DatabasePhysician utilizationPatientsSurgical repair of nasal septal perforations: A systematic review and meta‐analysis
Fermin J, Bui R, McCoul E, Alt J, Avila‐Quintero V, Chang B, Yim M. Surgical repair of nasal septal perforations: A systematic review and meta‐analysis. International Forum Of Allergy & Rhinology 2022, 12: 1104-1119. PMID: 34978162, DOI: 10.1002/alr.22965.Peer-Reviewed Original ResearchConceptsNasal septal perforationEndonasal approachSurgical managementSurgical repairSeptal perforationSuccess rateElectronic database searchCINAHL Plus databasesMedian MINORS scoreRandom-effects modelUse of graftsEnglish-language studiesNSP repairPooled proportionInterposition graftMethodological IndexStudy criteriaPrimary diagnosisSurgical approachMINORS scoreInclusion criteriaOutcome measuresUnilateral flapModerate heterogeneityBilateral flaps
2021
Assessment of Perceptions of Mental Health vs Medical Health Plan Networks Among US Adults With Private Insurance
Busch SH, Kyanko K. Assessment of Perceptions of Mental Health vs Medical Health Plan Networks Among US Adults With Private Insurance. JAMA Network Open 2021, 4: e2130770. PMID: 34677592, PMCID: PMC8536951, DOI: 10.1001/jamanetworkopen.2021.30770.Peer-Reviewed Original ResearchConceptsMental health treatmentPrimary care practitionersMental health careHealth treatmentMental healthMental health practitionersUS adultsCare practitionersHealth provider networksPrivate insuranceHealth practitionersSpecialty mental healthNon-Hispanic white individualsHealth carePrimary care practicesAddiction Equity ActInsurance-related barriersMental Health ParitySerious psychological distressMental health networkHealth plan's networkOnline research panelStudy criteriaPatients' perceptionsHealth ParityExamining the Association of Billed Advance Care Planning With End-of-Life Hospital Admissions Among Advanced Cancer Patients in Hospice
Prater LC, O’Rourke B, Schnell P, Xu W, Li Y, Gustin J, Lockwood B, Lustberg M, White S, Happ MB, Retchin SM, Wickizer TM, Bose-Brill S. Examining the Association of Billed Advance Care Planning With End-of-Life Hospital Admissions Among Advanced Cancer Patients in Hospice. American Journal Of Hospice And Palliative Medicine® 2021, 39: 504-510. PMID: 34427154, DOI: 10.1177/10499091211039449.Peer-Reviewed Original ResearchConceptsAdvance care planningDays of lifeHospital admissionAdvanced cancerCare planningACP servicesCross-sectional retrospective cohort studySystematic advance care planningLife hospital admissionsMedical claims analysisRetrospective cohort studyAdvanced cancer patientsInpatient hospital admissionsPopulation of patientsAdvanced cancer diagnosisQuality of careHospice referralCohort studyIBM MarketScanEOL outcomesInpatient admissionsStudy criteriaCancer patientsHospice careCare preferencesEsophageal Dilation and Other Clinical Factors Associated With Pulmonary Function Decline in Patients With Systemic Sclerosis
Showalter K, Hoffmann A, Richardson C, Aaby D, Lee J, Dematte J, Agrawal R, Savas H, Wu X, Chang RW, Hinchcliff M. Esophageal Dilation and Other Clinical Factors Associated With Pulmonary Function Decline in Patients With Systemic Sclerosis. The Journal Of Rheumatology 2021, 48: 1830-1838. PMID: 34266985, PMCID: PMC8985598, DOI: 10.3899/jrheum.210533.Peer-Reviewed Original ResearchConceptsRadiographic interstitial lung diseaseInterstitial lung diseasePulmonary function testsSystemic sclerosisEsophageal dilationPulmonary function declineFVC declineClinical factorsEsophageal diameterFunction declineScl-70 positivitySSc-ILD patientsSubanalysis of patientsScl-70Function testsPrognostic implicationsVital capacityLung diseaseStudy criteriaI autoantibodiesRisk factorsPFT declineDiffusion capacityPatientsLinear mixed effects models
2020
Systematic review and meta‐analysis of the moderating effect of rs1799971 in OPRM1, the mu‐opioid receptor gene, on response to naltrexone treatment of alcohol use disorder
Hartwell EE, Feinn R, Morris PE, Gelernter J, Krystal J, Arias AJ, Hoffman M, Petrakis I, Gueorguieva R, Schacht JP, Oslin D, Anton RF, Kranzler HR. Systematic review and meta‐analysis of the moderating effect of rs1799971 in OPRM1, the mu‐opioid receptor gene, on response to naltrexone treatment of alcohol use disorder. Addiction 2020, 115: 1426-1437. PMID: 31961981, PMCID: PMC7340566, DOI: 10.1111/add.14975.Peer-Reviewed Original ResearchConceptsAsn40Asp single-nucleotide polymorphismRandomized clinical trialsAlcohol use disorderNaltrexone treatmentMu-opioid receptor geneUse disordersSingle nucleotide polymorphismsPlacebo-controlled randomized clinical trialsSystematic reviewPublication biasOpioid receptor antagonist naltrexoneWide inter-individual variabilityHeavy drinkingRisk of biasNaltrexone treatment responseReceptor geneRandom-effects modelAlcohol consumption outcomesAntagonist naltrexoneInter-individual variabilityStudy criteriaClinical trialsNucleotide polymorphismsTreatment responseMinor allele
2019
Shared-patient physician networks and their impact on the uptake of genomic testing in breast cancer
Rotter J, Wilson L, Greiner MA, Pollack CE, Dinan M. Shared-patient physician networks and their impact on the uptake of genomic testing in breast cancer. Breast Cancer Research And Treatment 2019, 176: 445-451. PMID: 31028607, PMCID: PMC6556129, DOI: 10.1007/s10549-019-05248-2.Peer-Reviewed Original ResearchConceptsPatient-level analysisOncotype DXBreast cancerMedical oncologistsEarly-stage breast cancerGenomic testingPhysician networksODX testingMore patientsRetrospective studySEER-MedicareStudy criteriaSuboptimal treatmentCancer patientsMedian numberModifiable driversModifiable meansPatientsOncologistsLogistic mixed modelsEarly adoption periodWomenCancerPhysiciansGenomic assays
2018
1901. Safety, Tolerability, and Efficacy of Fluoxetine as an Antiviral for Enterovirus D68 Associated Acute Flaccid Myelitis: A Retrospective Multicenter Cohort Study
Messacar K, Sillau S, Hopkins S, Otten C, Wilson-Murphy M, Wong B, Santoro J, Treister A, Tokhie H, Torres A, Zabrocki L, Glanternik J, Hurst A, Martin J, Schreiner T, Makhani N, DeBiasi R, Kruer M, Tremoulet A, Van Haren K, Desai J, Benson L, Gorman M, Abzug M, Tyler K, Dominguez S. 1901. Safety, Tolerability, and Efficacy of Fluoxetine as an Antiviral for Enterovirus D68 Associated Acute Flaccid Myelitis: A Retrospective Multicenter Cohort Study. Open Forum Infectious Diseases 2018, 5: s546-s546. PMCID: PMC6254028, DOI: 10.1093/ofid/ofy210.1557.Peer-Reviewed Original ResearchAcute flaccid myelitisFluoxetine-treated patientsSerious adverse eventsMulticenter cohort studyEfficacy of fluoxetineEV-D68Cohort studyInitial examinationSevere paralysisRetrospective multicenter cohort studyPoor long-term outcomesAdverse effectsDose of fluoxetinePropensity-adjusted analysisLong-term disabilityLong-term outcomesPotential antiviral therapiesUntreated controlsAdverse eventsMost patientsEfficacy signalsPrimary outcomeAntiviral therapyStudy criteriaEffective therapySafety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis
Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology 2018, 92: e2118-e2126. PMID: 30413631, PMCID: PMC6512883, DOI: 10.1212/wnl.0000000000006670.Peer-Reviewed Original ResearchConceptsAcute flaccid myelitisSerious adverse eventsFluoxetine-treated patientsEfficacy of fluoxetineEV-D68Initial examinationPoor long-term outcomesImproved neurologic outcomeMulticenter cohort studyClass IV evidenceAdverse effect ratesDose of fluoxetinePropensity-adjusted analysisLong-term outcomesUnexposed patientsNeurologic outcomeUntreated patientsAdverse eventsCohort studyPrimary outcomeUS patientsStudy criteriaEnterovirus D68PatientsEffect ratePatient, Family, and Community Advisory Councils in Health Care and Research: a Systematic Review
Oldfield BJ, Harrison MA, Genao I, Greene AT, Pappas ME, Glover JG, Rosenthal MS. Patient, Family, and Community Advisory Councils in Health Care and Research: a Systematic Review. Journal Of General Internal Medicine 2018, 34: 1292-1303. PMID: 30051331, PMCID: PMC6614241, DOI: 10.1007/s11606-018-4565-9.Peer-Reviewed Original ResearchConceptsPFAC membersSystematic reviewObservational studyPatient engagementHigh-quality observational studiesHealth systemRisk of biasPatient engagement strategiesTeam of physiciansHigh-quality medical careHealth care systemCommunity Advisory CouncilRandomized studyPROSPERO databaseStudy criteriaRealist synthesisResultsEighteen articlesStandardized measurement toolsStudy participationHigh riskPatient inputMedical careHealth system leadershipVeterans AffairsPatients
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