2024
Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea
Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea. European Respiratory Journal 2024, 65: 2401183. PMID: 39572221, PMCID: PMC12301966, DOI: 10.1183/13993003.01183-2024.Peer-Reviewed Original ResearchEffect of continuous positive airway pressureContinuous positive airway pressureObstructive sleep apneaSleep apneaArousal thresholdApnea Positive Pressure Long-term Efficacy StudySham continuous positive airway pressureEffect of CPAP treatmentPositive airway pressureLong-term efficacy studiesAssociated with neurocognitive dysfunctionCPAP treatmentAirway pressureSham-controlled trialApneaRandomized trialsSecondary outcomesNeurocognitive dysfunctionNeurocognitive outcomesTotal timeEfficacy studiesNeurocognitive functionSecondary analysisArTHExecutive functionEnhancing Within-Person Estimation of Neurocognition and the Prediction of Externalizing Behaviors in Adolescents
Paskewitz S, Brazil I, Yildirim I, Ruiz S, Baskin-Sommers A. Enhancing Within-Person Estimation of Neurocognition and the Prediction of Externalizing Behaviors in Adolescents. Computational Psychiatry 2024, 8: 119-141. PMID: 39070965, PMCID: PMC11276473, DOI: 10.5334/cpsy.112.Peer-Reviewed Original ResearchLatent profile analysisExternalizing behaviorsNeurocognitive functionAdolescent Brain Cognitive Development StudyPrediction of externalizing behaviorsCognitive Development StudyPerson-centered analysesWithin-person estimatesWorking memoryLanguage abilityWithin-personLatent profilesGood model fitNeurocognitive dataDevelopment of assessmentNeurocognitive dysfunctionRule-breakingDecades of researchAdolescentsModel fitEmpirical foundationProfile analysisExternalitiesBehavioral patternsDevelopment studies
2023
Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome
Marinkovic K, White D, Myers A, Parker K, Arienzo D, Mason G. Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome. Brain Sciences 2023, 13: 1666. PMID: 38137114, PMCID: PMC10741691, DOI: 10.3390/brainsci13121666.Peer-Reviewed Original ResearchAcute COVID-19 illnessCOVID-19 illnessGABA levelsN-acetylaspartatePost-acute COVID-19 syndromeCortical GABA levelsPersistent cognitive dysfunctionPost-acute sequelaeCOVID-19 syndromeExcitation/inhibition imbalancePoor sleep qualityProton magnetic resonance spectroscopyDepression/anxietyQuality of lifePersistent neuroinflammationBrain fogCortical hyperexcitabilityLong COVIDAlcohol intakeCognitive dysfunctionNeuronal integrityNeurocognitive dysfunctionNeurochemical aspectsSleep qualityOccipital cortexImpact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure
Tirziu D, Kołodziejczak M, Grubman D, Carrión C, Driskell L, Ahmad Y, Petrie M, Omerovic E, Redfors B, Fremes S, Browndyke J, Lansky A. Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101198. PMID: 39131066, PMCID: PMC11308118, DOI: 10.1016/j.jscai.2023.101198.Peer-Reviewed Original ResearchIschemic heart failureHeart failureNeurocognitive dysfunctionCognitive impairmentCoronary Artery Bypass GraftingArtery Bypass GraftingChronic cerebral hypoperfusionCoronary artery bypassPercutaneous coronary interventionPoor cognitive functionArtery bypassBypass GraftingCardiovascular outcomesCerebral hypoperfusionCoronary revascularizationCerebral hypoxiaCoronary interventionNeurologic injuryCardiac outputWorse outcomesBrain damageBrain injuryPatient outcomesInvasive approachPatient managementLung endothelium, tau, and amyloids in health and disease
Balczon R, Lin M, Voth S, Nelson A, Schupp J, Wagener B, Pittet J, Stevens T. Lung endothelium, tau, and amyloids in health and disease. Physiological Reviews 2023, 104: 533-587. PMID: 37561137, PMCID: PMC11281824, DOI: 10.1152/physrev.00006.2023.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEnd-organ dysfunctionLung endotheliumLower respiratory tract infectionsRespiratory tract infectionsAlveolar-capillary barrierLung capillary endotheliumTract infectionsImmune responseNeurocognitive dysfunctionBarrier integrityProtein tauLung capillariesInfectionCapillary endotheliumDysfunctionEpithelial cellsEndotheliumTau variantsVascular nicheTauHost-pathogen interactionsType ICytotoxic activityCytotoxicAmyloid variantsDelirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications
Akgün K, Krishnan S, Tate J, Bryant K, Pisani M, Re V, Rentsch C, Crothers K, Gordon K, Justice A, team F. Delirium among people aging with and without HIV: Role of alcohol and Neurocognitively active medications. Journal Of The American Geriatrics Society 2023, 71: 1861-1872. PMID: 36786300, PMCID: PMC10258127, DOI: 10.1111/jgs.18265.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification Test-ConsumptionActive medicationAlcohol useOdds ratioRelative riskDose-response associationDate of admissionSeverity of illnessIndependent dose-response associationsRace/ethnicityInpatient deliriumIndex dateMedication exposureRole of alcoholHIV statusMultivariable analysisMedication countNeurocognitive dysfunctionUnderappreciated causeDeliriumHigh incidencePWHMedicationsPWOHLogistic regression
2022
Latent profile analysis of data from the brief inventory of neurocognitive impairment (BINI) to develop neuro-cognitive profiles among opioid-dependent patients in drug treatment
Gunstad J, Disabato D, Shrestha R, Sanborn V, Mistler CB, Copenhaver MM. Latent profile analysis of data from the brief inventory of neurocognitive impairment (BINI) to develop neuro-cognitive profiles among opioid-dependent patients in drug treatment. Journal Of Addictive Diseases 2022, 41: 120-127. PMID: 35615880, PMCID: PMC9699904, DOI: 10.1080/10550887.2022.2080626.Peer-Reviewed Original ResearchConceptsLatent profile analysisNeurocognitive dysfunctionBrief inventoryNeuro-cognitive profileNeuro-cognitive impairmentSelf-reported neurocognitive symptomsProfile analysisOpioid-dependent patientsOpioid use disorderTreatment outcomesNeurocognitive impairmentDrug treatment outcomesMultiple domainsTreatment programUse disordersIntervention strategiesIndividual treatment needsNeurocognitive symptomsDrug treatment settingsTreatment settingsMethadone maintenance treatment programAccommodation strategiesModerate concernMaintenance treatment programOptimal treatment outcomes
2020
Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment
Copenhaver MM, Sanborn V, Shrestha R, Mistler C, Gunstad J. Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment. Journal Of Addictive Diseases 2020, 39: 166-174. PMID: 33047651, PMCID: PMC11395862, DOI: 10.1080/10550887.2020.1831129.Peer-Reviewed Original ResearchConceptsMethadone maintenance therapyDrug treatmentNeurocognitive dysfunctionNeurocognitive impairmentOpioid use disorderPossible clinical utilityAccommodation of patientsNIH ToolboxSubjective cognitive dysfunctionMaintenance therapyObjective cognitive testingSpecific neurocognitive profileTreatment outcomesCognitive dysfunctionClinical utilityUse disordersBrief inventoryObjective test performanceDysfunctionCognitive testingCutoff scoreNeurocognitive profileTest batteryObjective performanceImpairment
2019
Exosomal MicroRNAs Associate With Neuropsychological Performance in Individuals With HIV Infection on Antiretroviral Therapy.
OʼMeara T, Kong Y, Chiarella J, Price RW, Chaudhury R, Liu X, Spudich S, Robertson K, Emu B, Lu L. Exosomal MicroRNAs Associate With Neuropsychological Performance in Individuals With HIV Infection on Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: 514-522. PMID: 31714431, PMCID: PMC6857839, DOI: 10.1097/qai.0000000000002187.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyNeuropsychological performanceAntiretroviral therapyViral suppressionHIV infectionNeurocognitive dysfunctionExo-miRNAsEarly infection groupCentral nervous systemSystemic viral suppressionTyrosine receptor kinaseInfection groupChronic infectionPLWHCross-sectional examinationNervous systemEarly infectionNeuropsychological scoresInfectionConsistent findingNeuropsychological batteryHIVNeurodegeneration pathwaysDysfunctionTherapy
2018
Chapter 7 Diet, Obesity, and Physical Inactivity Linking Diabetes and Dementia
Espeland M, Small D, Stoeckel L. Chapter 7 Diet, Obesity, and Physical Inactivity Linking Diabetes and Dementia. 2018, 117-141. DOI: 10.1016/b978-0-12-809454-9.00007-x.Peer-Reviewed Original ResearchRisk factorsMetabolic dysfunctionModifiable risk factorsDevelopment of dementiaComplex multifactorial interactionPhysical inactivityCognitive dysfunctionNeurocognitive dysfunctionPhysical activityNeurocognitive impairmentObesityDysfunctionDiabetesDementiaMultifactorial interactionsDietFactorsImpairment
2016
Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Research 2016, 5: 353. PMID: 27303627, PMCID: PMC4897751, DOI: 10.12688/f1000research.8300.2.Peer-Reviewed Original ResearchNeurocognitive dysfunctionMetabolic dysfunctionImportant public health relevancePublic health relevanceVascular dementiaEpidemiologic evidenceInsulin resistanceKidney diseaseNeurocognitive impairmentDysfunctionAlzheimer's diseaseHealth relevanceDiabetesDiseaseScientific evidenceNational InstituteDementiaPatientsDigestiveImpairmentComplex mechanisms“White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
Stoeckel L, Arvanitakis Z, Gandy S, Small D, Kahn C, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. “White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Research 2016, 5: 353. DOI: 10.12688/f1000research.8300.1.Peer-Reviewed Original ResearchNeurocognitive dysfunctionMetabolic dysfunctionImportant public health relevancePublic health relevanceVascular dementiaEpidemiologic evidenceInsulin resistanceKidney diseaseNeurocognitive impairmentDysfunctionAlzheimer's diseaseHealth relevanceDiabetesDiseaseScientific evidenceNational InstituteDementiaMeeting summaryPatientsDigestiveImpairmentComplex mechanisms
2014
Treatment of HIV in the CNS: Effects of Antiretroviral Therapy and the Promise of Non-Antiretroviral Therapeutics
Peluso MJ, Spudich S. Treatment of HIV in the CNS: Effects of Antiretroviral Therapy and the Promise of Non-Antiretroviral Therapeutics. Current HIV/AIDS Reports 2014, 11: 353-362. PMID: 25063356, DOI: 10.1007/s11904-014-0223-y.Peer-Reviewed Original ResearchConceptsCentral nervous systemAntiretroviral therapyNew neurologic abnormalitiesTrajectory of HIVAIDS dementia complexSpectrum of HIVTreatment of HIVPersistent handViral suppressionNeurologic manifestationsAsymptomatic diseaseHIV infectionNeurologic abnormalitiesNeurocognitive disordersNeurologic diseaseNeurocognitive dysfunctionTherapeutic modalitiesNervous systemHIVSevere impairmentTherapyDiseasePatientsDysfunctionPathophysiology
2013
HIV and Neurocognitive Dysfunction
Spudich S. HIV and Neurocognitive Dysfunction. Current HIV/AIDS Reports 2013, 10: 235-243. PMID: 23860944, PMCID: PMC3732773, DOI: 10.1007/s11904-013-0171-y.Peer-Reviewed Original ResearchConceptsIrreversible CNS injuryEffective antiretroviral therapySpectrum of HIVQuality of lifeEffect of treatmentCommunity of patientsAntiretroviral therapyCNS infectionNeurologic injuryHIV infectionProgressive injuryImmune activationCNS injuryCognitive dysfunctionNeurocognitive disordersNeurocognitive dysfunctionHIVCognitive impairmentViral replicationInjuryBeneficial reductionDysfunctionInfectionDisordersPatientsAmelioration of Acute Sequelae of Blast Induced Mild Traumatic Brain Injury by N-Acetyl Cysteine: A Double-Blind, Placebo Controlled Study
Hoffer ME, Balaban C, Slade MD, Tsao JW, Hoffer B. Amelioration of Acute Sequelae of Blast Induced Mild Traumatic Brain Injury by N-Acetyl Cysteine: A Double-Blind, Placebo Controlled Study. PLOS ONE 2013, 8: e54163. PMID: 23372680, PMCID: PMC3553161, DOI: 10.1371/journal.pone.0054163.Peer-Reviewed Original ResearchConceptsMild traumatic brain injuryN-acetyl cysteineTraumatic brain injuryBrain injuryOutcome measuresPlacebo-controlled studyPlacebo Controlled StudyLong-term outcomesMain outcome measuresReported side effectsService membersActive duty service membersU.S. service membersAcute sequelaeSymptom resolutionTerm outcomesControlled StudyNAC treatmentSleep disturbancesHearing lossNeurocognitive dysfunctionBaseline evaluationCivilian mild traumatic brain injuryBlast exposurePlacebo
2010
High dose D-serine in the treatment of schizophrenia
Kantrowitz JT, Malhotra AK, Cornblatt B, Silipo G, Balla A, Suckow RF, D'Souza C, Saksa J, Woods SW, Javitt DC. High dose D-serine in the treatment of schizophrenia. Schizophrenia Research 2010, 121: 125-130. PMID: 20541910, PMCID: PMC3111070, DOI: 10.1016/j.schres.2010.05.012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceAntipsychotic AgentsChi-Square DistributionCognition DisordersDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesRegression AnalysisSchizophreniaSerineTreatment OutcomeYoung AdultConceptsD-serineBrain N-methyl-D-aspartate receptorsPlasma D-serine levelsN-methyl-D-aspartate receptorsSafety of dosesSignificant dose-dependent increaseDouble-blind investigationOpen-label trialDose-escalation studyDouble-blind studyLarge effect size improvementsTreatment of schizophreniaD-serine levelsPotential novel treatmentPharmacokinetics/pharmacodynamicsDose-dependent increaseNon-significant improvementEffect size improvementsMedication phasePersistent symptomsEscalation studyBrain levelsPlasma levelsPK analysisNeurocognitive dysfunction
2008
Epidemiology of obstructive sleep apnea: a population-based perspective
Lee W, Nagubadi S, Kryger MH, Mokhlesi B. Epidemiology of obstructive sleep apnea: a population-based perspective. Expert Review Of Respiratory Medicine 2008, 2: 349-364. PMID: 19690624, PMCID: PMC2727690, DOI: 10.1586/17476348.2.3.349.Peer-Reviewed Original ResearchObstructive sleep apneaSleep apneaAdult obstructive sleep apneaCongestive heart failureCoronary artery diseaseHealth care burdenPopulation-based studyPopulation-based perspectiveAdverse medical conditionsGlobal obesity epidemicSimilar prevalence ratesCardiovascular mortalityOSA populationArtery diseaseHeart failureOSA syndromeInsulin resistanceRisk factorsCare burdenNeurocognitive dysfunctionMedical conditionsPrevalence ratesObesity epidemicMethodologic differencesDiagnostic resources
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