2025
Outcomes of medical and surgical management in infectious intracranial aneurysms: a multicenter cohort analysis
Alawieh A, Dimisko L, Zohdy Y, Koo A, Saad H, Baba B, Newman S, Grossberg J, Matouk C, Cawley C, Pradilla G, Reisner A, Fox W, Perez-Vega C, Burkhardt J, Salem M, Jabbour P, Naamani K, Schmidt R, Gooch M, Starke R, Abdelsalam A, Lu V, Levitt M, Chalhoub R, Kobeissy F, Spiotta A, Barrow D, Howard B. Outcomes of medical and surgical management in infectious intracranial aneurysms: a multicenter cohort analysis. Journal Of NeuroInterventional Surgery 2025, jnis-2025-023421. PMID: 40409986, DOI: 10.1136/jnis-2025-023421.Peer-Reviewed Original ResearchInfectious intracranial aneurysmsModified Rankin ScaleOutcome predictorsManagement of infectious intracranial aneurysmsEndovascular interventionIntracranial aneurysmsMedical managementComplication of systemic infectionRetrospective registry-based cohort studyHigh-risk patientsRegistry-based cohort studyStandardized management guidelinesTertiary care centerLimitations of medical managementPredictors of failureMultivariate logistic regressionDays of initiationMulticenter cohort analysisInfective endocarditisTreatment failureSurgical managementMulticenter cohortAneurysm sizeCase seriesClinical decision-makingFeasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes
Zhao Q, Hu W, Xia Y, Dai S, Wu X, Chen J, Yuan X, Zhong T, Xi X, Wang Q. Feasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes. Scientific Reports 2025, 15: 17386. PMID: 40389469, PMCID: PMC12089500, DOI: 10.1038/s41598-025-00179-z.Peer-Reviewed Original ResearchConceptsGene signatureLow-risk score groupIncreased metastasis riskLow-risk patientsSensitive to immunotherapyUnivariate Cox regression analysisReduced immune infiltrationCox regression analysisPersonalized therapeutic strategiesAggressive bone malignancyOsteosarcoma outcomesPersonalized treatment strategiesHigh-risk scoreOverall survivalHigher mortality rateProlonged survivalMetastasis riskMulticenter cohortImmune infiltrationPoor prognosisRisk stratificationC-indexDrug sensitivityClinical managementPrognostic toolIntrathecal Dexamethasone as a FIRES Extinguisher: A 12-Patient Clinical Experience with Usage of Intrathecal Dexamethasone for Febrile Infection-Related Epilepsy Syndrome
Farias-Moeller R, Hanin A, Ahsan S, Brooks J, Caganap S, Czeisler B, Cheuret E, Cocuzzo B, Hahn C, Kyureghyan H, Marcoux M, Mohamed R, Park C, Stern Zimmer M, Barun V, Lai Y, Hirsch L. Intrathecal Dexamethasone as a FIRES Extinguisher: A 12-Patient Clinical Experience with Usage of Intrathecal Dexamethasone for Febrile Infection-Related Epilepsy Syndrome. Neurocritical Care 2025, 1-9. PMID: 40279013, DOI: 10.1007/s12028-025-02254-9.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeIT-DEXLong-term outcomesIntrathecal dexamethasoneDosing strategiesEpilepsy syndromesElevated levels of proinflammatory markersLevels of proinflammatory markersRefractory status epilepticusRefractory status epilepticus onsetStatus epilepticus onsetInternational multicenter cohortPersistently elevated levelsEvaluates treatment timeNo adverse effectsMedian doseResultsAll patientsCytokine profileMulticenter cohortCytokine analysisStatus epilepticusClinical outcomesContinuous infusionProinflammatory markersRetrospective analysisThe Effect of Prenatal Marijuana Exposure on White Matter Microstructure and Cortical Morphology During Late Childhood.
Acosta-Rodriguez H, Bobba P, Zeevi T, Ment L, Payabvash S. The Effect of Prenatal Marijuana Exposure on White Matter Microstructure and Cortical Morphology During Late Childhood. American Journal Of Neuroradiology 2025, ajnr.a8774. PMID: 40194858, DOI: 10.3174/ajnr.a8774.Peer-Reviewed Original ResearchPrenatal marijuana exposureEffects of prenatal marijuana exposurePrenatal exposure to marijuanaExposure to marijuanaMarijuana exposurePregnant womenWhite matter microstructureBrain neurodevelopmentFractional anisotropyAssociated with brain alterationsAdolescent Brain Cognitive Development StudyLate childhoodReduced cortical surface areaAdolescent Brain Cognitive DevelopmentReduced white matter integrityMarijuana consumptionMarkers of brain healthCross-sectional studyDirect group comparisonsNeonatal outcomesCognitive Development StudyMulticenter cohortNeurite densityWhite matter integrityCortical surface areaPhoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018
Sanchez-Pinto L, Daniels L, Atreya M, Faustino E, Farris R, Geva A, Khemani R, Rogerson C, Shah S, Weiss S, Bennett T. Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018. Pediatric Critical Care Medicine 2025, 26: e155-e165. PMID: 39982153, PMCID: PMC11792981, DOI: 10.1097/pcc.0000000000003675.Peer-Reviewed Original ResearchConceptsInternational Pediatric Sepsis Consensus ConferenceInternational Pediatric Sepsis Consensus Conference criteriaPhoenix criteriaCritically Ill ChildrenSepsis criteriaPICU admissionCohort of critically ill childrenOrgan dysfunction scoreIll childrenMulticenter cohort studyHigher risk of mortalityMortality of patientsAge groupsIn-Hospital MortalityRisk of mortalitySeverity of illnessDiscrimination of mortalityBloodstream infectionsSuspected infectionMulticenter cohortSeptic shockSepsis scoreDysfunction scorePatient subgroupsRetrospective analysis
2024
Trigeminal neuralgia within the disease course of MS: Diagnostic and therapeutic implications from a multicenter cohort
Laakso S, Oh J, Raufdeen F, Jones A, Reiskanen H, Feb K, Levit E, Solomon A. Trigeminal neuralgia within the disease course of MS: Diagnostic and therapeutic implications from a multicenter cohort. Multiple Sclerosis Journal 2024, 31: 607-611. PMID: 39727322, DOI: 10.1177/13524585241309257.Peer-Reviewed Original ResearchTrigeminal neuralgiaClinical relapseMultiple sclerosisActive diseaseEvidence of active diseaseDisease course of MSAssociated with multiple sclerosisCourse of MSDemyelination symptomsMulticenter cohortDisease courseTherapeutic decisionsTherapeutic implicationsMS diagnosisNeuralgiaRelapseDiseaseOnsetSclerosisLongitudinal Characterization of SARS-CoV-2 Immunity in Hemodialysis Patients Post Omicron
Karaba A, Xue J, Johnston T, Traut C, Dalrymple L, Kossmann R, Blankson J, Parikh C, Ray S. Longitudinal Characterization of SARS-CoV-2 Immunity in Hemodialysis Patients Post Omicron. Kidney International Reports 2024, 10: 406-415. PMID: 39990910, PMCID: PMC11843127, DOI: 10.1016/j.ekir.2024.11.012.Peer-Reviewed Original ResearchT cell responsesT cellsHealthy controlsCOVID-19 vaccineAntibody responsePositive T-cell responsesResponse to COVID-19 vaccinationPaired Wilcoxon rank sum testSARS-CoV-2 immunityObservational multicenter cohortFisher's exact testDose of COVID-19 vaccineWilcoxon rank sum testVaccinated healthy controlsSevere COVID-19SARS-CoV-2 responseAnti-SARS-CoV-2 IgGRank sum testAnti-SARS-CoV-2Response to spikesTransmission-based precautionsMulticenter cohortSurrogate neutralizationExact testACE2 inhibitionEstablishing feasibility and reliability of subcutaneous fat measurements by ultrasound in very preterm infants
Buck C, Santoro K, Shabanova V, Martin C, Taylor S. Establishing feasibility and reliability of subcutaneous fat measurements by ultrasound in very preterm infants. Pediatric Research 2024, 96: 1724-1731. PMID: 39069538, PMCID: PMC11772127, DOI: 10.1038/s41390-024-03439-2.Peer-Reviewed Original ResearchVery preterm infantsBody composition assessmentPreterm infantsPostmenstrual ageMarkers of metabolic healthFat distributionBedside ultrasoundCohort of very preterm infantsComposition assessmentWeeks' PMA,Metabolic healthIntra-rater intraclass correlation coefficientBrain growthBody composition metricsBody composition outcomesBedside ultrasound techniqueRegional fat distributionPoint of care ultrasoundIntraclass correlation coefficientPostmenstrual weeksMulticenter cohortRegional fatSubcutaneous fat distributionComposite outcomeSubcutaneous fat measurementsIdentifying Variation in Intraoperative Management of Brain-Dead Organ Donors and Opportunities for Improvement: A Multicenter Perioperative Outcomes Group Analysis
Lele A, Vail E, O’Reilly-Shah V, DeGraw X, Domino K, Walters A, Fong C, Gomez C, Naik B, Mori M, Schonberger R, Deshpande R, Souter M, Committee T. Identifying Variation in Intraoperative Management of Brain-Dead Organ Donors and Opportunities for Improvement: A Multicenter Perioperative Outcomes Group Analysis. Anesthesia & Analgesia 2024, 140: 41-50. PMID: 39167559, DOI: 10.1213/ane.0000000000007001.Peer-Reviewed Original ResearchIntraclass correlation coefficientMulticenter Perioperative Outcomes GroupOrgan procurement organization regionBrain-dead organ donorsNon-Hispanic whitesPoisson regression analysisOrgan procurement organizationsIntraoperative eventsUS hospitalsYears of ageMedication useIncidence of hypotensionOrgan donorsManagement of brain-dead donorsPrimary outcomeManagement of brain-dead organ donorsMixed-effects Poisson regression analysisIntravenous heparinVasoactive medicationsBrain-dead donorsMulticenter cohortIntraoperative managementTransplant outcomesCase volumeMm HgHost-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology
Phan H, Tsitsiklis A, Maguire C, Haddad E, Becker P, Kim-Schulze S, Lee B, Chen J, Hoch A, Pickering H, van Zalm P, Altman M, Augustine A, Calfee C, Bosinger S, Cairns C, Eckalbar W, Guan L, Jayavelu N, Kleinstein S, Krammer F, Maecker H, Ozonoff A, Peters B, Rouphael N, Montgomery R, Reed E, Schaenman J, Steen H, Levy O, Diray-Arce J, Langelier C, Erle D, Hendrickson C, Kangelaris K, Nguyen V, Lee D, Chak S, Ghale R, Gonzalez A, Jauregui A, Leroux C, Altamirano L, Rashid A, Willmore A, Woodruff P, Krummel M, Carrillo S, Ward A, Patel R, Wilson M, Dandekar R, Alvarenga B, Rajan J, Schroeder A, Fragiadakis G, Mick E, Guerrero Y, Love C, Maliskova L, Adkisson M, Ehrlich L, Melamed E, Rousseau J, Hurley K, Geltman J, Siles N, Rogers J, Kutzler M, Bernui M, Cusimano G, Connors J, Woloszczuk K, Joyner D, Edwards C, Lin E, Melnyk N, Powell D, Kim J, Goonewardene I, Simmons B, Smith C, Martens M, Croen B, Semenza N, Bell M, Furukawa S, McLin R, Tegos G, Rogowski B, Mege N, Ulring K, Holland S, Rosen L, Lee S, Vaysman T, Fernandez-Sesma A, Simon V, Van Bakel H, Gonzalez-Reiche A, Qi J, Carreño J, Singh G, Raskin A, Tcheou J, Khalil Z, van de Guchte A, Farrugia K, Khan Z, Kelly G, Srivastava K, Eaker L, Bermúdez González M, Mulder L, Beach K, Fatou B, Smolen K, Viode A, van Haren S, Jha M, Kho A, Milliren C, Chang A, McEnaney K, Barton B, Lentucci C, Murphy M, Saluvan M, Shaheen T, Liu S, Syphurs C, Albert M, Hayati A, Bryant R, Abraham J, Salehi-Rad R, Rivera A, Sen S, Elashoff D, Ward D, Presnell S, Kohr B, Arnett A, Boddapati A, Tharp G, Pellegrini K, Johnson B, Panganiban B, Huerta C, Anderson E, Samaha H, Sevransky J, Bristow L, Beagle E, Cowan D, Hamilton S, Hodder T, Esserman D, Brito A, Rothman J, Grubaugh N, Ko A, Hafler D, Shaw A, Gygi J, Pawar S, Konstorum A, Chen E, Cotsapas C, Wang X, Xu L, Dela Cruz C, Iwasaki A, Mohanty S, Nelson A, Zhao Y, Farhadian S, Asashima H, Pulendran B, Nadeau R, Rosenberg-Hasson Y, Leipold M, Sigal N, Rogers A, Fernandez A, Manohar M, Do E, Chang I, Vita R, Westendorf K, Corry D, Kheradmand F, Song L, Nelson E, Baden L, Mendez K, Lasky-Su J, Tong A, Rooks R, Sekaly R, Fourati S, McComsey G, Harris P, Sieg S, Ribeiro S, Overton J, Rahman A, Hutton S, Michelotti G, Wong K, Seyfert-Margolis V, Metcalf J, Agudelo Higuita N, Sinko L, Booth J, Messer W, Hough C, Siegel S, Sullivan P, Lu Z, Kraft M, Bime C, Mosier J, Erickson H, Schunk R, Kimura H, Conway M, Atkinson M, Brakenridge S, Ungaro R, Manning B, Oberhaus J, Guirgis F, Borresen B, Anderson M. Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology. Science Translational Medicine 2024, 16: eadj5154. PMID: 38630846, PMCID: PMC11931290, DOI: 10.1126/scitranslmed.adj5154.Peer-Reviewed Original ResearchConceptsPro-inflammatory genesViral clearanceUpper airwayImmune signaling pathwaysInduction of pro-inflammatory genesBiomarkers of disease severityDelayed viral clearanceImpaired viral clearanceSevere coronavirus disease 2019B cell populationsAge-dependent up-regulationExpression of pro-inflammatory genesHost immune responseSignaling pathwayType I interferon gene expressionCOVID-19 immunopathologyInnate Immune Signaling PathwaysSerum chemokinesAge-dependent impairmentNaive TMulticenter cohortNasal transcriptomeAcute respiratory syndrome coronavirus 2Monocyte populationsSerum protein profilesSerum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis
Yamazaki T, Kouno T, Hsu C, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Schnabl B. Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis. Hepatology 2024, 80: 403-417. PMID: 38377466, PMCID: PMC11268475, DOI: 10.1097/hep.0000000000000777.Peer-Reviewed Original ResearchAlcohol-associated hepatitisAlcohol use disorderSevere AHAH patientsAhR activationMicrobiota-derived tryptophan metabolitesSurvival rateAssociated with high mortalityCumulative survival rateAssociated with survivalAryl hydrocarbon receptor activationMulticenter cohortFecal metabolomePrognostic markerTryptophan metabolitesReceptor activationAryl hydrocarbon receptorPatientsUse disorderAH cohortSerumHigher mortalityAhRHepatitisCohort
2023
Sex, Genotype, and Liver Volume Progression as Risk of Hospitalization Determinants in Autosomal Dominant Polycystic Liver Disease
Schönauer R, Sierks D, Boerrigter M, Jawaid T, Caroff L, Audrezet M, Friedrich A, Shaw M, Degenhardt J, Forberger M, de Fallois J, Bläker H, Bergmann C, Gödiker J, Schindler P, Schlevogt B, Müller R, Berg T, Patterson I, Griffiths W, Sayer J, Consortium G, Ambrose J, Arumugam P, Bevers R, Bleda M, Boardman-Pretty F, Boustred C, Brittain H, Caulfield M, Chan G, Elgar G, Fowler T, Giess A, Hamblin A, Henderson S, Hubbard T, Jackson R, Jones L, Kasperaviciute D, Kayikci M, Kousathanas A, Lahnstein L, Leigh S, Leong I, Lopez J, Maleady-Crowe F, McEntagart M, Minneci F, Moutsianas L, Mueller M, Murugaesu N, Need A, O’Donovan P, Odhams C, Patch C, Pereira M, Perez-Gil D, Pullinger J, Rahim T, Rendon A, Rogers T, Savage K, Sawant K, Scott R, Siddiq A, Sieghart A, Smith S, Sosinsky A, Stuckey A, Tanguy M, Tavares A, Thomas E, Thompson S, Tucci A, Welland M, Williams E, Witkowska K, Wood S, Popp B, Torres V, Hogan M, Somlo S, Watnick T, Nevens F, Besse W, Gall E, Harris P, Drenth J, Halbritter J. Sex, Genotype, and Liver Volume Progression as Risk of Hospitalization Determinants in Autosomal Dominant Polycystic Liver Disease. Gastroenterology 2023, 166: 902-914. PMID: 38101549, DOI: 10.1053/j.gastro.2023.12.007.Peer-Reviewed Original ResearchAutosomal dominant polycystic liver diseasePolycystic liver diseaseDisease-related hospitalizationsLiver diseaseLiver eventsPathogenic variantsPrimary clinical end pointCombination of female sexCohort of patientsClinical end pointsInternational multicenter cohortPrediction of disease progressionGenotype-phenotype correlationPrimary clinical endpointTotal liver volumeUnderlying genetic defectSymptomatic hepatomegalyDesign of randomized controlled trialsRandomized Controlled TrialsFemale patientsIndependent of sexMulticenter cohortFemale preponderanceRare conditionSymptomatic diseaseSafety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study
Rodriguez‐Calienes A, Oliver M, Hassan A, Vivanco‐Suarez J, Divani A, Ribo M, Petersen N, Abraham M, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Quispe‐Orozco D, Galecio‐Castillo M, Alhajala H, Malaga M, Farooqui M, Jovin T, Jumaa M, Ortega‐Gutierrez S. Safety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.123.001020.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageIntravenous cangrelorIntracranial hemorrhageStent thrombosisSafety profilePetechial hemorrhagesTandem lesionsType 2Parenchymal hematoma type 2Inverse probabilityInternational multicenter cohortSimilar safety profileAcute ischemic strokeObservational cohort studyMyocardial infarction protocolDAPT regimensIntraprocedural administrationLoading therapyAntiplatelet therapyCohort studyIschemic strokeLesion interventionMulticenter cohortEndovascular treatmentInfarction protocolsThe International Cardiac Arrest Research Consortium Electroencephalography Database
Amorim E, Zheng W, Ghassemi M, Aghaeeaval M, Kandhare P, Karukonda V, Lee J, Herman S, Sivaraju A, Gaspard N, Hofmeijer J, van Putten M, Sameni R, Reyna M, Clifford G, Westover M. The International Cardiac Arrest Research Consortium Electroencephalography Database. Critical Care Medicine 2023, 51: 1802-1811. PMID: 37855659, PMCID: PMC10841086, DOI: 10.1097/ccm.0000000000006074.Peer-Reviewed Original ResearchConceptsCardiac arrestNeurologic outcomeCerebral Performance Category scaleContinuous electroencephalography monitoringGood functional recoverySevere neurologic disabilityIctal-interictal continuumIndividuals 16 yearsBrain injury researchCardiac arrest researchMost patientsNeurologic disabilityMulticenter cohortSpontaneous circulationComatose patientsFunctional recoveryEpileptiform activityElectroencephalography monitoringTeaching hospitalBackground continuityClinical dataBurst suppressionPatientsEpileptiform patternsSpike frequencySafety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions
Rodriguez-Calienes A, Galecio-Castillo M, Farooqui M, Hassan A, Jumaa M, Divani A, Ribo M, Abraham M, Petersen N, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Tekle W, Alhajala H, Ikram A, Rizzo F, Qureshi A, Begunova L, Matsoukas S, Vigilante N, Salazar-Marioni S, Abdalkader M, Gordon W, Soomro J, Turabova C, Vivanco-Suarez J, Mokin M, Yavagal D, Jovin T, Sheth S, Ortega-Gutierrez S. Safety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions. Stroke 2023, 54: 2522-2533. PMID: 37602387, PMCID: PMC10599264, DOI: 10.1161/strokeaha.123.042966.Peer-Reviewed Original ResearchConceptsRisk of sICHParenchymal hematoma type 2Symptomatic intracranial hemorrhageRankin Scale score 0Intravenous antiplatelet therapyIntravenous thrombolysisFavorable functional outcomeMechanical thrombectomyHemorrhagic transformationFunctional outcomeType 2Antiplatelet therapyHospital mortalitySuccessful reperfusionComplete reperfusionScore 0Tandem lesionsAnterior circulation tandem lesionsExcellent functional outcomeIVT treatmentStroke centersMulticenter cohortPrimary outcomeRevascularization techniquesAlone groupLiving Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria
Ivanics T, Claasen M, Samstein B, Emond J, Fox A, Pomfret E, Pomposelli J, Tabrizian P, Florman S, Mehta N, Roberts J, Emamaullee J, Genyk Y, Hernandez-Alejandro R, Tomiyama K, Sasaki K, Hashimoto K, Nagai S, Abouljoud M, Olthoff K, Hoteit M, Heimbach J, Taner T, Liapakis A, Mulligan D, Sapisochin G, Halazun K, Group O. Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria. Annals Of Surgery 2023, 279: 104-111. PMID: 37522174, DOI: 10.1097/sla.0000000000006049.Peer-Reviewed Original ResearchConceptsUniversity of California San FranciscoMilan criteriaDonor liver transplantationHepatocellular carcinomaOverall survivalLiver transplantationPosttransplantation survivalEvaluate long-term oncologic outcomesUniversity of California San Francisco criteriaLiving donor liver transplantationRecurrence-free survivalKaplan-Meier methodTransplant selection criteriaProportion of patientsAdult LDLT recipientsNorth American centersLong-term survivalLiver transplant waitlistCalifornia San FranciscoLDLT recipientsMulticenter cohortConsensus guidelinesTransplantationPatientsPosttransplantationA Multiclass Radiomics Method–Based WHO Severity Scale for Improving COVID-19 Patient Assessment and Disease Characterization From CT Scans
Henao J, Depotter A, Bower D, Bajercius H, Todorova P, Saint-James H, de Mortanges A, Barroso M, He J, Yang J, You C, Staib L, Gange C, Ledda R, Caminiti C, Silva M, Cortopassi I, Dela Cruz C, Hautz W, Bonel H, Sverzellati N, Duncan J, Reyes M, Poellinger A. A Multiclass Radiomics Method–Based WHO Severity Scale for Improving COVID-19 Patient Assessment and Disease Characterization From CT Scans. Investigative Radiology 2023, 58: 882-893. PMID: 37493348, PMCID: PMC10662611, DOI: 10.1097/rli.0000000000001005.Peer-Reviewed Original ResearchConceptsCOVID-19 positive patientsClinical Progression ScaleLung lesionsLesion modelDisease severityGround-glass opacitiesCOVID-19 patientsRadiologist assessmentExpert thoracic radiologistsMulticenter cohortPleural effusionDisease extentRetrospective studyDevelopment cohortPatient assessmentTomography scanCT scanSeverity ScalePatient's diseaseTissue lesionsThoracic radiologistsLesionsPatientsRadiomics modelRadiomic featuresRole of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort
Grønseth S, Rogne T, Heggelund L, Åsvold B, Afset J, Damås J. Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort. International Journal Of Infectious Diseases 2023, 134: 177-186. PMID: 37339716, DOI: 10.1016/j.ijid.2023.06.013.Peer-Reviewed Original ResearchConceptsCharlson Comorbidity IndexHIV-negative patientsPneumocystis pneumoniaRisk stratificationFungal burdenMulticenter cohortPolymerase chain reactionAbnormal leukocyte countComorbid cardiovascular diseaseLow serum albuminBronchoalveolar lavage fluidC-reactive proteinChain reactionHigher fungal burdenReal-time polymerase chain reactionProbable Pneumocystis pneumoniaCycle threshold valuesComorbidity indexCorticosteroid useLavage fluidSemiquantitative real-time polymerase chain reactionLeukocyte countImmunological disordersCardiovascular diseaseRetrospective analysisPatient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis
Mathis M, Janda A, Kheterpal S, Schonberger R, Pagani F, Engoren M, Mentz G, Shook D, Muehlschlegel J, Group M. Patient-, Clinician-, and Institution-level Variation in Inotrope Use for Cardiac Surgery: A Multicenter Observational Analysis. Anesthesiology 2023, 139: 122-141. PMID: 37094103, PMCID: PMC10524016, DOI: 10.1097/aln.0000000000004593.Peer-Reviewed Original ResearchConceptsInotrope useCardiac surgeryHome medicationsAdjusted median odds ratioPulmonary circulation disordersAdult cardiac surgeryMechanical circulatory supportMedian odds ratioMedical school affiliationHome inotropesInotrope infusionInotrope therapyInotropic therapyCardiopulmonary bypassHeart failureMulticenter cohortPrimary outcomeCirculatory supportBlack raceCirculation disordersOdds ratioCommunity hospitalObservational studySame patientPatientsIn-Hospital Observation on Oral Diuretics After Treatment for Acute Decompensated Heart Failure: Evaluating the Utility
Ivey-Miranda J, Rao V, Cox Z, Moreno-Villagomez J, Mahoney D, Maulion C, Bellumkonda L, Turner J, Collins S, Wilson F, Krumholz H, Testani J. In-Hospital Observation on Oral Diuretics After Treatment for Acute Decompensated Heart Failure: Evaluating the Utility. Circulation Heart Failure 2023, 16: e010206. PMID: 36896716, PMCID: PMC10186250, DOI: 10.1161/circheartfailure.122.010206.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureDecompensated heart failureDiuretic responseDiuretic dosingOral diureticsHeart failureMulticenter cohortHospital observationLower readmission ratesNet fluid balanceDays postdischargeReadmission ratesHospital readmissionUrine outputReadmission riskFluid statusFluid balanceHospital measuresDose selectionCohortProvider decisionsWeight changeReadmissionDiureticsPatients
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