2024
Sex, Acute Kidney Injury, and Age: A Prospective Cohort Study
Golestaneh L, Basalely A, Linkermann A, El-Achkar T, Kim R, Neugarten J. Sex, Acute Kidney Injury, and Age: A Prospective Cohort Study. American Journal Of Kidney Diseases 2024, 85: 329-338.e1. PMID: 39447957, DOI: 10.1053/j.ajkd.2024.10.003.Peer-Reviewed Original ResearchConceptsRisk of acute kidney injuryAcute kidney injuryFemale sex hormonesSex hormonesKidney injuryRelative risk of acute kidney injuryOdds of acute kidney injuryAnimal models of kidney diseaseRisk factorsAcute kidney injury incidenceHospital-acquired acute kidney injuryWomen of fertile ageModels of kidney diseaseAbstractText Label="PLAIN-LANGUAGE SUMMARYAge groupsEquation logistic regressionSeverity of illnessPostmenopausal womenKDIGO definitionAbstractText Label="RATIONALEObstetric diagnosisAge categoriesMale sexCounts of hospitalizationsMontefiore Health SystemProgestogen-driven B7-H4 contributes to onco-fetal immune tolerance
Yu J, Yan Y, Li S, Xu Y, Parolia A, Rizvi S, Wang W, Zhai Y, Xiao R, Li X, Liao P, Zhou J, Okla K, Lin H, Lin X, Grove S, Wei S, Vatan L, Hu J, Szumilo J, Kotarski J, Freeman Z, Skala S, Wicha M, Cho K, Chinnaiyan A, Schon S, Wen F, Kryczek I, Wang S, Chen L, Zou W. Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance. Cell 2024, 187: 4713-4732.e19. PMID: 38968937, PMCID: PMC11344674, DOI: 10.1016/j.cell.2024.06.012.Peer-Reviewed Original ResearchB7-H4Immune toleranceProgesterone receptorCD8<sup>+</sup> T cell exhaustionImmune tolerance checkpointB7-H4 expressionT cell exhaustionImmune tolerance mechanismsMaternal-fetal interfaceBreast cancer modelFemale sex hormonesBreast cancer progressionBreast cancer cellsTolerance checkpointsFetal resorptionHuman cancer typesHormonal screeningImmune activationPregnancy modelCancer modelsSex hormonesCell exhaustionPR antagonistsGenetic deficiencyCancer cells
2022
Are there sex differences in risk for exertional heat stroke? A translational approach
Giersch GEW, Garcia CK, Stachenfeld N, Charkoudian N. Are there sex differences in risk for exertional heat stroke? A translational approach. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2022, 107: 1136-1143. PMID: 35598159, DOI: 10.1113/ep090402.Peer-Reviewed Original ResearchConceptsExertional heat strokeHeat strokeRisk factorsTranslational approachCentral nervous system dysfunctionNervous system dysfunctionFemale sex hormonesSex differencesHuman researchOrgan damageFatal conditionSystem dysfunctionSex hormonesPhysical activityStrokeTranslational modelOccupational workersRiskMilitary personnelAnimalsTreatmentHuman modelReviewFuture investigationsPhysiological differences
2020
Impact of Puberty in Girls on Prevalence of Primary Headache Disorder Among Female Schoolchildren in Kuwait
Alashqar A, Shuaibi S, Ahmed SF, AlThufairi H, Owayed S, AlHamdan F, Alroughani R, Al-Hashel JY. Impact of Puberty in Girls on Prevalence of Primary Headache Disorder Among Female Schoolchildren in Kuwait. Frontiers In Neurology 2020, 11: 594. PMID: 32765391, PMCID: PMC7379333, DOI: 10.3389/fneur.2020.00594.Peer-Reviewed Original ResearchPrimary headache disordersHeadache disordersPrimary headachesPediatric populationMean agePostpubertal femalesMigraine headacheHigh riskProbable medication-overuse headacheFemale schoolchildrenMedication overuse headacheImpact of pubertyPathophysiology of headacheFemale sex hormonesPrevalence of headacheCross-sectional studyTension-type headacheHeadache-Attributed RestrictionImpaired Participation (HARDSHIP) questionnaireChronic headacheSex hormonesLifetime prevalenceMenarchal statusPostpubertal girlsPrepubertal femalesLong-term efficacy and safety of subcutaneous C1-inhibitor in women with hereditary angioedema: subgroup analysis from an open-label extension of a phase 3 trial
Levy DS, Farkas H, Riedl MA, Hsu FI, Brooks JP, Cicardi M, Feuersenger H, Pragst I, Reshef A. Long-term efficacy and safety of subcutaneous C1-inhibitor in women with hereditary angioedema: subgroup analysis from an open-label extension of a phase 3 trial. Allergy, Asthma & Clinical Immunology 2020, 16: 8. PMID: 32042283, PMCID: PMC7001333, DOI: 10.1186/s13223-020-0409-3.Peer-Reviewed Original ResearchOpen-label extensionC1-INHHealthy babyFemale subjectsFirst trimesterSubgroup analysisHereditary angioedemaHAE-C1INHIU/Severe angioedema attacksSubcutaneous C1-INHPhase 3 trialParallel-arm trialAttacks/monthLong-term efficacyFemale sex hormonesPre-study periodSubgroup of subjectsHAE attacksRoutine prophylaxisEfficacy endpointEligible subjectsUneventful pregnancyAngioedema attacksSex hormones
2019
Rhythmic Fluctuations in Levels of Liver Enzymes During Menstrual Cycles of Healthy Women and Effects of Body Weight
Lai C, Jadhav S, Njei B, Ye A, Wactawski-Wende J, Mumford S, Schisterman E, Rotman Y. Rhythmic Fluctuations in Levels of Liver Enzymes During Menstrual Cycles of Healthy Women and Effects of Body Weight. Clinical Gastroenterology And Hepatology 2019, 18: 2055-2063.e2. PMID: 31811951, PMCID: PMC7269853, DOI: 10.1016/j.cgh.2019.11.047.Peer-Reviewed Original ResearchConceptsLevels of liver enzymesMenstrual cycleLevels of alanine aminotransferaseBody mass indexLiver enzymesAlanine aminotransferaseSex hormonesMenstruating womenMass indexAssociation of sex hormonesPost hoc analysis of dataPhases of menstrual cycleAlkaline phosphataseHealthy menstruating womenNormal menstrual cycleAlanine aminotransferase valuesFemale sex hormonesMid-follicular phaseAbstractText Label="RESULTS">Levels of estrogenMarkers of oxidative stressLiver enzyme measurementsLevels of progesteroneLevels of alkaline phosphataseNon-reproductive organs
2018
Role of Exogenous Progesterone in the Treatment of Men and Women with Substance Use Disorders: A Narrative Review
Peltier MR, Sofuoglu M. Role of Exogenous Progesterone in the Treatment of Men and Women with Substance Use Disorders: A Narrative Review. CNS Drugs 2018, 32: 421-435. PMID: 29761343, PMCID: PMC6235727, DOI: 10.1007/s40263-018-0525-5.Peer-Reviewed Original ResearchConceptsSubstance use disordersExogenous progesteroneUse disordersTreatment of SUDsNovel pharmacological treatmentsFemale sex hormonesTreatment of menNovel pharmacological interventionsTobacco/nicotineFemale substance usersDrugs of abuseMetabolite allopregnanolonePharmacological treatmentPreliminary efficacySex hormonesPharmacological interventionsAvailable interventionsNovel treatmentsAllopregnanoloneEuphoric effectsProgesteroneNarrative reviewLiterature searchSubstance useSubstance users
2014
Postmenopausal Hypertension and Sodium Sensitivity
Kim J, Kim T, Lee H, Lee S, Wang T. Postmenopausal Hypertension and Sodium Sensitivity. Journal Of Menopausal Medicine 2014, 20: 1-6. PMID: 25371885, PMCID: PMC4217569, DOI: 10.6118/jmm.2014.20.1.1.Peer-Reviewed Original ResearchReduced systolic BPBlood pressureSystolic BPSex hormonesDevelopment of postmenopausal hypertensionOral hormone replacement therapyEffect of salt intakeElevation of systolic BPAngiotensin type 2 receptorPrevalence of salt sensitivityAnti-aldosterone activityHormone replacement therapyLack of estrogenWomen to levelsIncidence rate of hypertensionLow-salt dietPost-menopausal womenType 2 receptorFemale sex hormonesRegulation of arterial pressureRenal regulatory mechanismsNitric oxideSalt sensitivityStimulate nitric oxideRates of hypertension
2011
Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance
Wenner MM, Taylor HS, Stachenfeld NS. Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance. The Journal Of Physiology 2011, 589: 975-986. PMID: 21173076, PMCID: PMC3060374, DOI: 10.1113/jphysiol.2010.194563.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceHigh orthostatic toleranceOrthostatic toleranceAdrenergic responseAdrenergic responsivenessNitric oxide synthase inhibitor NG-monomethylEndogenous sex hormone productionSynthase inhibitor NG-monomethylSkin blood flow responseBlood flow responseInhibitor NG-monomethylSex hormone productionFemale sex hormonesLower body negative pressure testSkin blood flowGnRH antagonistProgesterone administrationOrthostatic intoleranceNG-monomethylPeripheral αMicrodialysis infusionSex hormonesCyclooxygenase pathwayHT womenAdrenergic control
2010
Peripheral microvascular responses to norepinephrine in women with orthostatic intolerance
Wenner M, Taylor H, Stachenfeld N. Peripheral microvascular responses to norepinephrine in women with orthostatic intolerance. The FASEB Journal 2010, 24: 991.17-991.17. DOI: 10.1096/fasebj.24.1_supplement.991.17.Peer-Reviewed Original ResearchCumulative stress indexVasoconstrictor responsesAdrenergic responseMaximal lower body negative pressureLower body negative pressurePeripheral microvascular responseEffects of estradiolBody negative pressureFemale sex hormonesSkin blood flowEndogenous E2GnRH antagonistNE infusionDaily administrationMicrovascular responsesCutaneous microvasculatureOrthostatic intoleranceOrthostatic toleranceSex hormonesBlood flowSkin microvasculatureAdrenergic stimulationDay 4Hormone treatmentDay 13
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