Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsYifan Yuan
Assistant Professor AdjunctAbout
Research
Publications
2025
Adrenomedullin Is Enriched in Human Lung Vascular Niche and Enhances Endothelial Cell Maturation in Bioengineered Lung Models
Yoon Y, Kirk S, Raredon M, Kaminski N, Niklason L, Yuan Y. Adrenomedullin Is Enriched in Human Lung Vascular Niche and Enhances Endothelial Cell Maturation in Bioengineered Lung Models. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7243-a7243. DOI: 10.1164/ajrccm.2025.211.abstracts.a7243.Peer-Reviewed Original ResearchAdrenomedullin Enhances Vascular Integrity and Endothelial Cell Maturation in Bioengineered Lung Models
YOON Y, Kirk S, Promnares K, Karki P, Birukov K, Yuan Y. Adrenomedullin Enhances Vascular Integrity and Endothelial Cell Maturation in Bioengineered Lung Models. Physiology 2025, 40: 1257. DOI: 10.1152/physiol.2025.40.s1.1257.Peer-Reviewed Original ResearchVascular barrier functionEndothelial cell maturationShear stressElectric cell impedance sensingCell maturationBarrier functionMicrovascular nicheAngiopoietin-1Single-cell RNA sequencingParacrine signalingVascular modelLung modelEndothelial cell barrier functionVascular integrityEndothelial cell markersCell barrier functionEndothelial cell integrityAdjacent cell typesAnti-inflammatory responseRNA sequencingNative vasculatureCellular phenotypesFluid flowIn vitro modelGene expressionVEGF-D, unlike VEGF-A, improves vascular integrity in the lung and exerts a protective effect during acute lung injury
Yuan Y, Sharma L, Tang W, Yoon Y, Kirk S, Birukov K, Kaminski N. VEGF-D, unlike VEGF-A, improves vascular integrity in the lung and exerts a protective effect during acute lung injury. Physiology 2025, 40: 0734. DOI: 10.1152/physiol.2025.40.s1.0734.Peer-Reviewed Original ResearchAcute lung injuryAcute respiratory distress syndromeImmune cell infiltrationVEGF-DIdiopathic pulmonary fibrosisChronic obstructive pulmonary diseaseVEGF-AVascular integrityMicrovascular nicheAnti-inflammatory propertiesLung injuryCell infiltrationTNF-aLung tissueParacrine signalingPulmonary vascular integrityBarrier functionLung injury indexLevels of pro-inflammatory markersRespiratory distress syndromeTherapeutic targetTumor necrosis factor-aEffects of VEGF-ABronchoalveolar lavage fluidImproving vascular integrityDamage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection
Kim J, Yuan Y, Agaronyan K, Zhao A, Wang V, Gau D, Toosi N, Gupta G, Essayas H, Kaminski A, McGovern J, Yu S, Woo S, Lee C, Gandhi S, Saber T, Saleh T, Hu B, Sun Y, Ishikawa G, Bain W, Evankovich J, Chen L, Yun H, Herzog E, Dela Cruz C, Ryu C, Sharma L. Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection. Mucosal Immunology 2025, 18: 537-548. PMID: 39884393, PMCID: PMC12205908, DOI: 10.1016/j.mucimm.2025.01.008.Peer-Reviewed Original ResearchToll-like receptor 9Anti-influenza immunityToll-like receptor 9 activationImpaired viral clearanceViral clearanceMyeloid cellsTissue injuryInflammatory responseInfluenza infectionPersistent inflammationLung injuryTissue damageToll-like receptor 9 deficiencyReceptor 9Toll-like receptor 9 signalingToll-like receptor 9 ligandInfection of immune cellsInfluenza-infected individualsPersistent lung injuryTLR9-/- miceInfected myeloid cellsInflammatory lung injurySensing tissue damageUnmethylated CpG DNA sequencesMitochondrial DNA
2024
Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency
Park J, Riaz M, Qin L, Zhang W, Batty L, Fooladi S, Kural M, Li X, Luo H, Xu Z, Wang J, Banno K, Gu S, Yuan Y, Anderson C, Ellis M, Zhou J, Luo J, Shi X, Shin J, Liu Y, Lee S, Yoder M, Elder R, Mak M, Thorn S, Sinusas A, Gruber P, Hwa J, Tellides G, Niklason L, Qyang Y. Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency. Cell Stem Cell 2024, 32: 137-143.e6. PMID: 39644899, PMCID: PMC11698629, DOI: 10.1016/j.stem.2024.11.006.Peer-Reviewed Original ResearchTissue-engineered vascular conduitsSingle-ventricle congenital heart defectsEndothelial cellsBiodegradable polymeric scaffoldsGraft patencyAutologous bone marrow cellsAntithrombotic functionCongenital heart defectsInferior vena cava graftHiPSC-derived endothelial cellsBone marrow cellsHuman umbilical arteryDecellularized human umbilical arteriesPolymeric scaffoldsHost endothelial cellsHuman induced pluripotent stem cell (hiPSC)-derived endothelial cellsUmbilical arteryHeart defectsVascular conduitsMarrow cellsFlow bioreactorVena cava graftNude ratsGraft stenosisClinical trialsSingle-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury. Physiology 2024, 39: 1314. DOI: 10.1152/physiol.2024.39.s1.1314.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisAcute lung injuryChronic obstructive pulmonary diseaseAcute respiratory distress syndromeAnalysis of cell-cell communicationVEGF-DMicrovascular nicheSingle-cell RNA-seqLung injury modelSingle-cell RNA-seq analysisLung injuryCell-cell communicationLigand-receptor pairsLPS-induced lung injury modelRNA-seqAdjacent cell typesPulmonary diseaseInjury modelHuman lung endothelial cellsBarrier functionImmune cell infiltrationTumor necrosis factor-aRespiratory distress syndromeLung vascular integrityGene expressionVEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. VEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury. 2024, a4694-a4694. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4694.Peer-Reviewed Original Research
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