2024
Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US
Lin Z, Ye J, Allore H, Gill T, Chen X. Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US. JAMA Internal Medicine 2024, 184: 904-914. PMID: 38805197, PMCID: PMC11134283, DOI: 10.1001/jamainternmed.2024.1132.Peer-Reviewed Original ResearchEarly-life circumstancesLate-life cognitionRacial disparitiesCross-sectional studyBlack participantsWhite participantsCognitive scoresCognitive impairmentRacial differencesTelephone Interview for Cognitive StatusHealth and Retirement StudyAssociated with racial disparitiesPromote health equityPrevalence of cognitive impairmentIntervention of cognitive impairmentNon-Hispanic blacksSurvey of US adultsNon-Hispanic whitesReduce racial disparitiesPrimary explanatory variableSubstantial racial differencesHealth equityRetirement StudyOlder AdultsUS adultsA single item screen for clinically significant insomnia symptoms in community‐living older adults
Webster L, Hobbs J, Farhadian S, Gill T, Miner B. A single item screen for clinically significant insomnia symptoms in community‐living older adults. Journal Of The American Geriatrics Society 2024 PMID: 39007457, DOI: 10.1111/jgs.19086.Peer-Reviewed Original ResearchInsomnia severity and daytime sleepiness in caregivers of advanced age
Webster L, Ali T, Sharninghausen J, Hajduk A, Gill T, Miner B. Insomnia severity and daytime sleepiness in caregivers of advanced age. Frontiers In Sleep 2024, 3: 1404684. DOI: 10.3389/frsle.2024.1404684.Peer-Reviewed Original ResearchInsomnia Severity IndexNon-caregiversCaregiver statusOlder caregiversPoor self-rated healthSelf-rated healthLow physical activityClinically significant insomnia symptomsSleep disturbanceMultivariable-adjusted modelsRates of depressionRisk of sleep disturbancesInsomnia severityPrevalence of insomniaLevel of insomniaAdvanced ageCaregiver burdenPhysical activityFunctional disabilityCaregiversStandardized questionnaireMultivariate regression analysisInsomnia symptomsPhysical profileCognitive impairmentIn-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeAPOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study
Clocchiatti‐Tuozzo S, Szejko N, Rivier C, Renedo D, Huo S, Sheth K, Gill T, Falcone G. APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study. Journal Of The American Geriatrics Society 2024 PMID: 38946154, DOI: 10.1111/jgs.19043.Peer-Reviewed Original ResearchRisk of dementiaOutcome of dementiaAssociated with lower riskOlder adultsRetirement StudySecondary analysisEffects of tested interventionsHealth and Retirement StudyClinical trials of older adultsApo E4Composite outcomePrimary analysisHigh riskLow riskCox proportional hazards modelsProportional hazards modelMultivariate Cox proportional hazards modelDementiaAPOE genotypeClinical trialsHazards modelDisabilityParticipantsFunctional outcomesHeart diseaseA Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression
Oikonomou E, Holste G, Yuan N, Coppi A, McNamara R, Haynes N, Vora A, Velazquez E, Li F, Menon V, Kapadia S, Gill T, Nadkarni G, Krumholz H, Wang Z, Ouyang D, Khera R. A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression. JAMA Cardiology 2024, 9: 534-544. PMID: 38581644, PMCID: PMC10999005, DOI: 10.1001/jamacardio.2024.0595.Peer-Reviewed Original ResearchCardiac magnetic resonanceAortic valve replacementCardiac magnetic resonance imagingAV VmaxSevere ASAortic stenosisCohort studyPeak aortic valve velocityCohort study of patientsAortic valve velocityCohort of patientsTraditional cardiovascular risk factorsAssociated with faster progressionStudy of patientsCedars-Sinai Medical CenterAssociated with AS developmentCardiovascular risk factorsCardiovascular imaging modalitiesIndependent of ageModerate ASEjection fractionEchocardiographic studiesValve replacementRisk stratificationCardiac structureAssessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study
Esserman D, Greene E, Latham N, Kane M, Lu C, Peduzzi P, Gill T, Ganz D. Assessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study. Contemporary Clinical Trials 2024, 142: 107572. PMID: 38740298, DOI: 10.1016/j.cct.2024.107572.Peer-Reviewed Original ResearchElectronic health record dataElectronic health recordsOutcome ascertainmentDevelop Confidence in EldersElectronic health record platformsClinical sitesPrimary care practicesHealth record dataMulti-site trialMulti-site clinical trialCare practicesHealth recordsAssess readinessAcute clinical outcomesHealthcare systemRecord dataClinical trialsReduce injuriesData qualityData comprehensionChecklistStudy dataClinical trial sitesVariable data qualityAscertainmentSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stay0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults
Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. 0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults. Sleep 2024, 47: a99-a99. DOI: 10.1093/sleep/zsae067.0230.Peer-Reviewed Original ResearchOlder adultsAssociated with ageCommunity-living older adultsSleep midpointSeven-daySelf-reported sleep complaintsDays of actigraphyChi-square testTwo-sample t-testActivity countsNo significant differencePearson correlation coefficientAdverse outcomesCT groupMinority raceVariability of chronotypeAdvanced ageObservational studyMorningness-Eveningness QuestionnaireMeasures of chronotypeDemographic factorsSleep onsetModerate correlationSleep disturbanceSignificant difference0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status
Miner B, Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Gill T, Yaggi H. 0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status. Sleep 2024, 47: a133-a133. DOI: 10.1093/sleep/zsae067.0309.Peer-Reviewed Original ResearchTotal sleep timeIntraclass correlation coefficientMeasure total sleep timeMild cognitive impairmentCognitive statusSleep complaintsNight of home-based polysomnographyHome-based polysomnographySelf-reported sleep complaintsCommunity-living older adultsBetween-group differencesPaired t-testPresence of mild cognitive impairmentExcellent concordanceSleep timeAcceptable alternativeWASOPolysomnographyReduced concordancePSGSleep disturbanceOlder personsOlder adultsPeople of colorWomen0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons
Miner B, Pan Y, Cho G, Knauert M, Yaggi H, Gill T, Stone K, Ensrud K, Zeitzer J, Yaffe K, Doyle M. 0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons. Sleep 2024, 47: a324-a325. DOI: 10.1093/sleep/zsae067.0757.Peer-Reviewed Original ResearchAssociated with increased mortality riskAssociation of insomniaMortality riskOlder personsShort sleep durationOsteoporotic fracturesAdjusted modelsStudy of Osteoporotic FracturesSleep durationHigher mortality riskCox proportional hazards modelsMen Sleep StudyNormal sleepProportional hazards modelAssociated with mortalitySevere sleep-disordered breathingUnadjusted modelsUnadjusted analysisCausal pathwaysSleep-disordered breathingFollow-up timePrevalence ratesReference groupHazards modelRisk phenotypesChronic Kidney Disease and Risk of Intracerebral Hemorrhage: The Role of Hypertension as a Mediator (S34.004)
Vanent K, Rivier C, Matouk C, Levitt M, Leslie-Mazwi T, Gill T, Sheth K, Falcone G. Chronic Kidney Disease and Risk of Intracerebral Hemorrhage: The Role of Hypertension as a Mediator (S34.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205783.Peer-Reviewed Original ResearchEnhanced Benefits of the Life’s Essential 8 in APOE Epsilon 4 Carriers (P3-5.014)
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Torres-Lopez V, De Havenon A, Sheth K, Gill T, Falcone G. Enhanced Benefits of the Life’s Essential 8 in APOE Epsilon 4 Carriers (P3-5.014). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206215.Peer-Reviewed Original ResearchLife’s Essential 8 and Brain Health Clinical Outcomes in Middle-aged Adults (P2-15.003)
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Torres-Lopez V, De Havenon A, Sheth K, Gill T, Falcone G. Life’s Essential 8 and Brain Health Clinical Outcomes in Middle-aged Adults (P2-15.003). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206195.Peer-Reviewed Original ResearchEpigenetic Age and Brain Health Events: Findings from the Health and Retirement Study (P2-9.004)
Rivier C, Szejko N, Renedo D, De Havenon A, Sheth K, Gill T, Falcone G. Epigenetic Age and Brain Health Events: Findings from the Health and Retirement Study (P2-9.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204975.Peer-Reviewed Original ResearchValidation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data
Ganz D, Esserman D, Latham N, Kane M, Min L, Gill T, Reuben D, Peduzzi P, Greene E. Validation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data. The Journals Of Gerontology Series A 2024, 79: glae096. PMID: 38566617, PMCID: PMC11167485, DOI: 10.1093/gerona/glae096.Peer-Reviewed Original ResearchFee-for-serviceFall injuriesMedicare AdvantageMedicare dataTrial armsHealthcare systemDevelop Confidence in EldersArea under the receiver operating characteristic curveMedicare fee-for-serviceStratified resultsMedicareReduce injuriesMedical attentionObservational studyStrideReceiver operating characteristic curveCalendar monthMA dataInjuryData sourcesHealthcareArmReference standardTrialsWindow sizeAssociations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults
Lee S, McAvay G, Geda M, Chattopadhyay S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Cohen A, Ferrante L. Associations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults. The Journals Of Gerontology Series A 2024, 79: glae092. PMID: 38558166, PMCID: PMC11059296, DOI: 10.1093/gerona/glae092.Peer-Reviewed Original ResearchConceptsLow social supportMental health symptomsSocial supportSymptom burdenHealth symptomsFollow-up assessmentCOVID-19 hospitalizationMedical Outcomes Study Social Support SurveyPhysical symptomsAssociation of social supportEdmonton Symptom Assessment SystemPatient Health Questionnaire-4Burden of physical symptomsMental health symptom burdenModified Edmonton Symptom Assessment SystemSocial Support SurveyParticipants' mean ageAssociated with higher burdenSupport SurveyOlder survivorsSymptom managementOlder AdultsMental healthHispanic ethnicityLongitudinal associationsThe NIA Paul B. Beeson Emerging Leaders Career Development Program: An enduring public–private partnership
Barr R, van der Willik O, Yaffe K, Gill T. The NIA Paul B. Beeson Emerging Leaders Career Development Program: An enduring public–private partnership. Journal Of The American Geriatrics Society 2024, 72: 1639-1641. PMID: 38366686, DOI: 10.1111/jgs.18802.Peer-Reviewed Original ResearchTraining and supporting subspecialty clinician–scientists in aging research through GEMSSTAR and Clin‐STAR
Gill T, Sherman A, van der Willik O, Yaffe K, Walston J. Training and supporting subspecialty clinician–scientists in aging research through GEMSSTAR and Clin‐STAR. Journal Of The American Geriatrics Society 2024, 72: 1634-1638. PMID: 38366774, PMCID: PMC11090703, DOI: 10.1111/jgs.18811.Peer-Reviewed Original ResearchThe dementia care study (D‐CARE): Recruitment strategies and demographic characteristics of participants in a pragmatic randomized trial of dementia care
Yang M, Samper‐Ternent R, Volpi E, Green A, Lichtenstein M, Araujo K, Borek P, Charpentier P, Dziura J, Gill T, Galloway R, Greene E, Lenoir K, Peduzzi P, Meng C, Reese J, Shelton A, Skokos E, Summapund J, Unger E, Reuben D, Williamson J, Stevens A. The dementia care study (D‐CARE): Recruitment strategies and demographic characteristics of participants in a pragmatic randomized trial of dementia care. Alzheimer's & Dementia 2024, 20: 2575-2588. PMID: 38358084, PMCID: PMC11032530, DOI: 10.1002/alz.13698.Peer-Reviewed Original ResearchElectronic health recordsPragmatic clinical trialsRecruitment strategiesDementia careApproaches to dementia careDementia care studiesCommunity-dwelling dyadsDyads of personsDiagnosis of dementiaHealth system patientsDemographic characteristics of participantsPragmatic randomized trialCharacteristics of participantsPragmatic research studiesFamily caregiversHealth recordsHealth systemCare studiesPLWDSystem patientsDemographic characteristicsD-CAREDementiaCaregiversClinical trial sites