2016
Energy sources identify metabolic phenotypes in pancreatic cancer
Liang C, Qin Y, Zhang B, Ji S, Shi S, Xu W, Liu J, Xiang J, Liang D, Hu Q, Liu L, Liu C, Luo G, Ni Q, Xu J, Yu X. Energy sources identify metabolic phenotypes in pancreatic cancer. Acta Biochimica Et Biophysica Sinica 2016, 48: 969-979. PMID: 27649892, DOI: 10.1093/abbs/gmw097.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaWarburg phenotypeMetabolic phenotypeInducing different metabolic phenotypesCancer metabolic reprogrammingPancreatic ductal adenocarcinoma treatmentHallmarks of cancerStratified pancreatic ductal adenocarcinomaIndividual metabolic phenotypeMetabolic reprogrammingMetabolic pathwaysMetabolic typeDuctal adenocarcinomaMalignant tumorsHeterogeneous diseasePhenotypeTherapeutic approachesEnergy metabolismMetabolic featuresMetabolic diseasesMetabolic inhibitorsNutritional substratesMetabolite detectionDiseaseGlutaminolysis
2015
Lymph node status predicts the benefit of adjuvant chemoradiotherapy for patients with resected pancreatic cancer
Liu Z, Luo G, Guo M, Jin K, Xiao Z, Liu L, Liu C, Xu J, Ni Q, Long J, Yu X. Lymph node status predicts the benefit of adjuvant chemoradiotherapy for patients with resected pancreatic cancer. Pancreatology 2015, 15: 253-258. PMID: 25921232, DOI: 10.1016/j.pan.2015.03.012.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsChemoradiotherapy, AdjuvantDeoxycytidineFemaleHumansLymph NodesLymphatic MetastasisMaleMiddle AgedPancreatectomyPancreatic NeoplasmsRetrospective StudiesSurvival AnalysisTreatment OutcomeConceptsAdjuvant chemoradiotherapyLymph node statusNode statusPancreatic cancerPancreatic adenocarcinomaDifferent lymph node statusCurative R0 resectionEffect of chemoradiotherapyImproved median OSLN-negative diseaseLN-positive diseaseRole of lymphOverall median survivalMedian OSAdjuvant therapyR0 resectionMedian survivalPositive diseaseNegative diseaseChemoradiotherapyPatientsMultivariate analysisDiseaseLymphAdenocarcinoma
2012
Influence of Donor Microbiota on the Severity of Experimental Graft-versus-Host-Disease
Tawara I, Liu C, Tamaki H, Toubai T, Sun Y, Evers R, Nieves E, Mathewson N, Nunez G, Reddy P. Influence of Donor Microbiota on the Severity of Experimental Graft-versus-Host-Disease. Transplantation And Cellular Therapy 2012, 19: 164-168. PMID: 22982686, PMCID: PMC3529780, DOI: 10.1016/j.bbmt.2012.09.001.Peer-Reviewed Original ResearchConceptsSeverity of GVHDDonor microbiotaHost diseaseT cellsT cell-mediated alloresponsesGerm-free donorsSeverity of graftAlloreactive T cellsRelevant murine modelImmune responseMurine modelRecipient microbiotaExperimental graftGVHDSeverityMicrobiotaRecent dataGraftMicrobial floraAlloresponsesCellsDisease
2011
Host Basophils Are Dispensable for Induction of Donor T Helper 2 Cell Differentiation and Severity of Experimental Graft-versus-Host Disease
Tawara I, Nieves E, Liu C, Evers R, Toubai T, Sun Y, Alrubaie M, Reddy P. Host Basophils Are Dispensable for Induction of Donor T Helper 2 Cell Differentiation and Severity of Experimental Graft-versus-Host Disease. Transplantation And Cellular Therapy 2011, 17: 1747-1753. PMID: 21871863, PMCID: PMC3220796, DOI: 10.1016/j.bbmt.2011.08.013.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsAllogeneic bone marrow transplantationSeverity of GVHDBone marrow transplantationHost diseaseTh2 responsesMarrow transplantationDonor T cell proliferationDonor T-cell responsesInduction of graftT cell responsesT cell proliferationT helper 2 (Th2) cell differentiationTh2 polarizationLymphocyte responsesExperimental graftGVHDCell responsesBasophilsCell proliferationSeverityTransplantationGraftRecent dataDisease
2010
Developmental plasticity of stem cells and diseases
Luo G, Long J, Zhang B, Liu C, Xu J, Yu X, Ni Q. Developmental plasticity of stem cells and diseases. Medical Hypotheses 2010, 75: 507-510. PMID: 20691545, DOI: 10.1016/j.mehy.2010.07.007.Peer-Reviewed Original Research
2009
T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease
Iclozan C, Yu Y, Liu C, Liang Y, Yi T, Anasetti C, Yu X. T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease. Transplantation And Cellular Therapy 2009, 16: 170-178. PMID: 19804837, PMCID: PMC3876952, DOI: 10.1016/j.bbmt.2009.09.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBody WeightBone Marrow TransplantationCD3 ComplexCells, CulturedGraft vs Host DiseaseGraft vs Host ReactionInterferon-gammaInterleukin-17MiceMice, Inbred StrainsMice, TransgenicNuclear Receptor Subfamily 1, Group F, Member 3Severity of Illness IndexSurvival AnalysisTh1 CellsTime FactorsT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTumor Necrosis Factor-alphaWhole Body ImagingConceptsHost diseaseBALB/c recipientsBone marrow transplantation settingAcute Graft-VersusT helper17 cellsGVHD target organsInduction of graftPathogenesis of GVHDCD4 T cellsGraft-VersusGVHD developmentC recipientsT helperTh17 cellsAllogeneic recipientsAutoimmune diseasesC57BL/6 miceSyngeneic recipientsTransplantation settingGVHDT cellsIFN-gammaTarget organsSuperior expansionDisease
2008
Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells
Gatza E, Rogers C, Clouthier S, Lowler K, Tawara I, Liu C, Reddy P, Ferrara J. Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells. Blood 2008, 112: 1515-1521. PMID: 18411417, PMCID: PMC2515148, DOI: 10.1182/blood-2007-11-125542.Peer-Reviewed Original ResearchConceptsRegulatory T cellsExtracorporeal photopheresisHost diseaseT cellsDonor regulatory T cellsCutaneous T-cell lymphomaOngoing immune responseImmune-mediated diseasesT-cell lymphomaRelevant murine modelWhite blood cellsImmune responseMurine modelLymphocyte apoptosisImmune systemExperimental graftBlood cellsDiseaseECP treatmentGVHDPhotopheresisGraftDirect inductionCellsApoptosisRepopulation of human hepatocytes in immunodeficient mice
Liu C, Witek R, Bess J, Zhu H, Lin P. Repopulation of human hepatocytes in immunodeficient mice. The FASEB Journal 2008, 22: 465.4-465.4. DOI: 10.1096/fasebj.22.1_supplement.465.4.Peer-Reviewed Original ResearchHuman hepatitis C virusHuman hepatocytesHepatitis C virusTime of hepatectomyHumanized mouse modelHuman liver diseaseRepopulation efficiencyLiver diseaseC virusHepatocyte repopulationImmunodeficient miceMouse modelTransgenic miceLiver tissueHepatocyte proliferationPartial hepatectomyMiceSerum samplesMonocrotalineMouse liverHepatectomyHepatocytesDiseaseLiverProtein markers
2007
Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
Borsotti C, Franklin A, Lu S, Kim T, Smith O, Suh D, King C, Chow A, Liu C, Alpdogan O, van den Brink M. Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity. Blood 2007, 110: 783-786. PMID: 17395784, PMCID: PMC1924485, DOI: 10.1182/blood-2006-10-054510.Peer-Reviewed Original ResearchConceptsT cellsTNF-alpha converting enzymeGVT activityHost diseaseTumor activityAllogeneic bone marrow transplantationDonor T cellsBone marrow transplantationMurine BMT modelWild-type T cellsLess GVHDMarrow transplantationBMT modelNecrosis factorEndogenous TNFSoluble TNFGVHDConverting enzymeGraftTNFDiseaseRecipientsSoluble moleculesCellsMemTNF
2006
A critical role of Sema4D (CD100) in reducing graft-versus-host disease in a murine major mismatch transplant
Duran-Struuck R, Rogers C, Clouthier S, Gatza E, Liu C, Kumanogoh A, Reddy P, Ferrara J. A critical role of Sema4D (CD100) in reducing graft-versus-host disease in a murine major mismatch transplant. Transplantation And Cellular Therapy 2006, 12: 59-60. DOI: 10.1016/j.bbmt.2005.11.185.Peer-Reviewed Original Research
2005
Suberoylanilide hydroxamic acid modulates the innate and allostimulatory responses of dendritic cells and regulates experimental acute graft-versus-host disease
Reddy P, Maeda Y, Lowler K, Liu C, Dinarello C, Ferrara J. Suberoylanilide hydroxamic acid modulates the innate and allostimulatory responses of dendritic cells and regulates experimental acute graft-versus-host disease. Transplantation And Cellular Therapy 2005, 11: 48. DOI: 10.1016/j.bbmt.2004.12.142.Peer-Reviewed Original Research
2004
Host Dendritic Cells Alone Are Sufficient to Initiate Acute Graft-versus-Host Disease
Duffner U, Maeda Y, Cooke K, Reddy P, Ordemann R, Liu C, Ferrara J, Teshima T. Host Dendritic Cells Alone Are Sufficient to Initiate Acute Graft-versus-Host Disease. The Journal Of Immunology 2004, 172: 7393-7398. PMID: 15187116, DOI: 10.4049/jimmunol.172.12.7393.Peer-Reviewed Original ResearchConceptsHost dendritic cellsDendritic cellsB cellsT cellsAcute GVHDHost diseaseHost-derived dendritic cellsLethal acute GVHDAllogeneic dendritic cellsII-deficient miceMHC class IIMHC class IAcute graftChimeric recipientsHost APCsAPC subsetsAlloantigen expressionGVHDMHC classClass IIClass IRobust proliferationSelective targetingGraftDisease
2002
Erratum: Acute graft-versus-host disease does not require alloantigen expression on host epithelium
Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke K, Ferrara J. Erratum: Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nature Medicine 2002, 8: 1039-1039. DOI: 10.1038/nm0902-1039a.Peer-Reviewed Original Research