Philip Sarrel, MD
Research & Publications
Biography
News
Research Summary
Summary of research interests: Ovarian hormones are vasoactive steroids affecting the hemodynamics factors involved in arterial tone and blood flow. Genomic actions in the vascular endothelium and smooth muscle as well as non-genomic actions of steroids in these cells are clinically significant. We have taken an interdisciplinary approach (GYN/ Neurology; GYN/Cardiology and GYN/Psychiatry) to studying women with histories of migraine, stroke, myocardial infarction, angina and psychological depression to determine the role of hormone deficiency and the actions of treatment with estrogens and progestins.Work also includes study of androgen effects on blood flow and sexual function.
Estrogen avoidance after hysterectomy/oophorectomy and premature ovarian failure. The healthcare and economic burden of estrogen avoidance.
Coauthors
Selected Publications
- Incremental direct and indirect costs of untreated vasomotor symptomsSarrel P, Portman D, Lefebvre P, Lafeuille MH, Grittner AM, Fortier J, Gravel J, Duh MS, Aupperle PM. Incremental direct and indirect costs of untreated vasomotor symptoms. Menopause The Journal Of The North American Menopause Society 2015, 22: 260-266. PMID: 25714236, DOI: 10.1097/gme.0000000000000320.
- The mortality toll of estrogen avoidance: an analysis of excess deaths among hysterectomized women aged 50 to 59 years.Sarrel PM, Njike VY, Vinante V, Katz DL. The mortality toll of estrogen avoidance: an analysis of excess deaths among hysterectomized women aged 50 to 59 years. American Journal Of Public Health 2013, 103: 1583-8. PMID: 23865654, PMCID: PMC3780684, DOI: 10.2105/ajph.2013.301295.
- Medroxyprogesterone acetate and dihydrotestosterone induce coronary hyperreactivity in intact male rhesus monkeys.Mishra RG, Hermsmeyer RK, Miyagawa K, Sarrel P, Uchida B, Stanczyk FZ, Burry KA, Illingworth DR, Nordt FJ. Medroxyprogesterone acetate and dihydrotestosterone induce coronary hyperreactivity in intact male rhesus monkeys. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 3706-14. PMID: 15769993, PMCID: PMC1473190, DOI: 10.1210/jc.2004-1557.
- Estrogen therapy and risk of cognitive decline: Results from the Women's Estrogen for Stroke Trial (WEST)Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. Estrogen therapy and risk of cognitive decline: Results from the Women's Estrogen for Stroke Trial (WEST). American Journal Of Obstetrics And Gynecology 2005, 192: 387-393. PMID: 15695976, DOI: 10.1016/j.ajog.2004.08.017.
- Raloxifene and endothelial function in healthy postmenopausal womenSarrel PM, Nawaz H, Chan W, Fuchs M, Katz DL. Raloxifene and endothelial function in healthy postmenopausal women. American Journal Of Obstetrics And Gynecology 2003, 188: 304-309. PMID: 12592230, DOI: 10.1067/mob.2003.28.
- Androgen deficiency: menopause and estrogen-related factorsSarrel PM. Androgen deficiency: menopause and estrogen-related factors. Fertility And Sterility 2002, 77: 63-67. PMID: 12007905, DOI: 10.1016/s0015-0282(02)02967-9.