Zhengxing Zhang, PhD
Associate Research ScientistCards
About
Research
Publications
2025
Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.
Ahmad A, Ghim M, Kukreja G, Neishabouri A, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Morrison T, Zhang J, Huang Y, Liu C, Yu S, Sadeghi M. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis. Journal Of Nuclear Medicine 2025, 66: 425-433. PMID: 39915119, PMCID: PMC11876730, DOI: 10.2967/jnumed.124.268832.Peer-Reviewed Original ResearchConceptsPulmonary fibrosisTracer uptakeLung uptakeMurine model of pulmonary fibrosisModel of pulmonary fibrosisMice 3 wkEffect of antifibrotic therapyCollagen turnoverInterstitial lung diseaseClinical diagnostic methodsSPECT/CT imagingHybrid tracersLung histologyAntifibrotic therapyControl miceDisease activityMurine modelLung diseaseMice 8Tissue fibrosisPatient managementLiver uptakeSPECT/CTFibrosisSPECT images
2024
Molecular Imaging of Collagen Turnover in Myocardial Infarction
Neishabouri A, Ghim M, Ahmad A, Kukreja G, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Zhang J, Huang H, Yu S, Sadeghi M. Molecular Imaging of Collagen Turnover in Myocardial Infarction. Journal Of Nuclear Cardiology 2024, 38: 101998. DOI: 10.1016/j.nuclcard.2024.101998.Peer-Reviewed Original Research
2023
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Ahmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.Peer-Reviewed Original ResearchConceptsF-NaF PET/CTCalcific aortic valve diseaseBicuspid aortic valvePET/CTAortic valve calcificationAortic valve diseaseAortic valveAortic stenosisValve calcificationValvular calcificationValve diseaseF-NaFSubset of miceTricuspid aortic valveDevelopment of calcificationSignificant correlationUnderwent echocardiographyMedical therapyHigh prevalencePreclinical modelsMurine modelTherapeutic interventionsAge groupsAutoradiography dataMultimodality imaging
2013
ChemInform Abstract: TaMe3Cl2‐Catalyzed Intermolecular Hydroaminoalkylation: A Simple Complex for Enhanced Reactivity and Expanded Substrate Scope.
Zhang Z, Hamel J, Schafer L. ChemInform Abstract: TaMe3Cl2‐Catalyzed Intermolecular Hydroaminoalkylation: A Simple Complex for Enhanced Reactivity and Expanded Substrate Scope. ChemInform 2013, 44: no-no. DOI: 10.1002/chin.201346053.Peer-Reviewed Original ResearchTaMe3Cl2‐Catalyzed Intermolecular Hydroaminoalkylation: A Simple Complex for Enhanced Reactivity and Expanded Substrate Scope
Zhang Z, Hamel J, Schafer L. TaMe3Cl2‐Catalyzed Intermolecular Hydroaminoalkylation: A Simple Complex for Enhanced Reactivity and Expanded Substrate Scope. Chemistry - A European Journal 2013, 19: 8751-8754. PMID: 23686833, DOI: 10.1002/chem.201300992.Peer-Reviewed Original ResearchChemInform Abstract: Regioselective Synthesis of Substituted Naphthalenes and Phenanthrenes by FeCl3‐Promoted Annulation of Aryl and Naphthyl Acetaldehydes with Alkynes.
Bu X, Hong L, Liu R, Hong J, Zhang Z, Zhou X. ChemInform Abstract: Regioselective Synthesis of Substituted Naphthalenes and Phenanthrenes by FeCl3‐Promoted Annulation of Aryl and Naphthyl Acetaldehydes with Alkynes. ChemInform 2013, 44: no-no. DOI: 10.1002/chin.201305032.Peer-Reviewed Original Research
2012
Regioselective synthesis of substituted naphthalenes and phenanthrenes by FeCl3-promoted annulation of aryl and naphthyl acetaldehydes with alkynes
Bu X, Hong L, Liu R, Hong J, Zhang Z, Zhou X. Regioselective synthesis of substituted naphthalenes and phenanthrenes by FeCl3-promoted annulation of aryl and naphthyl acetaldehydes with alkynes. Tetrahedron 2012, 68: 7960-7965. DOI: 10.1016/j.tet.2012.07.007.Peer-Reviewed Original ResearchOxidation and coupling of β-diketiminate ligand in lanthanide complexes: Novel eight-nuclear lanthanide clusters with μ-, μ 3 -Cl, and μ 4 -O bridge
Zhang J, Zhang Z, Chen Z, Zhou X. Oxidation and coupling of β-diketiminate ligand in lanthanide complexes: Novel eight-nuclear lanthanide clusters with μ-, μ 3 -Cl, and μ 4 -O bridge. Dalton Transactions 2012, 41: 357-359. PMID: 22080353, DOI: 10.1039/c1dt11383f.Peer-Reviewed Original Research
2011
Facile Synthesis of Organolanthanide Hydrides with Metallic Potassium: Crystal Structures and Reactivity
Zhang J, Yi W, Zhang Z, Chen Z, Zhou X. Facile Synthesis of Organolanthanide Hydrides with Metallic Potassium: Crystal Structures and Reactivity. Organometallics 2011, 30: 4320-4324. DOI: 10.1021/om2003877.Peer-Reviewed Original ResearchSolid-state structuresMetallic potassiumFacile synthesisComplexes 1Solid-state structures of complexes 1X-ray single-crystal diffraction analysisStructures of complexes 1Single-crystal diffraction analysisLn–H bondsTert-butyl isocyanideStructure determination resultsNeutral hydridesTHF resultsModerate yieldsNeutral dimerTert-butylSpectroscopic propertiesCrystal structureHydrogen atomsDiffraction analysisHydrideX-rayElemental analysisIsocyanideReactivitySyntheses, Structures, and Reactivities of Homometallic Rare‐Earth‐Metal Multimethyl Methylidene and Oxo Complexes
Hong J, Zhang L, Yu X, Li M, Zhang Z, Zheng P, Nishiura M, Hou Z, Zhou X. Syntheses, Structures, and Reactivities of Homometallic Rare‐Earth‐Metal Multimethyl Methylidene and Oxo Complexes. Chemistry - A European Journal 2011, 17: 2130-2137. PMID: 21294180, DOI: 10.1002/chem.201002670.Peer-Reviewed Original ResearchEquivalents of AlMe(3C-H bond activationX-ray diffraction determinationEquivalent of ketoneHeterometallic trinuclear complexesComplex 4bComplexes 4aMethylidene complexTHF moleculesTrinuclear complexesOxo complexesBond activationInsertion productsC-HNMR spectroscopyX-rayElemental analysisAlMe(3KetonesReactionAmbient temperatureComplexTHF/tolueneTrinuclearMethylidene