2023
Apolipoprotein E polymorphism‐dependent effects on cellular function
Beyer B, Levine Z. Apolipoprotein E polymorphism‐dependent effects on cellular function. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.077424.Peer-Reviewed Original ResearchApolipoprotein EStructure:function relationshipsCombination of cell-basedIsogenic hiPSC linesTransport of lipidsSubcellular localizationE4 isoformCellular functionsFunction of apolipoprotein EBiophysical approachesLiving cellsTransport of E2Cell typesCo-localizationCentral nervous systemLipoprotein particlesIsoformsHuman astrocytesRelationship of apolipoprotein EHiPSC linesCell-basedInvestigate mechanismsApolipoproteinCellsOrganelles
2009
Electroporating Fields Target Oxidatively Damaged Areas in the Cell Membrane
Vernier PT, Levine ZA, Wu YH, Joubert V, Ziegler MJ, Mir LM, Tieleman DP. Electroporating Fields Target Oxidatively Damaged Areas in the Cell Membrane. PLOS ONE 2009, 4: e7966. PMID: 19956595, PMCID: PMC2779261, DOI: 10.1371/journal.pone.0007966.Peer-Reviewed Original ResearchConceptsLiving cellsComplex biomolecular assembliesPlasma membraneMolecular basisGenetic materialMembrane componentsCell membraneBiomolecular assembliesPermeabilization procedureModel membranesElectroporation protocolReversible electropermeabilizationOxidative stressElectropermeabilizationMembraneCell suspensionsDetailed understandingMolecular dynamics simulationsGene therapyCellsConsiderable knowledgeAssemblyDynamics simulationsPharmaceutical agents