Xin Yang, PhD
Postdoctoral AssociateAbout
Research
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Featured Publications
Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice
Yang X, Wang Z, Niu J, Zhai R, Xue X, Wu G, Fang Y, Meng G, Yuan H, Zhao L, Zhang C. Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice. Microbiome 2023, 11: 62. PMID: 36978130, PMCID: PMC10052834, DOI: 10.1186/s40168-023-01507-z.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetesBeta-cell destructionGut microbiotaGut microbiomeDextran sulfate sodium treatmentAutoimmune type 1 diabetesCell destructionIDD developmentDysbiotic gut microbiotaGerm-free micePotential human relevanceType 1 diabetesNormal gut microbiomeGut pathobiontPancreatic inflammationC57BL/6 miceLocal inflammationNormal dietWildtype miceAnimal modelsDiabetesSodium treatmentPathobiontsPancreasHuman relevanceTlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Gut microbiotaGut microbial communityTransferred to germ-free miceB cellsGerm-free miceTLR9 deficiencyKO miceGene sequencesGerminal center B cellsMicrobial communitiesMarginal zone B cellsGut dysbiosisFollicular helper cellsSelf-DNAMetabolic homeostasisAssociated with increased frequencyPro-inflammatory stateFat tissue inflammationGutHigh-fat dietMicrobiotaHelper cellsT cellsControl miceBile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice
Yang X, Xu Y, Li J, Ran X, Gu Z, Song L, Zhang L, Wen L, Ji G, Wang R. Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice. MSystems 2024, 9: e00127-24. PMID: 38934542, PMCID: PMC11265269, DOI: 10.1128/msystems.00127-24.Peer-Reviewed Original ResearchGut microbiotaGut microbiota dysbiosisDysregulated gut microbiotaGut microbiota transplantationGerm-free miceVirulence factorsSmall intestinal bacteriaBile acid homeostasisMicrobiota dysbiosisDecreased diversityMicrobiota imbalanceMicrobiotaMouse model of cholestasisBile acidsMouse modelIntestinal bacteriaAcid homeostasisMicrobiota transplantationClinical management of patientsGutHepatic bile acidsLong-term effectsPre-clinical findingsModel of cholestasisManagement of patientsGut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D
Yang X, Huang J, Peng J, Wang P, Wong F, Wang R, Wang D, Wen L. Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D. Frontiers In Immunology 2024, 15: 1413177. PMID: 38903498, PMCID: PMC11187306, DOI: 10.3389/fimmu.2024.1413177.Peer-Reviewed Original ResearchGut microbiotaGerm-free miceToll-like receptor 9Increased gut permeabilityIntestinal microbiotaGut permeabilityT1D developmentGut microbiota compositionFecal samplesTransferred to germ-free miceGut barrier integrityBreg cell differentiationMicrobiota influenceMucin degradationMicrobiota compositionBreg cellsAltered microbiotaMicrobiota impactMicrobiotaGene expressionImmune regulationDevelopment of T1DCell differentiationGutNOD miceGut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome
Geng L, Yang X, Sun J, Ran X, Zhou D, Ye M, Wen L, Wang R, Chen M. Gut Microbiota Modulation by Inulin Improves Metabolism and Ovarian Function in Polycystic Ovary Syndrome. Advanced Science 2025, 12: 2412558. PMID: 40192074, PMCID: PMC12120758, DOI: 10.1002/advs.202412558.Peer-Reviewed Original ResearchConceptsCo-abundance groupsGut microbiotaFecal microbiota transplantationGut microbiota regulationEffects of inulinGut microbiota modulationModulating gut microbiotaAntibiotic-treated miceLipopolysaccharide-binding proteinPolycystic ovary syndromeBifidobacterium speciesMicrobiota regulationMicrobiota modulationPCOS miceBiosynthesis capacityFecal SCFA contentInulin treatmentSCFA contentMicrobiota transplantationMicrobiotaLipid accumulationGutProtective effect of inulinGlucolipid metabolismPCOS cohort
2025
In Vitro Assessment of the Prebiotic Effects of Poria Cocos Polysaccharides Using Fecal Microbiota from Normal-Weight and Obese Children.
Qiu DY, Liu XQ, Luo Y, Chen X, Zhang WN, Yang X, Luo FH, Wang RR. In Vitro Assessment of the Prebiotic Effects of Poria Cocos Polysaccharides Using Fecal Microbiota from Normal-Weight and Obese Children. Foods 2025, 14 PMID: 41376015, DOI: 10.3390/foods14234077.Peer-Reviewed Original ResearchBacterial guilds, not genus-level taxa, mediate the protective effects of time-restricted feeding against high-fat diet-induced obesity in mice.
Ghosh S, Li Y, Yang X, Wu G, Zhang C, Zhao L. Bacterial guilds, not genus-level taxa, mediate the protective effects of time-restricted feeding against high-fat diet-induced obesity in mice. ISME Commun 2025, 5: ycaf127. PMID: 41080527, DOI: 10.1093/ismeco/ycaf127.Peer-Reviewed Original ResearchThe novel synbiotic (Lactiplantibacillus plantarum and galacto-oligosaccharides) ameliorates obesity-related metabolic dysfunction: Arginine as a key mediator signaling molecule
Shi R, Wei J, Ye J, Song X, Yang X, Zhang Y, Liu S, Ren J, Wang D, Zhao Z, Liu Z, Wang Y, Zhao B, Xiao C, Dai X, Ai L, Liu X. The novel synbiotic (Lactiplantibacillus plantarum and galacto-oligosaccharides) ameliorates obesity-related metabolic dysfunction: Arginine as a key mediator signaling molecule. Journal Of Advanced Research 2025 PMID: 40545235, DOI: 10.1016/j.jare.2025.06.041.Peer-Reviewed Original ResearchGalacto-oligosaccharidesGenome-wide analysisGut microbiota compositionAMPK Signaling PathwayLipid metabolismArginine productionCAZy databaseHigh-fat diet-induced obese miceMicrobiota compositionMicrobiota analysisAMPK pathwayDiet-induced obese miceSignaling moleculesASS1 geneSignaling pathwayGrowth substrateObesity-related metabolic dysfunctionImprove lipid metabolismAMPKAttenuate obesityArginineSynthesis inhibitionObese miceSerum arginine levelsPathway
2024
Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury
Pan H, Song D, Wang Z, Yang X, Luo P, Li W, Li Y, Gong M, Zhang C. Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury. Gut Microbes 2024, 16: 2439534. PMID: 39673542, PMCID: PMC11649229, DOI: 10.1080/19490976.2024.2439534.Peer-Reviewed Original ResearchConceptsGut microbiotaDrug-induced liver injuryIndole-3-lactic acidComposition of human gut microbiotaWestern style dietDietary modulators of gut microbiotaModulation of gut microbiotaHuman gut microbiotaGut microbiota transplantationModulating gut microbiotaSusceptibility to drug-induced liver injuryIncidence of drug-induced liver injuryDietary fiber interventionLiver injuryDiet-induced variationsBile acid metabolismMicrobiotaTranslocation of lipopolysaccharideImprove liver functionSignaling pathwayDietary shiftsMicrobiota transplantationFiber interventionAcid metabolismIntestinal barrierThe profile of blood microbiome in new-onset type 1 diabetes children
Yuan X, Yang X, Xu Z, Li J, Sun C, Chen R, Wei H, Chen L, Du H, Li G, Yang Y, Chen X, Cui L, Fu J, Wu J, Chen Z, Fang X, Su Z, Zhang M, Wu J, Chen X, Zhou J, Luo Y, Zhang L, Wang R, Luo F. The profile of blood microbiome in new-onset type 1 diabetes children. IScience 2024, 27: 110252. PMID: 39027370, PMCID: PMC11255850, DOI: 10.1016/j.isci.2024.110252.Peer-Reviewed Original ResearchBlood microbiomeRRNA gene sequencesMicrobiome of patientsGene sequencesOral microbiomePICRUSt analysisMicrobial featuresMicrobiome signaturesPathogenic bacteriaMicrobiomeTranslocation of bacteriaPotential translocationBacteriaRandom forest analysisType 1 diabetic childrenGutNew-onset T1DDiscriminatory powerType 1 diabetesForest analysisOral cavityIncreasing diversityInduce inflammationPICRUStGenus
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