Xue Yan Peng
Research Associate Internal Medicine PulmonaryCards
About
Research
Publications
2026
B19-07 NGF-TrkA Signaling Drives Sympathetic Nerve-Dependent Pulmonary Fibrosis
Aber R, Ishikawa G, Peng X, Ghincea A, Herzog E. B19-07 NGF-TrkA Signaling Drives Sympathetic Nerve-Dependent Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.2437. DOI: 10.1093/ajrccm/aamag162.2437.Peer-Reviewed Original ResearchNerve growth factorAnti-NGF IgGBronchoalveolar lavageSympathetic innervationWhite blood cellsHuman lung fibroblastsPulmonary fibrosisFunctional blockadeLung fibroblastsBlockade of nerve growth factorNeutralization of nerve growth factorSystemic administrationNerve growth factor expressionWild-type miceNGF-TrkA signalingTropomyosin receptor kinase ANerve growth factor concentrationPulmonary Fibrosis FoundationGanglia in vitroFibrosis in vivoLung fibrosis in vivoNeurons co-culturedMasson's trichrome stainingTGF-b signalingHigh-affinity receptor
2025
Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis
Trujillo G, Regueiro-Ren A, Liu C, Hu B, Sun Y, Ahangari F, Fiorini V, Ishikawa G, Al Jumaily K, Khoury J, McGovern J, Lee C, Peng X, Pivarnik T, Sun H, Walia A, Woo S, Yu S, Antin-Ozerkis D, Sauler M, Kaminski N, Herzog E, Ryu C. Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 91-102. PMID: 39189851, PMCID: PMC11755360, DOI: 10.1164/rccm.202401-0065oc.Peer-Reviewed Original ResearchToll-like receptor 9Model of pulmonary fibrosisIdiopathic pulmonary fibrosisPulmonary fibrosisFibroproliferative responseLung diseaseIdiopathic pulmonary fibrosis cohortsExpression of toll-like receptor 9Toll-like receptor 9 activationTransplant-free survivalExpression of MCP-1Cohort of patientsSlow clinical progressionFibrotic lung diseaseAccelerated disease courseFatal lung diseaseIP-10Pharmacodynamic endpointsPreclinical modelsDisease courseClinical progressionPlasma mtDNAMCP-1Receptor 9Mouse model
2024
Metagenomic Insight into the Associated Microbiome in Plasmodia of Myxomycetes
Peng X, Li S, Dou W, Li M, Gontcharov A, Peng Z, Qi B, Wang Q, Li Y. Metagenomic Insight into the Associated Microbiome in Plasmodia of Myxomycetes. Microorganisms 2024, 12: 2540. PMID: 39770743, PMCID: PMC11677963, DOI: 10.3390/microorganisms12122540.Peer-Reviewed Original ResearchCommunity compositionMicrobial functional profilesHost-specific selectionMicrobial community compositionCharacteristics of microbiotaCulture-based studiesSpecies of bacteriaBacteria community compositionPhagocytosis of bacteriaFunctional traitsMetagenomic sequencingMyxomycete speciesAssociated microbiomeAmplicon sequencingFunctional redundancyMetagenomic insightsMicrobial communitiesMyxomycetesSpecies-specificBacteria speciesDominant bacteriaBacteriaFunctional roleFunctional analysisPlasmodiaRetraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3
Lee C, He C, Park J, Lee J, Kamle S, Ma B, Akosman B, Cortez R, Chen E, Zhou Y, Herzog E, Ryu C, Peng X, Rosas I, Poli S, Bostwick C, Choi A, Elias J, Lee C. Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Science Alliance 2024, 7: e202402987. PMID: 39209538, PMCID: PMC11361373, DOI: 10.26508/lsa.202402987.Peer-Reviewed Original Research
2023
Genome size and GC content of myxomycetes
Li S, Qi B, Peng X, Wang W, Wang W, Liu P, Liu B, Peng Z, Wang Q, Li Y. Genome size and GC content of myxomycetes. European Journal Of Protistology 2023, 90: 125991. PMID: 37331249, DOI: 10.1016/j.ejop.2023.125991.Peer-Reviewed Original ResearchConceptsDark-spored cladeGenome sizeGC contentMyxomycete speciesAnalysis of genome sizeGC content evolutionGenome size dataGenome size variationPhylogeny-based analysesGenome sequenceMyxomycete studiesSpore sizeGenomeCladeMyxomycetesSize variationSpeciesFlow cytometryAmoebozoaContent evolutionSporesSequenceSize dataExtensive surveyCytometry
2022
Diversity of bacterial communities in the plasmodia of myxomycetes
Li S, Qi B, Wang W, Peng X, Gontcharov A, Liu B, Wang Q, Li Y. Diversity of bacterial communities in the plasmodia of myxomycetes. BMC Microbiology 2022, 22: 314. PMID: 36544088, PMCID: PMC9773492, DOI: 10.1186/s12866-022-02725-5.Peer-Reviewed Original ResearchConceptsOperational taxonomic unitsBacterial communitiesBacterial operational taxonomic unitsDiversity of bacterial communitiesGroups of eukaryotesFruiting body stageBacterial community compositionCommunity functional compositionResultsThe bacterial communityRRNA amplicon sequencingAssociated with bacteriaDistinctive life cycleTaxonomic unitsMyxomycete speciesCommunity compositionAmplicon sequencingBacterial diversityUnique bacteriaBacteria diversityDominant phylaMyxomycetesGram-negativeMyxomycete plasmodiaBacteriaFunctional composition
2018
Physical and biochemical interactions drive fibrocytes accumulation in the scleroderma lung matrix
Sun H, Winkler J, Minasyan M, Pan H, Desai O, Pellowe A, Li J, Peng X, Gonzalez A, Herzog E. Physical and biochemical interactions drive fibrocytes accumulation in the scleroderma lung matrix. 2018, lsc-1176. DOI: 10.1183/13993003.congress-2018.lsc-1176.Peer-Reviewed Original Research
2014
Role of Chitinase 3-Like-1 and Semaphorin 7A in Pulmonary Melanoma Metastasis
Ma B, Lee C, Herzog E, Peng X, Koo J, Elias J. Role of Chitinase 3-Like-1 and Semaphorin 7A in Pulmonary Melanoma Metastasis. American Journal Of Respiratory And Critical Care Medicine 2014, 189: a3510-a3510. DOI: 10.1164/ajrccm-conference.2014.189.1_meetingabstracts.a3510.Peer-Reviewed Original Research
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