2012
Enhanced phosphoserine insertion during Escherichia coli protein synthesis via partial UAG codon reassignment and release factor 1 deletion
Heinemann IU, Rovner AJ, Aerni HR, Rogulina S, Cheng L, Olds W, Fischer JT, Söll D, Isaacs FJ, Rinehart J. Enhanced phosphoserine insertion during Escherichia coli protein synthesis via partial UAG codon reassignment and release factor 1 deletion. FEBS Letters 2012, 586: 3716-3722. PMID: 22982858, PMCID: PMC3473164, DOI: 10.1016/j.febslet.2012.08.031.Peer-Reviewed Original ResearchConceptsUAG codonEscherichia coli protein synthesisRelease factor 1Aminoacyl-tRNA synthetaseCellular fitnessCodon reassignmentEssential genesElongation factorPhosphoserine phosphataseProtein synthesisRF-1Protein yieldTranslation systemFactor 1CodonAccompanying lossGFPUAAGenesSynthetaseDeletionWNK4FitnessPhosphataseExpression
2008
Acute Myeloid Leukemia in Mice Associated with Retrovirally-Mediated Overexpression of HOXB4
Zhang H, Chen W, Rogulina S, Lee H, Forget B. Acute Myeloid Leukemia in Mice Associated with Retrovirally-Mediated Overexpression of HOXB4. Blood 2008, 112: 4484. DOI: 10.1182/blood.v112.11.4484.4484.Peer-Reviewed Original ResearchRetroviral integration sitesOverexpression of HOXB4Hematopoietic stem cellsIntegration sitesBone marrow cellsIntron 1Ability of HSCsIntrons of genesMurine bone marrow cellsEffect of knockdownNorthern blot analysisStem cell markers c-KitControl bone marrow cellsN-ras genePRDM16 geneLMO2 geneKb upstreamMRNA accumulationHOXB4Leukemic bone marrow cellsGFP retrovirusCombinatorial fashionGenesLeukemic cellsIntron 2