2021
TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use
Doulias P, Nakamura T, Scott H, McKercher S, Sultan A, Deal A, Albertolle M, Ischiropoulos H, Lipton S. TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use. Journal Of NeuroVirology 2021, 27: 367-378. PMID: 33876414, PMCID: PMC8477648, DOI: 10.1007/s13365-021-00970-4.Peer-Reviewed Original ResearchConceptsNeurocognitive disordersMeth usePathogenesis of HIVHuman postmortem brainAberrant protein S-nitrosylationCNS pathologyControl brainsSynaptic damageS-nitrosylationHIV-1Metabolic compromisePostmortem brainsMethamphetamine useNitric oxideDrug abuseRedox stressNitrosative stressBrainHIVProtein S-nitrosylationDisordersS-nitrosoproteomeSystematic inhibitionTCA cycle enzymesPathogenesis
2016
The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study
Marquine M, Montoya J, Umlauf A, Fazeli P, Gouaux B, Heaton R, Ellis R, Letendre S, Grant I, Moore D, Group F, Heaton R, Grant I, Atkinson J, Ellis R, Letendre S, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Letendre S, McCutchan J, Best B, Schrier R, Rosario D, Heaton R, Atkinson J, Woods S, Marcotte T, Cherner M, Moore D, Dawson M, Fennema-Notestine C, Buchsbaum M, Hesselink J, Archibald S, Brown G, Buxton R, Dale A, Liu T, Masliah E, Achim C, Smith D, Richman D, McCutchan J, Cherner M, Achim C, Lipton S, Atkinson J, Marquie-Beck J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study. Clinical Infectious Diseases 2016, 63: 694-702. PMID: 27199461, PMCID: PMC4981756, DOI: 10.1093/cid/ciw328.Peer-Reviewed Original ResearchConceptsVACS Index scoreVeterans Aging Cohort Study (VACS) IndexHigher VACS Index scoresVACS IndexNeurocognitive impairmentIndex scoreT-scoreNeurocognitive changesHIV Neurobehavioral Research ProgramStudy indicesIncident neurocognitive impairmentHuman immunodeficiency virusGlobal deficit scoreSubgroup of personsUpper quartile groupGlobal T-scoresLongitudinal neurocognitive changesCohort studyDeficit scoresImmunodeficiency virusLowest quartileNeurocognitive statusNeurocognitive functionDisease severityComprehensive neurocognitive batteryPill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults
Sheppard D, Weber E, Casaletto K, Avci G, Woods S, Grant I, Atkinson J, Ellis R, McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, Heaton R, Cherner M, Iudicello J, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, McCutchan J, Achim C, Lipton S, Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. Pill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults. Journal Of The Association Of Nurses In AIDS Care 2016, 27: 595-607. PMID: 27160771, PMCID: PMC4976032, DOI: 10.1016/j.jana.2016.03.006.Peer-Reviewed Original ResearchConceptsLow pill burdenPill burdenYoung HIVMedication Event Monitoring SystemHigh pill burdenAntiretroviral therapy adherenceEvent Monitoring SystemARV adherenceOlder HIVAntiretroviral adherenceTherapy adherenceHIVOlder groupAdherenceSuboptimal useHigher likelihoodBurdenTime-based prospective memoryMeasures of PMAdultsAssociationNonadherenceHealth-Related Everyday Functioning in the Internet Age: HIV-Associated Neurocognitive Disorders Disrupt Online Pharmacy and Health Chart Navigation Skills
Woods S, Iudicello J, Morgan E, Cameron M, Doyle K, Smith T, Cushman C, Group T, Grant I, Atkinson J, Ellis R, McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, Heaton R, Cherner M, Iudicello J, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, McCutchan J, Achim C, Lipton S, Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A, DeLuca J, Goverover Y, Franklin D, Corkran S. Health-Related Everyday Functioning in the Internet Age: HIV-Associated Neurocognitive Disorders Disrupt Online Pharmacy and Health Chart Navigation Skills. Archives Of Clinical Neuropsychology 2016, 31: 176-185. PMID: 26743327, PMCID: PMC4758381, DOI: 10.1093/arclin/acv090.Peer-Reviewed Original ResearchConceptsHealth-related behaviorsNeurocognitive disordersHigh plasma viral loadHIV-Associated Neurocognitive DisordersPlasma viral loadEffects of HIVLow health literacyImportant health-related behaviorsHIV infectionViral loadHealth literacyYears of educationOnline pharmaciesStudy participantsPharmacyDisordersFrequent Internet useParticipantsHealthcare managementSeronegativesHIVNavigation skillsInfectionIndividuals
2014
Self-Predictions of Prospective Memory in HIV-Associated Neurocognitive Disorders: Evidence of a Metamemory Deficit
Casaletto K, Doyle K, Weber E, Woods S, Heaton R, Grant I, Atkinson J, Ellis R, Letendre S, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Letendre S, McCutchan J, Best B, Schrier R, Rosario D, Heaton R, Atkinson J, Woods S, Psy D, Marcotte T, Cherner M, Moore D, Dawson M, Fennema-Notestine C, Buchsbaum M, Hesselink J, Archibald S, Brown G, Buxton R, Dale A, Liu T, Masliah E, Achim C, Smith D, Richman D, McCutchan J, Cherner M, Achim C, Lipton S, Atkinson J, Marquie-Beck J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. Self-Predictions of Prospective Memory in HIV-Associated Neurocognitive Disorders: Evidence of a Metamemory Deficit. Archives Of Clinical Neuropsychology 2014, 29: 818-827. PMID: 25404005, PMCID: PMC4296161, DOI: 10.1093/arclin/acu061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS Dementia ComplexAwarenessFemaleHIV InfectionsHumansMaleMemory, EpisodicMiddle AgedSelf-AssessmentConceptsPM performancePM abilitiesProspective memoryPM functioningHand individualsCompensatory strategy useSelf-reported predictionGroup-level differencesEveryday lifeNeurocognitive disordersMetamemory deficitHIV-Associated Neurocognitive DisordersStrategy useExecutive dysfunctionSelf-PredictionPossible deficitsDaily functioningModerate deficitsHand groupPM symptomsOverconfidenceAntiretroviral nonadherenceFunctioningDeficitsMemoryShallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection
Fazeli P, Doyle K, Scott J, Iudicello J, Casaletto K, Weber E, Moore D, Morgan E, Grant I, Woods S, Hampton Atkinson J, Ellis R, Allen McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Allen McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, LeBlanc S, Heaton R, Woods S, Cherner M, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, Allen McCutchan J, Achim C, Lipton S, Hampton Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. Shallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection. Archives Of Clinical Neuropsychology 2014, 29: 278-288. PMID: 24695591, PMCID: PMC4000232, DOI: 10.1093/arclin/acu009.Peer-Reviewed Original ResearchConceptsCalifornia Verbal Learning Test-Second EditionMemory deficitsIADL dependenceReal-world functioningLogical Memory subtestInstrumental activitiesMemory subtestsShallow encodingRecency effectMemory predictorsDaily livingOlder adultsWorse performanceForgettingOlder groupEncodingOlder HIVADL questionnaireHIV infectionRisk factorsDeficitsHIVAdultsSubtestsYounger cohorts
2011
Are Time- and Event-based Prospective Memory Comparably Affected in HIV Infection?â€
Zogg J, Woods S, Weber E, Doyle K, Grant I, Group T, Atkinson J, Ellis R, McCutchan J, Marcotte T, Hale B, Ellis R, McCutchan J, Letendre S, Capparelli E, Schrier R, Heaton R, Cherner M, Moore D, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Everall I, Langford T, Richman D, Smith D, McCutchan J, Everall I, Lipton S, McCutchan J, Atkinson J, Ellis R, Letendre S, Atkinson J, von Jaeger R, Gamst A, Cushman C, Masys D, Abramson I, Ake C, Vaida F. Are Time- and Event-based Prospective Memory Comparably Affected in HIV Infection?†. Archives Of Clinical Neuropsychology 2011, 26: 250-259. PMID: 21459901, PMCID: PMC3081684, DOI: 10.1093/arclin/acr020.Peer-Reviewed Original ResearchConceptsEvent-based ProMIntentions Screening TestTime-based tasksEvent-based tasksMulti-process theoryTrend-level effectsProspective memoryCue typesCognitive architectureAttention/Executive functionVerbal fluencyPrefrontal systemsSubset of participantsStrategic monitoringParallel subscalesGreater deficitsRetrieval processStrategic processMemoryMain effectNeurocognitive disordersTaskDeficitsPrior studies
2005
HIV leucoencephalopathy and TNFα expression in neurones
Rostasy K, Monti L, Lipton S, Hedreen J, Gonzalez R, Navia B. HIV leucoencephalopathy and TNFα expression in neurones. Journal Of Neurology Neurosurgery & Psychiatry 2005, 76: 960. PMID: 15965202, PMCID: PMC1739718, DOI: 10.1136/jnnp.2004.036889.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS Dementia ComplexAnti-Retroviral AgentsBasal GangliaBiopsyBrainDiffusion Magnetic Resonance ImagingDisease ProgressionFollow-Up StudiesFrontal LobeHIV Envelope Protein gp41HumansMacrophagesMaleMicrogliaMiddle AgedNeurologic ExaminationNeuronsNeuropsychological TestsSaquinavirStavudineTreatment OutcomeTumor Necrosis Factor-alphaZidovudineConceptsAIDS dementia complexPathogenesis of ADCImaging studiesMicroglia/macrophage activationProgressive formDeep white matter changesMicroglia/macrophagesExpression of TNFalphaWhite matter changesNecrosis factor alphaMeans of immunohistochemistryViral protein expressionNeuroradiological featuresAntiretroviral treatmentHIV infectionThird patientBrain biopsyProgressive dementiaDementia complexTreatment regimensBasal gangliaClinical historyFactor alphaTNFα expressionFrontal cortex
1998
A phase I/II trial of nimodipine for HIV-related neurologic complications
Navia B, Dafni U, Simpson D, Tucker T, Singer E, McArthur J, Yiannoutsos C, Zaborski L, Lipton S. A phase I/II trial of nimodipine for HIV-related neurologic complications. Neurology 1998, 51: 221-228. PMID: 9674806, DOI: 10.1212/wnl.51.1.221.Peer-Reviewed Original ResearchConceptsAIDS dementia complexVoltage-dependent calcium channel antagonistsPhase I/II trialSevere AIDS-dementia complexHigh-dose armPhase II studyFurther clinical trialsCalcium channel antagonistsNPZ-8Adjuvant treatmentAntiretroviral therapyII trialNeurologic complicationsNeuropsychological z scoresNeuronal injuryHIV infectionPeripheral neuropathyTreat analysisCSF levelsDementia complexImmune activationClinical trialsNeurologic disordersChannel antagonistsPossible efficacy
1990
A syndrome of asymmetric limb weakness with motor conduction block.
Krarup C, Stewart J, Sumner A, Pestronk A, Lipton S. A syndrome of asymmetric limb weakness with motor conduction block. Neurology 1990, 40: 118-27. PMID: 2296357, DOI: 10.1212/wnl.40.1.118.Peer-Reviewed Original ResearchConceptsAsymmetric limb weaknessLimb weaknessConduction studiesConduction blockMotor nerve conduction studiesImmune suppressive therapySame nerve segmentAnti-GM1 antibodiesMotor conduction blockNerve conduction studiesSensory conduction studiesSural nerve biopsyAsialo-GM1 antibodyNormal cranial nervesSuppressive therapyNerve biopsyNerve segmentsMotor fibersCranial nervesSensory abnormalitiesPatientsSelective involvementMinimal improvementElevated levelsHigh levels
1986
Prevention of classic migraine headache by digital massage of the superficial temporal arteries during visual aura
Lipton S. Prevention of classic migraine headache by digital massage of the superficial temporal arteries during visual aura. Annals Of Neurology 1986, 19: 515-516. PMID: 3717913, DOI: 10.1002/ana.410190521.Peer-Reviewed Original Research
1984
Candidal infection in the central nervous system
Lipton S, Hickey W, Morris J, Loscalzo J. Candidal infection in the central nervous system. The American Journal Of Medicine 1984, 76: 101-108. PMID: 6691350, DOI: 10.1016/0002-9343(84)90757-5.Peer-Reviewed Original ResearchConceptsMycotic aneurysmCandidal infectionAntemortem diagnosisAmphotericin BCentral nervous system involvementCentral nervous system candidiasisPercent of patientsCerebrospinal fluid examinationNervous system involvementCentral nervous systemCerebral mycosisInadequate eradicationMeningeal formCerebral involvementParenchymal infectionFluid examinationUnrecognized lesionsDrug therapySystem involvementCerebral vesselsFungus ballRisk factorsDisease entityEarly diagnosisSignificant incidence