2001
Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor
Choi Y, Chen H, Lipton S. Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor. Journal Of Neuroscience 2001, 21: 392-400. PMID: 11160420, PMCID: PMC6763802, DOI: 10.1523/jneurosci.21-02-00392.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCells, CulturedCysteineDithiothreitolDose-Response Relationship, DrugDrug SynergismGlycineHistidineMesylatesMutagenesis, Site-DirectedN-MethylaspartateOocytesOxidation-ReductionPatch-Clamp TechniquesReceptors, N-Methyl-D-AspartateStructure-Activity RelationshipSulfhydryl ReagentsTransfectionXenopusZinc
1999
Signaling Events in NMDA Receptor‐Induced Apoptosis in Cerebrocortical Cultures
BUDD S, LIPTON S. Signaling Events in NMDA Receptor‐Induced Apoptosis in Cerebrocortical Cultures. Annals Of The New York Academy Of Sciences 1999, 893: 261-264. PMID: 10672244, DOI: 10.1111/j.1749-6632.1999.tb07832.x.Peer-Reviewed Original Research
1997
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor
Lipton S, Kim W, Choi Y, Kumar S, D’Emilia D, Rayudu P, Arnelle D, Stamler J. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 5923-5928. PMID: 9159176, PMCID: PMC20882, DOI: 10.1073/pnas.94.11.5923.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAdultAnimalsCells, CulturedCerebral CortexChildDizocilpine MaleateEmbryo, MammalianEvoked PotentialsGlycineHomocysteineHumansKineticsKynurenic AcidNeuronsNeurotoxinsN-MethylaspartateRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateConceptsN-methyl-D-aspartate receptorsGlycine coagonist siteHomocysteine neurotoxicityNeuronal damageHead traumaVascular diseaseTotal homocysteineNeurotoxic concentrationsGlycine levelsCoagonist siteNeuroprotective activityCoagulation systemNervous systemDisease pathogenesisPartial antagonistExcessive Ca2HomocysteineAdverse effectsElevated levelsPathological conditionsDual actionVessel wallReceptorsReactive oxygen generationPathogenesis
1995
Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells
Pan Z, Bahring R, Grantyn R, Lipton. Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells. Journal Of Neuroscience 1995, 15: 1384-1391. PMID: 7869105, PMCID: PMC6577822, DOI: 10.1523/jneurosci.15-02-01384.1995.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsRat retinal ganglion cellsGlycine-evoked currentsGanglion cellsInhibitory neurotransmissionSingle retinal ganglion cellsInhibitory neurotransmitter systemsWhole-cell recordingsInhibitory receptor systemsModulatory systemAction of glutathioneNeurotransmitter systemsReceptor stimulationMammalian CNSMammalian retinaSingle agentEndogenous redox agentsReceptor systemPatch pipetteGABADifferential modulationGABAANeurotransmissionRetinaExtracellular glutathione
1992
l-Homocysteic acid selectively activates N-methyl-d-aspartate receptors of rat retinal ganglion cells
Zhang D, Lipton S. l-Homocysteic acid selectively activates N-methyl-d-aspartate receptors of rat retinal ganglion cells. Neuroscience Letters 1992, 139: 173-177. PMID: 1351663, DOI: 10.1016/0304-3940(92)90545-i.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsGanglion cellsRat RGCsN-methyl-D-aspartate receptorsNMDA receptor-channel complexConcentrations of NMDAL-homocysteic acidWhole-cell recordingsReceptor-channel complexRetinal transmittersMaximal responseHomocysteic acidNMDAPatch electrodePossible roleMillimolar concentrationsHCACellsReceptorsResponse
1991
Redox modulatory site of the NMDA receptor–channel complex: Regulation by oxidized glutathione
Sucher N, Lipton S. Redox modulatory site of the NMDA receptor–channel complex: Regulation by oxidized glutathione. Journal Of Neuroscience Research 1991, 30: 582-591. PMID: 1666131, DOI: 10.1002/jnr.490300316.Peer-Reviewed Original ResearchConceptsRedox modulatory siteNMDA receptor-channel complexReceptor-channel complexModulatory siteNMDA responsesFura-2 digital imagingRetinal ganglion cell neuronsWhole-cell current responsesPatch-clamp recording techniquesGanglion cell neuronsCo-agonist glycineIntracellular calcium concentrationCultures of ratNMDA subtypeNMDA receptorsGlutamate receptorsCell neuronsHigh extracellularExtracellular applicationComplete recoveryCalcium concentrationFurther decrementRecording techniquesPredominant actionNMDA
1988
Characterization of GABA- and glycine-induced currents of solitary rodent retinal ganglion cells in culture
Tauck D, Frosch M, Lipton S. Characterization of GABA- and glycine-induced currents of solitary rodent retinal ganglion cells in culture. Neuroscience 1988, 27: 193-203. PMID: 3200439, DOI: 10.1016/0306-4522(88)90230-8.Peer-Reviewed Original ResearchConceptsGanglion cellsBicuculline methiodideRodent retinal ganglion cellsReversal potentialRetinal ganglion cellsWhole-cell recordingsAgonist-induced currentsRodent retinaD-tubocurarineMicroM GABAMicroM glycineReceptor desensitizationGABAPatch electrodeDesensitizationStrychnineMembrane conductancePicrotoxininMethiodideTaurineCellsSolitary cellsSpace clampTissue cultureResponse