1996
Elevated Glutamate Levels in the Vitreous Body of Humans and Monkeys With Glaucoma
Dreyer E, Zurakowski D, Schumer R, Podos S, Lipton S. Elevated Glutamate Levels in the Vitreous Body of Humans and Monkeys With Glaucoma. JAMA Ophthalmology 1996, 114: 299-305. PMID: 8600890, DOI: 10.1001/archopht.1996.01100130295012.Peer-Reviewed Original ResearchConceptsExcitatory amino acid glutamateRetinal ganglion cellsAmino acid glutamateVitreous bodyGlaucomatous eyesGanglion cellsGlutamate levelsRetinal ganglion cell neuronsOptic nerve damageGroup of patientsElevated glutamate levelsGanglion cell neuronsLevels of glutamateEyes of monkeysNerve damageControl eyesVisual dysfunctionNonglaucomatous eyesCataract extractionPosterior capsuleInadvertent ruptureDisease processGlaucomaCell neuronsPatients
1991
N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro
Sucher N, Aizenman E, Lipton. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. Journal Of Neuroscience 1991, 11: 966-971. PMID: 1672708, PMCID: PMC6575374, DOI: 10.1523/jneurosci.11-04-00966.1991.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsNMDA receptorsGanglion cellsEndogenous GluKA receptorsSpecific NMDA receptor antagonistN-methyl-D-aspartate antagonistsRetinal ganglion cell deathRat retinal ganglion cellsDoses of NMDAGanglion cell deathSpecific NMDA antagonistNMDA receptor antagonistOwn specific receptorsPatch-clamp electrophysiology experimentsAddition of kainateMicroM kainateKainate neurotoxicityReceptor antagonistNMDA antagonistsKainateCellular injuryExogenous glutamateSpecific receptorsDetectable inhibitionCryopreservation of postnatal rat retinal ganglion cells: Persistence of voltage- and ligand-gated ionic currents
Sucher N, Cheng T, Lipton S. Cryopreservation of postnatal rat retinal ganglion cells: Persistence of voltage- and ligand-gated ionic currents. Neuroscience 1991, 43: 135-150. PMID: 1717883, DOI: 10.1016/0306-4522(91)90423-l.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsPostnatal rat retinal ganglion cellsOutward currentsRat retinal ganglion cellsCultured retinal ganglion cellsTetraethylammonium-sensitive currentPostnatal retinal ganglion cellsInhibitory amino acidsRetinal cell suspensionsWhole-cell modePatch-clamp techniqueWhole-cell configurationBicuculline methiodideMicroM tetrodotoxinChloride-selective currentsPharmacological sensitivityPotassium currentMicroM Cd2Prolonged time courseAction potentialsProlonged componentsVoltage protocolsSignificant differencesTime course
1988
Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat.
Aizenman E, Frosch M, Lipton S. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. The Journal Of Physiology 1988, 396: 75-91. PMID: 2842491, PMCID: PMC1192034, DOI: 10.1113/jphysiol.1988.sp016951.Peer-Reviewed Original ResearchConceptsNon-desensitizing currentsDesensitizing componentGanglion cellsInward currentsExcitatory amino acid receptorsExcitatory amino acid responsesAgonist concentrationsWhole-cell voltage-clamp techniqueAmino acid receptorsL-glutamate responsesRetinal ganglion cellsHigh agonist concentrationsAmino acid responsesVoltage-clamp techniqueMicroM kynurenateQuisqualate responseMicroM kainateNMDA responsesNMDA currentsRat retinaAgonist doseQuisqualateAcid receptorsPharmacological propertiesAcid response