2001
Chapter 51 Retinal ganglion cells, glaucoma and neuroprotection
Lipton S. Chapter 51 Retinal ganglion cells, glaucoma and neuroprotection. Progress In Brain Research 2001, 131: 713-718. PMID: 11420983, DOI: 10.1016/s0079-6123(01)31055-5.Peer-Reviewed Original Research
1998
Calcium, free radicals and excitotoxins in neuronal apoptosis
Lipton S, Nicotera P. Calcium, free radicals and excitotoxins in neuronal apoptosis. Cell Calcium 1998, 23: 165-171. PMID: 9601612, DOI: 10.1016/s0143-4160(98)90115-4.Peer-Reviewed Original Research
1995
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton S. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 7162-7166. PMID: 7638161, PMCID: PMC41299, DOI: 10.1073/pnas.92.16.7162.Peer-Reviewed Original ResearchConceptsForm of neurotoxicityN-methyl-D-aspartate receptor-mediated neurotoxicityCell damageChronic neurologic disordersNeuronal cell damageCortical cell culturesFinal common pathwayNitric oxide/Superoxide dismutaseS-nitrosocysteineAIDS dementiaNecrotic cell damageFocal ischemiaAcute swellingInitial insultCortical neuronsNeurologic disordersAlzheimer's diseaseNitric oxideNMDANeurodegenerative diseasesHuntington's diseaseIntense exposureNeurotoxicityCommon pathway
1993
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
Lipton S, Choi Y, Pan Z, Lei S, Chen H, Sucher N, Loscalzo J, Singel D, Stamler J. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 1993, 364: 626-632. PMID: 8394509, DOI: 10.1038/364626a0.Peer-Reviewed Original ResearchConceptsNitrogen monoxideRedox-based mechanismComplex redox chemistryS-nitrosylationRedox milieuRedox versatilityRedox chemistryAlternative redox statesNitrosonium ionReceptor thiolsRedox stateNeurotoxic speciesNMDA receptor activityReceptor activationNMDA receptor activationReactionFormation of peroxynitriteThiols