2022
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging
Cabral‐Miranda F, Tamburini G, Martinez G, Ardiles A, Medinas D, Gerakis Y, Hung M, Vidal R, Fuentealba M, Miedema T, Duran‐Aniotz C, Diaz J, Ibaceta‐Gonzalez C, Sabusap C, Bermedo‐Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi S, Lipton S, Kennedy B, Henriquez J, Cárdenas J, Plate L, Palacios A, Hetz C. Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. The EMBO Journal 2022, 41: embj2022111952. PMID: 36314651, PMCID: PMC9670206, DOI: 10.15252/embj.2022111952.Peer-Reviewed Original ResearchConceptsUnfolded protein responseER stress sensor IRE1Stress sensor IRE1IRE1/XBP1 signalingTranscription factor XBP1Mammalian brain agingNeurodegenerative diseasesProteostasis networkEndoplasmic reticulum stressProteomic profilingProtein responseCell senescenceGenetic disruptionBrain agingXBP1 expressionReticulum stressMammalian brainMajor risk factorActive formHealthy brain agingSynaptic functionXBP1Age-related cognitive declinePathwayHippocampal tissue
2016
The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study
Marquine M, Montoya J, Umlauf A, Fazeli P, Gouaux B, Heaton R, Ellis R, Letendre S, Grant I, Moore D, Group F, Heaton R, Grant I, Atkinson J, Ellis R, Letendre S, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Letendre S, McCutchan J, Best B, Schrier R, Rosario D, Heaton R, Atkinson J, Woods S, Marcotte T, Cherner M, Moore D, Dawson M, Fennema-Notestine C, Buchsbaum M, Hesselink J, Archibald S, Brown G, Buxton R, Dale A, Liu T, Masliah E, Achim C, Smith D, Richman D, McCutchan J, Cherner M, Achim C, Lipton S, Atkinson J, Marquie-Beck J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study. Clinical Infectious Diseases 2016, 63: 694-702. PMID: 27199461, PMCID: PMC4981756, DOI: 10.1093/cid/ciw328.Peer-Reviewed Original ResearchConceptsVACS Index scoreVeterans Aging Cohort Study (VACS) IndexHigher VACS Index scoresVACS IndexNeurocognitive impairmentIndex scoreT-scoreNeurocognitive changesHIV Neurobehavioral Research ProgramStudy indicesIncident neurocognitive impairmentHuman immunodeficiency virusGlobal deficit scoreSubgroup of personsUpper quartile groupGlobal T-scoresLongitudinal neurocognitive changesCohort studyDeficit scoresImmunodeficiency virusLowest quartileNeurocognitive statusNeurocognitive functionDisease severityComprehensive neurocognitive battery
2014
Shallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection
Fazeli P, Doyle K, Scott J, Iudicello J, Casaletto K, Weber E, Moore D, Morgan E, Grant I, Woods S, Hampton Atkinson J, Ellis R, Allen McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Allen McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, LeBlanc S, Heaton R, Woods S, Cherner M, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, Allen McCutchan J, Achim C, Lipton S, Hampton Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. Shallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection. Archives Of Clinical Neuropsychology 2014, 29: 278-288. PMID: 24695591, PMCID: PMC4000232, DOI: 10.1093/arclin/acu009.Peer-Reviewed Original ResearchConceptsCalifornia Verbal Learning Test-Second EditionMemory deficitsIADL dependenceReal-world functioningLogical Memory subtestInstrumental activitiesMemory subtestsShallow encodingRecency effectMemory predictorsDaily livingOlder adultsWorse performanceForgettingOlder groupEncodingOlder HIVADL questionnaireHIV infectionRisk factorsDeficitsHIVAdultsSubtestsYounger cohorts
2001
Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging
Le D, Lipton S. Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging. Drugs & Aging 2001, 18: 717-724. PMID: 11735619, DOI: 10.2165/00002512-200118100-00001.Peer-Reviewed Original ResearchConceptsReceptor antagonistN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate (NMDA) receptor complexSafe NMDA antagonistMultiple clinical trialsNMDA receptor antagonistChronic painClinical trialsNMDA antagonistsGlutamate receptorsParkinson's diseaseNeurological disordersNeurodegenerative diseasesDiseaseAdverse effectsAntagonistReceptor complexCurrent useDrugsAdequate levelPainMemantineDysfunctionNitroglycerinStroke
1995
Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
Sucher N, Akbarian S, Chi C, Leclerc C, Awobuluyi M, Deitcher D, Wu M, Yuan J, Jones E, Lipton. Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain. Journal Of Neuroscience 1995, 15: 6509-6520. PMID: 7472413, PMCID: PMC6578025, DOI: 10.1523/jneurosci.15-10-06509.1995.Peer-Reviewed Original ResearchConceptsLateral olfactory tractLayer VOlfactory tractEntorhinal cortexRegional expression patternsPostnatal day 1NMDA receptor subunitsFunction of NMDARsGlutamate-activated channelsCA1 fieldInferior colliculiRodent CNSAdult brainLayers IIDay 1Triple combinationRodent brainAxonal outgrowthMRNA expressionReceptor subunitsBrain developmentNMDARSubiculumExpression patternsNeocortex