1997
Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice
Le D, Das S, Wang Y, Yoshizawa T, Sasaki Y, Takasu M, Nemes A, Mendelsohn M, Dikkes P, Lipton S, Nakanishi N. Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice. Brain Research 1997, 52: 235-241. PMID: 9495544, DOI: 10.1016/s0169-328x(97)00261-1.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsBrainCell DeathCerebral CortexCrosses, GeneticDisease SusceptibilityFemaleGenetic VariationHeterozygoteIschemic Attack, TransientMaleMiceMice, Inbred C57BLMice, Inbred CBAMice, TransgenicNeocortexNeuronsPolymerase Chain ReactionReceptors, AMPATranscription, GeneticConceptsNeuronal cell deathMiddle cerebral arteryWild-type neuronsTransgenic miceAMPA receptorsCerebral ischemiaFocal ischemiaGluR2 flipExcitatory amino acid receptorsCell deathAcute cerebral ischemiaGlobal cerebral ischemiaAmino acid receptorsAMPAR-mediated currentsGlutamate receptor antagonistsPermanent focal ischemiaGenetic mouse modelsWild-type controlsExcitotoxic damageEAA receptorsLarge infarctionCerebral arteryFocal strokeGlutamate excitotoxicityNeuronal death
1995
Assignment of Human Myocyte-Specific Enhancer Binding Factor 2C (hMEF2C) to Human Chromosome 5q14 and Evidence That MEF2C Is Evolutionarily Conserved
Krainc D, Haas M, Ward D, Lipton S, Bruns G, Leifer D. Assignment of Human Myocyte-Specific Enhancer Binding Factor 2C (hMEF2C) to Human Chromosome 5q14 and Evidence That MEF2C Is Evolutionarily Conserved. Genomics 1995, 29: 809-811. PMID: 8575784, DOI: 10.1006/geno.1995.9927.Peer-Reviewed Original ResearchAnimalsBase SequenceBiological EvolutionBrainChromosome MappingChromosomes, Human, Pair 5Conserved SequenceDNA PrimersDNA-Binding ProteinsGene LibraryHumansHybrid CellsKaryotypingMADS Domain ProteinsMammalsMEF2 Transcription FactorsMolecular Sequence DataMyogenic Regulatory FactorsPolymerase Chain ReactionRestriction MappingRodentiaTranscription FactorsDevelopmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
Sucher N, Akbarian S, Chi C, Leclerc C, Awobuluyi M, Deitcher D, Wu M, Yuan J, Jones E, Lipton. Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain. Journal Of Neuroscience 1995, 15: 6509-6520. PMID: 7472413, PMCID: PMC6578025, DOI: 10.1523/jneurosci.15-10-06509.1995.Peer-Reviewed Original ResearchConceptsLateral olfactory tractLayer VOlfactory tractEntorhinal cortexRegional expression patternsPostnatal day 1NMDA receptor subunitsFunction of NMDARsGlutamate-activated channelsCA1 fieldInferior colliculiRodent CNSAdult brainLayers IIDay 1Triple combinationRodent brainAxonal outgrowthMRNA expressionReceptor subunitsBrain developmentNMDARSubiculumExpression patternsNeocortexCo-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells
Zhang D, Sucher N, Lipton S. Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells. Neuroscience 1995, 67: 177-188. PMID: 7477898, DOI: 10.1016/0306-4522(94)00627-h.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsD-aspartate receptorsReceptor-operated channelsGanglion cellsWhole-cell currentsPermeable AMPA/kainate channelsAMPA/kainate channelsLow Ca2Only permeant cationExtracellular solutionPatch-clamp techniqueSecond groupFirst groupKainate channelsFlop splice variantsPolymerase chain reactionGlutamate receptorsConcentrations of AMPAPattern of expressionReceptorsChain reactionSole charge carrierCurrent-voltage relationshipPredominant expression
1993
Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells.
Sucher N, Brose N, Deitcher D, Awobuluyi M, Gasic G, Bading H, Cepko C, Greenberg M, Jahn R, Heinemann S, Lipton S. Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. Journal Of Biological Chemistry 1993, 268: 22299-22304. PMID: 8226739, DOI: 10.1016/s0021-9258(18)41528-1.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsAstrocytesBase SequenceCell DifferentiationCell LineCells, CulturedDimethylphenylpiperazinium IodideDNA PrimersGene ExpressionGene Expression Regulation, NeoplasticGenetic VariationHippocampusHumansKidneyMacromolecular SubstancesMembrane PotentialsMolecular Sequence DataMolecular WeightNerve Growth FactorsN-MethylaspartatePC12 CellsPolymerase Chain ReactionReceptors, N-Methyl-D-AspartateRNA, MessengerSynaptic MembranesTranscription, GeneticTransfectionConceptsNMDAR1 proteinPC12 cellsPost-transcriptional controlPost-transcriptional mechanismsNative PC12 cellsParticular cell typeUndifferentiated rat pheochromocytoma (PC12) cellsExpression of RNAPC12 cell lineTranslational regulationIsoform CRat pheochromocytoma cellsNorthern hybridizationExpression vectorReceptor proteinCell typesIon channelsProteinFunctional NMDACell linesPheochromocytoma cellsCytomegalovirus promoterModel systemRNAExpressionhMEF2C gene encodes skeletal muscle- and brain-specific transcription factors.
McDermott J, Cardoso M, Yu Y, Andres V, Leifer D, Krainc D, Lipton S, Nadal-Ginard B. hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Molecular And Cellular Biology 1993, 13: 2564-2577. PMID: 8455629, PMCID: PMC359588, DOI: 10.1128/mcb.13.4.2564.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAmino Acid SequenceAnimalsBase SequenceBrainCells, CulturedCloning, MolecularConsensus SequenceDNA-Binding ProteinsGene ExpressionGenesHumansImmunologic TechniquesIn Vitro TechniquesMEF2 Transcription FactorsMiceMolecular Sequence DataMusclesMyogenic Regulatory FactorsNeuronsOligodeoxyribonucleotidesPolymerase Chain ReactionRNA, MessengerSequence AlignmentTissue DistributionTranscription FactorsTranscription, GeneticConceptsSkeletal muscleSubset of neuronsCortical neuronsBrain-specific transcription factorTranscription factorsMRNA levelsPotential targetTrans-activating activityMuscleMEF2 transcription factorsNeuronsBrainBrain transcriptsMEF2 factorsMuscle-specific enhancerExpressionMyogenic differentiationTissue-specific isoformsUbiquitous expressionFactorsTissue-specific patternsGenesNeurogenesis