2001
Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor
Choi Y, Chen H, Lipton S. Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor. Journal Of Neuroscience 2001, 21: 392-400. PMID: 11160420, PMCID: PMC6763802, DOI: 10.1523/jneurosci.21-02-00392.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCells, CulturedCysteineDithiothreitolDose-Response Relationship, DrugDrug SynergismGlycineHistidineMesylatesMutagenesis, Site-DirectedN-MethylaspartateOocytesOxidation-ReductionPatch-Clamp TechniquesReceptors, N-Methyl-D-AspartateStructure-Activity RelationshipSulfhydryl ReagentsTransfectionXenopusZinc
1998
Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
Das S, Sasaki Y, Rothe T, Premkumar L, Takasu M, Crandall J, Dikkes P, Conner D, Rayudu P, Cheung W, Chen H, Lipton S, Nakanishi N. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 1998, 393: 377-381. PMID: 9620802, DOI: 10.1038/30748.Peer-Reviewed Original ResearchConceptsNMDA receptorsReceptor subunit NR1Synaptic refinementSpine densityNMDA receptor subunit NR3ANMDA responsesNMDA subclassSmall unitary conductanceNMDAR activitySubunit NR1NMDAR subunitsCerebrocortical neuronsDendritic spinesSynaptic plasticityNR1 subunitMice resultsSingle-channel recordingsGenetic knockoutSynaptic elementsHeteromultimeric channelsNR1NR3AXenopus oocytesUnitary conductanceNMDACloning and characterization of mouse GABAC receptor subunits
Greka A, Koolen J, Lipton S, Zhang D. Cloning and characterization of mouse GABAC receptor subunits. Neuroreport 1998, 9: 229-232. PMID: 9507960, DOI: 10.1097/00001756-199801260-00010.Peer-Reviewed Original Research
1995
Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
Sucher N, Akbarian S, Chi C, Leclerc C, Awobuluyi M, Deitcher D, Wu M, Yuan J, Jones E, Lipton. Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain. Journal Of Neuroscience 1995, 15: 6509-6520. PMID: 7472413, PMCID: PMC6578025, DOI: 10.1523/jneurosci.15-10-06509.1995.Peer-Reviewed Original ResearchConceptsLateral olfactory tractLayer VOlfactory tractEntorhinal cortexRegional expression patternsPostnatal day 1NMDA receptor subunitsFunction of NMDARsGlutamate-activated channelsCA1 fieldInferior colliculiRodent CNSAdult brainLayers IIDay 1Triple combinationRodent brainAxonal outgrowthMRNA expressionReceptor subunitsBrain developmentNMDARSubiculumExpression patternsNeocortex
1994
Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor
Sullivan J, Traynelis S, Chen H, Escobar W, Heinemann S, Lipton S. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron 1994, 13: 929-936. PMID: 7524561, DOI: 10.1016/0896-6273(94)90258-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCysteineDithiothreitolElectrophysiologyFemaleIon Channel GatingIon ChannelsMolecular Sequence DataMutagenesis, Site-DirectedN-MethylaspartateOocytesOxidation-ReductionPatch-Clamp TechniquesRatsReceptors, N-Methyl-D-AspartateRecombinant ProteinsSpermineStructure-Activity RelationshipXenopus