2001
Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor
Choi Y, Chen H, Lipton S. Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor. Journal Of Neuroscience 2001, 21: 392-400. PMID: 11160420, PMCID: PMC6763802, DOI: 10.1523/jneurosci.21-02-00392.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCells, CulturedCysteineDithiothreitolDose-Response Relationship, DrugDrug SynergismGlycineHistidineMesylatesMutagenesis, Site-DirectedN-MethylaspartateOocytesOxidation-ReductionPatch-Clamp TechniquesReceptors, N-Methyl-D-AspartateStructure-Activity RelationshipSulfhydryl ReagentsTransfectionXenopusZinc
1995
Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block.
Zhang D, Pan Z, Zhang X, Brideau A, Lipton S. Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11756-11760. PMID: 8524843, PMCID: PMC40481, DOI: 10.1073/pnas.92.25.11756.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceChloride ChannelsCloning, MolecularDose-Response Relationship, DrugDrug ResistanceElectric ConductivityGABA AntagonistsIon ChannelsMethionineMolecular Sequence DataMutagenesis, Site-DirectedPicrotoxinProtein ConformationRatsReceptors, GABARetinaSequence Homology, Amino AcidSesterterpenesStructure-Activity RelationshipConceptsGABAC responsesRat retinaRho 2 subunitsGamma-aminobutyric acidPTX resistanceHeteromeric receptorsReceptor subunitsFunctional homomeric receptorsRho 1 receptorsGABA receptor subunitsInhibitory neurotransmissionMechanism of blockGABA receptorsMammalian retinaConvulsant picrotoxininHomomeric receptorsRat receptorRetinaIonotropic receptorsReceptorsChannel blockPicrotoxininSecond membrane-spanning regionNative receptorPredominant determinant
1994
Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor
Sullivan J, Traynelis S, Chen H, Escobar W, Heinemann S, Lipton S. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron 1994, 13: 929-936. PMID: 7524561, DOI: 10.1016/0896-6273(94)90258-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCysteineDithiothreitolElectrophysiologyFemaleIon Channel GatingIon ChannelsMolecular Sequence DataMutagenesis, Site-DirectedN-MethylaspartateOocytesOxidation-ReductionPatch-Clamp TechniquesRatsReceptors, N-Methyl-D-AspartateRecombinant ProteinsSpermineStructure-Activity RelationshipXenopus