2004
Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond
Kaul M, Lipton S. Signaling pathways to neuronal damage and apoptosis in human immunodeficiency virus type 1-associated dementia: Chemokine receptors, excitotoxicity, and beyond. Journal Of NeuroVirology 2004, 10: 97-101. PMID: 14982746, DOI: 10.1080/753312759.Peer-Reviewed Original ResearchConceptsNeuronal damageChemokine receptorsN-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicityHuman immunodeficiency virus-1 (HIV-1) infectionHuman immunodeficiency virus type 1Immunodeficiency virus type 1Applicable therapeutic interventionReceptor-mediated excitotoxicityVirus-1 infectionVirus type 1HIV infectionInflammatory factorsHIV-1Therapeutic interventionsType 1Downstream mechanismsExcitotoxicityDementiaInfectionReceptorsNeuropathologyPathwayDamage
1995
Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease.
Bukrinsky M, Nottet H, Schmidtmayerova H, Dubrovsky L, Flanagan C, Mullins M, Lipton S, Gendelman H. Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. Journal Of Experimental Medicine 1995, 181: 735-745. PMID: 7530762, PMCID: PMC2191885, DOI: 10.1084/jem.181.2.735.Peer-Reviewed Original ResearchConceptsEffector cell functionInducible NO synthaseBrain tissueAIDS patientsHIV-1Human immunodeficiency virus (HIV) persistenceHuman immunodeficiency virus type 1Human monocytesNitric oxide synthase activityImmunodeficiency virus type 1HIV-macrophage interactionsPediatric AIDS patientsHIV-1 diseaseCell functionHIV-1 infectionMacrophage antigen presentationExpression of NOSOxide synthase activityVirus-infected macrophagesPostmortem brain tissueVirus type 1Productive viral replicationCultured human monocytesHIV encephalitisHIV replication
1994
AIDS‐Related Dementia and Calcium Homeostasisa
LIPTON S. AIDS‐Related Dementia and Calcium Homeostasisa. Annals Of The New York Academy Of Sciences 1994, 747: 205-224. PMID: 7847672, DOI: 10.1111/j.1749-6632.1994.tb44411.x.Peer-Reviewed Original ResearchConceptsNeuronal injuryN-methyl-D-aspartate (NMDA) receptor-operated channelsHuman immunodeficiency virus type 1Arachidonic acidHIV-1 envelope protein gp120Immunodeficiency virus type 1Existence of HIVDeath of neuronsBrains of patientsCalcium channel antagonistsVoltage-dependent Ca2Interleukin-1 betaReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisHalf of childrenEnvelope protein gp120Platelet-activating factorThird of adultsVirus type 1Dysfunction of cognitionGamma interferon stimulationNeuropathic painAIDS dementiaUpdate on current models of HIV-related neuronal injury: Platelet-activating factor, arachidonic acid and nitric oxide
Lipton S, Yeh M, Dreyer E. Update on current models of HIV-related neuronal injury: Platelet-activating factor, arachidonic acid and nitric oxide. Advances In Neuroimmunology 1994, 4: 181-188. PMID: 7874385, DOI: 10.1016/s0960-5428(06)80255-x.Peer-Reviewed Original ResearchConceptsMacrophages/microgliaNeuronal injuryPlatelet-activating factorArachidonic acidHuman immunodeficiency virus type 1Nitric oxideHIV-1 envelope protein gp120Immunodeficiency virus type 1N-methyl-D-aspartate agonistExistence of HIVBrains of patientsHalf of childrenEnvelope protein gp120Third of adultsVirus type 1Dysfunction of cognitionDemise of neuronsNeurological manifestationsImmunodeficiency syndromeAIDS patientsProtein gp120Neurotoxic substancesHIVMonocytoid cellsExcessive influx
1990
Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies.
Kaiser P, Offermann J, Lipton S. Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies. Neurology 1990, 40: 1757-61. PMID: 2234433, DOI: 10.1212/wnl.40.11.1757.Peer-Reviewed Original ResearchConceptsAnti-CD4 antibodiesNeuronal injuryHuman immunodeficiency virus type 1Retinal ganglion cell neuronsImmunodeficiency virus type 1Absence of superinfectionHIV-1 envelope proteinAnti-gp120 antibodiesGanglion cell neuronsRat T cellsForm of neurotoxicityVirus type 1Envelope proteinNeurologic manifestationsVisual lossImmunodeficiency syndromeCentral neuronsT cellsT lymphocytesHIV-1Protein gp120CD4 moleculeCell neuronsGp120Type 1HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists
Dreyer E, Kaiser P, Offermann J, Lipton S. HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists. Science 1990, 248: 364-367. PMID: 2326646, DOI: 10.1126/science.2326646.Peer-Reviewed Original ResearchConceptsCalcium channel antagonistsHuman immunodeficiency virus type 1Channel antagonistsIntracellular calciumNeuronal injuryDihydropyridine calcium channel antagonist nimodipineCalcium channel antagonist nimodipineImmunodeficiency virus type 1Rodent retinal ganglion cellsGp120-induced increaseChannel antagonist nimodipineRetinal ganglion cellsIntracellular free calciumDose-dependent fashionGp120 envelope proteinVirus type 1Envelope proteinAntagonist nimodipineControl immunoglobulinGanglion cellsHippocampal neuronsProtein gp120Viral envelope proteinsExtracellular calciumNeuronal toxicity