1998
Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
Das S, Sasaki Y, Rothe T, Premkumar L, Takasu M, Crandall J, Dikkes P, Conner D, Rayudu P, Cheung W, Chen H, Lipton S, Nakanishi N. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 1998, 393: 377-381. PMID: 9620802, DOI: 10.1038/30748.Peer-Reviewed Original ResearchConceptsNMDA receptorsReceptor subunit NR1Synaptic refinementSpine densityNMDA receptor subunit NR3ANMDA responsesNMDA subclassSmall unitary conductanceNMDAR activitySubunit NR1NMDAR subunitsCerebrocortical neuronsDendritic spinesSynaptic plasticityNR1 subunitMice resultsSingle-channel recordingsGenetic knockoutSynaptic elementsHeteromultimeric channelsNR1NR3AXenopus oocytesUnitary conductanceNMDA
1989
GABA-activated single channel currents in outside-out membrane patches from rat retinal ganglion cells
Lipton S. GABA-activated single channel currents in outside-out membrane patches from rat retinal ganglion cells. Visual Neuroscience 1989, 3: 275-279. PMID: 2487107, DOI: 10.1017/s0952523800010026.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGamma-aminobutyric acidGanglion cellsWhole-cell currentsMammalian retinal ganglion cellsRat retinal ganglion cellsLarge whole-cell currentsMammalian central nervous systemWhole-cell recordingsCentral nervous systemPatch-clamp methodInhibitory transmitterWhole-cell responsesNervous systemCell-free patchesNervous tissueGABAA channelsRapid rundownDesensitization kineticsSingle-channel recordingsChannel currentsSingle-channel currentsExcised patch configurationsSingle-channel eventsUnitary conductance
1987
Voltage‐dependent conductances of solitary ganglion cells dissociated from the rat retina.
Lipton S, Tauck D. Voltage‐dependent conductances of solitary ganglion cells dissociated from the rat retina. The Journal Of Physiology 1987, 385: 361-391. PMID: 2443669, PMCID: PMC1192350, DOI: 10.1113/jphysiol.1987.sp016497.Peer-Reviewed Original ResearchConceptsWhole-cell recordingsRetinal ganglion cellsGanglion cellsPatch pipetteMicroM TTXRat retinaAction potentialsMM TEASlow action potentialsPatch-clamp recordingsSingle-channel recordingsCentral mammalian neuronesConventional intracellular electrodesCurrent-clamp conditionsWhole-cell currentsVoltage-clamp experimentsIntracellular recordingsVoltage-clamp analysisPharmacological agentsExtracellular Ca2Inactivation time constantsMicroM Cd2Conventional intracellularElectrophysiological propertiesFast spikes