1998
NEURONAL INJURY ASSOCIATED WITH HIV-1: Approaches to Treatment
Lipton S. NEURONAL INJURY ASSOCIATED WITH HIV-1: Approaches to Treatment. The Annual Review Of Pharmacology And Toxicology 1998, 38: 159-177. PMID: 9597152, DOI: 10.1146/annurev.pharmtox.38.1.159.Peer-Reviewed Original ResearchConceptsNeuronal injuryNeuronal damageHIV-1-associated cognitive/motor complexN-methyl-D-aspartate (NMDA) receptor-operated channelsCognitive/motor complexAIDS dementia complexHIV-1 resultsHIV-1 infectionExistence of HIVBrains of patientsReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayPlatelet-activating factorFree radicalsAIDS dementiaReactive astrocytesDementia complexCognitive dysfunctionNMDA antagonistsExcessive activationNeuronal susceptibilityPharmacological interventionsHIV-1Excessive influx
1996
Similarity of Neuronal Cell Injury and Death in AIDS Dementia and Focal Cerebral Ischemia: Potential Treatment with NMDA Open‐Channel Blockers and Nitric Oxide‐Related Species
Lipton S. Similarity of Neuronal Cell Injury and Death in AIDS Dementia and Focal Cerebral Ischemia: Potential Treatment with NMDA Open‐Channel Blockers and Nitric Oxide‐Related Species. Brain Pathology 1996, 6: 507-517. PMID: 8944320, DOI: 10.1111/j.1750-3639.1996.tb00879.x.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaNeuronal cell deathAIDS dementiaNeuronal injuryCerebral ischemiaNeuronal damageCell injuryHIV-1-associated cognitive/motor complexN-methyl-D-aspartate (NMDA) receptor-operated channelsCognitive/motor complexNMDA open-channel blockersHIV-1 envelope protein gp120Cell deathHIV-1 resultsExistence of HIVNeuronal cell injuryReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayEnvelope protein gp120Platelet-activating factorFree radicalsOpen channel blockerAIDS brainsIschemic coreAIDS Dementia as a Form of Excitotoxicity: Potential Therapy with NMDA Open-Channel Blockers and Redox Congeners of Nitric Oxide
Lipton S. AIDS Dementia as a Form of Excitotoxicity: Potential Therapy with NMDA Open-Channel Blockers and Redox Congeners of Nitric Oxide. Gwumc Department Of Biochemistry And Molecular Biology Annual Spring Symposia 1996, 341-356. DOI: 10.1007/978-1-4899-0209-2_41.Peer-Reviewed Original ResearchRedox modulatory siteNMDA receptorsOpen channel blockerNeuronal injuryNeuronal damageN-methyl-D-aspartate (NMDA) receptor-operated channelsModulatory siteNMDA open-channel blockersNitric oxideHIV-1 envelope protein gp120Forms of excitotoxicityAIDS dementia complexHIV-1 resultsExcitatory amino acidsMacrophages/microgliaExistence of HIVReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisEnvelope protein gp120Platelet-activating factorReceptor/channel complexNormal neuronal functionNMDA receptor/channel complex
1995
Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells
Zhang D, Sucher N, Lipton S. Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells. Neuroscience 1995, 67: 177-188. PMID: 7477898, DOI: 10.1016/0306-4522(94)00627-h.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsD-aspartate receptorsReceptor-operated channelsGanglion cellsWhole-cell currentsPermeable AMPA/kainate channelsAMPA/kainate channelsLow Ca2Only permeant cationExtracellular solutionPatch-clamp techniqueSecond groupFirst groupKainate channelsFlop splice variantsPolymerase chain reactionGlutamate receptorsConcentrations of AMPAPattern of expressionReceptorsChain reactionSole charge carrierCurrent-voltage relationshipPredominant expression
1994
Neuronal Injury Associated with HIV-1 and Potential Treatment with Calcium-Channel and NMDA Antagonists
Lipton S. Neuronal Injury Associated with HIV-1 and Potential Treatment with Calcium-Channel and NMDA Antagonists. Developmental Neuroscience 1994, 16: 145-151. PMID: 7705221, DOI: 10.1159/000112101.Peer-Reviewed Original ResearchConceptsNMDA antagonistsHIV-1HIV-1 envelope protein gp120Existence of HIVBrains of patientsCalcium channel antagonistsVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisEnvelope protein gp120Platelet-activating factorDemise of neuronsInjury AssociatedAIDS dementiaNeuronal injuryGlutamate reuptakeNeurological manifestationsGlutamate releaseImmunodeficiency syndromeChannel antagonistsPharmacological interventionsProtein gp120Lateral sclerosisAIDS‐Related Dementia and Calcium Homeostasisa
LIPTON S. AIDS‐Related Dementia and Calcium Homeostasisa. Annals Of The New York Academy Of Sciences 1994, 747: 205-224. PMID: 7847672, DOI: 10.1111/j.1749-6632.1994.tb44411.x.Peer-Reviewed Original ResearchConceptsNeuronal injuryN-methyl-D-aspartate (NMDA) receptor-operated channelsHuman immunodeficiency virus type 1Arachidonic acidHIV-1 envelope protein gp120Immunodeficiency virus type 1Existence of HIVDeath of neuronsBrains of patientsCalcium channel antagonistsVoltage-dependent Ca2Interleukin-1 betaReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisHalf of childrenEnvelope protein gp120Platelet-activating factorThird of adultsVirus type 1Dysfunction of cognitionGamma interferon stimulationNeuropathic painAIDS dementiaHIV-related neuronal injury
Lipton S. HIV-related neuronal injury. Molecular Neurobiology 1994, 8: 181-196. PMID: 7999315, DOI: 10.1007/bf02780669.Peer-Reviewed Original ResearchConceptsArachidonic acidExistence of HIVCalcium channel antagonistsVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisPlatelet-activating factorDysfunction of cognitionDemise of neuronsNeuropathic painAdult patientsAIDS dementiaNeuronal injuryNeurological manifestationsNeuronal damageImmunodeficiency syndromeAIDS patientsChannel antagonistsNMDA antagonistsNeuronal susceptibilityPharmacological interventionsLateral sclerosisParkinson's diseaseCa2+, N-Methyl-d-Aspartate Receptors, and Aids-Related Neuronal Injury
Lipton S. Ca2+, N-Methyl-d-Aspartate Receptors, and Aids-Related Neuronal Injury. International Review Of Neurobiology 1994, 36: 1-27. PMID: 7822116, DOI: 10.1016/s0074-7742(08)60301-3.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate (NMDA) receptor-operated channelsN-methyl-D-aspartate receptorsHIV-1 envelope protein gp120Existence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisEnvelope protein gp120Demise of neuronsNeuronal injuryAIDS patientsNeuronal susceptibilityPharmacological interventionsProtein gp120Lateral sclerosisParkinson's diseaseMacrophage productionInduces releaseHIVNitric oxideNeurodegenerative diseasesDiseaseHuntington's disease
1992
Models of neuronal injury in AIDS: another role for the NMDA receptor?
Lipton S. Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends In Neurosciences 1992, 15: 75-79. PMID: 1373919, DOI: 10.1016/0166-2236(92)90013-x.Peer-Reviewed Original ResearchConceptsNMDA receptor-operated channelsExistence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayDysfunction of cognitionDemise of neuronsNeuronal injuryNeurological manifestationsNeuronal damageImmunodeficiency syndromeAIDS patientsNMDA receptorsNeuronal susceptibilityPharmacological interventionsType 1 resultsCommon pathwayNeuronsPatientsInjuryTwo-thirdsHIVDysfunctionEpilepsy
1991
Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture
Sucher N, Lei S, Lipton S. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Research 1991, 551: 297-302. PMID: 1680525, DOI: 10.1016/0006-8993(91)90944-q.Peer-Reviewed Original ResearchConceptsCalcium channel antagonistsRetinal ganglion cellsChannel antagonistsGanglion cellsPostnatal rat retinal ganglion cellsNMDA receptor-operated channelsRat retinal ganglion cellsNMDA receptor-mediated neurotoxicityVoltage-dependent calcium channelsSelective NMDA antagonistDihydropyridine calcium channel antagonistReceptor-operated channelsVoltage-dependent Ca2Patch-clamp recordingsNMDA antagonistsNMDA receptorsSubsequent toxic effectsCalcium channelsExogenous glutamateRetinal culturesAntagonistL-typeEarly riseInjurious effectsToxic effects
1990
Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons
Levy D, Sucher N, Lipton S. Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons. Neuroscience Letters 1990, 110: 291-296. PMID: 1970145, DOI: 10.1016/0304-3940(90)90862-4.Peer-Reviewed Original ResearchConceptsCentral neuronsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeNMDA receptor-mediated toxicityAmyotrophic lateral sclerosis-ParkinsonismAcute neurological injuryGlutamate-induced deathNMDA receptor sitesSurvival of neuronsRetinal ganglion cellsMammalian central neuronsReceptor-operated channelsChronic degenerative diseasesReceptor-mediated toxicityHypoxia-ischemiaNMDA neurotoxicityDementia complexNeurological injurySimilar pathogenesisGanglion cellsGlutamate receptorsEnhanced killingRedox modulationDegenerative diseasesHuntington's disease