1992
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
Lei S, Pan Z, Aggarwal S, Chen H, Hartman J, Sucher N, Lipton S. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron 1992, 8: 1087-1099. PMID: 1376999, DOI: 10.1016/0896-6273(92)90130-6.Peer-Reviewed Original Researchl-Homocysteic acid selectively activates N-methyl-d-aspartate receptors of rat retinal ganglion cells
Zhang D, Lipton S. l-Homocysteic acid selectively activates N-methyl-d-aspartate receptors of rat retinal ganglion cells. Neuroscience Letters 1992, 139: 173-177. PMID: 1351663, DOI: 10.1016/0304-3940(92)90545-i.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsGanglion cellsRat RGCsN-methyl-D-aspartate receptorsNMDA receptor-channel complexConcentrations of NMDAL-homocysteic acidWhole-cell recordingsReceptor-channel complexRetinal transmittersMaximal responseHomocysteic acidNMDAPatch electrodePossible roleMillimolar concentrationsHCACellsReceptorsResponse
1991
Redox modulatory site of the NMDA receptor–channel complex: Regulation by oxidized glutathione
Sucher N, Lipton S. Redox modulatory site of the NMDA receptor–channel complex: Regulation by oxidized glutathione. Journal Of Neuroscience Research 1991, 30: 582-591. PMID: 1666131, DOI: 10.1002/jnr.490300316.Peer-Reviewed Original ResearchConceptsRedox modulatory siteNMDA receptor-channel complexReceptor-channel complexModulatory siteNMDA responsesFura-2 digital imagingRetinal ganglion cell neuronsWhole-cell current responsesPatch-clamp recording techniquesGanglion cell neuronsCo-agonist glycineIntracellular calcium concentrationCultures of ratNMDA subtypeNMDA receptorsGlutamate receptorsCell neuronsHigh extracellularExtracellular applicationComplete recoveryCalcium concentrationFurther decrementRecording techniquesPredominant actionNMDAGlutathione prevents N -methyl-d-aspartate receptor-mediated neurotoxicity
Levy D, Sucher N, Lipton S. Glutathione prevents N -methyl-d-aspartate receptor-mediated neurotoxicity. Neuroreport 1991, 2: 345-347. PMID: 1832987, DOI: 10.1097/00001756-199106000-00011.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor-mediated neurotoxicityNMDA receptor-channel complexSafe NMDA antagonistNMDA receptor activationPossible therapeutic modalityReceptor-channel complexNeuronal damageNMDA antagonistsNMDA receptorsTherapeutic modalitiesExcessive stimulationNeurodegenerative conditionsReceptor activationExtracellular mechanismsAntagonistPresent studyGlutathioneNeuroprotectionNeurotoxicityStrokeN-methylTraumaBrainReceptors
1989
Selective modulation of NMDA responses by reduction and oxidation
Aizenman E, Lipton S, Loring R. Selective modulation of NMDA responses by reduction and oxidation. Neuron 1989, 2: 1257-1263. PMID: 2696504, DOI: 10.1016/0896-6273(89)90310-3.Peer-Reviewed Original Research